NCF1

Functionⁱ

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).3 Publications

GO - Molecular functionⁱ

electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 2848318
phosphatidylinositol-3,4-bisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12356722
phosphatidylinositol binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12356722
SH3 domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7938008
superoxide-generating NADPH oxidase activator activity Source: GO_Central
superoxide-generating NADPH oxidase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2547247

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: Ensembl
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 2848318
cellular response to cadmium ion
Source: CAFA
Inferred from direct assayⁱ
- 26514923
cellular response to reactive oxygen species
Source: CAFA
Inferred from direct assayⁱ
- 26514923
innate immune response
Source: BHF-UCL
Traceable author statementⁱ
- 7938008
podosome assembly Source: GO_Central
positive regulation of epidermal growth factor-activated receptor activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 26514923
positive regulation of JNK cascade
Source: CAFA
Inferred from mutant phenotypeⁱ
- 26514923
positive regulation of p38MAPK cascade
Source: CAFA
Inferred from mutant phenotypeⁱ
- 26514923
positive regulation of phosphatidylinositol 3-kinase signaling
Source: CAFA
Inferred from mutant phenotypeⁱ
- 26514923
positive regulation of transcription, DNA-templated
Source: CAFA
Inferred from mutant phenotypeⁱ
- 26514923
protein targeting to membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 12356722
respiratory burst
Source: BHF-UCL
Traceable author statementⁱ
- 7938008
superoxide anion generation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2547247
superoxide metabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 7938008
vascular endothelial growth factor receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Lipid-binding

Ligand

Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
SIGNORⁱ	P14598

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neutrophil cytosol factor 1 Short name: NCF-1 Alternative name(s): 47 kDa autosomal chronic granulomatous disease protein 47 kDa neutrophil oxidase factor NCF-47K Neutrophil NADPH oxidase factor 1 Nox organizer 2 Nox-organizing protein 2 SH3 and PX domain-containing protein 1A p47-phox
Gene namesⁱ	Name:NCF1 Synonyms:NOXO2, SH3PXD1A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158517.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7660 NCF1
MIMⁱ	608512 gene
neXtProtⁱ	NX_P14598

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	43	R → Q: Reduces affinity for membranes enriched in phosphatidylinositol 3,4-bisphosphate. 1 Publication	1
Mutagenesisⁱ	90	R → A: Reduces affinity for membranes enriched in phosphatidylinositol 3,4-bisphosphate.	1
Mutagenesisⁱ	263	W → R: Abolishes autoinhibition and promotes phospholipid binding. 1 Publication	1
Mutagenesisⁱ	303	S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-304; E-328; E-359 and E-370. 1 Publication	1
Mutagenesisⁱ	304	S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-328; E-359 and E-370. 1 Publication	1
Mutagenesisⁱ	328	S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-304; E-359 and E-370. 1 Publication	1
Mutagenesisⁱ	359	S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-304; E-328 and E-370. 1 Publication	1
Mutagenesisⁱ	370	S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-304; E-328 and E-359. 1 Publication	1

Keywords - Diseaseⁱ

Chronic granulomatous disease, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	653361
GeneReviewsⁱ	NCF1
MalaCards human disease database More...MalaCardsⁱ	NCF1
MIMⁱ	233700 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000158517
Orphanetⁱ	379 Chronic granulomatous disease
PharmGKBⁱ	PA31463

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00514 Dextromethorphan

DrugBankⁱ

DB00514 Dextromethorphan

Polymorphism and mutation databases

DMDMⁱ	325511390

DMDMⁱ

325511390

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096762	1 – 390	Neutrophil cytosol factor 1Add BLAST		390

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	303	Phosphoserine1 Publication	1
Modified residueⁱ	304	Phosphoserine1 Publication	1
Modified residueⁱ	320	Phosphoserine1 Publication	1
Modified residueⁱ	328	Phosphoserine1 Publication	1
Modified residueⁱ	345	Phosphoserine1 Publication	1
Modified residueⁱ	348	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.2 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14598
PaxDbⁱ	P14598
PeptideAtlas More...PeptideAtlasⁱ	P14598
PRIDEⁱ	P14598
ProteomicsDBⁱ	53060 53061 [P14598-2]

PTM databases

iPTMnetⁱ	P14598
PhosphoSitePlusⁱ	P14598

Expressionⁱ

Tissue specificityⁱ

Detected in peripheral blood monocytes and neutrophils (at protein level).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000158517 Expressed in 91 organ(s), highest expression level in blood
ExpressionAtlasⁱ	P14598 baseline and differential
Genevisibleⁱ	P14598 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004524 HPA047836 HPA052095

HPAⁱ

CAB004524
HPA047836
HPA052095

Interactionⁱ

Subunit structureⁱ

Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts (via C-terminus) with NCF2 (via the C-terminal SH3 domain). Interacts with NCF4. Interacts with CYBB. Interacts (via the second SH3 domain) with CYBA. Interacts with NOXA1. Interacts with ADAM15. Interacts with TRAF4. Interacts with FASLG. Interacts with PARK7 (via C-terminus); the interaction is enhanced by LPS and modulates NCF1 phosphorylation and membrane translocation (By similarity).By similarity11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ABI1	Q8IZP0	5	EBI-395044,EBI-375446
ACTB	P60709	3	EBI-395044,EBI-353944
CYBA	P13498	7	EBI-395044,EBI-986058
GNAI2	P04899	2	EBI-395044,EBI-353997
HSPA8	P11142	2	EBI-395044,EBI-351896
NCF2	P19878	13	EBI-395044,EBI-489611
NCF4	Q15080	2	EBI-395044,EBI-1036870
PRKCZ	Q05513	3	EBI-395044,EBI-295351

GO - Molecular functionⁱ

SH3 domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7938008

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	575724, 40 interactors
Database of interacting proteins More...DIPⁱ	DIP-126N
ELMⁱ	P14598
IntActⁱ	P14598, 18 interactors
Molecular INTeraction database More...MINTⁱ	P14598
STRINGⁱ	9606.ENSP00000289473

Chemistry databases

BindingDBⁱ

P14598

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 17	Combined sources	12
Beta strandⁱ	19 – 21	Combined sources	3
Beta strandⁱ	23 – 32	Combined sources	10
Beta strandⁱ	37 – 42	Combined sources	6
Helixⁱ	44 – 57	Combined sources	14
Turnⁱ	59 – 63	Combined sources	5
Helixⁱ	67 – 69	Combined sources	3
Helixⁱ	78 – 80	Combined sources	3
Helixⁱ	84 – 101	Combined sources	18
Helixⁱ	106 – 109	Combined sources	4
Helixⁱ	112 – 118	Combined sources	7
Helixⁱ	122 – 125	Combined sources	4
Beta strandⁱ	137 – 140	Combined sources	4
Beta strandⁱ	153 – 155	Combined sources	3
Beta strandⁱ	159 – 162	Combined sources	4
Beta strandⁱ	171 – 174	Combined sources	4
Beta strandⁱ	182 – 187	Combined sources	6
Beta strandⁱ	195 – 198	Combined sources	4
Beta strandⁱ	202 – 206	Combined sources	5
Helixⁱ	207 – 209	Combined sources	3
Beta strandⁱ	210 – 214	Combined sources	5
Beta strandⁱ	229 – 235	Combined sources	7
Beta strandⁱ	241 – 244	Combined sources	4
Beta strandⁱ	252 – 257	Combined sources	6
Beta strandⁱ	262 – 268	Combined sources	7
Beta strandⁱ	271 – 276	Combined sources	6
Helixⁱ	277 – 279	Combined sources	3
Beta strandⁱ	280 – 282	Combined sources	3
Helixⁱ	287 – 292	Combined sources	6
Helixⁱ	302 – 304	Combined sources	3
Helixⁱ	321 – 328	Combined sources	8
Helixⁱ	371 – 376	Combined sources	6
Helixⁱ	380 – 385	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P14598
SMRⁱ	P14598
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14598

EvolutionaryTraceⁱ

P14598

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 125	PXPROSITE-ProRule annotationAdd BLAST	122
Domainⁱ	156 – 215	SH3 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	226 – 285	SH3 2PROSITE-ProRule annotationAdd BLAST	60

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	211 – 254	Asp/Glu-rich (highly acidic)Add BLAST		44
Compositional biasⁱ	292 – 390	Arg/Lys-rich (highly basic)Add BLAST		99

Domainⁱ

The PX domain mediates interaction with phosphatidylinositol 3,4-bisphosphate and other anionic phospholipids. In the autoinhibited, unphosphorylated state an intramolecular interaction with the C-terminal SH3 domain precludes phospholipid binding and interaction with CYBA. Phosphorylation disrupts the autoinhibited state.2 Publications

Keywords - Domainⁱ

Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	ENOG410IRR3 Eukaryota ENOG410YYZE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063010
HOVERGENⁱ	HBG002055
InParanoidⁱ	P14598
KEGG Orthology (KO) More...KOⁱ	K08011
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CBF
PhylomeDBⁱ	P14598
TreeFamⁱ	TF329347

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06887 PX_p47phox, 1 hit cd12021 SH3_p47phox_1, 1 hit cd12022 SH3_p47phox_2, 1 hit
Gene3Dⁱ	3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR015039 NADPH_oxidase_p47Phox_C IPR035756 NCF1_SH3_1 IPR035757 NCF1_SH3_2 IPR032136 NECFESHC IPR001655 P47PHOX IPR001683 Phox IPR036871 PX_dom_sf IPR034909 PX_p47phox IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR15706:SF6 PTHR15706:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16621 NECFESHC, 1 hit PF08944 p47_phox_C, 1 hit PF00787 PX, 1 hit PF00018 SH3_1, 2 hits
PRINTSⁱ	PR00498 P47PHOX
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit SM00326 SH3, 2 hits
SUPFAMⁱ	SSF50044 SSF50044, 2 hits SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit PS50002 SH3, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P14598-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF 
        60         70         80         90        100
HKTLKEMFPI EAGAINPENR IIPHLPAPKW FDGQRAAENR QGTLTEYCST 
       110        120        130        140        150
LMSLPTKISR CPHLLDFFKV RPDDLKLPTD NQTKKPETYL MPKDGKSTAT 
       160        170        180        190        200
DITGPIILQT YRAIANYEKT SGSEMALSTG DVVEVVEKSE SGWWFCQMKA 
       210        220        230        240        250
KRGWIPASFL EPLDSPDETE DPEPNYAGEP YVAIKAYTAV EGDEVSLLEG 
       260        270        280        290        300
EAVEVIHKLL DGWWVIRKDD VTGYFPSMYL QKSGQDVSQA QRQIKRGAPP 
       310        320        330        340        350
RRSSIRNAHS IHQRSRKRLS QDAYRRNSVR FLQQRRRQAR PGPQSPGSPL 
       360        370        380        390
EEERQTQRSK PQPAVPPRPS ADLILNRCSE STKRKLASAV

Length:390

Mass (Da):44,682

Last modified:April 25, 2018 - v4

Checksum:ⁱ3D91EDC99A1B6417

GO

Isoform 2 (identifier: P14598-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
193-193: W → QTSHLTGLLP...LDGYGTVCSL
194-390: Missing.

« Hide

        10         20         30         40         50
MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF 
        60         70         80         90        100
HKTLKEMFPI EAGAINPENR IIPHLPAPKW FDGQRAAENR QGTLTEYCST 
       110        120        130        140        150
LMSLPTKISR CPHLLDFFKV RPDDLKLPTD NQTKKPETYL MPKDGKSTAT 
       160        170        180        190        200
DITGPIILQT YRAIANYEKT SGSEMALSTG DVVEVVEKSE SGQTSHLTGL 
       210        220        230        240        250
LPLVLRNPQP QAPCQGSGSL APGRTPALLG ALNVLPTLWV AFCLSVHPVV 
       260        270 
AVGICAWQAG AGHVCVFCLD GYGTVCSL

Note: Due to intron retention.

Show »

Length:278

Mass (Da):30,811

Checksum:ⁱEF0F962E9881E8A0

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J155	C9J155_HUMAN	Neutrophil cytosol factor 1 Neutrophil cytosol factor 1	NCF1	163	Annotation score:
H7C1S1	H7C1S1_HUMAN	Neutrophil cytosol factor 1 Neutrophil cytosol factor 1	NCF1	146	Annotation score:
A0A087X1W0	A0A087X1W0_HUMAN	Neutrophil cytosol factor 1 Neutrophil cytosol factor 1	NCF1	52	Annotation score:

Sequence cautionⁱ

The sequence BAF84783 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAG54596 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	200	A → T in AAK19516 (PubMed:11740866).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012476	42	R → Q in CGD1. 1 PublicationCorresponds to variant dbSNP:rs119103270EnsemblClinVar.	1
Natural variantⁱVAR_014735	90	R → H Polymorphism; may influence susceptibility to systemic lupus erythematosus. 1 PublicationCorresponds to variant dbSNP:rs13447Ensembl.	1
Natural variantⁱVAR_018479	99	S → G2 PublicationsCorresponds to variant dbSNP:rs10614Ensembl.	1
Natural variantⁱVAR_012477	160	T → S2 Publications	1
Natural variantⁱVAR_012478	166	N → D4 PublicationsCorresponds to variant dbSNP:rs782555266Ensembl.	1
Natural variantⁱVAR_018476	258	K → E1 Publication	1
Natural variantⁱVAR_012479	262	G → S1 PublicationCorresponds to variant dbSNP:rs1489201208Ensembl.	1
Natural variantⁱVAR_012480	308	A → V2 PublicationsCorresponds to variant dbSNP:rs13739Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035032	193	W → QTSHLTGLLPLVLRNPQPQA PCQGSGSLAPGRTPALLGAL NVLPTLWVAFCLSVHPVVAV GICAWQAGAGHVCVFCLDGY GTVCSL in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_035033	194 – 390	Missing in isoform 2. 1 PublicationAdd BLAST		197

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25665 mRNA Translation: AAA57209.1 M55067 mRNA Translation: AAA59901.1 AH005796 Genomic DNA Translation: AAB95193.1 AF184614 Genomic DNA Translation: AAF34737.1 AF330625 mRNA Translation: AAK19516.1 AF330626 mRNA Translation: AAK19517.1 AF330627 mRNA Translation: AAK19518.1 AK127905 mRNA Translation: BAG54596.1 Different initiation. AK292094 mRNA Translation: BAF84783.1 Different initiation. AK223217 mRNA Translation: BAD96937.1 AC004883 Genomic DNA No translation available. AC083884 Genomic DNA Translation: AAS07465.1 AC124781 Genomic DNA No translation available. BC002816 mRNA Translation: AAH02816.1 BC065731 mRNA Translation: AAH65731.1 U25793 mRNA Translation: AAA93232.1 DQ314878 Genomic DNA Translation: ABC40737.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34657.1 [P14598-1]
PIRⁱ	A35926 A39249
NCBI Reference Sequences More...RefSeqⁱ	NP_000256.4, NM_000265.5 [P14598-1]
UniGeneⁱ	Hs.647047 Hs.648940 Hs.655201

Genome annotation databases

Ensemblⁱ	ENST00000289473; ENSP00000289473; ENSG00000158517 [P14598-1]
GeneIDⁱ	653361
KEGGⁱ	hsa:653361
UCSC genome browser More...UCSCⁱ	uc003ubb.5 human [P14598-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14598-2	cDNA, FLJ79451, highly similar to Neutrophil cytosol factor 1		HUMAN		278	UniRef100_P14598-2

Protein	Similar proteins		Species	Score	Length	Source
P14598	Putative neutrophil cytosol factor 1B		HUMAN		391	UniRef90_P14598
NCF1 isoform 3		PANTR		390
Neutrophil cytosol factor 1		CALJA		390
Uncharacterized protein		MACMU		390
Uncharacterized protein		MACFA		390
+27
P14598-2	cDNA, FLJ79451, highly similar to Neutrophil cytosol factor 1		HUMAN		278	UniRef90_P14598-2
cDNA FLJ56767, highly similar to Neutrophil cytosol factor 1		HUMAN		254
cDNA, FLJ79228, highly similar to Neutrophil cytosol factor 1		HUMAN		254

Protein	Similar proteins		Species	Score	Length	Source
P14598	Putative neutrophil cytosol factor 1B		HUMAN		391	UniRef50_P14598
Uncharacterized protein		PANPA		390
NCF1 isoform 3		PANTR		390
Uncharacterized protein		MACNE		390
Uncharacterized protein		PAPAN		390
+244
P14598-2	cDNA, FLJ79451, highly similar to Neutrophil cytosol factor 1		HUMAN		278	UniRef50_P14598-2
Neutrophil cytosolic factor 1		BOVIN		283
Putative neutrophil cytosol factor 1C (Fragment)		NEOVI		289
UPI000661D09B		CAVPO		309
UPI0004DFEA16		URSMA		249
+4

Cross-referencesⁱ

Web resourcesⁱ

NCF1base

NCF1 deficiency database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25665 mRNA Translation: AAA57209.1 M55067 mRNA Translation: AAA59901.1 AH005796 Genomic DNA Translation: AAB95193.1 AF184614 Genomic DNA Translation: AAF34737.1 AF330625 mRNA Translation: AAK19516.1 AF330626 mRNA Translation: AAK19517.1 AF330627 mRNA Translation: AAK19518.1 AK127905 mRNA Translation: BAG54596.1 Different initiation. AK292094 mRNA Translation: BAF84783.1 Different initiation. AK223217 mRNA Translation: BAD96937.1 AC004883 Genomic DNA No translation available. AC083884 Genomic DNA Translation: AAS07465.1 AC124781 Genomic DNA No translation available. BC002816 mRNA Translation: AAH02816.1 BC065731 mRNA Translation: AAH65731.1 U25793 mRNA Translation: AAA93232.1 DQ314878 Genomic DNA Translation: ABC40737.1
CCDSⁱ	CCDS34657.1 [P14598-1]
PIRⁱ	A35926 A39249
RefSeqⁱ	NP_000256.4, NM_000265.5 [P14598-1]
UniGeneⁱ	Hs.647047 Hs.648940 Hs.655201

