UniProtKB - P14598 (NCF1_HUMAN)
Neutrophil cytosol factor 1
NCF1
Functioni
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
3 PublicationsGO - Molecular functioni
- electron transfer activity Source: UniProtKB
- phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
- phosphatidylinositol binding Source: UniProtKB
- SH3 domain binding Source: BHF-UCL
- superoxide-generating NAD(P)H oxidase activity Source: CAFA
- superoxide-generating NADPH oxidase activator activity Source: GO_Central
GO - Biological processi
- apoptotic process Source: Ensembl
- cellular defense response Source: ProtInc
- cellular response to cadmium ion Source: CAFA
- cellular response to reactive oxygen species Source: CAFA
- innate immune response Source: BHF-UCL
- positive regulation of epidermal growth factor-activated receptor activity Source: CAFA
- positive regulation of JNK cascade Source: CAFA
- positive regulation of p38MAPK cascade Source: CAFA
- positive regulation of phosphatidylinositol 3-kinase signaling Source: CAFA
- positive regulation of transcription, DNA-templated Source: CAFA
- protein targeting to membrane Source: UniProtKB
- reactive oxygen species biosynthetic process Source: Ensembl
- regulation of respiratory burst involved in inflammatory response Source: Ensembl
- respiratory burst Source: GO_Central
- superoxide anion generation Source: GO_Central
- superoxide metabolic process Source: BHF-UCL
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P14598 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-1236973, Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-3299685, Detoxification of Reactive Oxygen Species R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5668599, RHO GTPases Activate NADPH Oxidases R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013423, RAC3 GTPase cycle |
SignaLinki | P14598 |
SIGNORi | P14598 |
Names & Taxonomyi
Protein namesi | Recommended name: Neutrophil cytosol factor 1Short name: NCF-1 Alternative name(s): 47 kDa autosomal chronic granulomatous disease protein 47 kDa neutrophil oxidase factor NCF-47K Neutrophil NADPH oxidase factor 1 Nox organizer 2 Nox-organizing protein 2 SH3 and PX domain-containing protein 1A p47-phox |
Gene namesi | Name:NCF1 Synonyms:NOXO2, SH3PXD1A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7660, NCF1 |
MIMi | 608512, gene |
neXtProti | NX_P14598 |
VEuPathDBi | HostDB:ENSG00000158517 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Lysosome
- phagolysosome Source: Reactome
Plasma Membrane
- NADPH oxidase complex Source: UniProtKB
- plasma membrane Source: CAFA
Other locations
- cytoplasm Source: GO_Central
- dendrite Source: Ensembl
- extrinsic component of membrane Source: UniProtKB
- membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Granulomatous disease, chronic, autosomal recessive, 1 (CGD1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012476 | 42 | R → Q in CGD1. 1 PublicationCorresponds to variant dbSNP:rs119103270EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 | R → Q: Reduces affinity for membranes enriched in phosphatidylinositol 3,4-bisphosphate. 1 Publication | 1 | |
Mutagenesisi | 90 | R → A: Reduces affinity for membranes enriched in phosphatidylinositol 3,4-bisphosphate. | 1 | |
Mutagenesisi | 263 | W → R: Abolishes autoinhibition and promotes phospholipid binding. 1 Publication | 1 | |
Mutagenesisi | 303 | S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-304; E-328; E-359 and E-370. 1 Publication | 1 | |
Mutagenesisi | 304 | S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-328; E-359 and E-370. 1 Publication | 1 | |
Mutagenesisi | 328 | S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-304; E-359 and E-370. 1 Publication | 1 | |
Mutagenesisi | 359 | S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-304; E-328 and E-370. 1 Publication | 1 | |
Mutagenesisi | 370 | S → E: Abolishes autoinhibition and promotes phospholipid binding; when associated with E-303; E-304; E-328 and E-359. 1 Publication | 1 |
Keywords - Diseasei
Chronic granulomatous disease, Disease variantOrganism-specific databases
DisGeNETi | 653361 |
GeneReviewsi | NCF1 |
MalaCardsi | NCF1 |
MIMi | 233700, phenotype |
OpenTargetsi | ENSG00000158517 |
Orphaneti | 379, Chronic granulomatous disease 904, Williams syndrome |
PharmGKBi | PA31463 |
Miscellaneous databases
Pharosi | P14598, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1613743 |
DrugBanki | DB00514, Dextromethorphan |
Genetic variation databases
BioMutai | NCF1 |
DMDMi | 325511390 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096762 | 1 – 390 | Neutrophil cytosol factor 1Add BLAST | 390 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 303 | Phosphoserine1 Publication | 1 | |
Modified residuei | 304 | Phosphoserine1 Publication | 1 | |
Modified residuei | 320 | Phosphoserine1 Publication | 1 | |
Modified residuei | 328 | Phosphoserine1 Publication | 1 | |
Modified residuei | 345 | Phosphoserine1 Publication | 1 | |
Modified residuei | 348 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P14598 |
MassIVEi | P14598 |
PaxDbi | P14598 |
PeptideAtlasi | P14598 |
PRIDEi | P14598 |
ProteomicsDBi | 53060 [P14598-1] 53061 [P14598-2] |
PTM databases
iPTMneti | P14598 |
PhosphoSitePlusi | P14598 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000158517, Expressed in blood and 113 other tissues |
ExpressionAtlasi | P14598, baseline and differential |
Genevisiblei | P14598, HS |
Organism-specific databases
HPAi | ENSG00000158517, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4.
Interacts (via C-terminus) with NCF2 (via the C-terminal SH3 domain).
Interacts with NCF4.
Interacts with CYBB.
Interacts (via the second SH3 domain) with CYBA.
Interacts with NOXA1.
Interacts with ADAM15.
Interacts with TRAF4.
Interacts with FASLG.
Interacts with PARK7 (via C-terminus); the interaction is enhanced by LPS and modulates NCF1 phosphorylation and membrane translocation (By similarity).
By similarity11 PublicationsBinary interactionsi
P14598
GO - Molecular functioni
- SH3 domain binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 575724, 84 interactors |
ComplexPortali | CPX-1017, Phagocyte NADPH oxidase complex, RAC1 variant CPX-6134, Phagocyte NADPH oxidase complex, RAC2 variant CPX-6135, Phagocyte NADPH oxidase complex, RAC3 variant |
DIPi | DIP-126N |
ELMi | P14598 |
IntActi | P14598, 61 interactors |
MINTi | P14598 |
STRINGi | 9606.ENSP00000289473 |
Chemistry databases
BindingDBi | P14598 |
Miscellaneous databases
RNActi | P14598, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P14598 |
BMRBi | P14598 |
SASBDBi | P14598 |
SMRi | P14598 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14598 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 125 | PXPROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 156 – 215 | SH3 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 226 – 285 | SH3 2PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 285 – 390 | DisorderedSequence analysisAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 375 – 390 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG4773, Eukaryota |
GeneTreei | ENSGT00940000160014 |
HOGENOMi | CLU_030529_0_0_1 |
InParanoidi | P14598 |
OMAi | WWVVRKD |
OrthoDBi | 1183210at2759 |
PhylomeDBi | P14598 |
TreeFami | TF329347 |
Family and domain databases
CDDi | cd06887, PX_p47phox, 1 hit cd12021, SH3_p47phox_1, 1 hit cd12022, SH3_p47phox_2, 1 hit |
DisProti | DP02254 |
Gene3Di | 3.30.1520.10, 1 hit |
IDEALi | IID00597 |
InterProi | View protein in InterPro IPR015039, NADPH_oxidase_p47Phox_C IPR035756, NCF1_SH3_1 IPR035757, NCF1_SH3_2 IPR032136, NECFESHC IPR001655, P47PHOX IPR001683, PX_dom IPR036871, PX_dom_sf IPR034909, PX_p47phox IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15706:SF6, PTHR15706:SF6, 1 hit |
Pfami | View protein in Pfam PF16621, NECFESHC, 1 hit PF08944, p47_phox_C, 1 hit PF00787, PX, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00498, P47PHOX |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 2 hits SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS50002, SH3, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF
60 70 80 90 100
HKTLKEMFPI EAGAINPENR IIPHLPAPKW FDGQRAAENR QGTLTEYCST
110 120 130 140 150
LMSLPTKISR CPHLLDFFKV RPDDLKLPTD NQTKKPETYL MPKDGKSTAT
160 170 180 190 200
DITGPIILQT YRAIANYEKT SGSEMALSTG DVVEVVEKSE SGWWFCQMKA
210 220 230 240 250
KRGWIPASFL EPLDSPDETE DPEPNYAGEP YVAIKAYTAV EGDEVSLLEG
260 270 280 290 300
EAVEVIHKLL DGWWVIRKDD VTGYFPSMYL QKSGQDVSQA QRQIKRGAPP
310 320 330 340 350
RRSSIRNAHS IHQRSRKRLS QDAYRRNSVR FLQQRRRQAR PGPQSPGSPL
360 370 380 390
EEERQTQRSK PQPAVPPRPS ADLILNRCSE STKRKLASAV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J155 | C9J155_HUMAN | Neutrophil cytosol factor 1 | NCF1 | 163 | Annotation score: | ||
H7C1S1 | H7C1S1_HUMAN | Neutrophil cytosol factor 1 | NCF1 | 146 | Annotation score: | ||
A0A087X1W0 | A0A087X1W0_HUMAN | Neutrophil cytosol factor 1 | NCF1 | 52 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 200 | A → T in AAK19516 (PubMed:11740866).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012476 | 42 | R → Q in CGD1. 1 PublicationCorresponds to variant dbSNP:rs119103270EnsemblClinVar. | 1 | |
Natural variantiVAR_014735 | 90 | R → H May influence susceptibility to systemic lupus erythematosus. 1 PublicationCorresponds to variant dbSNP:rs13447Ensembl. | 1 | |
Natural variantiVAR_018479 | 99 | S → G2 PublicationsCorresponds to variant dbSNP:rs10614Ensembl. | 1 | |
Natural variantiVAR_012477 | 160 | T → S2 Publications | 1 | |
Natural variantiVAR_012478 | 166 | N → D4 PublicationsCorresponds to variant dbSNP:rs782555266Ensembl. | 1 | |
Natural variantiVAR_018476 | 258 | K → E1 Publication | 1 | |
Natural variantiVAR_012479 | 262 | G → S1 PublicationCorresponds to variant dbSNP:rs1489201208Ensembl. | 1 | |
Natural variantiVAR_012480 | 308 | A → V2 PublicationsCorresponds to variant dbSNP:rs13739EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035032 | 193 | W → QTSHLTGLLPLVLRNPQPQA PCQGSGSLAPGRTPALLGAL NVLPTLWVAFCLSVHPVVAV GICAWQAGAGHVCVFCLDGY GTVCSL in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_035033 | 194 – 390 | Missing in isoform 2. 1 PublicationAdd BLAST | 197 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25665 mRNA Translation: AAA57209.1 M55067 mRNA Translation: AAA59901.1 AH005796 Genomic DNA Translation: AAB95193.1 AF184614 Genomic DNA Translation: AAF34737.1 AF330625 mRNA Translation: AAK19516.1 AF330626 mRNA Translation: AAK19517.1 AF330627 mRNA Translation: AAK19518.1 AK127905 mRNA Translation: BAG54596.1 Different initiation. AK292094 mRNA Translation: BAF84783.1 Different initiation. AK223217 mRNA Translation: BAD96937.1 AC004883 Genomic DNA No translation available. AC083884 Genomic DNA Translation: AAS07465.1 AC124781 Genomic DNA No translation available. BC002816 mRNA Translation: AAH02816.1 BC065731 mRNA Translation: AAH65731.1 U25793 mRNA Translation: AAA93232.1 DQ314878 Genomic DNA Translation: ABC40737.1 |
CCDSi | CCDS34657.1 [P14598-1] |
PIRi | A35926, A39249 |
RefSeqi | NP_000256.4, NM_000265.5 [P14598-1] |
Genome annotation databases
Ensembli | ENST00000289473.11; ENSP00000289473.4; ENSG00000158517.16 |
GeneIDi | 653361 |
KEGGi | hsa:653361 |
MANE-Selecti | ENST00000289473.11; ENSP00000289473.4; NM_000265.7; NP_000256.4 |
UCSCi | uc003ubb.5, human [P14598-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NCF1base NCF1 deficiency database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25665 mRNA Translation: AAA57209.1 M55067 mRNA Translation: AAA59901.1 AH005796 Genomic DNA Translation: AAB95193.1 AF184614 Genomic DNA Translation: AAF34737.1 AF330625 mRNA Translation: AAK19516.1 AF330626 mRNA Translation: AAK19517.1 AF330627 mRNA Translation: AAK19518.1 AK127905 mRNA Translation: BAG54596.1 Different initiation. AK292094 mRNA Translation: BAF84783.1 Different initiation. AK223217 mRNA Translation: BAD96937.1 AC004883 Genomic DNA No translation available. AC083884 Genomic DNA Translation: AAS07465.1 AC124781 Genomic DNA No translation available. BC002816 mRNA Translation: AAH02816.1 BC065731 mRNA Translation: AAH65731.1 U25793 mRNA Translation: AAA93232.1 DQ314878 Genomic DNA Translation: ABC40737.1 |
CCDSi | CCDS34657.1 [P14598-1] |
PIRi | A35926, A39249 |
RefSeqi | NP_000256.4, NM_000265.5 [P14598-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GD5 | NMR | - | A | 1-128 | [»] | |
1K4U | NMR | - | P | 359-390 | [»] | |
1KQ6 | X-ray | 1.18 | A | 1-141 | [»] | |
1NG2 | X-ray | 1.70 | A | 156-340 | [»] | |
1O7K | X-ray | 2.00 | A/B/C | 1-123 | [»] | |
1OV3 | X-ray | 1.80 | A/B | 156-285 | [»] | |
1UEC | X-ray | 1.82 | A | 151-340 | [»] | |
1W70 | X-ray | 1.46 | C/D | 360-372 | [»] | |
1WLP | NMR | - | B | 151-286 | [»] | |
AlphaFoldDBi | P14598 | |||||
BMRBi | P14598 | |||||
SASBDBi | P14598 | |||||
SMRi | P14598 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 575724, 84 interactors |
ComplexPortali | CPX-1017, Phagocyte NADPH oxidase complex, RAC1 variant CPX-6134, Phagocyte NADPH oxidase complex, RAC2 variant CPX-6135, Phagocyte NADPH oxidase complex, RAC3 variant |
DIPi | DIP-126N |
ELMi | P14598 |
IntActi | P14598, 61 interactors |
MINTi | P14598 |
STRINGi | 9606.ENSP00000289473 |
Chemistry databases
BindingDBi | P14598 |
ChEMBLi | CHEMBL1613743 |
DrugBanki | DB00514, Dextromethorphan |
PTM databases
iPTMneti | P14598 |
PhosphoSitePlusi | P14598 |
Genetic variation databases
BioMutai | NCF1 |
DMDMi | 325511390 |
Proteomic databases
jPOSTi | P14598 |
MassIVEi | P14598 |
PaxDbi | P14598 |
PeptideAtlasi | P14598 |
PRIDEi | P14598 |
ProteomicsDBi | 53060 [P14598-1] 53061 [P14598-2] |
Protocols and materials databases
Antibodypediai | 3863, 948 antibodies from 39 providers |
DNASUi | 653361 |
Genome annotation databases
Ensembli | ENST00000289473.11; ENSP00000289473.4; ENSG00000158517.16 |
GeneIDi | 653361 |
KEGGi | hsa:653361 |
MANE-Selecti | ENST00000289473.11; ENSP00000289473.4; NM_000265.7; NP_000256.4 |
UCSCi | uc003ubb.5, human [P14598-1] |
Organism-specific databases
CTDi | 653361 |
DisGeNETi | 653361 |
GeneCardsi | NCF1 |
GeneReviewsi | NCF1 |
HGNCi | HGNC:7660, NCF1 |
HPAi | ENSG00000158517, Tissue enhanced (bone marrow, lymphoid tissue) |
MalaCardsi | NCF1 |
MIMi | 233700, phenotype 608512, gene |
neXtProti | NX_P14598 |
OpenTargetsi | ENSG00000158517 |
Orphaneti | 379, Chronic granulomatous disease 904, Williams syndrome |
PharmGKBi | PA31463 |
VEuPathDBi | HostDB:ENSG00000158517 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4773, Eukaryota |
GeneTreei | ENSGT00940000160014 |
HOGENOMi | CLU_030529_0_0_1 |
InParanoidi | P14598 |
OMAi | WWVVRKD |
OrthoDBi | 1183210at2759 |
PhylomeDBi | P14598 |
TreeFami | TF329347 |
Enzyme and pathway databases
PathwayCommonsi | P14598 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-1236973, Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-3299685, Detoxification of Reactive Oxygen Species R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5668599, RHO GTPases Activate NADPH Oxidases R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013423, RAC3 GTPase cycle |
SignaLinki | P14598 |
SIGNORi | P14598 |
Miscellaneous databases
BioGRID-ORCSi | 653361, 40 hits in 1065 CRISPR screens |
ChiTaRSi | NCF1, human |
EvolutionaryTracei | P14598 |
GeneWikii | Neutrophil_cytosolic_factor_1 |
GenomeRNAii | 653361 |
Pharosi | P14598, Tbio |
PROi | PR:P14598 |
RNActi | P14598, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158517, Expressed in blood and 113 other tissues |
ExpressionAtlasi | P14598, baseline and differential |
Genevisiblei | P14598, HS |
Family and domain databases
CDDi | cd06887, PX_p47phox, 1 hit cd12021, SH3_p47phox_1, 1 hit cd12022, SH3_p47phox_2, 1 hit |
DisProti | DP02254 |
Gene3Di | 3.30.1520.10, 1 hit |
IDEALi | IID00597 |
InterProi | View protein in InterPro IPR015039, NADPH_oxidase_p47Phox_C IPR035756, NCF1_SH3_1 IPR035757, NCF1_SH3_2 IPR032136, NECFESHC IPR001655, P47PHOX IPR001683, PX_dom IPR036871, PX_dom_sf IPR034909, PX_p47phox IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15706:SF6, PTHR15706:SF6, 1 hit |
Pfami | View protein in Pfam PF16621, NECFESHC, 1 hit PF08944, p47_phox_C, 1 hit PF00787, PX, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00498, P47PHOX |
SMARTi | View protein in SMART SM00312, PX, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 2 hits SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit PS50002, SH3, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | NCF1_HUMAN | |
Accessioni | P14598Primary (citable) accession number: P14598 Secondary accession number(s): A6NEH2 Q9UMU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 25, 2018 | |
Last modified: | May 25, 2022 | |
This is version 245 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references