Substance-P receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• substance P receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2."
    Kwatra M.M., Schwinn D.A., Schreurs J., Blank J.L., Kim C.M., Benovic J.L., Krause J.E., Caron M.G., Lefkowitz R.J.
    J. Biol. Chem. 268:9161-9164(1993) [PubMed] [Europe PMC] [Abstract]
• tachykinin receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• acute inflammatory response Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons."
    McCarson K.E.
    Neuroscience 93:361-370(1999) [PubMed] [Europe PMC] [Abstract]
• aggressive behavior Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The effect of neurokinin1 receptor blockade on territorial aggression and in a model of violent aggression."
    Halasz J., Toth M., Mikics E., Hrabovszky E., Barsy B., Barsvari B., Haller J.
    Biol. Psychiatry 63:271-278(2008) [PubMed] [Europe PMC] [Abstract]
• angiotensin-mediated drinking behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Further evidence that central tachykinin NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in rats."
    Polidori C., Ciccocioppo R., De Caro G., Massi M.
    Peptides 19:149-155(1998) [PubMed] [Europe PMC] [Abstract]
• associative learning Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats."
    Kertes E., Laszlo K., Berta B., Lenard L.
    Behav. Brain Res. 198:397-403(2009) [PubMed] [Europe PMC] [Abstract]
• behavioral response to pain Source: RGDInferred from mutant phenotypeⁱ
  • "NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin."
    Pacharinsak C., Khasabov S.G., Beitz A.J., Simone D.A.
    Pain 139:34-46(2008) [PubMed] [Europe PMC] [Abstract]
• eating behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats."
    Malik N.M., Liu Y.L., Cole N., Sanger G.J., Andrews P.L.
    Eur. J. Pharmacol. 555:164-173(2007) [PubMed] [Europe PMC] [Abstract]
• learning or memory Source: RGDInferred from mutant phenotypeⁱ
  • "The role of substance P in the marginal division of the neostriatum in learning and memory is mediated through the neurokinin 1 receptor in rats."
    Liu X.M., Shu S.Y., Zeng C.C., Cai Y.F., Zhang K.H., Wang C.X., Fang J.
    Neurochem. Res. 36:1896-1902(2011) [PubMed] [Europe PMC] [Abstract]
• long-term memory Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats."
    Kertes E., Laszlo K., Berta B., Lenard L.
    Behav. Brain Res. 198:397-403(2009) [PubMed] [Europe PMC] [Abstract]
• neuropeptide signaling pathway Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia."
    Ikeda H., Heinke B., Ruscheweyh R., Sandkuhler J.
    Science 299:1237-1240(2003) [PubMed] [Europe PMC] [Abstract]
• operant conditioning Source: RGDInferred from mutant phenotypeⁱ
  • "Intrathecal administration of neurokinin 1 and neurokinin 2 receptor antagonists undermines the savings effect in spinal rats seen in an instrumental learning paradigm."
    Baumbauer K.M., Young E.E., Hoy K.C. Jr., Joynes R.L.
    Behav. Neurosci. 121:186-199(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of action potential Source: RGDInferred from mutant phenotypeⁱ
  • "Physiological and morphological properties of, and effect of substance P on, neurons in the A7 catecholamine cell group in rats."
    Min M.Y., Wu Y.W., Shih P.Y., Lu H.W., Lin C.C., Wu Y., Li M.J., Yang H.W.
    Neuroscience 153:1020-1033(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats."
    Wang Y., Novotny M., Quaiserova-Mocko V., Swain G.M., Wang D.H.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:R1517-23(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Substance P regulates migration in rat intestinal epithelial cells."
    Turner D.J., Martin P.C., Rao J.N., Greenspon J., Zou T., Bass B.L., Wang J.Y., Strauch E.D.
    Ann. Surg. 245:408-414(2007) [PubMed] [Europe PMC] [Abstract]
  • "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro."
    Li M., Shang Y.X., Wei B., Yang Y.G.
    J Inflamm (Lond) 8:18-18(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "Substance P regulates migration in rat intestinal epithelial cells."
    Turner D.J., Martin P.C., Rao J.N., Greenspon J., Zou T., Bass B.L., Wang J.Y., Strauch E.D.
