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UniProtKB - P14602 (HSPB1_MOUSE)

Entry version 203 (25 May 2022)
Sequence version 3 (01 Jun 1994)
Previous versions | rss
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Protein

Heat shock protein beta-1

Gene

Hspb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394).

Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-9009391, Extra-nuclear estrogen signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock protein beta-1
Short name:
HspB1
Alternative name(s):
Growth-related 25 kDa protein
Heat shock 25 kDa protein
Short name:
HSP 25
Heat shock 27 kDa protein
Short name:
HSP 27
p25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hspb1
Synonyms:Hsp25, Hsp27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:96240, Hspb1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000004951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile with no apparent morphological abnormalities in tissues under physiological conditions.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001259281 – 209Heat shock protein beta-1Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12Omega-N-methylarginineCombined sources1
Modified residuei13PhosphoserineBy similarity1
Modified residuei15Phosphoserine; by MAPKAPK2, MAPKAPK3, PKA and PKC2 Publications1
Modified residuei27PhosphoserineBy similarity1
Modified residuei86Phosphoserine; by MAPKAPK2, MAPKAPK3, MAPKAPK5, PKA and PKCCombined sources2 Publications1
Modified residuei87PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei127N6-acetyllysineBy similarity1
Modified residuei178PhosphothreonineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon exposure to protein kinase C activators and heat shock (By similarity). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:1860870, PubMed:21575178, PubMed:8093612).By similarity4 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14602

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14602

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14602

PeptideAtlas

More...PeptideAtlasi		P14602

PRoteomics IDEntifications database

More...PRIDEi		P14602

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		273278 [P14602-1]
273279 [P14602-2]
273280 [P14602-3]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00128522
IPI00468068
P14602

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P14602

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P14602

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14602

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000004951, Expressed in lens of camera-type eye and 74 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14602, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin (By similarity).

Interacts with TGFB1I1 (PubMed:11546764).

Interacts with CRYAB (By similarity).

Interacts with HSPB8 (PubMed:11342557).

Interacts with HSPBAP1 (PubMed:10751411).

By similarity3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		200449, 22 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14602

Protein interaction database and analysis system

More...IntActi		P14602, 12 interactors

Molecular INTeraction database

More...MINTi		P14602

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000005077

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14602, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P14602

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14602

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 188sHSPPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 209Interaction with TGFB1I1By similarityAdd BLAST136

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3591, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155882

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_095001_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14602

Identification of Orthologs from Complete Genome Data

More...OMAi		EEWAQWF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14602

TreeFam database of animal gene trees

More...TreeFami		TF105049

Family and domain databases

Conserved Domains Database

More...CDDi		cd06475, ACD_HspB1_like, 1 hit

Database of protein disorder

More...DisProti		DP00142

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002068, A-crystallin/Hsp20_dom
IPR037876, ACD_HspB1
IPR001436, Alpha-crystallin/sHSP_animal
IPR008978, HSP20-like_chaperone

The PANTHER Classification System

More...PANTHERi		PTHR45640, PTHR45640, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00011, HSP20, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00299, ACRYSTALLIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49764, SSF49764, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01031, SHSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P14602-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA 
        60         70         80         90        100
GWPGYVRPLP AATAEGPAAV TLAAPAFSRA LNRQLSSGVS EIRQTADRWR 
       110        120        130        140        150
VSLDVNHFAP EELTVKTKEG VVEITGKHEE RQDEHGYISR CFTRKYTLPP 
       160        170        180        190        200
GVDPTLVSSS LSPEGTLTVE APLPKAVTQS AEITIPVTFE ARAQIGGPEA 

GKSEQSGAK
Length:209
Mass (Da):23,014
Last modified:June 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31BD9FAF4E107C50
GO
Isoform B (identifier: P14602-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-72: Missing.

Show »
Length:197
Mass (Da):21,961
Checksum:i071D3C112509C01A
GO
Isoform C (identifier: P14602-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-70: Missing.

