CCNB1

Functionⁱ

Essential for the control of the cell cycle at the G2/M (mitosis) transition.2 Publications

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase activator activity
Source: CAFA
Inferred from direct assayⁱ
- 24746669
cyclin-dependent protein serine/threonine kinase activity Source: Reactome
histone kinase activity Source: Ensembl
patched binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11331587
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12524548
ubiquitin-like protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15749827

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anaphase-promoting complex-dependent catabolic process Source: Reactome
cell division Source: UniProtKB-KW
cellular response to fatty acid Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to iron(III) ion Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
digestive tract development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
histone H3-S10 phosphorylation involved in chromosome condensation Source: Ensembl
in utero embryonic development Source: Ensembl
mitotic metaphase plate congression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18195732
mitotic nuclear envelope disassembly Source: Reactome
mitotic spindle organization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18195732
negative regulation of gene expression Source: Ensembl
negative regulation of protein phosphorylation Source: Ensembl
oocyte maturation Source: Ensembl
positive regulation of attachment of spindle microtubules to kinetochore
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18195732
positive regulation of cardiac muscle cell proliferation Source: Ensembl
positive regulation of fibroblast proliferation Source: Ensembl
positive regulation of G2/M transition of mitotic cell cycle
Source: CAFA
Inferred from direct assayⁱ
- 24746669
positive regulation of histone phosphorylation Source: Ensembl
positive regulation of mitochondrial ATP synthesis coupled electron transport
Source: CAFA
Inferred from direct assayⁱ
- 24746669
positive regulation of mitotic cell cycle
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18195732
positive regulation of mRNA 3'-end processing Source: Ensembl
protein-containing complex assembly Source: Ensembl
regulation of cell cycle Source: Reactome
regulation of chromosome condensation Source: Ensembl
regulation of mitotic cell cycle spindle assembly checkpoint
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18195732
response to DDT Source: Ensembl
response to mechanical stimulus Source: Ensembl
spermatogenesis Source: Ensembl
tissue regeneration Source: Ensembl
ventricular cardiac muscle cell development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-156711 Polo-like kinase mediated events R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176412 Phosphorylation of the APC/C R-HSA-176417 Phosphorylation of Emi1 R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-4419969 Depolymerisation of the Nuclear Lamina R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-68875 Mitotic Prophase R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8878166 Transcriptional regulation by RUNX2
SignaLinkⁱ	P14635
SIGNORⁱ	P14635

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G2/mitotic-specific cyclin-B1
Gene namesⁱ	Name:CCNB1 Synonyms:CCNB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134057.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1579 CCNB1
MIMⁱ	123836 gene
neXtProtⁱ	NX_P14635

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	133	S → A: Strongly impairs phosphorylation by PLK1. 2 Publications		1
Mutagenesisⁱ	147	S → A: Does not affect phosphorylation by PLK1. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	891
Open Targets More...OpenTargetsⁱ	ENSG00000134057
PharmGKBⁱ	PA95

Chemistry databases

ChEMBLⁱ	CHEMBL2412

ChEMBLⁱ

CHEMBL2412

Polymorphism and mutation databases

BioMutaⁱ	CCNB1
DMDMⁱ	116176

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080350	1 – 433	G2/mitotic-specific cyclin-B1Add BLAST		433

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	73	N6-acetyllysineCombined sources	1
Modified residueⁱ	126	Phosphoserine; by CDK12 Publications	1
Modified residueⁱ	128	Phosphoserine1 Publication	1
Modified residueⁱ	133	Phosphoserine; by PLK12 Publications	1
Modified residueⁱ	147	Phosphoserine2 Publications	1
Modified residueⁱ	321	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.1 Publication

Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P14635
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14635
PaxDbⁱ	P14635
PeptideAtlas More...PeptideAtlasⁱ	P14635
PRIDEⁱ	P14635
ProteomicsDBⁱ	53068

PTM databases

iPTMnetⁱ	P14635
PhosphoSitePlusⁱ	P14635

Expressionⁱ

Developmental stageⁱ

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134057 Expressed in 168 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CCNB1
ExpressionAtlasⁱ	P14635 baseline and differential
Genevisibleⁱ	P14635 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000115 CAB003804 HPA030741 HPA061448

