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UniProtKB - P14635 (CCNB1_HUMAN)

Entry version 217 (02 Jun 2021)
Sequence version 1 (01 Apr 1990)
Previous versions | rss
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Protein

G2/mitotic-specific cyclin-B1

Gene

CCNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14635

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-113507, E2F-enabled inhibition of pre-replication complex formation
R-HSA-156711, Polo-like kinase mediated events
R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176412, Phosphorylation of the APC/C
R-HSA-176417, Phosphorylation of Emi1
R-HSA-2299718, Condensation of Prophase Chromosomes
R-HSA-2465910, MASTL Facilitates Mitotic Progression
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2514853, Condensation of Prometaphase Chromosomes
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-4419969, Depolymerisation of the Nuclear Lamina
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-68875, Mitotic Prophase
R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478, G2/M DNA replication checkpoint
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8878166, Transcriptional regulation by RUNX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14635

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14635

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNB1
Synonyms:CCNB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1579, CCNB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123836, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14635

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134057.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi133S → A: Strongly impairs phosphorylation by PLK1. 2 Publications1
Mutagenesisi147S → A: Does not affect phosphorylation by PLK1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		891

Open Targets

More...OpenTargetsi		ENSG00000134057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA95

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14635, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2412

DrugCentral

More...DrugCentrali		P14635

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCNB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116176

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000803501 – 433G2/mitotic-specific cyclin-B1Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73N6-acetyllysineCombined sources1
Modified residuei126Phosphoserine; by CDK12 Publications1
Modified residuei128Phosphoserine1 Publication1
Modified residuei133Phosphoserine; by PLK12 Publications1
Modified residuei147Phosphoserine2 Publications1
Modified residuei321PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.1 Publication
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1236

Encyclopedia of Proteome Dynamics

More...EPDi		P14635

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14635

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14635

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14635

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14635

PeptideAtlas

More...PeptideAtlasi		P14635

PRoteomics IDEntifications database

More...PRIDEi		P14635

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53068 [P14635-1]
65222

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14635

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P14635

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14635

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P14635

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134057, Expressed in secondary oocyte and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14635, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14635, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134057, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10.

Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.

Interacts with CCNF; interaction is required for nuclear localization.

Interacts with CDK5RAP3 (PubMed:15790566).

Interacts with RFPL4A and UBE2A (By similarity).

Interacts with INCA1 (PubMed:21540187).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107332, 176 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2007, Cyclin B1-CDK1 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14635

Database of interacting proteins

More...DIPi		DIP-59N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P14635

Protein interaction database and analysis system

More...IntActi		P14635, 77 interactors

Molecular INTeraction database

More...MINTi		P14635

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256442

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14635

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14635, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14635

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14635

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 47DisorderedSequence analysisAdd BLAST29
Regioni93 – 116DisorderedSequence analysisAdd BLAST24
Regioni169 – 177Interaction with CDK29
Regioni258 – 261Interaction with CDK24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0653, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020695_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14635

Identification of Orthologs from Complete Genome Data

More...OMAi		CAEENCQ

Database of Orthologous Groups

More...OrthoDBi		993640at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14635

TreeFam database of animal gene trees

More...TreeFami		TF101001

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 2 hits

Database of protein disorder

More...DisProti		DP00223

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00141

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001771, Cyclin_A_B_D_E, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14635-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN 
        60         70         80         90        100
KVSEQLQAKM PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE 
       110        120        130        140        150
PEPEPEPEPV KEEKLSPEPI LVDTASPSPM ETSGCAPAEE DLCQAFSDVI 
       160        170        180        190        200
LAVNDVDAED GADPNLCSEY VKDIYAYLRQ LEEEQAVRPK YLLGREVTGN 
       210        220        230        240        250
MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP KKMLQLVGVT 
       260        270        280        290        300
AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP 
       310        320        330        340        350
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC 
       360        370        380        390        400
LALKILDNGE WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV 
       410        420        430 
KNKYATSKHA KISTLPQLNS ALVQDLAKAV AKV
Length:433
Mass (Da):48,337
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2C4767AE8A11EC0
GO
Isoform 2 (identifier: P14635-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-398: Missing.

Show »
Length:396
Mass (Da):44,102
Checksum:i1B7AFCE21614F6D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHI0D6RHI0_HUMAN
G2/mitotic-specific cyclin-B1
CCNB1
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC90E9PC90_HUMAN
G2/mitotic-specific cyclin-B1
CCNB1
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA62H0YA62_HUMAN
G2/mitotic-specific cyclin-B1
CCNB1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9U8H0Y9U8_HUMAN
G2/mitotic-specific cyclin-B1
CCNB1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108E → G in BAF82120 (PubMed:14702039).Curated1
Sequence conflicti153V → A in BAF82120 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053892362 – 398Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M25753 mRNA No translation available.
AY338491 Genomic DNA Translation: AAP88038.1
AK289431 mRNA Translation: BAF82120.1
BT020128 mRNA Translation: AAV38930.1
AC010273 Genomic DNA No translation available.
AC022107 Genomic DNA No translation available.
BC006510 mRNA Translation: AAH06510.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3997.1 [P14635-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A32992

NCBI Reference Sequences

More...RefSeqi		NP_114172.1, NM_031966.3 [P14635-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256442; ENSP00000256442; ENSG00000134057 [P14635-1]
ENST00000505500; ENSP00000424588; ENSG00000134057 [P14635-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:891

UCSC genome browser

More...UCSCi		uc003jvm.4, human [P14635-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25753 mRNA No translation available.
AY338491 Genomic DNA Translation: AAP88038.1
AK289431 mRNA Translation: BAF82120.1
BT020128 mRNA Translation: AAV38930.1
AC010273 Genomic DNA No translation available.
AC022107 Genomic DNA No translation available.
BC006510 mRNA Translation: AAH06510.1
CCDSiCCDS3997.1 [P14635-1]
PIRiA32992
RefSeqiNP_114172.1, NM_031966.3 [P14635-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B9RX-ray2.90A/B165-433[»]
2JGZX-ray2.90B167-426[»]
4Y72X-ray2.30B165-433[»]
4YC3X-ray2.70B165-433[»]
5HQ0X-ray2.30B165-433[»]
5LQFX-ray2.06B/E165-433[»]
6GU2X-ray2.00B165-433[»]
6GU3X-ray2.65B165-433[»]
6GU4X-ray2.73B165-433[»]
SMRiP14635
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107332, 176 interactors
ComplexPortaliCPX-2007, Cyclin B1-CDK1 complex
CORUMiP14635
DIPiDIP-59N
ELMiP14635
IntActiP14635, 77 interactors
MINTiP14635
STRINGi9606.ENSP00000256442

Chemistry databases

BindingDBiP14635
ChEMBLiCHEMBL2412
DrugCentraliP14635

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

iPTMnetiP14635
MetOSiteiP14635
PhosphoSitePlusiP14635
SwissPalmiP14635

Genetic variation databases

BioMutaiCCNB1
DMDMi116176

Proteomic databases

CPTACiCPTAC-1236
EPDiP14635
jPOSTiP14635
MassIVEiP14635
MaxQBiP14635
PaxDbiP14635
PeptideAtlasiP14635
PRIDEiP14635
ProteomicsDBi53068 [P14635-1]
65222

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3537, 1863 antibodies

The DNASU plasmid repository

More...DNASUi		891

Genome annotation databases

EnsembliENST00000256442; ENSP00000256442; ENSG00000134057 [P14635-1]
ENST00000505500; ENSP00000424588; ENSG00000134057 [P14635-2]
GeneIDi891
KEGGihsa:891
UCSCiuc003jvm.4, human [P14635-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		891
DisGeNETi891

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCNB1
HGNCiHGNC:1579, CCNB1
HPAiENSG00000134057, Tissue enhanced (lymphoid)
MIMi123836, gene
neXtProtiNX_P14635
OpenTargetsiENSG00000134057
PharmGKBiPA95
VEuPathDBiHostDB:ENSG00000134057.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0653, Eukaryota
GeneTreeiENSGT00940000154586
HOGENOMiCLU_020695_2_1_1
InParanoidiP14635
OMAiCAEENCQ
OrthoDBi993640at2759
PhylomeDBiP14635
TreeFamiTF101001

Enzyme and pathway databases

PathwayCommonsiP14635
ReactomeiR-HSA-113507, E2F-enabled inhibition of pre-replication complex formation
R-HSA-156711, Polo-like kinase mediated events
R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176412, Phosphorylation of the APC/C
R-HSA-176417, Phosphorylation of Emi1
R-HSA-2299718, Condensation of Prophase Chromosomes
R-HSA-2465910, MASTL Facilitates Mitotic Progression
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2514853, Condensation of Prometaphase Chromosomes
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-4419969, Depolymerisation of the Nuclear Lamina
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-68875, Mitotic Prophase
R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478, G2/M DNA replication checkpoint
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8878166, Transcriptional regulation by RUNX2
SignaLinkiP14635
SIGNORiP14635

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		891, 502 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCNB1, human
EvolutionaryTraceiP14635

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cyclin_B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		891
PharosiP14635, Tchem

Protein Ontology

More...PROi		PR:P14635
RNActiP14635, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134057, Expressed in secondary oocyte and 182 other tissues
ExpressionAtlasiP14635, baseline and differential
GenevisibleiP14635, HS

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
DisProtiDP00223
IDEALiIID00141
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
PIRSFiPIRSF001771, Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14635
Secondary accession number(s): A8K066, Q5TZP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 2, 2021
This is version 217 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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