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Protein

Myosin light chain 6B

Gene

MYL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
SIGNORiP14649

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Myosin light chain 1 slow-twitch muscle A isoform
Short name:
MLC1sa
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:MYL6B
Synonyms:MLC1SA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196465.10
HGNCiHGNC:29823 MYL6B
MIMi609930 gene
neXtProtiNX_P14649

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi140465
OpenTargetsiENSG00000196465
PharmGKBiPA144596407

Polymorphism and mutation databases

BioMutaiMYL6B
DMDMi127153

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986951 – 208Myosin light chain 6BAdd BLAST208

Proteomic databases

EPDiP14649
MaxQBiP14649
PaxDbiP14649
PeptideAtlasiP14649
PRIDEiP14649
ProteomicsDBi53069

PTM databases

iPTMnetiP14649
PhosphoSitePlusiP14649
SwissPalmiP14649

Expressioni

Gene expression databases

BgeeiENSG00000196465 Expressed in 234 organ(s), highest expression level in muscle organ
CleanExiHS_MYL6B
ExpressionAtlasiP14649 baseline and differential
GenevisibleiP14649 HS

Organism-specific databases

HPAiHPA038887
HPA046859
HPA063034

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

Protein-protein interaction databases

BioGridi126617, 28 interactors
IntActiP14649, 20 interactors
MINTiP14649
STRINGi9606.ENSP00000207437

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14649
SMRiP14649
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14649

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 99EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini141 – 176EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini176 – 208EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP14649
KOiK12751
OMAiQGNVNYE
OrthoDBiEOG091G0TQL
PhylomeDBiP14649
TreeFamiTF351553

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P14649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP
60 70 80 90 100
PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP
110 120 130 140 150
TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF
160 170 180 190 200
RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA

FLKHILSV
Length:208
Mass (Da):22,764
Last modified:April 1, 1990 - v1
Checksum:i6F3DFAC6CCA9877E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1I5F8W1I5_HUMAN
Myosin light chain 6B
MYL6B
175Annotation score:
F8VSA2F8VSA2_HUMAN
Myosin light chain 6B
MYL6B
29Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16434 mRNA Translation: CAA34457.1
M31211 mRNA Translation: AAA36320.1
BC012425 mRNA Translation: AAH12425.1
BC014400 mRNA Translation: AAH14400.1
CCDSiCCDS8905.1
PIRiA34757 MOHUSA
RefSeqiNP_001186558.1, NM_001199629.1
NP_002466.1, NM_002475.4
UniGeneiHs.632731

Genome annotation databases

EnsembliENST00000550443; ENSP00000446643; ENSG00000196465
ENST00000553066; ENSP00000450385; ENSG00000196465
GeneIDi140465
KEGGihsa:140465
UCSCiuc001sjt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16434 mRNA Translation: CAA34457.1
M31211 mRNA Translation: AAA36320.1
BC012425 mRNA Translation: AAH12425.1
BC014400 mRNA Translation: AAH14400.1
CCDSiCCDS8905.1
PIRiA34757 MOHUSA
RefSeqiNP_001186558.1, NM_001199629.1
NP_002466.1, NM_002475.4
UniGeneiHs.632731

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortaliP14649
SMRiP14649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126617, 28 interactors
IntActiP14649, 20 interactors
MINTiP14649
STRINGi9606.ENSP00000207437

PTM databases

iPTMnetiP14649
PhosphoSitePlusiP14649
SwissPalmiP14649

Polymorphism and mutation databases

BioMutaiMYL6B
DMDMi127153

Proteomic databases

EPDiP14649
MaxQBiP14649
PaxDbiP14649
PeptideAtlasiP14649
PRIDEiP14649
ProteomicsDBi53069

Protocols and materials databases

DNASUi140465
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550443; ENSP00000446643; ENSG00000196465
ENST00000553066; ENSP00000450385; ENSG00000196465
GeneIDi140465
KEGGihsa:140465
UCSCiuc001sjt.4 human

Organism-specific databases

CTDi140465
DisGeNETi140465
EuPathDBiHostDB:ENSG00000196465.10
GeneCardsiMYL6B
HGNCiHGNC:29823 MYL6B
HPAiHPA038887
HPA046859
HPA063034
MIMi609930 gene
neXtProtiNX_P14649
OpenTargetsiENSG00000196465
PharmGKBiPA144596407
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP14649
KOiK12751
OMAiQGNVNYE
OrthoDBiEOG091G0TQL
PhylomeDBiP14649
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
SIGNORiP14649

Miscellaneous databases

EvolutionaryTraceiP14649
GeneWikiiMYL6B
GenomeRNAii140465
PROiPR:P14649
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196465 Expressed in 234 organ(s), highest expression level in muscle organ
CleanExiHS_MYL6B
ExpressionAtlasiP14649 baseline and differential
GenevisibleiP14649 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL6B_HUMAN
AccessioniPrimary (citable) accession number: P14649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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