HPAⁱ

CAB000115
CAB003804
HPA030741
HPA061448

Interactionⁱ

Subunit structureⁱ

Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187).By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCNB1IP1	Q9NPC3	2	EBI-495332,EBI-745269
CDK1	P06493	19	EBI-495332,EBI-444308
CDKN1B	P46527	2	EBI-495332,EBI-519280
DEDD	O75618-1	3	EBI-495332,EBI-15621191
FOXO1	Q12778	2	EBI-495332,EBI-1108782
PKMYT1	Q99640	5	EBI-495332,EBI-495308
PTCH1	Q13635	2	EBI-495332,EBI-8775406
UBE2K	P61086	2	EBI-495332,EBI-473850
UHRF2	Q96PU4	2	EBI-495332,EBI-625304

GO - Molecular functionⁱ

patched binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11331587
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12524548
ubiquitin-like protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15749827

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107332, 148 interactors
ComplexPortalⁱ	CPX-2007 Cyclin B1-CDK1 complex
CORUMⁱ	P14635
Database of interacting proteins More...DIPⁱ	DIP-59N
ELMⁱ	P14635
IntActⁱ	P14635, 61 interactors
Molecular INTeraction database More...MINTⁱ	P14635
STRINGⁱ	9606.ENSP00000256442

Chemistry databases

BindingDBⁱ

P14635

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	171 – 184	Combined sources	14
Turnⁱ	189 – 194	Combined sources	6
Beta strandⁱ	195 – 197	Combined sources	3
Helixⁱ	199 – 216	Combined sources	18
Helixⁱ	220 – 234	Combined sources	15
Helixⁱ	241 – 243	Combined sources	3
Helixⁱ	244 – 259	Combined sources	16
Helixⁱ	266 – 272	Combined sources	7
Beta strandⁱ	275 – 277	Combined sources	3
Helixⁱ	279 – 292	Combined sources	14
Turnⁱ	293 – 295	Combined sources	3
Helixⁱ	302 – 312	Combined sources	11
Helixⁱ	317 – 330	Combined sources	14
Helixⁱ	334 – 336	Combined sources	3
Beta strandⁱ	337 – 339	Combined sources	3
Helixⁱ	341 – 356	Combined sources	16
Helixⁱ	363 – 369	Combined sources	7
Helixⁱ	373 – 391	Combined sources	19
Helixⁱ	399 – 403	Combined sources	5
Helixⁱ	407 – 409	Combined sources	3
Helixⁱ	412 – 414	Combined sources	3
Helixⁱ	416 – 419	Combined sources	4
Helixⁱ	421 – 428	Combined sources	8

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00223
ProteinModelPortalⁱ	P14635
SMRⁱ	P14635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14635

EvolutionaryTraceⁱ

P14635

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	169 – 177	Interaction with CDK2		9
Regionⁱ	258 – 261	Interaction with CDK2		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	51 – 85	Lys-richAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000167672
HOVERGENⁱ	HBG061650
InParanoidⁱ	P14635
KEGG Orthology (KO) More...KOⁱ	K05868
OMAⁱ	HMTVKNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E9B
PhylomeDBⁱ	P14635
TreeFamⁱ	TF101001

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P14635-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN 
        60         70         80         90        100
KVSEQLQAKM PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE 
       110        120        130        140        150
PEPEPEPEPV KEEKLSPEPI LVDTASPSPM ETSGCAPAEE DLCQAFSDVI 
       160        170        180        190        200
LAVNDVDAED GADPNLCSEY VKDIYAYLRQ LEEEQAVRPK YLLGREVTGN 
       210        220        230        240        250
MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP KKMLQLVGVT 
       260        270        280        290        300
AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
       310        320        330        340        350
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC 
       360        370        380        390        400
LALKILDNGE WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV 
       410        420        430 
KNKYATSKHA KISTLPQLNS ALVQDLAKAV AKV

Length:433

Mass (Da):48,337

Last modified:April 1, 1990 - v1

Checksum:ⁱE2C4767AE8A11EC0

GO

Isoform 2 (identifier: P14635-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
362-398: Missing.

« Hide

        10         20         30         40         50
MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN 
        60         70         80         90        100
KVSEQLQAKM PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE 
       110        120        130        140        150
PEPEPEPEPV KEEKLSPEPI LVDTASPSPM ETSGCAPAEE DLCQAFSDVI 
       160        170        180        190        200
LAVNDVDAED GADPNLCSEY VKDIYAYLRQ LEEEQAVRPK YLLGREVTGN 
       210        220        230        240        250
MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP KKMLQLVGVT 
       260        270        280        290        300
AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
       310        320        330        340        350
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC 
       360        370        380        390 
LALKILDNGE WTVKNKYATS KHAKISTLPQ LNSALVQDLA KAVAKV

Note: No experimental confirmation available.

Show »

Length:396

Mass (Da):44,102

Checksum:ⁱ1B7AFCE21614F6D5

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PC90	E9PC90_HUMAN	G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B1	CCNB1	401	Annotation score:
D6RHI0	D6RHI0_HUMAN	G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B1	CCNB1	244	Annotation score:
H0YA62	H0YA62_HUMAN	G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B1	CCNB1	185	Annotation score:
H0Y9U8	H0Y9U8_HUMAN	G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B1	CCNB1	61	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	108	E → G in BAF82120 (PubMed:14702039).Curated		1
Sequence conflictⁱ	153	V → A in BAF82120 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053892	362 – 398	Missing in isoform 2. 1 PublicationAdd BLAST		37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25753 mRNA No translation available. AY338491 Genomic DNA Translation: AAP88038.1 AK289431 mRNA Translation: BAF82120.1 BT020128 mRNA Translation: AAV38930.1 AC010273 Genomic DNA No translation available. AC022107 Genomic DNA No translation available. BC006510 mRNA Translation: AAH06510.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3997.1 [P14635-1]
PIRⁱ	A32992
NCBI Reference Sequences More...RefSeqⁱ	NP_114172.1, NM_031966.3 [P14635-1]
UniGeneⁱ	Hs.23960

Genome annotation databases

Ensemblⁱ	ENST00000256442; ENSP00000256442; ENSG00000134057 [P14635-1] ENST00000505500; ENSP00000424588; ENSG00000134057 [P14635-2]
GeneIDⁱ	891
KEGGⁱ	hsa:891
UCSC genome browser More...UCSCⁱ	uc003jvm.4 human [P14635-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14635	Cyclin B1 (Fragment)		HUMAN		113	UniRef100_P14635
UPI000152655E		HUMAN		260

Protein	Similar proteins		Species	Score	Length	Source
P14635	Cyclin B1 (Fragment)		HUMAN		113	UniRef90_P14635
Uncharacterized protein		MANLE		433
Cyclin B1		PANTR		433
Uncharacterized protein		PAPAN		433
G2/mitotic-specific cyclin-B1 (Fragment)		MACMU		207
+55
P14635-2	Uncharacterized protein		PANPA		432	UniRef90_P14635-2
Uncharacterized protein		RHIBE		432
Uncharacterized protein		RHIRO		428
Cyclin B1		PANTR		425
Uncharacterized protein		COLAP		409
+10

Protein	Similar proteins		Species	Score	Length	Source
P14635	G2/mitotic-specific cyclin-B1		MOUSE		430	UniRef50_P14635
G2/mitotic-specific cyclin-B1		MESAU		429
G2/mitotic-specific cyclin-B1		CRIGR		429
G2/mitotic-specific cyclin-B1		RAT		423
G2/mitotic-specific cyclin-B1		BOVIN		427
+107
P14635-2	G2/mitotic-specific cyclin-B2		ANGJA		394	UniRef50_P14635-2
G2/mitotic-specific cyclin-B2		MOUSE		398
G2/mitotic-specific cyclin-B1		CARAU		397
G2/mitotic-specific cyclin-B1		XENLA		397
G2/mitotic-specific cyclin-B2		RANJA		392
+356

