Hspb1

Functionⁱ

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
protein binding involved in protein folding Source: UniProtKB
protein homodimerization activity Source: UniProtKB
protein kinase binding Source: MGI
protein kinase C binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 15731106
protein kinase C inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15731106
ubiquitin binding Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterograde axonal protein transport Source: UniProtKB
cellular response to vascular endothelial growth factor stimulus Source: MGI
chaperone-mediated protein folding Source: UniProtKB
intracellular signal transduction Source: MGI
negative regulation of apoptotic signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 15731106
negative regulation of oxidative stress-induced cell death Source: MGI
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 15731106
negative regulation of protein kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15731106
positive regulation of angiogenesis Source: MGI
positive regulation of blood vessel endothelial cell migration Source: MGI
positive regulation of endothelial cell chemotaxis Source: MGI
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: MGI
positive regulation of interleukin-1 beta production
Source: BHF-UCL
Inferred from direct assayⁱ
- 12385642
positive regulation of neuron projection development Source: MGI
positive regulation of tumor necrosis factor biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 12385642
regulation of I-kappaB kinase/NF-kappaB signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 12385642
regulation of protein phosphorylation Source: MGI
response to unfolded protein
Source: BHF-UCL
Non-traceable author statementⁱ
- 10859165
response to virus Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Stress response

Enzyme and pathway databases

Reactomeⁱ	R-MMU-4420097 VEGFA-VEGFR2 Pathway R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-5687128 MAPK6/MAPK4 signaling

Reactomeⁱ

R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock protein beta-1 Short name: HspB1 Alternative name(s): Growth-related 25 kDa protein Heat shock 25 kDa protein Short name: HSP 25 Heat shock 27 kDa protein Short name: HSP 27 p25
Gene namesⁱ	Name:Hspb1 Synonyms:Hsp25, Hsp27
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:96240 Hspb1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable and fertile with no apparent morphological abnormalities in tissues under physiological conditions.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000125928	1 – 209	Heat shock protein beta-1Add BLAST		209

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	13	PhosphoserineBy similarity	1
Modified residueⁱ	15	Phosphoserine; by MAPKAPK2, MAPKAPK3, PKA and PKC2 Publications	1
Modified residueⁱ	27	PhosphoserineBy similarity	1
Modified residueⁱ	86	Phosphoserine; by MAPKAPK2, MAPKAPK3, MAPKAPK5, PKA and PKCCombined sources2 Publications	1
Modified residueⁱ	87	PhosphoserineBy similarity	1
Modified residueⁱ	90	PhosphoserineBy similarity	1
Modified residueⁱ	102	PhosphoserineBy similarity	1
Modified residueⁱ	127	N6-acetyllysineBy similarity	1
Modified residueⁱ	178	PhosphothreonineBy similarity	1
Modified residueⁱ	180	PhosphoserineBy similarity	1
Modified residueⁱ	203	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated upon exposure to protein kinase C activators and heat shock (By similarity). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:1860870, PubMed:21575178, PubMed:8093612).By similarity4 Publications

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOSTⁱ	P14602
PaxDbⁱ	P14602
PeptideAtlas More...PeptideAtlasⁱ	P14602
PRIDEⁱ	P14602

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00128522 IPI00468068 P14602
SWISS-2DPAGEⁱ	P14602
UCD-2DPAGEⁱ	P14602

PTM databases

iPTMnetⁱ	P14602
PhosphoSitePlusⁱ	P14602

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000004951 Expressed in 23 organ(s), highest expression level in placenta
CleanExⁱ	MM_HSPB1
ExpressionAtlasⁱ	P14602 baseline and differential
Genevisibleⁱ	P14602 MM

Interactionⁱ

Subunit structureⁱ

Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin (By similarity). Interacts with TGFB1I1 (PubMed:11546764). Interacts with CRYAB (By similarity). Interacts with HSPB8 (PubMed:11342557). Interacts with HSPBAP1 (PubMed:10751411).By similarity3 Publications

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
protein binding involved in protein folding Source: UniProtKB
protein homodimerization activity Source: UniProtKB
protein kinase binding Source: MGI
protein kinase C binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 15731106
ubiquitin binding Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200449, 18 interactors
CORUMⁱ	P14602
IntActⁱ	P14602, 11 interactors
Molecular INTeraction database More...MINTⁱ	P14602
STRINGⁱ	10090.ENSMUSP00000005077

Structureⁱ

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00142
ProteinModelPortalⁱ	P14602
SMRⁱ	P14602
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	80 – 188	sHSPPROSITE-ProRule annotationAdd BLAST		109

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	74 – 209	Interaction with TGFB1I1By similarityAdd BLAST		136

Sequence similaritiesⁱ

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155882
HOGENOMⁱ	HOG000233955
HOVERGENⁱ	HBG054766
InParanoidⁱ	P14602
KEGG Orthology (KO) More...KOⁱ	K04455
OMAⁱ	FDQSFGM
Database of Orthologous Groups More...OrthoDBⁱ	1187096at2759
PhylomeDBⁱ	P14602
TreeFamⁱ	TF105049

