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UniProtKB - P14600 (NK1R_RAT)
Protein
Substance-P receptor
Gene
Tacr1
Organism
Rattus norvegicus (Rat)
Status
Functioni
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
GO - Molecular functioni
- substance P receptor activity Source: RGD
- tachykinin receptor activity Source: GO_Central
GO - Biological processi
- acute inflammatory response Source: RGD
- aggressive behavior Source: RGD
- angiotensin-mediated drinking behavior Source: RGD
- associative learning Source: RGD
- behavioral response to pain Source: RGD
- eating behavior Source: RGD
- learning or memory Source: RGD
- long-term memory Source: RGD
- neuropeptide signaling pathway Source: RGD
- operant conditioning Source: RGD
- positive regulation of action potential Source: RGD
- positive regulation of blood pressure Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of epithelial cell migration Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- positive regulation of flagellated sperm motility Source: RGD
- positive regulation of hormone secretion Source: RGD
- positive regulation of leukocyte migration Source: RGD
- positive regulation of lymphocyte proliferation Source: RGD
- positive regulation of ossification Source: RGD
- positive regulation of renal sodium excretion Source: RGD
- positive regulation of saliva secretion Source: RGD
- positive regulation of stress fiber assembly Source: RGD
- positive regulation of synaptic transmission, cholinergic Source: RGD
- positive regulation of synaptic transmission, GABAergic Source: RGD
- positive regulation of uterine smooth muscle contraction Source: RGD
- positive regulation of vascular permeability Source: RGD
- positive regulation of vasoconstriction Source: RGD
- regulation of blood pressure Source: RGD
- regulation of smooth muscle cell migration Source: RGD
- regulation of smooth muscle cell proliferation Source: RGD
- regulation of uterine smooth muscle contraction Source: RGD
- response to auditory stimulus Source: RGD
- response to electrical stimulus Source: RGD
- response to estradiol Source: RGD
- response to ethanol Source: RGD
- response to heat Source: RGD
- response to hormone Source: RGD
- response to morphine Source: RGD
- response to nicotine Source: RGD
- response to organic cyclic compound Source: RGD
- response to ozone Source: RGD
- response to pain Source: RGD
- response to progesterone Source: RGD
- sensory perception of pain Source: RGD
- smooth muscle contraction involved in micturition Source: RGD
- sperm ejaculation Source: RGD
- tachykinin receptor signaling pathway Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-380095, Tachykinin receptors bind tachykinins R-RNO-416476, G alpha (q) signalling events R-RNO-8856825, Cargo recognition for clathrin-mediated endocytosis R-RNO-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Substance-P receptorShort name: SPR Alternative name(s): NK-1 receptor Short name: NK-1R Tachykinin receptor 1 |
Gene namesi | Name:Tacr1 Synonyms:Tac1r |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3811, Tacr1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cell body Source: RGD
- cell periphery Source: RGD
- cell surface Source: RGD
- cytoplasm Source: RGD
- dendrite Source: RGD
- integral component of membrane Source: UniProtKB-KW
- sperm flagellum Source: RGD
- sperm head Source: RGD
- sperm midpiece Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 55 – 64 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 65 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 87 – 106 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 107 – 128 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 129 – 148 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 149 – 169 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 194 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 195 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 220 – 248 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 249 – 270 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 271 – 283 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 284 – 308 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 309 – 407 | CytoplasmicSequence analysisAdd BLAST | 99 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069888 | 1 – 407 | Substance-P receptorAdd BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 105 ↔ 180 | PROSITE-ProRule annotation | ||
Lipidationi | 322 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P14600 |
PTM databases
GlyGeni | P14600, 2 sites |
PhosphoSitePlusi | P14600 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000005853, Expressed in duodenum and 15 other tissues |
Genevisiblei | P14600, RN |
Interactioni
Subunit structurei
Interacts with ARRB1.
Protein-protein interaction databases
BioGRIDi | 246930, 2 interactors |
STRINGi | 10116.ENSRNOP00000007984 |
Chemistry databases
BindingDBi | P14600 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 362 – 407 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 377 – 407 | Polar residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4219, Eukaryota |
GeneTreei | ENSGT00940000153745 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | P14600 |
OMAi | LPFHVFF |
OrthoDBi | 715197at2759 |
PhylomeDBi | P14600 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001681, Neurokn_rcpt IPR000046, NK1_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01024, NEUROKININ1R PR00244, NEUROKININR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P14600-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY
110 120 130 140 150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK
360 370 380 390 400
VSRLETTIST VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS
FYSNMLA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 73 | N → D in AAB59726 (PubMed:2154852).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64236 , M64232, M64233, M64234, M64235 Genomic DNA Translation: AAA42176.1 J05097 mRNA Translation: AAA42175.1 M31477 mRNA Translation: AAB59726.1 |
PIRi | A38692, A34357 |
RefSeqi | NP_036799.1, NM_012667.2 |
Genome annotation databases
Ensembli | ENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853 |
GeneIDi | 24807 |
KEGGi | rno:24807 |
UCSCi | RGD:3811, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64236 , M64232, M64233, M64234, M64235 Genomic DNA Translation: AAA42176.1 J05097 mRNA Translation: AAA42175.1 M31477 mRNA Translation: AAB59726.1 |
PIRi | A38692, A34357 |
RefSeqi | NP_036799.1, NM_012667.2 |
3D structure databases
SMRi | P14600 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 246930, 2 interactors |
STRINGi | 10116.ENSRNOP00000007984 |
Chemistry databases
BindingDBi | P14600 |
ChEMBLi | CHEMBL4027 |
GuidetoPHARMACOLOGYi | 360 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P14600, 2 sites |
PhosphoSitePlusi | P14600 |
Proteomic databases
PaxDbi | P14600 |
Genome annotation databases
Ensembli | ENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853 |
GeneIDi | 24807 |
KEGGi | rno:24807 |
UCSCi | RGD:3811, rat |
Organism-specific databases
CTDi | 6869 |
RGDi | 3811, Tacr1 |
Phylogenomic databases
eggNOGi | KOG4219, Eukaryota |
GeneTreei | ENSGT00940000153745 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | P14600 |
OMAi | LPFHVFF |
OrthoDBi | 715197at2759 |
PhylomeDBi | P14600 |
TreeFami | TF315303 |
Enzyme and pathway databases
Reactomei | R-RNO-380095, Tachykinin receptors bind tachykinins R-RNO-416476, G alpha (q) signalling events R-RNO-8856825, Cargo recognition for clathrin-mediated endocytosis R-RNO-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:P14600 |
Gene expression databases
Bgeei | ENSRNOG00000005853, Expressed in duodenum and 15 other tissues |
Genevisiblei | P14600, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001681, Neurokn_rcpt IPR000046, NK1_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01024, NEUROKININ1R PR00244, NEUROKININR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NK1R_RAT | |
Accessioni | P14600Primary (citable) accession number: P14600 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families