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25753 mRNA No translation available. AY338491 Genomic DNA Translation: AAP88038.1 AK289431 mRNA Translation: BAF82120.1 BT020128 mRNA Translation: AAV38930.1 AC010273 Genomic DNA No translation available. AC022107 Genomic DNA No translation available. BC006510 mRNA Translation: AAH06510.1
CCDSⁱ	CCDS3997.1 [P14635-1]
PIRⁱ	A32992
RefSeqⁱ	NP_114172.1, NM_031966.3 [P14635-1]
UniGeneⁱ	Hs.23960

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2B9R	X-ray	2.90	A/B	165-433	[»]
	2JGZ	X-ray	2.90	B	167-426	[»]
	4Y72	X-ray	2.30	B	165-433	[»]
	4YC3	X-ray	2.70	B	165-433	[»]
	5HQ0	X-ray	2.30	B	165-433	[»]
	5LQF	X-ray	2.06	B/E	165-433	[»]
DisProtⁱ	DP00223
ProteinModelPortalⁱ	P14635
SMRⁱ	P14635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107332, 148 interactors
ComplexPortalⁱ	CPX-2007 Cyclin B1-CDK1 complex
CORUMⁱ	P14635
DIPⁱ	DIP-59N
ELMⁱ	P14635
IntActⁱ	P14635, 61 interactors
MINTⁱ	P14635
STRINGⁱ	9606.ENSP00000256442

Chemistry databases

BindingDBⁱ	P14635
ChEMBLⁱ	CHEMBL2412

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	P14635
PhosphoSitePlusⁱ	P14635

Polymorphism and mutation databases

BioMutaⁱ	CCNB1
DMDMⁱ	116176

Proteomic databases

EPDⁱ	P14635
MaxQBⁱ	P14635
PaxDbⁱ	P14635
PeptideAtlasⁱ	P14635
PRIDEⁱ	P14635
ProteomicsDBⁱ	53068

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	891
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000256442; ENSP00000256442; ENSG00000134057 [P14635-1] ENST00000505500; ENSP00000424588; ENSG00000134057 [P14635-2]
GeneIDⁱ	891
KEGGⁱ	hsa:891
UCSCⁱ	uc003jvm.4 human [P14635-1]

Organism-specific databases

CTDⁱ	891
DisGeNETⁱ	891
EuPathDBⁱ	HostDB:ENSG00000134057.14
GeneCardsⁱ	CCNB1
HGNCⁱ	HGNC:1579 CCNB1
HPAⁱ	CAB000115 CAB003804 HPA030741 HPA061448
MIMⁱ	123836 gene
neXtProtⁱ	NX_P14635
OpenTargetsⁱ	ENSG00000134057
PharmGKBⁱ	PA95
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000167672
HOVERGENⁱ	HBG061650
InParanoidⁱ	P14635
KOⁱ	K05868
OMAⁱ	HMTVKNK
OrthoDBⁱ	EOG091G0E9B
PhylomeDBⁱ	P14635
TreeFamⁱ	TF101001

Enzyme and pathway databases

Reactomeⁱ	R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-156711 Polo-like kinase mediated events R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176412 Phosphorylation of the APC/C R-HSA-176417 Phosphorylation of Emi1 R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-4419969 Depolymerisation of the Nuclear Lamina R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-68875 Mitotic Prophase R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8878166 Transcriptional regulation by RUNX2
SignaLinkⁱ	P14635
SIGNORⁱ	P14635

Miscellaneous databases

ChiTaRSⁱ	CCNB1 human
EvolutionaryTraceⁱ	P14635
GeneWikiⁱ	Cyclin_B1
GenomeRNAiⁱ	891
Protein Ontology More...PROⁱ	PR:P14635
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134057 Expressed in 168 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CCNB1
ExpressionAtlasⁱ	P14635 baseline and differential
Genevisibleⁱ	P14635 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNB1_HUMAN
Accessionⁱ	P14635Primary (citable) accession number: P14635 Secondary accession number(s): A8K066, Q5TZP9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	October 10, 2018
	This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P14635 (CCNB1_HUMAN)

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G2/mitotic-specific cyclin-B1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

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Keywords - Technical termⁱ