UniProtKB - P14556 (PA2B_NAJPA)
Protein
Basic phospholipase A2 nigexine
Gene
N/A
Organism
Naja pallida (Red spitting cobra)
Status
Functioni
Snake venom phospholipase A2 (PLA2) that shows anticoagulant activity, has cytotoxic activity and affects neuromuscular transmission in vitro. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.2 Publications
Caution
The venom of this snake was originally thought to be that of N.nigricollis.Curated
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationEC:3.1.1.4PROSITE-ProRule annotation
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 27 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 29 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 31 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 47 | By similarity | 1 | |
Metal bindingi | 48 | CalciumBy similarity | 1 | |
Active sitei | 92 | By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Blood coagulation cascade inhibiting toxin, Hemostasis impairing toxin, Hydrolase, Neurotoxin, Toxin |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 nigexine (EC:3.1.1.4)Short name: svPLA2 Alternative name(s): Phosphatidylcholine 2-acylhydrolase |
Organismi | Naja pallida (Red spitting cobra) |
Taxonomic identifieri | 8658 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Elapinae › Naja |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161672 | 1 – 118 | Basic phospholipase A2 nigexineAdd BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 11 ↔ 70 | By similarity | ||
Disulfide bondi | 26 ↔ 117 | By similarity | ||
Disulfide bondi | 28 ↔ 44 | By similarity | ||
Disulfide bondi | 43 ↔ 98 | By similarity | ||
Disulfide bondi | 50 ↔ 91 | By similarity | ||
Disulfide bondi | 59 ↔ 84 | By similarity | ||
Disulfide bondi | 77 ↔ 89 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 52 – 69 | Coagulation factor Xa binding motifAdd BLAST | 18 |
Sequence similaritiesi
Family and domain databases
CDDi | cd00125 PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211 PLipase_A2 IPR033112 PLipase_A2_Asp_AS IPR016090 PLipase_A2_dom IPR036444 PLipase_A2_dom_sf IPR033113 PLipase_A2_His_AS |
PANTHERi | PTHR11716 PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068 Phospholip_A2_1, 1 hit |
PRINTSi | PR00389 PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085 PA2c, 1 hit |
SUPFAMi | SSF48619 SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119 PA2_ASP, 1 hit PS00118 PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P14556-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
NLYQFKNMIH CTVPSRPWWH FADYGCYCGR GGKGTPIDDL DRCCQVHDNC
60 70 80 90 100
YEKAGKMGCW PYFTLYKYKC SKGTLTCNGR NGKCAAAVCN CDLVAANCFA
110
GAPYINANYN IDFKKRCQ
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P14556 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00125 PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211 PLipase_A2 IPR033112 PLipase_A2_Asp_AS IPR016090 PLipase_A2_dom IPR036444 PLipase_A2_dom_sf IPR033113 PLipase_A2_His_AS |
PANTHERi | PTHR11716 PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068 Phospholip_A2_1, 1 hit |
PRINTSi | PR00389 PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085 PA2c, 1 hit |
SUPFAMi | SSF48619 SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119 PA2_ASP, 1 hit PS00118 PA2_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2B_NAJPA | |
Accessioni | P14556Primary (citable) accession number: P14556 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | May 8, 2019 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families