    Ann. Surg. 245:408-414(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair."
    Oslund K.L., Hyde D.M., Putney L.F., Alfaro M.F., Walby W.F., Tyler N.K., Schelegle E.S.
    Am. J. Respir. Cell Mol. Biol. 39:279-288(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of flagellated sperm motility Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hormone secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Role of tachykinin receptors and melatonin in oxitocin secretion from isolated rat hypothalmo-neurohypophysial system."
    Juszczak M., Furykiewicz-Nykis K., Stempniak B.
    J. Physiol. Pharmacol. 55:739-749(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of leukocyte migration Source: RGDInferred from mutant phenotypeⁱ
  • "Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom."
    Costa S.K., Moreno R.A., Esquisatto L.C., Juliano L., Brain S.D., De Nucci G., Antunes E.
    Neurosci. Lett. 318:158-162(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lymphocyte proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity."
    Amantini C., Mosca M., Lucciarini R., Perfumi M.C., Santoni G.
    J. Pharmacol. Exp. Ther. 327:215-225(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ossification Source: RGDInferred from mutant phenotypeⁱ
  • "Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors."
    Goto T., Nakao K., Gunjigake K.K., Kido M.A., Kobayashi S., Tanaka T.
    Neuropeptides 41:25-31(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of renal sodium excretion Source: RGDInferred from mutant phenotypeⁱ
  • "Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors."
    Xie C., Sachs J.R., Wang D.H.
    J. Pharmacol. Exp. Ther. 325:751-757(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of saliva secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue."
    Bremer A.A., Tansky M.F., Wu M., Boyd N.D., Leeman S.E.
    Eur. J. Pharmacol. 423:143-147(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of stress fiber assembly Source: RGDInferred from mutant phenotypeⁱ
  • "Substance P regulates migration in rat intestinal epithelial cells."
    Turner D.J., Martin P.C., Rao J.N., Greenspon J., Zou T., Bass B.L., Wang J.Y., Strauch E.D.
    Ann. Surg. 245:408-414(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic transmission, cholinergic Source: RGDInferred from mutant phenotypeⁱ
  • "Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor transmission."
    Perez S., Tierney A., Deniau J.M., Kemel M.L.
    J. Neurochem. 103:2153-2163(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic transmission, GABAergic Source: RGDInferred from mutant phenotypeⁱ
  • "Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats."
    Chen C.Y., Bechtold A.G., Tabor J., Bonham A.C.
    J. Neurosci. 29:2754-2761(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of uterine smooth muscle contraction Source: RGDInferred from direct assayⁱ
  • "Estrogen-dependent regulation of neurokinin 3 receptor-mediated uterine contractility in the rat."
    Crane L.H., Williams M.J., Nimmo A.J., Hamlin G.P.
    Biol. Reprod. 67:1480-1487(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular permeability Source: RGDInferred from mutant phenotypeⁱ
  • "Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure."
    Li P.C., Chen W.C., Chang L.C., Lin S.C.
    Am. J. Physiol. Lung Cell Mol. Physiol. 294:L912-20(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "Colorectal distension enforce acute urinary bladder distension-induced hepatic vasoconstriction in the rat."
    Chen S.S., Yang C.C., Chien C.T.
    Neurosci. Lett. 443:257-260(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis."
    Cardenas A., Lowe R., Oh S., Bodkin S., Kenney T., Lamorte W.W., Afdhal N.H.
    Scand. J. Gastroenterol. 43:328-333(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of smooth muscle cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro."
    Li M., Shang Y.X., Wei B., Yang Y.G.
    J Inflamm (Lond) 8:18-18(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of smooth muscle cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro."
    Li M., Shang Y.X., Wei B., Yang Y.G.
    J Inflamm (Lond) 8:18-18(2011) [PubMed] [Europe PMC] [Abstract]
• response to auditory stimulus Source: RGDInferred from direct assayⁱ
  • "Neurokinin-1 receptors in cholinergic neurons of the rat ventral pallidum have a predominantly dendritic distribution that is affected by apomorphine when combined with startle-evoking auditory stimulation."
    Mengual E., Chan J., Lane D., San Luciano Palenzuela M., Hara Y., Lessard A., Pickel V.M.
    Neuroscience 151:711-724(2008) [PubMed] [Europe PMC] [Abstract]
• response to electrical stimulus Source: RGDInferred from expression patternⁱ
  • "Altered neuropeptide Y and neurokinin messenger RNA expression and receptor binding in stress-sensitised rats."
    de Lange R.P., Wiegant V.M., Stam R.
    Brain Res. 1212:35-47(2008) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment."
    Pinto F.M., Armesto C.P., Magraner J., Trujillo M., Martin J.D., Candenas M.L.
    Endocrinology 140:2526-2532(1999) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: RGDInferred from mutant phenotypeⁱ
  • "Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats."
    Camara P.R., Ferraz G.J., Franco-Penteado C.F., Sbragia-Neto L., Meirelles L.R., Teixeira S.A., Muscara M.N., Velloso L.A., Antunes E., Ferraz J.G.
    Eur. J. Pharmacol. 589:245-250(2008) [PubMed] [Europe PMC] [Abstract]
• response to heat Source: RGDInferred from mutant phenotypeⁱ
  • "Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia."
    Zhang H., Cang C.L., Kawasaki Y., Liang L.L., Zhang Y.Q., Ji R.R., Zhao Z.Q.
    J. Neurosci. 27:12067-12077(2007) [PubMed] [Europe PMC] [Abstract]
• response to hormone Source: RGDInferred from mutant phenotypeⁱ
  • "Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies."
    Juszczak M., Boczek-Leszczyk E., Stempniak B.
    J. Physiol. Pharmacol. 58:829-843(2007) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from expression patternⁱ
  • "Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats."
    Thomson L.M., Terman G.W., Zeng J., Lowe J., Chavkin C., Hermes S.M., Hegarty D.M., Aicher S.A.
    J Pain 9:11-19(2008) [PubMed] [Europe PMC] [Abstract]
• response to nicotine Source: RGDInferred from mutant phenotypeⁱ
  • "Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists."
    Khan I.M., Wart C.V., Singletary E.A., Stanislaus S., Deerinck T., Yaksh T.L., Printz M.P.
    Neuropharmacology 54:269-279(2008) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from direct assayⁱ
  • "Neurokinin-1 receptors in cholinergic neurons of the rat ventral pallidum have a predominantly dendritic distribution that is affected by apomorphine when combined with startle-evoking auditory stimulation."
    Mengual E., Chan J., Lane D., San Luciano Palenzuela M., Hara Y., Lessard A., Pickel V.M.
    Neuroscience 151:711-724(2008) [PubMed] [Europe PMC] [Abstract]
• response to ozone Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair."
    Oslund K.L., Hyde D.M., Putney L.F., Alfaro M.F., Walby W.F., Tyler N.K., Schelegle E.S.
    Am. J. Respir. Cell Mol. Biol. 39:279-288(2008) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment."
    Pinto F.M., Armesto C.P., Magraner J., Trujillo M., Martin J.D., Candenas M.L.
    Endocrinology 140:2526-2532(1999) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin."
    Pacharinsak C., Khasabov S.G., Beitz A.J., Simone D.A.
    Pain 139:34-46(2008) [PubMed] [Europe PMC] [Abstract]
• smooth muscle contraction involved in micturition Source: RGDInferred from mutant phenotypeⁱ
  • "Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury."
    Zhang X., Douglas K.L., Jin H., Eldaif B.M., Nassar R., Fraser M.O., Dolber P.C.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 295:R2084-96(2008) [PubMed] [Europe PMC] [Abstract]
• sperm ejaculation Source: RGDInferred from mutant phenotypeⁱ
  • "Role of the neurokinin-1 receptors in ejaculation in anesthetized rats."
    Clement P., Peeters M., Bernabe J., Laurin M., Alexandre L., Giuliano F.
    J Sex Med 6:126-134(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN 
        60         70         80         90        100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY 
       110        120        130        140        150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV 
       160        170        180        190        200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV 
       210        220        230        240        250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM 
       260        270        280        290        300
IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY 
       310        320        330        340        350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK 
       360        370        380        390        400
VSRLETTIST VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS 

FYSNMLA                                                

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries