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UniProtKB - P14550 (AK1A1_HUMAN)

Entry version 202 (22 Apr 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Aldo-keto reductase family 1 member A1

Gene

AKR1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=1426 nmol/min/mg enzyme for 4-hydroxynonenal1 Publication
    2. Vmax=268 nmol/min/mg enzyme for acrolein1 Publication
    3. Vmax=3460 nmol/min/mg enzyme for pyridine-3-carbaldehyde1 Publication
    4. Vmax=4273 nmol/min/mg enzyme for methylglyoxal1 Publication
    5. Vmax=1263 nmol/min/mg enzyme for D,L-glyceraldehyde1 Publication
    6. Vmax=5562 nmol/min/mg enzyme for D-glucuronic acid1 Publication
    7. Vmax=4983 nmol/min/mg enzyme for succinic semialdehyde1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei45NADPBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei50Proton donor1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80Lowers pKa of active site Tyr1 Publication1
    Binding sitei113Substrate1 Publication1
    Binding sitei184NADPBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi21 – 23NADPBy similarity3
    Nucleotide bindingi162 – 163NADPBy similarity2
    Nucleotide bindingi210 – 217NADPBy similarity8
    Nucleotide bindingi261 – 273NADPBy similarityAdd BLAST13

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.1.1.2 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-156590 Glutathione conjugation
    R-HSA-5661270 Formation of xylulose-5-phosphate

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P14550

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aldo-keto reductase family 1 member A1 (EC:1.1.1.21 Publication, EC:1.1.1.3721 Publication, EC:1.1.1.541 Publication)
    Alternative name(s):
    Alcohol dehydrogenase [NADP(+)]
    Aldehyde reductase
    Glucuronate reductase (EC:1.1.1.19By similarity)
    Glucuronolactone reductase (EC:1.1.1.20By similarity)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AKR1A1
    Synonyms:ALDR1, ALR
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:380 AKR1A1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		103830 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P14550

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50Y → F: Complete loss of enzymatic activity. 1 Publication1
    Mutagenesisi50Y → H: Complete loss of enzymatic activity. 1 Publication1
    Mutagenesisi80K → M: Complete loss of enzymatic activity. 1 Publication1
    Mutagenesisi113H → Q: Strong decrease in enzymatic activity. 1 Publication1
    Mutagenesisi299I → A: No change in enzymatic activity. 1 Publication1
    Mutagenesisi299I → C: No change in enzymatic activity. 1 Publication1
    Mutagenesisi300V → C: No change in enzymatic activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		10327

    Open Targets

    More...    OpenTargetsi    		ENSG00000117448

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA24674

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P14550 Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL2246

    Drug and drug target database

    More...    DrugBanki    		DB08904 Certolizumab pegol
    DB09130 Copper
    DB00997 Doxorubicin
    DB00898 Ethanol
    DB06077 Lumateperone
    DB00157 NADH
    DB03461 Nicotinamide adenine dinucleotide phosphate
    DB02383 Tolrestat

    DrugCentral

    More...    DrugCentrali    		P14550

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		AKR1A1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		113600

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246172 – 325Aldo-keto reductase family 1 member A1Add BLAST324

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
    Modified residuei4PhosphoserineBy similarity1
    Modified residuei38PhosphoserineCombined sources1
    Modified residuei127N6-acetyllysine; alternateBy similarity1
    Modified residuei127N6-succinyllysine; alternateBy similarity1
    Modified residuei145N6-succinyllysineBy similarity1
    Modified residuei211PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...    CPTACi    		CPTAC-10
    CPTAC-9

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P14550

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P14550

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P14550

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P14550

    PeptideAtlas

    More...    PeptideAtlasi    		P14550

    PRoteomics IDEntifications database

    More...    PRIDEi    		P14550

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		53058

    2D gel databases

    REPRODUCTION-2DPAGE

    More...    REPRODUCTION-2DPAGEi    		IPI00220271
    P14550

    Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

    More...    SWISS-2DPAGEi    		P14550

    University College Dublin 2-DE Proteome Database

    More...    UCD-2DPAGEi    		P14550

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P14550

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		P14550

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P14550

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P14550

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000117448 Expressed in nephron tubule and 223 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P14550 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P14550 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000117448 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		115610, 29 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P14550, 9 interactors

    Molecular INTeraction database

    More...    MINTi    		P14550

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000361140

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P14550

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P14550 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1325
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P14550

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P14550

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1577 Eukaryota
    COG0656 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000156539

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_023205_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P14550

    KEGG Orthology (KO)

    More...    KOi    		K00002

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		WATYNTR

    Database of Orthologous Groups

    More...    OrthoDBi    		1016440at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P14550

    TreeFam database of animal gene trees

    More...    TreeFami    		TF106492

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd06660 Aldo_ket_red, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.20.20.100, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR018170 Aldo/ket_reductase_CS
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11732 PTHR11732, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00248 Aldo_ket_red, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF000097 AKR, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00069 ALDKETRDTASE

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51430 SSF51430, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00798 ALDOKETO_REDUCTASE_1, 1 hit
    PS00062 ALDOKETO_REDUCTASE_2, 1 hit
    PS00063 ALDOKETO_REDUCTASE_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    P14550-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY 
            60         70         80         90        100
    GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA 
           110        120        130        140        150
    DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL 
           160        170        180        190        200
    VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC 
           210        220        230        240        250
    QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL 
           260        270        280        290        300
    RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV 
           310        320 
    PMLTVDGKRV PRDAGHPLYP FNDPY
    Length:325
    Mass (Da):36,573
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B27517EB754E37
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    Q5T621Q5T621_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1A1
    		147Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V9GYG2V9GYG2_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1A1
    		119Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V9GYP9V9GYP9_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1A1
    		140Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti305V → A in BAF85772 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04821252N → S Reduced activity towards daunorubicin. 1 PublicationCorresponds to variant dbSNP:rs2229540Ensembl.1
    Natural variantiVAR_05890955E → D Reduced activity towards daunorubicin. 1 PublicationCorresponds to variant dbSNP:rs6690497Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		J04794 mRNA Translation: AAA51711.1
    AF036683 AF036682 Genomic DNA Translation: AAB92369.1
    AF112485, AF112484 Genomic DNA Translation: AAF01260.1
    AK293083 mRNA Translation: BAF85772.1
    CR457010 mRNA Translation: CAG33291.1
    BT007003 mRNA Translation: AAP35649.1
    AL355480 Genomic DNA No translation available.
    CH471059 Genomic DNA Translation: EAX06970.1
    CH471059 Genomic DNA Translation: EAX06971.1
    CH471059 Genomic DNA Translation: EAX06972.1
    CH471059 Genomic DNA Translation: EAX06974.1
    BC000670 mRNA Translation: AAH00670.1
    BC005394 mRNA Translation: AAH05394.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS523.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A33851

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001189342.1, NM_001202413.1
    NP_001189343.1, NM_001202414.1
    NP_006057.1, NM_006066.3
    NP_697021.1, NM_153326.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000351829; ENSP00000312606; ENSG00000117448
    ENST00000372070; ENSP00000361140; ENSG00000117448
    ENST00000621846; ENSP00000480713; ENSG00000117448

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		10327

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:10327

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		J04794 mRNA Translation: AAA51711.1
    AF036683 AF036682 Genomic DNA Translation: AAB92369.1
    AF112485, AF112484 Genomic DNA Translation: AAF01260.1
    AK293083 mRNA Translation: BAF85772.1
    CR457010 mRNA Translation: CAG33291.1
    BT007003 mRNA Translation: AAP35649.1
    AL355480 Genomic DNA No translation available.
    CH471059 Genomic DNA Translation: EAX06970.1
    CH471059 Genomic DNA Translation: EAX06971.1
    CH471059 Genomic DNA Translation: EAX06972.1
    CH471059 Genomic DNA Translation: EAX06974.1
    BC000670 mRNA Translation: AAH00670.1
    BC005394 mRNA Translation: AAH05394.1
    CCDSiCCDS523.1
    PIRiA33851
    RefSeqiNP_001189342.1, NM_001202413.1
    NP_001189343.1, NM_001202414.1
    NP_006057.1, NM_006066.3
    NP_697021.1, NM_153326.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2ALRX-ray2.48A2-325[»]
    SMRiP14550
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi115610, 29 interactors
    IntActiP14550, 9 interactors
    MINTiP14550
    STRINGi9606.ENSP00000361140

    Chemistry databases

    BindingDBiP14550
    ChEMBLiCHEMBL2246
    DrugBankiDB08904 Certolizumab pegol
    DB09130 Copper
    DB00997 Doxorubicin
    DB00898 Ethanol
    DB06077 Lumateperone
    DB00157 NADH
    DB03461 Nicotinamide adenine dinucleotide phosphate
    DB02383 Tolrestat
    DrugCentraliP14550

    PTM databases

    iPTMnetiP14550
    MetOSiteiP14550
    PhosphoSitePlusiP14550
    SwissPalmiP14550

    Polymorphism and mutation databases

    BioMutaiAKR1A1
    DMDMi113600

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00220271
    P14550
    SWISS-2DPAGEiP14550
    UCD-2DPAGEiP14550

    Proteomic databases

    CPTACiCPTAC-10
    CPTAC-9
    EPDiP14550
    jPOSTiP14550
    MassIVEiP14550
    PaxDbiP14550
    PeptideAtlasiP14550
    PRIDEiP14550
    ProteomicsDBi53058

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		3338 548 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		10327

    Genome annotation databases

    EnsembliENST00000351829; ENSP00000312606; ENSG00000117448
    ENST00000372070; ENSP00000361140; ENSG00000117448
    ENST00000621846; ENSP00000480713; ENSG00000117448
    GeneIDi10327
    KEGGihsa:10327

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		10327
    DisGeNETi10327

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		AKR1A1
    HGNCiHGNC:380 AKR1A1
    HPAiENSG00000117448 Low tissue specificity
    MIMi103830 gene
    neXtProtiNX_P14550
    OpenTargetsiENSG00000117448
    PharmGKBiPA24674

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1577 Eukaryota
    COG0656 LUCA
    GeneTreeiENSGT00940000156539
    HOGENOMiCLU_023205_0_0_1
    InParanoidiP14550
    KOiK00002
    OMAiWATYNTR
    OrthoDBi1016440at2759
    PhylomeDBiP14550
    TreeFamiTF106492

    Enzyme and pathway databases

    BRENDAi1.1.1.2 2681
    ReactomeiR-HSA-156590 Glutathione conjugation
    R-HSA-5661270 Formation of xylulose-5-phosphate
    SABIO-RKiP14550

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		AKR1A1 human
    EvolutionaryTraceiP14550

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		Aldo-keto_reductase_family_1,_member_A1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		10327
    PharosiP14550 Tchem

    Protein Ontology

    More...    PROi    		PR:P14550
    RNActiP14550 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000117448 Expressed in nephron tubule and 223 other tissues
    ExpressionAtlasiP14550 baseline and differential
    GenevisibleiP14550 HS

    Family and domain databases

    CDDicd06660 Aldo_ket_red, 1 hit
    Gene3Di3.20.20.100, 1 hit
    InterProiView protein in InterPro
    IPR018170 Aldo/ket_reductase_CS
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf
    PANTHERiPTHR11732 PTHR11732, 1 hit
    PfamiView protein in Pfam
    PF00248 Aldo_ket_red, 1 hit
    PIRSFiPIRSF000097 AKR, 1 hit
    PRINTSiPR00069 ALDKETRDTASE
    SUPFAMiSSF51430 SSF51430, 1 hit
    PROSITEiView protein in PROSITE
    PS00798 ALDOKETO_REDUCTASE_1, 1 hit
    PS00062 ALDOKETO_REDUCTASE_2, 1 hit
    PS00063 ALDOKETO_REDUCTASE_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1A1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14550
    Secondary accession number(s): A8KAL8, D3DQ04, Q6IAZ4
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: April 22, 2020
    This is version 202 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
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