Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P14550 (AK1A1_HUMAN)

Entry version 212 (25 May 2022)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Aldo-keto reductase family 1 member A1

Gene

AKR1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318).

Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity).

Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097).

Displays no reductase activity towards retinoids (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. Vmax=1426 nmol/min/mg enzyme for 4-hydroxynonenal1 Publication
  2. Vmax=268 nmol/min/mg enzyme for acrolein1 Publication
  3. Vmax=3460 nmol/min/mg enzyme for pyridine-3-carbaldehyde1 Publication
  4. Vmax=4273 nmol/min/mg enzyme for methylglyoxal1 Publication
  5. Vmax=1263 nmol/min/mg enzyme for D,L-glyceraldehyde1 Publication
  6. Vmax=5562 nmol/min/mg enzyme for D-glucuronic acid1 Publication
  7. Vmax=4983 nmol/min/mg enzyme for succinic semialdehyde1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei45NADPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei50Proton donor1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80Lowers pKa of active site Tyr1 Publication1
Binding sitei113Substrate1 Publication1
Binding sitei184NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi21 – 23NADPBy similarity3
Nucleotide bindingi162 – 163NADPBy similarity2
Nucleotide bindingi210 – 217NADPBy similarity8
Nucleotide bindingi261 – 273NADPBy similarityAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14550

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156590, Glutathione conjugation
R-HSA-5661270, Formation of xylulose-5-phosphate

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P14550

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14550

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldo-keto reductase family 1 member A1 (EC:1.1.1.21 Publication, EC:1.1.1.3721 Publication, EC:1.1.1.541 Publication)
Alternative name(s):
Alcohol dehydrogenase [NADP(+)]
Aldehyde reductase
Glucuronate reductase (EC:1.1.1.19By similarity)
Glucuronolactone reductase (EC:1.1.1.20By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKR1A1
Synonyms:ALDR1, ALR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:380, AKR1A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		103830, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14550

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000117448

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50Y → F: Complete loss of enzymatic activity. 1 Publication1
Mutagenesisi50Y → H: Complete loss of enzymatic activity. 1 Publication1
Mutagenesisi80K → M: Complete loss of enzymatic activity. 1 Publication1
Mutagenesisi113H → Q: Strong decrease in enzymatic activity. 1 Publication1
Mutagenesisi299I → A: No change in enzymatic activity. 1 Publication1
Mutagenesisi299I → C: No change in enzymatic activity. 1 Publication1
Mutagenesisi300V → C: No change in enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10327

Open Targets

More...OpenTargetsi		ENSG00000117448

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14550, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2246

Drug and drug target database

More...DrugBanki		DB08904, Certolizumab pegol
DB09130, Copper
DB00997, Doxorubicin
DB00898, Ethanol
DB06077, Lumateperone
DB00157, NADH
DB03461, Nicotinamide adenine dinucleotide phosphate
DB06207, Silodosin
DB02383, Tolrestat

DrugCentral

More...DrugCentrali		P14550

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AKR1A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		113600

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246172 – 325Aldo-keto reductase family 1 member A1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineBy similarity1
Modified residuei38PhosphoserineCombined sources1
Modified residuei127N6-acetyllysine; alternateBy similarity1
Modified residuei127N6-succinyllysine; alternateBy similarity1
Modified residuei145N6-succinyllysineBy similarity1
Modified residuei211PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-10
CPTAC-9

Encyclopedia of Proteome Dynamics

More...EPDi		P14550

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14550

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14550

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14550

PeptideAtlas

More...PeptideAtlasi		P14550

PRoteomics IDEntifications database

More...PRIDEi		P14550

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53058

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00220271
P14550

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P14550

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P14550

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14550, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14550

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P14550

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14550

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P14550

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117448, Expressed in nephron tubule and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14550, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14550, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117448, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115610, 44 interactors

Protein interaction database and analysis system

More...IntActi		P14550, 14 interactors

Molecular INTeraction database

More...MINTi		P14550

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361140

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14550

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14550, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P14550

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14550

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14550

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1577, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023205_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14550

Identification of Orthologs from Complete Genome Data

More...OMAi		WRHPDEP

Database of Orthologous Groups

More...OrthoDBi		1016440at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14550

TreeFam database of animal gene trees

More...TreeFami		TF106492

Family and domain databases

Conserved Domains Database

More...CDDi		cd19106, AKR_AKR1A1-4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020471, AKR
IPR044481, AKR1A
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00248, Aldo_ket_red, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000097, AKR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00069, ALDKETRDTASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51430, SSF51430, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P14550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY 
        60         70         80         90        100
GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA 
       110        120        130        140        150
DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL 
       160        170        180        190        200
VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC 
       210        220        230        240        250
QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL 
       260        270        280        290        300
RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV 
       310        320 
PMLTVDGKRV PRDAGHPLYP FNDPY
Length:325
Mass (Da):36,573
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B27517EB754E37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T621Q5T621_HUMAN
Aldo-keto reductase family 1 member...
AKR1A1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYG2V9GYG2_HUMAN
Aldo-keto reductase family 1 member...
AKR1A1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYP9V9GYP9_HUMAN
Aldo-keto reductase family 1 member...
AKR1A1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti305V → A in BAF85772 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04821252N → S Reduced activity towards daunorubicin. 1 PublicationCorresponds to variant dbSNP:rs2229540Ensembl.1
Natural variantiVAR_05890955E → D Reduced activity towards daunorubicin. 1 PublicationCorresponds to variant dbSNP:rs6690497Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04794 mRNA Translation: AAA51711.1
AF036683 AF036682 Genomic DNA Translation: AAB92369.1
AF112485, AF112484 Genomic DNA Translation: AAF01260.1
AK293083 mRNA Translation: BAF85772.1
CR457010 mRNA Translation: CAG33291.1
BT007003 mRNA Translation: AAP35649.1
AL355480 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06970.1
CH471059 Genomic DNA Translation: EAX06971.1
CH471059 Genomic DNA Translation: EAX06972.1
CH471059 Genomic DNA Translation: EAX06974.1
BC000670 mRNA Translation: AAH00670.1
BC005394 mRNA Translation: AAH05394.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS523.1

