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Entry version 182 (16 Jan 2019)
Sequence version 1 (01 Jan 1990)
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Protein

Protein lin-12

Gene

lin-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in several cell fate decisions that require cell-cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • RNA polymerase II transcription factor binding Source: WormBase
  • transmembrane signaling receptor activity Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1912420 Pre-NOTCH Processing in Golgi
R-CEL-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-CEL-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-CEL-8941856 RUNX3 regulates NOTCH signaling
R-CEL-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-CEL-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-CEL-9604323 Negative regulation of NOTCH4 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P14585

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lin-12
Alternative name(s):
Abnormal cell lineage protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lin-12
ORF Names:R107.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
R107.8 ; CE00274 ; WBGene00003001 ; lin-12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini16 – 908ExtracellularSequence analysisAdd BLAST893
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei909 – 931HelicalSequence analysisAdd BLAST23
Topological domaini932 – 1429CytoplasmicSequence analysisAdd BLAST498

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000763416 – 1429Protein lin-12Add BLAST1414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 35By similarity
Disulfide bondi29 ↔ 49By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 60By similarity
Disulfide bondi118 ↔ 129By similarity
Disulfide bondi123 ↔ 138By similarity
Disulfide bondi140 ↔ 149By similarity
Disulfide bondi156 ↔ 169By similarity
Disulfide bondi163 ↔ 178By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 189By similarity
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi205 ↔ 227By similarity
Disulfide bondi221 ↔ 234By similarity
Disulfide bondi236 ↔ 245By similarity
Disulfide bondi254 ↔ 264By similarity
Disulfide bondi259 ↔ 273By similarity
Disulfide bondi275 ↔ 284By similarity
Disulfide bondi291 ↔ 302By similarity
Disulfide bondi296 ↔ 311By similarity
Disulfide bondi313 ↔ 322By similarity
Disulfide bondi327 ↔ 339By similarity
Disulfide bondi334 ↔ 351By similarity
Disulfide bondi353 ↔ 362By similarity
Disulfide bondi369 ↔ 381By similarity
Disulfide bondi375 ↔ 390By similarity
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi392 ↔ 401By similarity
Disulfide bondi408 ↔ 419By similarity
Disulfide bondi413 ↔ 429By similarity
Disulfide bondi431 ↔ 440By similarity
Disulfide bondi462 ↔ 475By similarity
Disulfide bondi469 ↔ 480By similarity
Disulfide bondi482 ↔ 491By similarity
Disulfide bondi507 ↔ 518By similarity
Disulfide bondi512 ↔ 529By similarity
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi531 ↔ 540By similarity
Disulfide bondi547 ↔ 558By similarity
Disulfide bondi552 ↔ 567By similarity
Disulfide bondi569 ↔ 578By similarity
Disulfide bondi586 ↔ 597By similarity
Disulfide bondi591 ↔ 607By similarity
Disulfide bondi609 ↔ 618By similarity
Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi638 ↔ 661By similarity
Disulfide bondi643 ↔ 656By similarity
Disulfide bondi652 ↔ 668By similarity
Disulfide bondi678 ↔ 702By similarity
Disulfide bondi684 ↔ 697By similarity
Disulfide bondi693 ↔ 709By similarity
Disulfide bondi716 ↔ 742By similarity
Disulfide bondi724 ↔ 737By similarity
Disulfide bondi733 ↔ 749By similarity
Glycosylationi751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi900N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14585

PRoteomics IDEntifications database

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PRIDEi
P14585

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003001 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with sel-10.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
sel-10Q937943EBI-326049,EBI-323098

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41481, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3152 CSL-Notch-Mastermind transcription factor complex

Database of interacting proteins

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DIPi
DIP-25208N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P14585

Protein interaction database and analysis system

More...
IntActi
P14585, 5 interactors

Molecular INTeraction database

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MINTi
P14585

STRING: functional protein association networks

More...
STRINGi
6239.R107.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FO1X-ray3.12E931-1301[»]
3BRDX-ray2.21D930-957[»]
3BRFX-ray2.47D938-950[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P14585

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P14585

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P14585

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 61EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini114 – 150EGF-like 2PROSITE-ProRule annotationAdd BLAST37
Domaini152 – 190EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini201 – 246EGF-like 4PROSITE-ProRule annotationAdd BLAST46
Domaini250 – 285EGF-like 5PROSITE-ProRule annotationAdd BLAST36
Domaini287 – 323EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini323 – 363EGF-like 7PROSITE-ProRule annotationAdd BLAST41
Domaini365 – 402EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini404 – 441EGF-like 9PROSITE-ProRule annotationAdd BLAST38
Domaini449 – 492EGF-like 10PROSITE-ProRule annotationAdd BLAST44
Domaini503 – 541EGF-like 11PROSITE-ProRule annotationAdd BLAST39
Domaini543 – 579EGF-like 12PROSITE-ProRule annotationAdd BLAST37
Domaini582 – 619EGF-like 13PROSITE-ProRule annotationAdd BLAST38
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati638 – 674LNR 1Add BLAST37
Repeati678 – 709LNR 2Add BLAST32
Repeati716 – 754LNR 3Add BLAST39
Repeati1093 – 1122ANK 1Add BLAST30
Repeati1126 – 1158ANK 2Add BLAST33
Repeati1162 – 1194ANK 3Add BLAST33
Repeati1206 – 1236ANK 4Add BLAST31
Repeati1240 – 1269ANK 5Add BLAST30

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000167944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112741

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P14585

Identification of Orthologs from Complete Genome Data

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OMAi
TCIDSPL

Database of Orthologous Groups

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OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P14585

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR035993 Notch-like_dom_sf
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00008 EGF, 6 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00181 EGF, 13 hits
SM00179 EGF_CA, 9 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 1 hit
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 12 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 13 hits
PS01187 EGF_CA, 2 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P14585-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIPTICFLF LLISLSKSLH IGSCLGLICG RNGHCHAGPV NGTQTSYWCR
60 70 80 90 100
CDEGFGGEYC EQQCDVSKCG ADEKCVFDKD YRMETCVCKD CDINGNSLLK
110 120 130 140 150
PSCPSGYGGD DCKTQGWCYP SVCMNGGQCI GAGNRAKCAC PDGFKGERCE
160 170 180 190 200
LDVNECEENK NACGNRSTCM NTLGTYICVC PQGFLPPDCL KPGNTSTVEF
210 220 230 240 250
KQPVCFLEIS ADHPDGRSMY CQNGGFCDKA SSKCQCPPGY HGSTCELLEK
260 270 280 290 300
EDSCASNPCS HGVCISFSGG FQCICDDGYS GSYCQEGKDN CVNNKCEAGS
310 320 330 340 350
KCINGVNSYF CDCPPERTGP YCEKMDCSAI PDICNHGTCI DSPLSEKAFE
360 370 380 390 400
CQCEPGYEGI LCEQDKNECL SENMCLNNGT CVNLPGSFRC DCARGFGGKW
410 420 430 440 450
CDEPLNMCQD FHCENDGTCM HTSDHSPVCQ CKNGFIGKRC EKECPIGFGG
460 470 480 490 500
VRCDLRLEIG ICSRQGGKCF NGGKCLSGFC VCPPDFTGNQ CEVNRKNGKS
510 520 530 540 550
SLSENLCLSD PCMNNATCID VDAHIGYACI CKQGFEGDIC ERHKDLCLEN
560 570 580 590 600
PCSNGGVCHQ HRESFSCDCP PGFYGNGCEQ EKMFRCLKST CQNGGVCINE
610 620 630 640 650
EEKGRKCECS YGFSGARCEE KINLTGFTEK DSLLRSVCEK RKCSERANDG
660 670 680 690 700
NCDADCNYAA CKFDGGDCSG KREPFSKCRY GNMCADFFAN GVCNQACNNE
710 720 730 740 750
ECLYDGMDCL PAVVRCPVKI REHCASRFAN GICDPECNTN GCGFDGGDCD
760 770 780 790 800
NETNATIITN IRITVQMDPK EFQVTGGQSL MEISSALRVT VRIQRDEEGP
810 820 830 840 850
LVFQWNGESE MDRVKMNERQ LTEQHVLSTS ISRKIKRSAT NIGVVVYLEV
860 870 880 890 900
QENCDTGKCL YKDAQSVVDS ISARLAKKGI DSFGIPISEA LVAEPRKSGN
910 920 930 940 950
NTGFLSWNAL LLIGAGCLIV MVVLMLGALP GNRTRKRRMI NASVWMPPME
960 970 980 990 1000
NEEKNRKNHQ SITSSQHSLL EASYDGYIKR QRNELQHYSL YPNPQGYGNG
1010 1020 1030 1040 1050
NDFLGDFNHT NLQIPTEPEP ESPIKLHTEA AGSYAITEPI TRESVNIIDP
1060 1070 1080 1090 1100
RHNRTVLHWI ASNSSAEKSE DLIVHEAKEC IAAGADVNAM DCDENTPLML
1110 1120 1130 1140 1150
AVLARRRRLV AYLMKAGADP TIYNKSERSA LHQAAANRDF GMMVYMLNST
1160 1170 1180 1190 1200
KLKGDIEELD RNGMTALMIV AHNEGRDQVA SAKLLVEKGA KVDYDGAARK
1210 1220 1230 1240 1250
DSEKYKGRTA LHYAAQVSNM PIVKYLVGEK GSNKDKQDED GKTPIMLAAQ
1260 1270 1280 1290 1300
EGRIEVVMYL IQQGASVEAV DATDHTARQL AQANNHHNIV DIFDRCRPER
1310 1320 1330 1340 1350
EYSMDLHIQH THQPQPSRKV TRAPKKQTSR SKKESASNSR DSTHLTPPPS
1360 1370 1380 1390 1400
DGSTSTPSPQ HFMNTTHTTP TSLNYLSPEY QTEAGSSEAF QPQCGAFGNG
1410 1420
EMWYTRASTS YTQMQNEPMT RYSEPAHYF
Length:1,429
Mass (Da):157,116
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i255EDD7A62C025DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M12069 Genomic DNA Translation: AAA70191.1
Z14092 Genomic DNA Translation: CAA78474.1

Protein sequence database of the Protein Information Resource

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PIRi
S06434

NCBI Reference Sequences

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RefSeqi
NP_499007.1, NM_066606.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.10278

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
R107.8; R107.8; WBGene00003001

Database of genes from NCBI RefSeq genomes

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GeneIDi
176282

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_R107.8

UCSC genome browser

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UCSCi
R107.8 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12069 Genomic DNA Translation: AAA70191.1
Z14092 Genomic DNA Translation: CAA78474.1
PIRiS06434
RefSeqiNP_499007.1, NM_066606.3
UniGeneiCel.10278

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FO1X-ray3.12E931-1301[»]
3BRDX-ray2.21D930-957[»]
3BRFX-ray2.47D938-950[»]
ProteinModelPortaliP14585
SMRiP14585
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41481, 19 interactors
ComplexPortaliCPX-3152 CSL-Notch-Mastermind transcription factor complex
DIPiDIP-25208N
ELMiP14585
IntActiP14585, 5 interactors
MINTiP14585
STRINGi6239.R107.8

Proteomic databases

PaxDbiP14585
PRIDEiP14585

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR107.8; R107.8; WBGene00003001
GeneIDi176282
KEGGicel:CELE_R107.8
UCSCiR107.8 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176282
WormBaseiR107.8 ; CE00274 ; WBGene00003001 ; lin-12

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000167944
HOGENOMiHOG000112741
InParanoidiP14585
OMAiTCIDSPL
OrthoDBi7525at2759
PhylomeDBiP14585

Enzyme and pathway databases

ReactomeiR-CEL-1912420 Pre-NOTCH Processing in Golgi
R-CEL-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-CEL-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-CEL-8941856 RUNX3 regulates NOTCH signaling
R-CEL-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-CEL-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-CEL-9604323 Negative regulation of NOTCH4 signaling
SignaLinkiP14585

Miscellaneous databases

EvolutionaryTraceiP14585

Protein Ontology

More...
PROi
PR:P14585

Gene expression databases

BgeeiWBGene00003001 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR035993 Notch-like_dom_sf
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00008 EGF, 6 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PRINTSiPR01452 LNOTCHREPEAT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00181 EGF, 13 hits
SM00179 EGF_CA, 9 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 1 hit
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 12 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 13 hits
PS01187 EGF_CA, 2 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIN12_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14585
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 16, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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