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06475 ACD_HspB1_like, 1 hit
Gene3Dⁱ	2.60.40.790, 1 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform A (identifier: P14602-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA 
        60         70         80         90        100
GWPGYVRPLP AATAEGPAAV TLAAPAFSRA LNRQLSSGVS EIRQTADRWR 
       110        120        130        140        150
VSLDVNHFAP EELTVKTKEG VVEITGKHEE RQDEHGYISR CFTRKYTLPP 
       160        170        180        190        200
GVDPTLVSSS LSPEGTLTVE APLPKAVTQS AEITIPVTFE ARAQIGGPEA 

GKSEQSGAK

Length:209

Mass (Da):23,014

Last modified:June 1, 1994 - v3

Checksum:ⁱ31BD9FAF4E107C50

GO

Isoform B (identifier: P14602-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
61-72: Missing.

« Hide

        10         20         30         40         50
MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA 
        60         70         80         90        100
GWPGYVRPLP AAPAFSRALN RQLSSGVSEI RQTADRWRVS LDVNHFAPEE 
       110        120        130        140        150
LTVKTKEGVV EITGKHEERQ DEHGYISRCF TRKYTLPPGV DPTLVSSSLS 
       160        170        180        190 
PEGTLTVEAP LPKAVTQSAE ITIPVTFEAR AQIGGPEAGK SEQSGAK

Show »

Length:197

Mass (Da):21,961

Checksum:ⁱ071D3C112509C01A

GO

Isoform C (identifier: P14602-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
37-70: Missing.

« Hide

        10         20         30         40         50
MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVTLAA PAFSRALNRQ 
        60         70         80         90        100
LSSGVSEIRQ TADRWRVSLD VNHFAPEELT VKTKEGVVEI TGKHEERQDE 
       110        120        130        140        150
HGYISRCFTR KYTLPPGVDP TLVSSSLSPE GTLTVEAPLP KAVTQSAEIT 
       160        170 
IPVTFEARAQ IGGPEAGKSE QSGAK

Show »

Length:175

Mass (Da):19,380

Checksum:ⁱAA7E60872B1C485B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3YZ06	D3YZ06_MOUSE		Heat shock protein beta-1 Heat shock protein beta-1	Hspb1	147	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	13	S → T in AAA18335 (PubMed:8132504).Curated	1
Sequence conflictⁱ	13	S → T in AAA18336 (PubMed:8132504).Curated	1
Sequence conflictⁱ	13	S → T in AAA18337 (PubMed:8132504).Curated	1
Sequence conflictⁱ	17	E → G in AAA18335 (PubMed:8132504).Curated	1
Sequence conflictⁱ	67 – 68	PA → L in AAA18335 (PubMed:8132504).Curated	2
Sequence conflictⁱ	99	Missing in CAA32818 (PubMed:2645135).Curated	1
Sequence conflictⁱ	99	Missing in CAB37341 (PubMed:2645135).Curated	1
Sequence conflictⁱ	108 – 109	FA → VI in CAA32818 (PubMed:2645135).Curated	2
Sequence conflictⁱ	108 – 109	FA → VI in CAB37341 (PubMed:2645135).Curated	2
Sequence conflictⁱ	141	C → Q AA sequence (PubMed:2645135).Curated	1
Sequence conflictⁱ	181	A → T in CAA32818 (PubMed:2645135).Curated	1
Sequence conflictⁱ	181	A → T in CAB37341 (PubMed:2645135).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002423	37 – 70	Missing in isoform C. 1 PublicationAdd BLAST		34
Alternative sequenceⁱVSP_002422	61 – 72	Missing in isoform B. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14687 mRNA Translation: CAA32818.1 X14686 mRNA Translation: CAB37341.1 L11609, L11608 Genomic DNA Translation: AAA37862.1 L07577 Genomic DNA Translation: AAA37861.1 U03560 mRNA Translation: AAA18335.1 U03561 mRNA Translation: AAA18336.1 U03562 mRNA Translation: AAA18337.1 BC018257 mRNA Translation: AAH18257.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39320.1 [P14602-1]
PIRⁱ	A53423 I49763 JN0679 S02143
NCBI Reference Sequences More...RefSeqⁱ	NP_038588.2, NM_013560.2 [P14602-1]
UniGeneⁱ	Mm.13849

Genome annotation databases

Ensemblⁱ	ENSMUST00000005077; ENSMUSP00000005077; ENSMUSG00000004951 [P14602-1]
GeneIDⁱ	15507
KEGGⁱ	mmu:15507
UCSC genome browser More...UCSCⁱ	uc008zze.2 mouse [P14602-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14602	Hspb1 protein		MOUSE		209	UniRef100_P14602
Heat shock protein beta-1		MOUSE		147

