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Protein

Substance-P receptor

Gene

Tacr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

GO - Molecular functioni

  • substance P receptor activity Source: RGD
  • tachykinin receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380095 Tachykinin receptors bind tachykinins
R-RNO-416476 G alpha (q) signalling events
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:Tacr1
Synonyms:Tac1r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3811 Tacr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 54Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini55 – 64CytoplasmicSequence analysis10
Transmembranei65 – 86Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini87 – 106ExtracellularSequence analysisAdd BLAST20
Transmembranei107 – 128Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini129 – 148CytoplasmicSequence analysisAdd BLAST20
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 194ExtracellularSequence analysisAdd BLAST25
Transmembranei195 – 219Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini220 – 248CytoplasmicSequence analysisAdd BLAST29
Transmembranei249 – 270Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini271 – 283ExtracellularSequence analysisAdd BLAST13
Transmembranei284 – 308Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini309 – 407CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4027
GuidetoPHARMACOLOGYi360

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698881 – 407Substance-P receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation
Lipidationi322S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP14600
PRIDEiP14600

PTM databases

PhosphoSitePlusiP14600

Expressioni

Gene expression databases

BgeeiENSRNOG00000005853 Expressed in 6 organ(s), highest expression level in colon
GenevisibleiP14600 RN

Interactioni

Subunit structurei

Interacts with ARRB1.

Protein-protein interaction databases

BioGridi246930, 1 interactor
STRINGi10116.ENSRNOP00000007984

Chemistry databases

BindingDBiP14600

Structurei

3D structure databases

ProteinModelPortaliP14600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219 Eukaryota
ENOG410XSC5 LUCA
GeneTreeiENSGT00930000150872
HOGENOMiHOG000013018
HOVERGENiHBG103412
InParanoidiP14600
KOiK04222
OMAiTESFSFY
OrthoDBiEOG091G0WYG
PhylomeDBiP14600
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001681 Neurokn_rcpt
IPR000046 NK1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01024 NEUROKININ1R
PR00244 NEUROKININR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P14600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY
110 120 130 140 150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK
360 370 380 390 400
VSRLETTIST VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS

FYSNMLA
Length:407
Mass (Da):46,366
Last modified:April 1, 1990 - v1
Checksum:iADF885A0BF551C96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73N → D in AAB59726 (PubMed:2154852).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64236
, M64232, M64233, M64234, M64235 Genomic DNA Translation: AAA42176.1
J05097 mRNA Translation: AAA42175.1
M31477 mRNA Translation: AAB59726.1
PIRiA38692 A34357
RefSeqiNP_036799.1, NM_012667.2
UniGeneiRn.89609

Genome annotation databases

EnsembliENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853
GeneIDi24807
KEGGirno:24807
UCSCiRGD:3811 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64236
, M64232, M64233, M64234, M64235 Genomic DNA Translation: AAA42176.1
J05097 mRNA Translation: AAA42175.1
M31477 mRNA Translation: AAB59726.1
PIRiA38692 A34357
RefSeqiNP_036799.1, NM_012667.2
UniGeneiRn.89609

3D structure databases

ProteinModelPortaliP14600
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246930, 1 interactor
STRINGi10116.ENSRNOP00000007984

Chemistry databases

BindingDBiP14600
ChEMBLiCHEMBL4027
GuidetoPHARMACOLOGYi360

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP14600

Proteomic databases

PaxDbiP14600
PRIDEiP14600

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853
GeneIDi24807
KEGGirno:24807
UCSCiRGD:3811 rat

Organism-specific databases

CTDi6869
RGDi3811 Tacr1

Phylogenomic databases

eggNOGiKOG4219 Eukaryota
ENOG410XSC5 LUCA
GeneTreeiENSGT00930000150872
HOGENOMiHOG000013018
HOVERGENiHBG103412
InParanoidiP14600
KOiK04222
OMAiTESFSFY
OrthoDBiEOG091G0WYG
PhylomeDBiP14600
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-RNO-380095 Tachykinin receptors bind tachykinins
R-RNO-416476 G alpha (q) signalling events
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

PROiPR:P14600

Gene expression databases

BgeeiENSRNOG00000005853 Expressed in 6 organ(s), highest expression level in colon
GenevisibleiP14600 RN

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001681 Neurokn_rcpt
IPR000046 NK1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01024 NEUROKININ1R
PR00244 NEUROKININR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNK1R_RAT
AccessioniPrimary (citable) accession number: P14600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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