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Protein

Acylphosphatase-2

Gene

ACYP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei24PROSITE-ProRule annotation1
Active sitei42PROSITE-ProRule annotation1

GO - Molecular functioni

  • acylphosphatase activity Source: GO_Central
  • identical protein binding Source: IntAct

GO - Biological processi

  • phosphate-containing compound metabolic process Source: ProtInc

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

SABIO-RKiP14621

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-2 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2
Gene namesi
Name:ACYP2
Synonyms:ACYP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170634.12
HGNCiHGNC:180 ACYP2
MIMi102595 gene
neXtProtiNX_P14621

Pathology & Biotechi

Organism-specific databases

DisGeNETi98
OpenTargetsiENSG00000170634
PharmGKBiPA24500

Chemistry databases

DrugBankiDB01942 Formic Acid

Polymorphism and mutation databases

BioMutaiACYP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001585422 – 99Acylphosphatase-2Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP14621
MaxQBiP14621
PaxDbiP14621
PeptideAtlasiP14621
PRIDEiP14621
ProteomicsDBi53066

PTM databases

iPTMnetiP14621
PhosphoSitePlusiP14621

Expressioni

Gene expression databases

BgeeiENSG00000170634 Expressed in 221 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ACYP2
ExpressionAtlasiP14621 baseline and differential
GenevisibleiP14621 HS

Organism-specific databases

HPAiHPA035301

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106613, 2 interactors
DIPiDIP-48449N
IntActiP14621, 3 interactors
STRINGi9606.ENSP00000378161

Structurei

3D structure databases

ProteinModelPortaliP14621
SMRiP14621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 99Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3360 Eukaryota
ENOG41126ER LUCA
GeneTreeiENSGT00390000011103
HOGENOMiHOG000292688
HOVERGENiHBG050454
InParanoidiP14621
KOiK01512
OMAiVNAMKSW
PhylomeDBiP14621
TreeFamiTF300288

Family and domain databases

InterProiView protein in InterPro
IPR020456 Acylphosphatase
IPR001792 Acylphosphatase-like_dom
IPR036046 Acylphosphatase-like_dom_sf
IPR017968 Acylphosphatase_CS
PANTHERiPTHR10029 PTHR10029, 1 hit
PfamiView protein in Pfam
PF00708 Acylphosphatase, 1 hit
PRINTSiPR00112 ACYLPHPHTASE
SUPFAMiSSF54975 SSF54975, 1 hit
PROSITEiView protein in PROSITE
PS00150 ACYLPHOSPHATASE_1, 1 hit
PS00151 ACYLPHOSPHATASE_2, 1 hit
PS51160 ACYLPHOSPHATASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P14621-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG
60 70 80 90
QVQGPEDKVN SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY
Length:99
Mass (Da):11,140
Last modified:January 23, 2007 - v2
Checksum:iAEDE40E45B6207A0
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQL2U3KQL2_HUMAN
Acylphosphatase
ACYP2
172Annotation score:
E9PF46E9PF46_HUMAN
Acylphosphatase
ACYP2
97Annotation score:
F8WA34F8WA34_HUMAN
Acylphosphatase
ACYP2
98Annotation score:
U3KPX1U3KPX1_HUMAN
Acylphosphatase
ACYP2
66Annotation score:
U3KPX8U3KPX8_HUMAN
Acylphosphatase-2
ACYP2
83Annotation score:
U3KQ94U3KQ94_HUMAN
Acylphosphatase-2
ACYP2 hCG_2040114
116Annotation score:
U3KQ09U3KQ09_HUMAN
Acylphosphatase-2
ACYP2
40Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012290 mRNA Translation: AAH12290.1
X84195 mRNA Translation: CAA58988.1
CCDSiCCDS1850.1
PIRiS59138 S52327
RefSeqiNP_612457.1, NM_138448.3
UniGeneiHs.516173
Hs.591587
Hs.642983

Genome annotation databases

EnsembliENST00000394666; ENSP00000378161; ENSG00000170634
GeneIDi98
KEGGihsa:98
UCSCiuc002rxq.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012290 mRNA Translation: AAH12290.1
X84195 mRNA Translation: CAA58988.1
CCDSiCCDS1850.1
PIRiS59138 S52327
RefSeqiNP_612457.1, NM_138448.3
UniGeneiHs.516173
Hs.591587
Hs.642983

3D structure databases

ProteinModelPortaliP14621
SMRiP14621
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106613, 2 interactors
DIPiDIP-48449N
IntActiP14621, 3 interactors
STRINGi9606.ENSP00000378161

Chemistry databases

DrugBankiDB01942 Formic Acid

PTM databases

iPTMnetiP14621
PhosphoSitePlusiP14621

Polymorphism and mutation databases

BioMutaiACYP2

Proteomic databases

EPDiP14621
MaxQBiP14621
PaxDbiP14621
PeptideAtlasiP14621
PRIDEiP14621
ProteomicsDBi53066

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394666; ENSP00000378161; ENSG00000170634
GeneIDi98
KEGGihsa:98
UCSCiuc002rxq.5 human

Organism-specific databases

CTDi98
DisGeNETi98
EuPathDBiHostDB:ENSG00000170634.12
GeneCardsiACYP2
HGNCiHGNC:180 ACYP2
HPAiHPA035301
MIMi102595 gene
neXtProtiNX_P14621
OpenTargetsiENSG00000170634
PharmGKBiPA24500
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3360 Eukaryota
ENOG41126ER LUCA
GeneTreeiENSGT00390000011103
HOGENOMiHOG000292688
HOVERGENiHBG050454
InParanoidiP14621
KOiK01512
OMAiVNAMKSW
PhylomeDBiP14621
TreeFamiTF300288

Enzyme and pathway databases

SABIO-RKiP14621

Miscellaneous databases

ChiTaRSiACYP2 human
GeneWikiiACYP2
GenomeRNAii98
PROiPR:P14621
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170634 Expressed in 221 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ACYP2
ExpressionAtlasiP14621 baseline and differential
GenevisibleiP14621 HS

Family and domain databases

InterProiView protein in InterPro
IPR020456 Acylphosphatase
IPR001792 Acylphosphatase-like_dom
IPR036046 Acylphosphatase-like_dom_sf
IPR017968 Acylphosphatase_CS
PANTHERiPTHR10029 PTHR10029, 1 hit
PfamiView protein in Pfam
PF00708 Acylphosphatase, 1 hit
PRINTSiPR00112 ACYLPHPHTASE
SUPFAMiSSF54975 SSF54975, 1 hit
PROSITEiView protein in PROSITE
PS00150 ACYLPHOSPHATASE_1, 1 hit
PS00151 ACYLPHOSPHATASE_2, 1 hit
PS51160 ACYLPHOSPHATASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACYP2_HUMAN
AccessioniPrimary (citable) accession number: P14621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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