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UniProtKB - P14543 (NID1_HUMAN)

Entry version 226 (25 May 2022)
Sequence version 3 (07 Jul 2009)
Previous versions | rss
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Protein

Nidogen-1

Gene

NID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14543

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-3000157, Laminin interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14543

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14543

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nidogen-1
Short name:
NID-1
Alternative name(s):
Entactin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NID1
Synonyms:NID
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7821, NID1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		131390, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14543

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116962

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4811

MalaCards human disease database

More...MalaCardsi		NID1

Open Targets

More...OpenTargetsi		ENSG00000116962

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		269215, Isolated Dandy-Walker malformation without hydrocephalus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14543, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00013, Urokinase

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NID1

Domain mapping of disease mutations (DMDM)

More...DMDMi		251757450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Add BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000766929 – 1247Nidogen-1Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei289SulfotyrosineSequence analysis1
Modified residuei296SulfotyrosineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi390 ↔ 403By similarity
Disulfide bondi397 ↔ 412By similarity
Disulfide bondi411 ↔ 618By similarity
Disulfide bondi414 ↔ 425By similarity
Disulfide bondi672 ↔ 685By similarity
Disulfide bondi679 ↔ 695By similarity
Disulfide bondi697 ↔ 708By similarity
Disulfide bondi714 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 750By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi769 ↔ 787By similarity
Disulfide bondi789 ↔ 800By similarity
Disulfide bondi806 ↔ 817By similarity
Disulfide bondi811 ↔ 826By similarity
Disulfide bondi828 ↔ 839By similarity
Disulfide bondi849 ↔ 878By similarity
Disulfide bondi889 ↔ 896By similarity
Disulfide bondi898 ↔ 919By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi922O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi935O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi1212 ↔ 1223By similarity
Disulfide bondi1219 ↔ 1232By similarity
Disulfide bondi1234 ↔ 1243By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14543

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14543

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14543

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14543

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14543

PeptideAtlas

More...PeptideAtlasi		P14543

PRoteomics IDEntifications database

More...PRIDEi		P14543

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53056 [P14543-1]
53057 [P14543-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14543, 10 sites, 4 O-linked glycans (9 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116962, Expressed in endometrium and 221 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14543, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116962, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1 and LGALS3BP (By similarity).

Interacts with PLXDC1.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110876, 26 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1265, Laminin111-nidogen complex
CPX-1282, Laminin211-nidogen complex
CPX-1285, Laminin221-nidogen complex

Protein interaction database and analysis system

More...IntActi		P14543, 18 interactors

Molecular INTeraction database

More...MINTi		P14543

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264187

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14543, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P14543

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14543

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini106 – 268NIDOPROSITE-ProRule annotationAdd BLAST163
Domaini386 – 426EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini430 – 667Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST238
Domaini668 – 709EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini710 – 751EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini758 – 801EGF-like 4PROSITE-ProRule annotationAdd BLAST44
Domaini802 – 840EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini846 – 919Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST74
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati990 – 1032LDL-receptor class B 1Add BLAST43
Repeati1033 – 1075LDL-receptor class B 2Add BLAST43
Repeati1076 – 1120LDL-receptor class B 3Add BLAST45
Repeati1121 – 1162LDL-receptor class B 4Add BLAST42
Domaini1208 – 1244EGF-like 6PROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi702 – 704Cell attachment site3

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1214, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003163_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14543

Identification of Orthologs from Complete Genome Data

More...OMAi		HVSRLQF

Database of Orthologous Groups

More...OrthoDBi		95286at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14543

TreeFam database of animal gene trees

More...TreeFami		TF320666

Family and domain databases

Conserved Domains Database

More...CDDi		cd00255, nidG2, 1 hit
cd00191, TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.30, 1 hit
2.40.155.10, 1 hit
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
IPR003886, NIDO_dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12662, cEGF, 1 hit
PF12947, EGF_3, 2 hits
PF07645, EGF_CA, 1 hit
PF07474, G2F, 1 hit
PF00058, Ldl_recept_b, 3 hits
PF06119, NIDO, 1 hit
PF00086, Thyroglobulin_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 4 hits
SM00682, G2F, 1 hit
SM00135, LY, 5 hits
SM00539, NIDO, 1 hit
SM00211, TY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 2 hits
SSF57610, SSF57610, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 2 hits
PS51120, LDLRB, 4 hits
PS51220, NIDO, 1 hit
PS50993, NIDOGEN_G2, 1 hit
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P14543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD 
        60         70         80         90        100
DFVSPALELS GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT 
       110        120        130        140        150
FGAVAPFLAD LDTTDGLGKV YYREDLSPSI TQRAAECVHR GFPEISFQPS 
       160        170        180        190        200
SAVVVTWESV APYQGPSRDP DQKGKRNTFQ AVLASSDSSS YAIFLYPEDG 
       210        220        230        240        250
LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA NDRESVENLA 
       260        270        280        290        300
KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 
       310        320        330        340        350
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT 
       360        370        380        390        400
RSFQLAVETF HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH 
       410        420        430        440        450
AECRDYATGF CCSCVAGYTG NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP 
       460        470        480        490        500
IVFENTDLHS YVVMNHGRSY TAISTIPETV GYSLLPLAPV GGIIGWMFAV 
       510        520        530        540        550
EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI DEHGHLTIDT 
       560        570        580        590        600
ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 
       610        620        630        640        650
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR 
       660        670        680        690        700
YALSNSIGPV REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG 
       710        720        730        740        750
FRGDGRTCYD IDECSEQPSV CGSHTICNNH PGTFRCECVE GYQFSDEGTC 
       760        770        780        790        800
VAVVDQRPIN YCETGLHNCD IPQRAQCIYT GGSSYTCSCL PGFSGDGQAC 
       810        820        830        840        850
QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV PGEVEKTRCQ 
       860        870        880        890        900
HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD 
       910        920        930        940        950
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ 
       960        970        980        990       1000
TGKIERLPLE GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP 
      1010       1020       1030       1040       1050
SIGRASLHGG EPTTIIRQDL GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL 
      1060       1070       1080       1090       1100
DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW TDWNRDNPKI ETSYMDGTNR 
      1110       1120       1130       1140       1150
RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ PSRRKALEGL 
      1160       1170       1180       1190       1200
QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT 
      1210       1220       1230       1240 
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK
Length:1,247
Mass (Da):136,377
Last modified:July 7, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCC839416525CD48
GO
Isoform 2 (identifier: P14543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Show »
Length:1,114
Mass (Da):122,017
Checksum:i177A25689611C3BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33 – 34EL → SS in CAA57709 (PubMed:7557988).Curated2
Sequence conflicti37 – 42FGPGQG → SAPDR in CAA57709 (PubMed:7557988).Curated6
Sequence conflicti653L → F in AAA59932 (PubMed:2574658).Curated1
Sequence conflicti653L → F in CAA57709 (PubMed:7557988).Curated1
Sequence conflicti1115T → H in AAA59932 (PubMed:2574658).Curated1
Sequence conflicti1115T → H in CAA57709 (PubMed:7557988).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05576031R → L. Corresponds to variant dbSNP:rs2071529EnsemblClinVar.1
Natural variantiVAR_05812360S → R1 PublicationCorresponds to variant dbSNP:rs17857302Ensembl.1
Natural variantiVAR_024264246V → I4 PublicationsCorresponds to variant dbSNP:rs10733133Ensembl.1
Natural variantiVAR_055761302R → H. Corresponds to variant dbSNP:rs16833183EnsemblClinVar.1
Natural variantiVAR_055762335R → H. Corresponds to variant dbSNP:rs34406281EnsemblClinVar.1
Natural variantiVAR_055763387R → H. Corresponds to variant dbSNP:rs16833154EnsemblClinVar.1
Natural variantiVAR_021904669Q → R. Corresponds to variant dbSNP:rs3738534EnsemblClinVar.1
Natural variantiVAR_058124807Q → H1 PublicationCorresponds to variant dbSNP:rs3738531Ensembl.1
Natural variantiVAR_055764970K → E. Corresponds to variant dbSNP:rs16833060EnsemblClinVar.1
Natural variantiVAR_0358351036F → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0557651163L → V. Corresponds to variant dbSNP:rs16833032EnsemblClinVar.1
Natural variantiVAR_0557661226T → I. Corresponds to variant dbSNP:rs6662744EnsemblClinVar.1
Natural variantiVAR_0581251246Q → R3 PublicationsCorresponds to variant dbSNP:rs3213190Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017254710 – 842Missing in isoform 2. 2 PublicationsAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M30269 mRNA Translation: AAA59932.1
X82245 X84837 Genomic DNA Translation: CAA57709.1
AL122018 Genomic DNA No translation available.
AL139161 Genomic DNA No translation available.
BC045606 mRNA Translation: AAH45606.1
AB209448 mRNA Translation: BAD92685.1
M27445 mRNA Translation: AAA57261.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1608.1 [P14543-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A33322, MMHUND