Protein sequence database of the Protein Information Resource

More...PIRi		A33851

NCBI Reference Sequences

More...RefSeqi		NP_001189342.1, NM_001202413.1
NP_001189343.1, NM_001202414.1
NP_006057.1, NM_006066.3
NP_697021.1, NM_153326.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000351829.9; ENSP00000312606.4; ENSG00000117448.14
ENST00000372070.7; ENSP00000361140.3; ENSG00000117448.14
ENST00000621846.4; ENSP00000480713.1; ENSG00000117448.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10327

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000351829.9; ENSP00000312606.4; NM_153326.3; NP_697021.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04794 mRNA Translation: AAA51711.1
AF036683 AF036682 Genomic DNA Translation: AAB92369.1
AF112485, AF112484 Genomic DNA Translation: AAF01260.1
AK293083 mRNA Translation: BAF85772.1
CR457010 mRNA Translation: CAG33291.1
BT007003 mRNA Translation: AAP35649.1
AL355480 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06970.1
CH471059 Genomic DNA Translation: EAX06971.1
CH471059 Genomic DNA Translation: EAX06972.1
CH471059 Genomic DNA Translation: EAX06974.1
BC000670 mRNA Translation: AAH00670.1
BC005394 mRNA Translation: AAH05394.1
CCDSiCCDS523.1
PIRiA33851
RefSeqiNP_001189342.1, NM_001202413.1
NP_001189343.1, NM_001202414.1
NP_006057.1, NM_006066.3
NP_697021.1, NM_153326.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ALRX-ray2.48A2-325[»]
AlphaFoldDBiP14550
SMRiP14550
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115610, 44 interactors
IntActiP14550, 14 interactors
MINTiP14550
STRINGi9606.ENSP00000361140

Chemistry databases

BindingDBiP14550
ChEMBLiCHEMBL2246
DrugBankiDB08904, Certolizumab pegol
DB09130, Copper
DB00997, Doxorubicin
DB00898, Ethanol
DB06077, Lumateperone
DB00157, NADH
DB03461, Nicotinamide adenine dinucleotide phosphate
DB06207, Silodosin
DB02383, Tolrestat
DrugCentraliP14550

PTM databases

GlyGeniP14550, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP14550
MetOSiteiP14550
PhosphoSitePlusiP14550
SwissPalmiP14550

Genetic variation databases

BioMutaiAKR1A1
DMDMi113600

2D gel databases

REPRODUCTION-2DPAGEiIPI00220271
P14550
SWISS-2DPAGEiP14550
UCD-2DPAGEiP14550

Proteomic databases

CPTACiCPTAC-10
CPTAC-9
EPDiP14550
jPOSTiP14550
MassIVEiP14550
PaxDbiP14550
PeptideAtlasiP14550
PRIDEiP14550
ProteomicsDBi53058

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3338, 574 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		10327

Genome annotation databases

EnsembliENST00000351829.9; ENSP00000312606.4; ENSG00000117448.14
ENST00000372070.7; ENSP00000361140.3; ENSG00000117448.14
ENST00000621846.4; ENSP00000480713.1; ENSG00000117448.14
GeneIDi10327
KEGGihsa:10327
MANE-SelectiENST00000351829.9; ENSP00000312606.4; NM_153326.3; NP_697021.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10327
DisGeNETi10327

GeneCards: human genes, protein and diseases

More...GeneCardsi		AKR1A1
HGNCiHGNC:380, AKR1A1
HPAiENSG00000117448, Low tissue specificity
MIMi103830, gene
neXtProtiNX_P14550
OpenTargetsiENSG00000117448
PharmGKBiPA24674
VEuPathDBiHostDB:ENSG00000117448

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1577, Eukaryota
GeneTreeiENSGT00940000156539
HOGENOMiCLU_023205_0_0_1
InParanoidiP14550
OMAiWRHPDEP
OrthoDBi1016440at2759
PhylomeDBiP14550
TreeFamiTF106492

Enzyme and pathway databases

BRENDAi1.1.1.2, 2681
PathwayCommonsiP14550
ReactomeiR-HSA-156590, Glutathione conjugation
R-HSA-5661270, Formation of xylulose-5-phosphate
SABIO-RKiP14550
SignaLinkiP14550

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10327, 13 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AKR1A1, human
EvolutionaryTraceiP14550

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Aldo-keto_reductase_family_1,_member_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10327
PharosiP14550, Tchem

Protein Ontology

More...PROi		PR:P14550
RNActiP14550, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117448, Expressed in nephron tubule and 239 other tissues
ExpressionAtlasiP14550, baseline and differential
GenevisibleiP14550, HS

Family and domain databases

CDDicd19106, AKR_AKR1A1-4, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR020471, AKR
IPR044481, AKR1A
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248, Aldo_ket_red, 1 hit
PIRSFiPIRSF000097, AKR, 1 hit
PRINTSiPR00069, ALDKETRDTASE
SUPFAMiSSF51430, SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14550
Secondary accession number(s): A8KAL8, D3DQ04, Q6IAZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again