Show »
Length:175
Mass (Da):19,380
Checksum:iAA7E60872B1C485B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZ06D3YZ06_MOUSE
Heat shock protein beta-1
Hspb1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13S → T in AAA18335 (PubMed:8132504).Curated1
Sequence conflicti13S → T in AAA18336 (PubMed:8132504).Curated1
Sequence conflicti13S → T in AAA18337 (PubMed:8132504).Curated1
Sequence conflicti17E → G in AAA18335 (PubMed:8132504).Curated1
Sequence conflicti67 – 68PA → L in AAA18335 (PubMed:8132504).Curated2
Sequence conflicti99Missing in CAA32818 (PubMed:2645135).Curated1
Sequence conflicti99Missing in CAB37341 (PubMed:2645135).Curated1
Sequence conflicti108 – 109FA → VI in CAA32818 (PubMed:2645135).Curated2
Sequence conflicti108 – 109FA → VI in CAB37341 (PubMed:2645135).Curated2
Sequence conflicti141C → Q AA sequence (PubMed:2645135).Curated1
Sequence conflicti181A → T in CAA32818 (PubMed:2645135).Curated1
Sequence conflicti181A → T in CAB37341 (PubMed:2645135).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00242337 – 70Missing in isoform C. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_00242261 – 72Missing in isoform B. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X14687 mRNA Translation: CAA32818.1
X14686 mRNA Translation: CAB37341.1
L11609, L11608 Genomic DNA Translation: AAA37862.1
L07577 Genomic DNA Translation: AAA37861.1
U03560 mRNA Translation: AAA18335.1
U03561 mRNA Translation: AAA18336.1
U03562 mRNA Translation: AAA18337.1
BC018257 mRNA Translation: AAH18257.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39320.1 [P14602-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A53423
I49763, JN0679
S02143

NCBI Reference Sequences

More...RefSeqi		NP_038588.2, NM_013560.2 [P14602-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000005077; ENSMUSP00000005077; ENSMUSG00000004951 [P14602-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		15507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:15507

UCSC genome browser

More...UCSCi		uc008zze.2, mouse [P14602-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14687 mRNA Translation: CAA32818.1
X14686 mRNA Translation: CAB37341.1
L11609, L11608 Genomic DNA Translation: AAA37862.1
L07577 Genomic DNA Translation: AAA37861.1
U03560 mRNA Translation: AAA18335.1
U03561 mRNA Translation: AAA18336.1
U03562 mRNA Translation: AAA18337.1
BC018257 mRNA Translation: AAH18257.1
CCDSiCCDS39320.1 [P14602-1]
PIRiA53423
I49763, JN0679
S02143
RefSeqiNP_038588.2, NM_013560.2 [P14602-1]

3D structure databases

AlphaFoldDBiP14602
SMRiP14602
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200449, 22 interactors
CORUMiP14602
IntActiP14602, 12 interactors
MINTiP14602
STRINGi10090.ENSMUSP00000005077

PTM databases

iPTMnetiP14602
PhosphoSitePlusiP14602

2D gel databases

REPRODUCTION-2DPAGEiIPI00128522
IPI00468068
P14602
SWISS-2DPAGEiP14602
UCD-2DPAGEiP14602

Proteomic databases

jPOSTiP14602
MaxQBiP14602
PaxDbiP14602
PeptideAtlasiP14602
PRIDEiP14602
ProteomicsDBi273278 [P14602-1]
273279 [P14602-2]
273280 [P14602-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		603, 3189 antibodies from 53 providers

The DNASU plasmid repository

More...DNASUi		15507

Genome annotation databases

EnsembliENSMUST00000005077; ENSMUSP00000005077; ENSMUSG00000004951 [P14602-1]
GeneIDi15507
KEGGimmu:15507
UCSCiuc008zze.2, mouse [P14602-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3315
MGIiMGI:96240, Hspb1
VEuPathDBiHostDB:ENSMUSG00000004951

Phylogenomic databases

eggNOGiKOG3591, Eukaryota
GeneTreeiENSGT00940000155882
HOGENOMiCLU_095001_0_0_1
InParanoidiP14602
OMAiEEWAQWF
PhylomeDBiP14602
TreeFamiTF105049

Enzyme and pathway databases

ReactomeiR-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-9009391, Extra-nuclear estrogen signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		15507, 4 hits in 71 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Hspb1, mouse

Protein Ontology

More...PROi		PR:P14602
RNActiP14602, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000004951, Expressed in lens of camera-type eye and 74 other tissues
GenevisibleiP14602, MM

Family and domain databases

CDDicd06475, ACD_HspB1_like, 1 hit
DisProtiDP00142
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068, A-crystallin/Hsp20_dom
IPR037876, ACD_HspB1
IPR001436, Alpha-crystallin/sHSP_animal
IPR008978, HSP20-like_chaperone
PANTHERiPTHR45640, PTHR45640, 1 hit
PfamiView protein in Pfam
PF00011, HSP20, 1 hit
PRINTSiPR00299, ACRYSTALLIN
SUPFAMiSSF49764, SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031, SHSP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSPB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14602
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: May 25, 2022
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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