NCBI Reference Sequences

More...RefSeqi		NP_002499.2, NM_002508.2 [P14543-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264187.7; ENSP00000264187.6; ENSG00000116962.15
ENST00000366595.7; ENSP00000355554.3; ENSG00000116962.15 [P14543-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4811

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4811

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000264187.7; ENSP00000264187.6; NM_002508.3; NP_002499.2

UCSC genome browser

More...UCSCi		uc001hxo.4, human [P14543-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30269 mRNA Translation: AAA59932.1
X82245 X84837 Genomic DNA Translation: CAA57709.1
AL122018 Genomic DNA No translation available.
AL139161 Genomic DNA No translation available.
BC045606 mRNA Translation: AAH45606.1
AB209448 mRNA Translation: BAD92685.1
M27445 mRNA Translation: AAA57261.1
CCDSiCCDS1608.1 [P14543-1]
PIRiA33322, MMHUND
RefSeqiNP_002499.2, NM_002508.2 [P14543-1]

3D structure databases

AlphaFoldDBiP14543
SMRiP14543
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110876, 26 interactors
ComplexPortaliCPX-1265, Laminin111-nidogen complex
CPX-1282, Laminin211-nidogen complex
CPX-1285, Laminin221-nidogen complex
IntActiP14543, 18 interactors
MINTiP14543
STRINGi9606.ENSP00000264187

Chemistry databases

DrugBankiDB00013, Urokinase

PTM databases

GlyGeniP14543, 10 sites, 4 O-linked glycans (9 sites)
iPTMnetiP14543
PhosphoSitePlusiP14543

Genetic variation databases

BioMutaiNID1
DMDMi251757450

Proteomic databases

EPDiP14543
jPOSTiP14543
MassIVEiP14543
MaxQBiP14543
PaxDbiP14543
PeptideAtlasiP14543
PRIDEiP14543
ProteomicsDBi53056 [P14543-1]
53057 [P14543-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4102, 426 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		4811

Genome annotation databases

EnsembliENST00000264187.7; ENSP00000264187.6; ENSG00000116962.15
ENST00000366595.7; ENSP00000355554.3; ENSG00000116962.15 [P14543-2]
GeneIDi4811
KEGGihsa:4811
MANE-SelectiENST00000264187.7; ENSP00000264187.6; NM_002508.3; NP_002499.2
UCSCiuc001hxo.4, human [P14543-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4811
DisGeNETi4811

GeneCards: human genes, protein and diseases

More...GeneCardsi		NID1
HGNCiHGNC:7821, NID1
HPAiENSG00000116962, Tissue enhanced (placenta)
MalaCardsiNID1
MIMi131390, gene
neXtProtiNX_P14543
OpenTargetsiENSG00000116962
Orphaneti269215, Isolated Dandy-Walker malformation without hydrocephalus
PharmGKBiPA31625
VEuPathDBiHostDB:ENSG00000116962

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1214, Eukaryota
GeneTreeiENSGT00940000156318
HOGENOMiCLU_003163_1_0_1
InParanoidiP14543
OMAiHVSRLQF
OrthoDBi95286at2759
PhylomeDBiP14543
TreeFamiTF320666

Enzyme and pathway databases

PathwayCommonsiP14543
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-3000157, Laminin interactions
SignaLinkiP14543
SIGNORiP14543

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4811, 12 hits in 1074 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NID1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Entactin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4811
PharosiP14543, Tbio

Protein Ontology

More...PROi		PR:P14543
RNActiP14543, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116962, Expressed in endometrium and 221 other tissues
GenevisibleiP14543, HS

Family and domain databases

CDDicd00255, nidG2, 1 hit
cd00191, TY, 1 hit
Gene3Di2.120.10.30, 1 hit
2.40.155.10, 1 hit
4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
IPR003886, NIDO_dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF12947, EGF_3, 2 hits
PF07645, EGF_CA, 1 hit
PF07474, G2F, 1 hit
PF00058, Ldl_recept_b, 3 hits
PF06119, NIDO, 1 hit
PF00086, Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 4 hits
SM00682, G2F, 1 hit
SM00135, LY, 5 hits
SM00539, NIDO, 1 hit
SM00211, TY, 1 hit
SUPFAMiSSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 2 hits
SSF57610, SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 2 hits
PS51120, LDLRB, 4 hits
PS51220, NIDO, 1 hit
PS50993, NIDOGEN_G2, 1 hit
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNID1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14543
Secondary accession number(s): Q14942
, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: May 25, 2022
This is version 226 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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