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GD5	NMR	-	A	1-128	[»]
	1K4U	NMR	-	P	359-390	[»]
	1KQ6	X-ray	1.18	A	1-141	[»]
	1NG2	X-ray	1.70	A	156-340	[»]
	1O7K	X-ray	2.00	A/B/C	1-123	[»]
	1OV3	X-ray	1.80	A/B	156-285	[»]
	1UEC	X-ray	1.82	A	151-340	[»]
	1W70	X-ray	1.46	C/D	360-372	[»]
	1WLP	NMR	-	B	151-286	[»]
ProteinModelPortalⁱ	P14598
SMRⁱ	P14598
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	575724, 40 interactors
DIPⁱ	DIP-126N
ELMⁱ	P14598
IntActⁱ	P14598, 18 interactors
MINTⁱ	P14598
STRINGⁱ	9606.ENSP00000289473

Chemistry databases

BindingDBⁱ	P14598
DrugBankⁱ	DB00514 Dextromethorphan

PTM databases

iPTMnetⁱ	P14598
PhosphoSitePlusⁱ	P14598

Polymorphism and mutation databases

DMDMⁱ	325511390

DMDMⁱ

325511390

Proteomic databases

MaxQBⁱ	P14598
PaxDbⁱ	P14598
PeptideAtlasⁱ	P14598
PRIDEⁱ	P14598
ProteomicsDBⁱ	53060 53061 [P14598-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	653361
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000289473; ENSP00000289473; ENSG00000158517 [P14598-1]
GeneIDⁱ	653361
KEGGⁱ	hsa:653361
UCSCⁱ	uc003ubb.5 human [P14598-1]

Organism-specific databases

CTDⁱ	653361
DisGeNETⁱ	653361
EuPathDBⁱ	HostDB:ENSG00000158517.13
GeneCardsⁱ	NCF1
GeneReviewsⁱ	NCF1
H-InvDBⁱ	HIX0033553
HGNCⁱ	HGNC:7660 NCF1
HPAⁱ	CAB004524 HPA047836 HPA052095
MalaCardsⁱ	NCF1
MIMⁱ	233700 phenotype 608512 gene
neXtProtⁱ	NX_P14598
OpenTargetsⁱ	ENSG00000158517
Orphanetⁱ	379 Chronic granulomatous disease
PharmGKBⁱ	PA31463
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IRR3 Eukaryota ENOG410YYZE LUCA
GeneTreeⁱ	ENSGT00530000063010
HOVERGENⁱ	HBG002055
InParanoidⁱ	P14598
KOⁱ	K08011
OrthoDBⁱ	EOG091G0CBF
PhylomeDBⁱ	P14598
TreeFamⁱ	TF329347

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
SIGNORⁱ	P14598

Miscellaneous databases

ChiTaRSⁱ	NCF1 human
EvolutionaryTraceⁱ	P14598
GeneWikiⁱ	Neutrophil_cytosolic_factor_1
GenomeRNAiⁱ	653361
Protein Ontology More...PROⁱ	PR:P14598
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158517 Expressed in 91 organ(s), highest expression level in blood
ExpressionAtlasⁱ	P14598 baseline and differential
Genevisibleⁱ	P14598 HS

Family and domain databases

CDDⁱ	cd06887 PX_p47phox, 1 hit cd12021 SH3_p47phox_1, 1 hit cd12022 SH3_p47phox_2, 1 hit
Gene3Dⁱ	3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR015039 NADPH_oxidase_p47Phox_C IPR035756 NCF1_SH3_1 IPR035757 NCF1_SH3_2 IPR032136 NECFESHC IPR001655 P47PHOX IPR001683 Phox IPR036871 PX_dom_sf IPR034909 PX_p47phox IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR15706:SF6 PTHR15706:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF16621 NECFESHC, 1 hit PF08944 p47_phox_C, 1 hit PF00787 PX, 1 hit PF00018 SH3_1, 2 hits
PRINTSⁱ	PR00498 P47PHOX
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit SM00326 SH3, 2 hits
SUPFAMⁱ	SSF50044 SSF50044, 2 hits SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit PS50002 SH3, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NCF1_HUMAN
Accessionⁱ	P14598Primary (citable) accession number: P14598 Secondary accession number(s): A6NEH2 Q9UMU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 25, 2018
	Last modified:	October 10, 2018
	This is version 222 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - P14598 (NCF1_HUMAN)

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Neutrophil cytosol factor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

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Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

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Keywords - Technical termⁱ