G2/mitotic-specific cyclin-B1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cyclin-dependent protein serine/threonine kinase activator activity Source: CAFA <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression."
    Wang Z., Fan M., Candas D., Zhang T.Q., Qin L., Eldridge A., Wachsmann-Hogiu S., Ahmed K.M., Chromy B.A., Nantajit D., Duru N., He F., Chen M., Finkel T., Weinstein L.S., Li J.J.
    Dev. Cell 29:217-232(2014) [PubMed] [Europe PMC] [Abstract]
• cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• histone kinase activity Source: Ensembl
• patched binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Patched1 interacts with cyclin B1 to regulate cell cycle progression."
    Barnes E.A., Kong M., Ollendorff V., Donoghue D.J.
    EMBO J. 20:2214-2223(2001) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "Active cyclin B1-Cdk1 first appears on centrosomes in prophase."
    Jackman M., Lindon C., Nigg E.A., Pines J.
    Nat. Cell Biol. 5:143-148(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-126; SER-133 AND SER-147, MUTAGENESIS OF SER-133 AND SER-147.
• ubiquitin-like protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • "A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro."
    Kobirumaki F., Miyauchi Y., Fukami K., Tanaka H.
    J. Biochem. 137:133-139(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anaphase-promoting complex-dependent catabolic process Source: Reactome
• cell division Source: UniProtKB-KW
• cellular response to fatty acid Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to iron(III) ion Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• digestive tract development Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
• G2/M transition of mitotic cell cycle Source: Reactome
• histone H3-S10 phosphorylation involved in chromosome condensation Source: Ensembl
• in utero embryonic development Source: Ensembl
• mitotic cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mitotic metaphase plate congression Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis."
    Chen Q., Zhang X., Jiang Q., Clarke P.R., Zhang C.
    Cell Res. 18:268-280(2008) [PubMed] [Europe PMC] [Abstract]
• mitotic nuclear envelope disassembly Source: Reactome
• mitotic spindle organization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis."
    Chen Q., Zhang X., Jiang Q., Clarke P.R., Zhang C.
    Cell Res. 18:268-280(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: Ensembl
• negative regulation of protein phosphorylation Source: Ensembl
• oocyte maturation Source: Ensembl
• positive regulation of attachment of spindle microtubules to kinetochore Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis."
    Chen Q., Zhang X., Jiang Q., Clarke P.R., Zhang C.
    Cell Res. 18:268-280(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle cell proliferation Source: Ensembl
• positive regulation of cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fibroblast proliferation Source: Ensembl
• positive regulation of G2/M transition of mitotic cell cycle Source: CAFAInferred from direct assayⁱ
  • "Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression."
    Wang Z., Fan M., Candas D., Zhang T.Q., Qin L., Eldridge A., Wachsmann-Hogiu S., Ahmed K.M., Chromy B.A., Nantajit D., Duru N., He F., Chen M., Finkel T., Weinstein L.S., Li J.J.
    Dev. Cell 29:217-232(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of histone phosphorylation Source: Ensembl
• positive regulation of mitochondrial ATP synthesis coupled electron transport Source: CAFAInferred from direct assayⁱ
  • "Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression."
    Wang Z., Fan M., Candas D., Zhang T.Q., Qin L., Eldridge A., Wachsmann-Hogiu S., Ahmed K.M., Chromy B.A., Nantajit D., Duru N., He F., Chen M., Finkel T., Weinstein L.S., Li J.J.
    Dev. Cell 29:217-232(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitotic cell cycle Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis."
    Chen Q., Zhang X., Jiang Q., Clarke P.R., Zhang C.
    Cell Res. 18:268-280(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mRNA 3'-end processing Source: Ensembl
• protein-containing complex assembly Source: Ensembl
• regulation of cell cycle Source: Reactome
• regulation of chromosome condensation Source: Ensembl
• regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle phase transition Source: Reactome
• regulation of mitotic cell cycle spindle assembly checkpoint Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis."
    Chen Q., Zhang X., Jiang Q., Clarke P.R., Zhang C.
    Cell Res. 18:268-280(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic nuclear division Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to DDT Source: Ensembl
• response to mechanical stimulus Source: Ensembl
• spermatogenesis Source: Ensembl
• tissue regeneration Source: Ensembl
• transcription initiation from RNA polymerase II promoter Source: Reactome
• ventricular cardiac muscle cell development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• patched binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Patched1 interacts with cyclin B1 to regulate cell cycle progression."
    Barnes E.A., Kong M., Ollendorff V., Donoghue D.J.
    EMBO J. 20:2214-2223(2001) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "Active cyclin B1-Cdk1 first appears on centrosomes in prophase."
    Jackman M., Lindon C., Nigg E.A., Pines J.
    Nat. Cell Biol. 5:143-148(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-126; SER-133 AND SER-147, MUTAGENESIS OF SER-133 AND SER-147.
• ubiquitin-like protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • "A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro."
    Kobirumaki F., Miyauchi Y., Fukami K., Tanaka H.
    J. Biochem. 137:133-139(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN 
        60         70         80         90        100
KVSEQLQAKM PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE 
       110        120        130        140        150
PEPEPEPEPV KEEKLSPEPI LVDTASPSPM ETSGCAPAEE DLCQAFSDVI 
       160        170        180        190        200
LAVNDVDAED GADPNLCSEY VKDIYAYLRQ LEEEQAVRPK YLLGREVTGN 
       210        220        230        240        250
MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP KKMLQLVGVT 
       260        270        280        290        300
AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
       310        320        330        340        350
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC 
       360        370        380        390        400
LALKILDNGE WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV 
       410        420        430 
KNKYATSKHA KISTLPQLNS ALVQDLAKAV AKV                   

        10         20         30         40         50
MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN 
        60         70         80         90        100
KVSEQLQAKM PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE 
       110        120        130        140        150
PEPEPEPEPV KEEKLSPEPI LVDTASPSPM ETSGCAPAEE DLCQAFSDVI 
       160        170        180        190        200
LAVNDVDAED GADPNLCSEY VKDIYAYLRQ LEEEQAVRPK YLLGREVTGN 
       210        220        230        240        250
MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP KKMLQLVGVT 
       260        270        280        290        300
AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
       310        320        330        340        350
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC 
       360        370        380        390 
LALKILDNGE WTVKNKYATS KHAKISTLPQ LNSALVQDLA KAVAKV     

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot