UniProtKB - P14602 (HSPB1_MOUSE)
Heat shock protein beta-1
Hspb1
Functioni
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein folding chaperone Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- protein kinase C binding Source: BHF-UCL
- protein kinase C inhibitor activity Source: BHF-UCL
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- ubiquitin binding Source: BHF-UCL
GO - Biological processi
- anterograde axonal protein transport Source: UniProtKB
- cellular response to vascular endothelial growth factor stimulus Source: MGI
- chaperone-mediated protein folding Source: UniProtKB
- intracellular signal transduction Source: MGI
- negative regulation of apoptotic signaling pathway Source: MGI
- negative regulation of oxidative stress-induced cell death Source: MGI
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of protein kinase activity Source: BHF-UCL
- negative regulation of regulatory T cell differentiation Source: MGI
- positive regulation of angiogenesis Source: MGI
- positive regulation of blood vessel endothelial cell migration Source: MGI
- positive regulation of endothelial cell chemotaxis Source: MGI
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: MGI
- positive regulation of interleukin-1 beta production Source: BHF-UCL
- positive regulation of neuron projection development Source: MGI
- positive regulation of tumor necrosis factor production Source: BHF-UCL
- regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
- regulation of protein phosphorylation Source: MGI
- response to unfolded protein Source: BHF-UCL
- response to virus Source: BHF-UCL
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Enzyme and pathway databases
Reactomei | R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-9009391, Extra-nuclear estrogen signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein beta-1Short name: HspB1 Alternative name(s): Growth-related 25 kDa protein Heat shock 25 kDa protein Short name: HSP 25 Heat shock 27 kDa protein Short name: HSP 27 p25 |
Gene namesi | Name:Hspb1 Synonyms:Hsp25, Hsp27 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96240, Hspb1 |
Subcellular locationi
Cytoskeleton
- spindle By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.By similarity
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
- postsynaptic density membrane Source: MGI
Other locations
- axon Source: MGI
- axon cytoplasm Source: GOC
- cardiac myofibril Source: MGI
- contractile fiber Source: MGI
- cytoplasm Source: MGI
- dendrite Source: MGI
- I band Source: MGI
- M band Source: MGI
- perikaryon Source: MGI
- proteasome complex Source: BHF-UCL
- synapse Source: MGI
- Z disc Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125928 | 1 – 209 | Heat shock protein beta-1Add BLAST | 209 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 15 | Phosphoserine; by MAPKAPK2, MAPKAPK3, PKA and PKC2 Publications | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | Phosphoserine; by MAPKAPK2, MAPKAPK3, MAPKAPK5, PKA and PKCCombined sources2 Publications | 1 | |
Modified residuei | 87 | PhosphoserineBy similarity | 1 | |
Modified residuei | 90 | PhosphoserineBy similarity | 1 | |
Modified residuei | 102 | PhosphoserineBy similarity | 1 | |
Modified residuei | 127 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 178 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 180 | PhosphoserineBy similarity | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
jPOSTi | P14602 |
PaxDbi | P14602 |
PeptideAtlasi | P14602 |
PRIDEi | P14602 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00128522 IPI00468068 P14602 |
SWISS-2DPAGEi | P14602 |
UCD-2DPAGEi | P14602 |
PTM databases
iPTMneti | P14602 |
PhosphoSitePlusi | P14602 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004951, Expressed in lens of camera-type eye and 56 other tissues |
Genevisiblei | P14602, MM |
Interactioni
Subunit structurei
Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin (By similarity).
Interacts with TGFB1I1 (PubMed:11546764).
Interacts with CRYAB (By similarity).
Interacts with HSPB8 (PubMed:11342557).
Interacts with HSPBAP1 (PubMed:10751411).
By similarity3 PublicationsGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- protein kinase C binding Source: BHF-UCL
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- ubiquitin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 200449, 21 interactors |
CORUMi | P14602 |
IntActi | P14602, 11 interactors |
MINTi | P14602 |
STRINGi | 10090.ENSMUSP00000005077 |
Miscellaneous databases
RNActi | P14602, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 188 | sHSPPROSITE-ProRule annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 74 – 209 | Interaction with TGFB1I1By similarityAdd BLAST | 136 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
GeneTreei | ENSGT00940000155882 |
HOGENOMi | CLU_095001_0_0_1 |
InParanoidi | P14602 |
OMAi | EEWAQWF |
PhylomeDBi | P14602 |
TreeFami | TF105049 |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
DisProti | DP00142 |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA
60 70 80 90 100
GWPGYVRPLP AATAEGPAAV TLAAPAFSRA LNRQLSSGVS EIRQTADRWR
110 120 130 140 150
VSLDVNHFAP EELTVKTKEG VVEITGKHEE RQDEHGYISR CFTRKYTLPP
160 170 180 190 200
GVDPTLVSSS LSPEGTLTVE APLPKAVTQS AEITIPVTFE ARAQIGGPEA
GKSEQSGAK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YZ06 | D3YZ06_MOUSE | Heat shock protein beta-1 | Hspb1 | 147 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | S → T in AAA18335 (PubMed:8132504).Curated | 1 | |
Sequence conflicti | 13 | S → T in AAA18336 (PubMed:8132504).Curated | 1 | |
Sequence conflicti | 13 | S → T in AAA18337 (PubMed:8132504).Curated | 1 | |
Sequence conflicti | 17 | E → G in AAA18335 (PubMed:8132504).Curated | 1 | |
Sequence conflicti | 67 – 68 | PA → L in AAA18335 (PubMed:8132504).Curated | 2 | |
Sequence conflicti | 99 | Missing in CAA32818 (PubMed:2645135).Curated | 1 | |
Sequence conflicti | 99 | Missing in CAB37341 (PubMed:2645135).Curated | 1 | |
Sequence conflicti | 108 – 109 | FA → VI in CAA32818 (PubMed:2645135).Curated | 2 | |
Sequence conflicti | 108 – 109 | FA → VI in CAB37341 (PubMed:2645135).Curated | 2 | |
Sequence conflicti | 141 | C → Q AA sequence (PubMed:2645135).Curated | 1 | |
Sequence conflicti | 181 | A → T in CAA32818 (PubMed:2645135).Curated | 1 | |
Sequence conflicti | 181 | A → T in CAB37341 (PubMed:2645135).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002423 | 37 – 70 | Missing in isoform C. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_002422 | 61 – 72 | Missing in isoform B. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14687 mRNA Translation: CAA32818.1 X14686 mRNA Translation: CAB37341.1 L11609, L11608 Genomic DNA Translation: AAA37862.1 L07577 Genomic DNA Translation: AAA37861.1 U03560 mRNA Translation: AAA18335.1 U03561 mRNA Translation: AAA18336.1 U03562 mRNA Translation: AAA18337.1 BC018257 mRNA Translation: AAH18257.1 |
CCDSi | CCDS39320.1 [P14602-1] |
PIRi | A53423 I49763, JN0679 S02143 |
RefSeqi | NP_038588.2, NM_013560.2 [P14602-1] |
Genome annotation databases
Ensembli | ENSMUST00000005077; ENSMUSP00000005077; ENSMUSG00000004951 [P14602-1] |
GeneIDi | 15507 |
KEGGi | mmu:15507 |
UCSCi | uc008zze.2, mouse [P14602-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14687 mRNA Translation: CAA32818.1 X14686 mRNA Translation: CAB37341.1 L11609, L11608 Genomic DNA Translation: AAA37862.1 L07577 Genomic DNA Translation: AAA37861.1 U03560 mRNA Translation: AAA18335.1 U03561 mRNA Translation: AAA18336.1 U03562 mRNA Translation: AAA18337.1 BC018257 mRNA Translation: AAH18257.1 |
CCDSi | CCDS39320.1 [P14602-1] |
PIRi | A53423 I49763, JN0679 S02143 |
RefSeqi | NP_038588.2, NM_013560.2 [P14602-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 200449, 21 interactors |
CORUMi | P14602 |
IntActi | P14602, 11 interactors |
MINTi | P14602 |
STRINGi | 10090.ENSMUSP00000005077 |
PTM databases
iPTMneti | P14602 |
PhosphoSitePlusi | P14602 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00128522 IPI00468068 P14602 |
SWISS-2DPAGEi | P14602 |
UCD-2DPAGEi | P14602 |
Proteomic databases
jPOSTi | P14602 |
PaxDbi | P14602 |
PeptideAtlasi | P14602 |
PRIDEi | P14602 |
Protocols and materials databases
Antibodypediai | 603, 3045 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000005077; ENSMUSP00000005077; ENSMUSG00000004951 [P14602-1] |
GeneIDi | 15507 |
KEGGi | mmu:15507 |
UCSCi | uc008zze.2, mouse [P14602-1] |
Organism-specific databases
CTDi | 3315 |
MGIi | MGI:96240, Hspb1 |
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
GeneTreei | ENSGT00940000155882 |
HOGENOMi | CLU_095001_0_0_1 |
InParanoidi | P14602 |
OMAi | EEWAQWF |
PhylomeDBi | P14602 |
TreeFami | TF105049 |
Enzyme and pathway databases
Reactomei | R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-9009391, Extra-nuclear estrogen signaling |
Miscellaneous databases
BioGRID-ORCSi | 15507, 3 hits in 17 CRISPR screens |
ChiTaRSi | Hspb1, mouse |
PROi | PR:P14602 |
RNActi | P14602, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004951, Expressed in lens of camera-type eye and 56 other tissues |
Genevisiblei | P14602, MM |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
DisProti | DP00142 |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSPB1_MOUSE | |
Accessioni | P14602Primary (citable) accession number: P14602 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 198 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families