AKR1A1

Functionⁱ

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).3 Publications

Catalytic activityⁱ

An alcohol + NADP⁺ = an aldehyde + NADPH.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	45	NADPBy similarity	1
Active siteⁱ	50	Proton donor1 Publication	1
Siteⁱ	80	Lowers pKa of active site Tyr1 Publication	1
Binding siteⁱ	113	Substrate1 Publication	1
Binding siteⁱ	184	NADPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	21 – 23	NADPBy similarity	3
Nucleotide bindingⁱ	162 – 163	NADPBy similarity	2
Nucleotide bindingⁱ	210 – 217	NADPBy similarity	8
Nucleotide bindingⁱ	261 – 273	NADPBy similarityAdd BLAST	13

GO - Molecular functionⁱ

alcohol dehydrogenase (NADP+) activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
alditol:NADP+ 1-oxidoreductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
aldo-keto reductase (NADP) activity Source: Reactome
electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 2498333
L-glucuronate reductase activity
Source: Reactome
Inferred from experimentⁱ
- 7669785
oxidoreductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aldehyde catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular aldehyde metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2498333
D-glucuronate catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glucose metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2498333
glucuronate catabolic process to xylulose 5-phosphate Source: Reactome
glutathione derivative biosynthetic process Source: Reactome
L-ascorbic acid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NADP

Enzyme and pathway databases

BRENDAⁱ	1.1.1.2 2681
Reactomeⁱ	R-HSA-156590 Glutathione conjugation R-HSA-5661270 Formation of xylulose-5-phosphate
SABIO-RKⁱ	P14550

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2) Alternative name(s): Aldehyde reductase Aldo-keto reductase family 1 member A1
Gene namesⁱ	Name:AKR1A1 Synonyms:ALDR1, ALR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117448.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:380 AKR1A1
MIMⁱ	103830 gene
neXtProtⁱ	NX_P14550

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	50	Y → F: Complete loss of enzymatic activity. 1 Publication	1
Mutagenesisⁱ	50	Y → H: Complete loss of enzymatic activity. 1 Publication	1
Mutagenesisⁱ	80	K → M: Complete loss of enzymatic activity. 1 Publication	1
Mutagenesisⁱ	113	H → Q: Strong decrease in enzymatic activity. 1 Publication	1
Mutagenesisⁱ	299	I → A: No change in enzymatic activity. 1 Publication	1
Mutagenesisⁱ	299	I → C: No change in enzymatic activity. 1 Publication	1
Mutagenesisⁱ	300	V → C: No change in enzymatic activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10327
Open Targets More...OpenTargetsⁱ	ENSG00000117448
PharmGKBⁱ	PA24674

Chemistry databases

ChEMBLⁱ	CHEMBL2246
Drug and drug target database More...DrugBankⁱ	DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose DB00997 Doxorubicin DB00898 Ethanol DB00157 NADH DB02383 Tolrestat

Polymorphism and mutation databases

BioMutaⁱ	AKR1A1
DMDMⁱ	113600

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000124617	2 – 325	Alcohol dehydrogenase [NADP(+)]Add BLAST		324

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	4	PhosphoserineBy similarity	1
Modified residueⁱ	38	PhosphoserineCombined sources	1
Modified residueⁱ	127	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	127	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	145	N6-succinyllysineBy similarity	1
Modified residueⁱ	211	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P14550
PaxDbⁱ	P14550
PeptideAtlas More...PeptideAtlasⁱ	P14550
PRIDEⁱ	P14550
ProteomicsDBⁱ	53058

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00220271 P14550
SWISS-2DPAGEⁱ	P14550
UCD-2DPAGEⁱ	P14550

PTM databases

iPTMnetⁱ	P14550
PhosphoSitePlusⁱ	P14550
SwissPalmⁱ	P14550

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000117448 Expressed in 224 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_AKR1A1
ExpressionAtlasⁱ	P14550 baseline and differential
Genevisibleⁱ	P14550 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006246 HPA017919 HPA019649 HPA027734

HPAⁱ

CAB006246
HPA017919
HPA019649
HPA027734

Interactionⁱ

Subunit structureⁱ

Monomer.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TERF2IP	Q9NYB0	2	EBI-372388,EBI-750109

With

Entry

#Exp.

IntAct

Notes

TERF2IP

Q9NYB0

2

EBI-372388,EBI-750109

Protein-protein interaction databases

BioGridⁱ	115610, 29 interactors
IntActⁱ	P14550, 5 interactors
STRINGⁱ	9606.ENSP00000312606

Chemistry databases

BindingDBⁱ

P14550

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 7	Combined sources	3
Beta strandⁱ	13 – 17	Combined sources	5
Helixⁱ	26 – 39	Combined sources	14
Beta strandⁱ	43 – 45	Combined sources	3
Helixⁱ	48 – 50	Combined sources	3
Helixⁱ	53 – 63	Combined sources	11
Beta strandⁱ	68 – 70	Combined sources	3
Helixⁱ	72 – 74	Combined sources	3
Beta strandⁱ	76 – 81	Combined sources	6
Helixⁱ	83 – 85	Combined sources	3
Helixⁱ	88 – 102	Combined sources	15
Beta strandⁱ	107 – 113	Combined sources	7
Beta strandⁱ	115 – 118	Combined sources	4
Beta strandⁱ	120 – 122	Combined sources	3
Helixⁱ	140 – 153	Combined sources	14
Beta strandⁱ	155 – 163	Combined sources	9
Helixⁱ	166 – 173	Combined sources	8
Beta strandⁱ	182 – 186	Combined sources	5
Helixⁱ	194 – 203	Combined sources	10
Beta strandⁱ	206 – 210	Combined sources	5
Helixⁱ	232 – 241	Combined sources	10
Helixⁱ	245 – 255	Combined sources	11
Helixⁱ	267 – 274	Combined sources	8
Helixⁱ	283 – 290	Combined sources	8
Beta strandⁱ	302 – 305	Combined sources	4
Beta strandⁱ	308 – 313	Combined sources	6
Beta strandⁱ	320 – 323	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P14550
SMRⁱ	P14550
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14550

EvolutionaryTraceⁱ

P14550

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1577 Eukaryota COG0656 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119041
HOGENOMⁱ	HOG000250272
HOVERGENⁱ	HBG000020
InParanoidⁱ	P14550
KEGG Orthology (KO) More...KOⁱ	K00002
OMAⁱ	IVPMITV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D69
PhylomeDBⁱ	P14550
TreeFamⁱ	TF106492

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR018170 Aldo/ket_reductase_CS IPR020471 Aldo/keto_reductase IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
PANTHERⁱ	PTHR11732 PTHR11732, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
PIRSFⁱ	PIRSF000097 AKR, 1 hit
PRINTSⁱ	PR00069 ALDKETRDTASE
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
PROSITEⁱ	View protein in PROSITE PS00798 ALDOKETO_REDUCTASE_1, 1 hit PS00062 ALDOKETO_REDUCTASE_2, 1 hit PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P14550-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY 
        60         70         80         90        100
GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA 
       110        120        130        140        150
DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL 
       160        170        180        190        200
VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC 
       210        220        230        240        250
QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL 
       260        270        280        290        300
RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV 
       310        320 
PMLTVDGKRV PRDAGHPLYP FNDPY

Length:325

Mass (Da):36,573

Last modified:January 23, 2007 - v3

Checksum:ⁱF6B27517EB754E37

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5T621	Q5T621_HUMAN	Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)]	AKR1A1	147	Annotation score:
V9GYP9	V9GYP9_HUMAN	Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)]	AKR1A1	140	Annotation score:
V9GYG2	V9GYG2_HUMAN	Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)]	AKR1A1	119	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	305	V → A in BAF85772 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048212	52	N → S Reduced activity towards daunorubicin. 1 PublicationCorresponds to variant dbSNP:rs2229540Ensembl.		1
Natural variantⁱVAR_058909	55	E → D Reduced activity towards daunorubicin. 1 PublicationCorresponds to variant dbSNP:rs6690497Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04794 mRNA Translation: AAA51711.1 AF036683 , AF036680, AF036681, AF036682 Genomic DNA Translation: AAB92369.1 AF112485, AF112484 Genomic DNA Translation: AAF01260.1 AK293083 mRNA Translation: BAF85772.1 CR457010 mRNA Translation: CAG33291.1 BT007003 mRNA Translation: AAP35649.1 AL355480 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06970.1 CH471059 Genomic DNA Translation: EAX06971.1 CH471059 Genomic DNA Translation: EAX06972.1 CH471059 Genomic DNA Translation: EAX06974.1 BC000670 mRNA Translation: AAH00670.1 BC005394 mRNA Translation: AAH05394.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS523.1
PIRⁱ	A33851
NCBI Reference Sequences More...RefSeqⁱ	NP_001189342.1, NM_001202413.1 NP_001189343.1, NM_001202414.1 NP_006057.1, NM_006066.3 NP_697021.1, NM_153326.2
UniGeneⁱ	Hs.474584 Hs.721160

Genome annotation databases

Ensemblⁱ	ENST00000351829; ENSP00000312606; ENSG00000117448 ENST00000372070; ENSP00000361140; ENSG00000117448 ENST00000621846; ENSP00000480713; ENSG00000117448
GeneIDⁱ	10327
KEGGⁱ	hsa:10327

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P14550	Epididymis secretory protein Li 6		HUMAN		325	UniRef100_P14550
Uncharacterized protein		PANPA		325
UPI000011057E		HUMAN		324
UPI0000EE30B6		HUMAN		214

Protein	Similar proteins		Species	Score	Length	Source
P14550	Alcohol dehydrogenase [NADP(+)]		BOVIN		325	UniRef90_P14550
Alcohol dehydrogenase [NADP(+)]		RAT		325
Alcohol dehydrogenase [NADP(+)]		PONAB		325
Alcohol dehydrogenase [NADP(+)]	)	MOUSE		325
Alcohol dehydrogenase [NADP(+)]	)	PIG		325
+112

Protein	Similar proteins		Species	Score	Length	Source
P14550	Alcohol dehydrogenase [NADP(+)]	)	MOUSE		325	UniRef50_P14550
Alcohol dehydrogenase [NADP(+)]		BOVIN		325
Alcohol dehydrogenase [NADP(+)]	)	PIG		325
Alcohol dehydrogenase [NADP(+)]		RAT		325
Alcohol dehydrogenase [NADP(+)]		PONAB		325
+224

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04794 mRNA Translation: AAA51711.1 AF036683 , AF036680, AF036681, AF036682 Genomic DNA Translation: AAB92369.1 AF112485, AF112484 Genomic DNA Translation: AAF01260.1 AK293083 mRNA Translation: BAF85772.1 CR457010 mRNA Translation: CAG33291.1 BT007003 mRNA Translation: AAP35649.1 AL355480 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06970.1 CH471059 Genomic DNA Translation: EAX06971.1 CH471059 Genomic DNA Translation: EAX06972.1 CH471059 Genomic DNA Translation: EAX06974.1 BC000670 mRNA Translation: AAH00670.1 BC005394 mRNA Translation: AAH05394.1
CCDSⁱ	CCDS523.1
PIRⁱ	A33851
RefSeqⁱ	NP_001189342.1, NM_001202413.1 NP_001189343.1, NM_001202414.1 NP_006057.1, NM_006066.3 NP_697021.1, NM_153326.2
UniGeneⁱ	Hs.474584 Hs.721160

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ALR	X-ray	2.48	A	2-325	[»]
ProteinModelPortalⁱ	P14550
SMRⁱ	P14550
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115610, 29 interactors
IntActⁱ	P14550, 5 interactors
STRINGⁱ	9606.ENSP00000312606

Chemistry databases

BindingDBⁱ	P14550
ChEMBLⁱ	CHEMBL2246
DrugBankⁱ	DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose DB00997 Doxorubicin DB00898 Ethanol DB00157 NADH DB02383 Tolrestat

PTM databases

iPTMnetⁱ	P14550
PhosphoSitePlusⁱ	P14550
SwissPalmⁱ	P14550

Polymorphism and mutation databases

BioMutaⁱ	AKR1A1
DMDMⁱ	113600

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00220271 P14550
SWISS-2DPAGEⁱ	P14550
UCD-2DPAGEⁱ	P14550

Proteomic databases

EPDⁱ	P14550
PaxDbⁱ	P14550
PeptideAtlasⁱ	P14550
PRIDEⁱ	P14550
ProteomicsDBⁱ	53058

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10327
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000351829; ENSP00000312606; ENSG00000117448 ENST00000372070; ENSP00000361140; ENSG00000117448 ENST00000621846; ENSP00000480713; ENSG00000117448
GeneIDⁱ	10327
KEGGⁱ	hsa:10327

Organism-specific databases

CTDⁱ	10327
DisGeNETⁱ	10327
EuPathDBⁱ	HostDB:ENSG00000117448.13
GeneCardsⁱ	AKR1A1
HGNCⁱ	HGNC:380 AKR1A1
HPAⁱ	CAB006246 HPA017919 HPA019649 HPA027734
MIMⁱ	103830 gene
neXtProtⁱ	NX_P14550
OpenTargetsⁱ	ENSG00000117448
PharmGKBⁱ	PA24674
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1577 Eukaryota COG0656 LUCA
GeneTreeⁱ	ENSGT00760000119041
HOGENOMⁱ	HOG000250272
HOVERGENⁱ	HBG000020
InParanoidⁱ	P14550
KOⁱ	K00002
OMAⁱ	IVPMITV
OrthoDBⁱ	EOG091G0D69
PhylomeDBⁱ	P14550
TreeFamⁱ	TF106492

Enzyme and pathway databases

BRENDAⁱ	1.1.1.2 2681
Reactomeⁱ	R-HSA-156590 Glutathione conjugation R-HSA-5661270 Formation of xylulose-5-phosphate
SABIO-RKⁱ	P14550

Miscellaneous databases

ChiTaRSⁱ	AKR1A1 human
EvolutionaryTraceⁱ	P14550
GeneWikiⁱ	Aldo-keto_reductase_family_1,_member_A1
GenomeRNAiⁱ	10327
Protein Ontology More...PROⁱ	PR:P14550
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117448 Expressed in 224 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_AKR1A1
ExpressionAtlasⁱ	P14550 baseline and differential
Genevisibleⁱ	P14550 HS

Family and domain databases

CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR018170 Aldo/ket_reductase_CS IPR020471 Aldo/keto_reductase IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
PANTHERⁱ	PTHR11732 PTHR11732, 1 hit
Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
PIRSFⁱ	PIRSF000097 AKR, 1 hit
PRINTSⁱ	PR00069 ALDKETRDTASE
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
PROSITEⁱ	View protein in PROSITE PS00798 ALDOKETO_REDUCTASE_1, 1 hit PS00062 ALDOKETO_REDUCTASE_2, 1 hit PS00063 ALDOKETO_REDUCTASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AK1A1_HUMAN
Accessionⁱ	P14550Primary (citable) accession number: P14550 Secondary accession number(s): A8KAL8, D3DQ04, Q6IAZ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P14550 (AK1A1_HUMAN)

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Alcohol dehydrogenase [NADP(+)]

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