Protein	Similar proteins		Species	Score	Length	Source
P14602	Hspb1 protein		MOUSE		209	UniRef90_P14602
Heat shock protein beta-1		CANLF		209
heat shock protein beta-1		Florida manatee		209
Heat shock protein family B (small) member 1		HORSE		209
UPI000719509A		southern white rhinoceros		259
+3
P14602-2	Heat shock protein beta-1		CASCN		207	UniRef90_P14602-2
HSP27 protein (Fragment)		CAPHI		183
UPI0004D08953		GALVR		207
UPI000333E6B4		OCTDE		200
UPI00069867E0		CHILA		200

Protein	Similar proteins		Species	Score	Length	Source
P14602	Heat shock protein beta-1	)	HUMAN		205	UniRef50_P04792
Heat shock protein beta-1		MACMU		205
HSPB1 isoform 1		PANTR		205
Heat shock protein family B (small) member 1		PANPA		205
Heat shock protein family B (small) member 1		GORGO		205
+51
P14602-2	Heat shock protein beta-1		CASCN		207	UniRef50_P14602-2
HSP27 protein (Fragment)		CAPHI		183
Heat shock protein beta-1		CHEMY		215
Heat shock protein, alpha-crystallin-related, 1		Periophthalmus magnuspinnatus		195
Heat shock protein family B (small) member 1		XENTR		212
+144
P14602-3	Isoform B of Heat shock protein beta-1		MOUSE		197	UniRef50_P14602-2
Heat shock protein beta-1		CASCN		207
HSP27 protein (Fragment)		CAPHI		183
Heat shock protein beta-1		CHEMY		215
Heat shock protein, alpha-crystallin-related, 1		Periophthalmus magnuspinnatus		195
+144

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14687 mRNA Translation: CAA32818.1 X14686 mRNA Translation: CAB37341.1 L11609, L11608 Genomic DNA Translation: AAA37862.1 L07577 Genomic DNA Translation: AAA37861.1 U03560 mRNA Translation: AAA18335.1 U03561 mRNA Translation: AAA18336.1 U03562 mRNA Translation: AAA18337.1 BC018257 mRNA Translation: AAH18257.1
CCDSⁱ	CCDS39320.1 [P14602-1]
PIRⁱ	A53423 I49763 JN0679 S02143
RefSeqⁱ	NP_038588.2, NM_013560.2 [P14602-1]
UniGeneⁱ	Mm.13849

3D structure databases

DisProtⁱ	DP00142
ProteinModelPortalⁱ	P14602
SMRⁱ	P14602
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200449, 18 interactors
CORUMⁱ	P14602
IntActⁱ	P14602, 11 interactors
MINTⁱ	P14602
STRINGⁱ	10090.ENSMUSP00000005077

PTM databases

iPTMnetⁱ	P14602
PhosphoSitePlusⁱ	P14602

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00128522 IPI00468068 P14602
SWISS-2DPAGEⁱ	P14602
UCD-2DPAGEⁱ	P14602

Proteomic databases

jPOSTⁱ	P14602
PaxDbⁱ	P14602
PeptideAtlasⁱ	P14602
PRIDEⁱ	P14602

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005077; ENSMUSP00000005077; ENSMUSG00000004951 [P14602-1]
GeneIDⁱ	15507
KEGGⁱ	mmu:15507
UCSCⁱ	uc008zze.2 mouse [P14602-1]

Organism-specific databases

CTDⁱ	3315
MGIⁱ	MGI:96240 Hspb1

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
GeneTreeⁱ	ENSGT00940000155882
HOGENOMⁱ	HOG000233955
HOVERGENⁱ	HBG054766
InParanoidⁱ	P14602
KOⁱ	K04455
OMAⁱ	FDQSFGM
OrthoDBⁱ	1187096at2759
PhylomeDBⁱ	P14602
TreeFamⁱ	TF105049

Enzyme and pathway databases

Reactomeⁱ	R-MMU-4420097 VEGFA-VEGFR2 Pathway R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-5687128 MAPK6/MAPK4 signaling

Reactomeⁱ

R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-5687128 MAPK6/MAPK4 signaling

Miscellaneous databases

ChiTaRSⁱ	Hsbp1 mouse
Protein Ontology More...PROⁱ	PR:P14602
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000004951 Expressed in 23 organ(s), highest expression level in placenta
CleanExⁱ	MM_HSPB1
ExpressionAtlasⁱ	P14602 baseline and differential
Genevisibleⁱ	P14602 MM

Family and domain databases

CDDⁱ	cd06475 ACD_HspB1_like, 1 hit
Gene3Dⁱ	2.60.40.790, 1 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSPB1_MOUSE
Accessionⁱ	P14602Primary (citable) accession number: P14602
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	June 1, 1994
	Last modified:	January 16, 2019
	This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

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Supporting data

UniProtKB - P14602 (HSPB1_MOUSE)

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Heat shock protein beta-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