Substance-P receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• substance P receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 7683643
• tachykinin receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635

GO - Biological processⁱ

• acute inflammatory response Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 10430499
• aggressive behavior Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17678879
• angiotensin-mediated drinking behavior Source: RGDInferred from mutant phenotypeⁱ
  • 9437747
• associative learning Source: RGDInferred from mutant phenotypeⁱ
  • 19071162
• behavioral response to pain Source: RGDInferred from mutant phenotypeⁱ
  • 18407414
• eating behavior Source: RGDInferred from mutant phenotypeⁱ
  • 17141213
• learning or memory Source: RGDInferred from mutant phenotypeⁱ
  • 21611833
• long-term memory Source: RGDInferred from mutant phenotypeⁱ
  • 19071162
• neuropeptide signaling pathway Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 12595694
• operant conditioning Source: RGDInferred from mutant phenotypeⁱ
  • 17324063
• positive regulation of action potential Source: RGDInferred from mutant phenotypeⁱ
  • 18440151
• positive regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • 18337316
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • 17435548
  • 21777465
• positive regulation of epithelial cell migration Source: RGDInferred from mutant phenotypeⁱ
  • 17435548
• positive regulation of epithelial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • 18390473
• positive regulation of flagellated sperm motility Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of hormone secretion Source: RGDInferred from mutant phenotypeⁱ
  • 15613740
• positive regulation of leukocyte migration Source: RGDInferred from mutant phenotypeⁱ
  • 11803123
• positive regulation of lymphocyte proliferation Source: RGDInferred from mutant phenotypeⁱ
  • 18621988
• positive regulation of ossification Source: RGDInferred from mutant phenotypeⁱ
  • 17204323
• positive regulation of renal sodium excretion Source: RGDInferred from mutant phenotypeⁱ
  • 18364471
• positive regulation of saliva secretion Source: RGDInferred from mutant phenotypeⁱ
  • 11448478
• positive regulation of stress fiber assembly Source: RGDInferred from mutant phenotypeⁱ
  • 17435548
• positive regulation of synaptic transmission, cholinergic Source: RGDInferred from mutant phenotypeⁱ
  • 17949415
• positive regulation of synaptic transmission, GABAergic Source: RGDInferred from mutant phenotypeⁱ
  • 19261870
• positive regulation of uterine smooth muscle contraction Source: RGDInferred from direct assayⁱ
  • 12390879
• positive regulation of vascular permeability Source: RGDInferred from mutant phenotypeⁱ
  • 18326823
• positive regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • 18602450
• regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • 18938661
• regulation of smooth muscle cell migration Source: RGDInferred from mutant phenotypeⁱ
  • 21777465
• regulation of smooth muscle cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • 21777465
• response to auditory stimulus Source: RGDInferred from direct assayⁱ
  • 18178320
• response to electrical stimulus Source: RGDInferred from expression patternⁱ
  • 18440496
• response to estradiol Source: RGDInferred from expression patternⁱ
  • 10342838
• response to ethanol Source: RGDInferred from mutant phenotypeⁱ
  • 18555214
• response to heat Source: RGDInferred from mutant phenotypeⁱ
  • 17978048
• response to hormone Source: RGDInferred from mutant phenotypeⁱ
  • 18195491
• response to morphine Source: RGDInferred from expression patternⁱ
  • 17950674
• response to nicotine Source: RGDInferred from mutant phenotypeⁱ
  • 18037142
• response to organic cyclic compound Source: RGDInferred from direct assayⁱ
  • 18178320
• response to ozone Source: RGDInferred from mutant phenotypeⁱ
  • 18390473
• response to progesterone Source: RGDInferred from expression patternⁱ
  • 10342838
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • 18407414
• smooth muscle contraction involved in micturition Source: RGDInferred from mutant phenotypeⁱ
  • 18945947
• sperm ejaculation Source: RGDInferred from mutant phenotypeⁱ
  • 19170843

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN 
        60         70         80         90        100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY 
       110        120        130        140        150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV 
       160        170        180        190        200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV 
       210        220        230        240        250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM 
       260        270        280        290        300
IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY 
       310        320        330        340        350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK 
       360        370        380        390        400
VSRLETTIST VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS 

FYSNMLA                                                

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries