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Entry version 213 (13 Nov 2019)
Sequence version 3 (07 Jul 2009)
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Protein

Nidogen-1

Gene

NID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-3000157 Laminin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nidogen-1
Short name:
NID-1
Alternative name(s):
Entactin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NID1
Synonyms:NID
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7821 NID1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131390 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4811

Open Targets

More...
OpenTargetsi
ENSG00000116962

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
217 Isolated Dandy-Walker malformation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P14543

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00013 Urokinase

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NID1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
251757450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Add BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000766929 – 1247Nidogen-1Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei289SulfotyrosineSequence analysis1
Modified residuei296SulfotyrosineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi390 ↔ 403By similarity
Disulfide bondi397 ↔ 412By similarity
Disulfide bondi411 ↔ 618By similarity
Disulfide bondi414 ↔ 425By similarity
Disulfide bondi672 ↔ 685By similarity
Disulfide bondi679 ↔ 695By similarity
Disulfide bondi697 ↔ 708By similarity
Disulfide bondi714 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 750By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi769 ↔ 787By similarity
Disulfide bondi789 ↔ 800By similarity
Disulfide bondi806 ↔ 817By similarity
Disulfide bondi811 ↔ 826By similarity
Disulfide bondi828 ↔ 839By similarity
Disulfide bondi849 ↔ 878By similarity
Disulfide bondi889 ↔ 896By similarity
Disulfide bondi898 ↔ 919By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi922O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi935O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi1212 ↔ 1223By similarity
Disulfide bondi1219 ↔ 1232By similarity
Disulfide bondi1234 ↔ 1243By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P14543

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P14543

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P14543

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P14543

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14543

PeptideAtlas

More...
PeptideAtlasi
P14543

PRoteomics IDEntifications database

More...
PRIDEi
P14543

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53056 [P14543-1]
53057 [P14543-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P14543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116962 Expressed in 208 organ(s), highest expression level in endometrium

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P14543 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010044

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1 and LGALS3BP (By similarity).

Interacts with PLXDC1.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110876, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1265 Laminin111-nidogen complex
CPX-1282 Laminin211-nidogen complex
CPX-1285 Laminin221-nidogen complex

Protein interaction database and analysis system

More...
IntActi
P14543, 17 interactors

Molecular INTeraction database

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MINTi
P14543

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264187

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P14543

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini106 – 268NIDOPROSITE-ProRule annotationAdd BLAST163
Domaini386 – 426EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini430 – 667Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST238
Domaini668 – 709EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini710 – 751EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini758 – 801EGF-like 4PROSITE-ProRule annotationAdd BLAST44
Domaini802 – 840EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini846 – 919Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST74
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati990 – 1032LDL-receptor class B 1Add BLAST43
Repeati1033 – 1075LDL-receptor class B 2Add BLAST43
Repeati1076 – 1120LDL-receptor class B 3Add BLAST45
Repeati1121 – 1162LDL-receptor class B 4Add BLAST42
Domaini1208 – 1244EGF-like 6PROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi702 – 704Cell attachment site3

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1214 Eukaryota
ENOG410XR8N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000072712

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14543

KEGG Orthology (KO)

More...
KOi
K06826

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFRCECE

Database of Orthologous Groups

More...
OrthoDBi
95286at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14543

TreeFam database of animal gene trees

More...
TreeFami
TF320666

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00255 nidG2, 1 hit
cd00191 TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
IPR003886 NIDO_dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
PF07474 G2F, 1 hit
PF00058 Ldl_recept_b, 3 hits
PF06119 NIDO, 1 hit
PF00086 Thyroglobulin_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00682 G2F, 1 hit
SM00135 LY, 5 hits
SM00539 NIDO, 1 hit
SM00211 TY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 2 hits
SSF57610 SSF57610, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 2 hits
PS51120 LDLRB, 4 hits
PS51220 NIDO, 1 hit
PS50993 NIDOGEN_G2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P14543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD
60 70 80 90 100
DFVSPALELS GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT
110 120 130 140 150
FGAVAPFLAD LDTTDGLGKV YYREDLSPSI TQRAAECVHR GFPEISFQPS
160 170 180 190 200
SAVVVTWESV APYQGPSRDP DQKGKRNTFQ AVLASSDSSS YAIFLYPEDG
210 220 230 240 250
LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA NDRESVENLA
260 270 280 290 300
KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT
310 320 330 340 350
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT
360 370 380 390 400
RSFQLAVETF HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH
410 420 430 440 450
AECRDYATGF CCSCVAGYTG NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP
460 470 480 490 500
IVFENTDLHS YVVMNHGRSY TAISTIPETV GYSLLPLAPV GGIIGWMFAV
510 520 530 540 550
EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI DEHGHLTIDT
560 570 580 590 600
ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS
610 620 630 640 650
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR
660 670 680 690 700
YALSNSIGPV REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG
710 720 730 740 750
FRGDGRTCYD IDECSEQPSV CGSHTICNNH PGTFRCECVE GYQFSDEGTC
760 770 780 790 800
VAVVDQRPIN YCETGLHNCD IPQRAQCIYT GGSSYTCSCL PGFSGDGQAC
810 820 830 840 850
QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV PGEVEKTRCQ
860 870 880 890 900
HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD
910 920 930 940 950
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ
960 970 980 990 1000
TGKIERLPLE GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP
1010 1020 1030 1040 1050
SIGRASLHGG EPTTIIRQDL GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL
1060 1070 1080 1090 1100
DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW TDWNRDNPKI ETSYMDGTNR
1110 1120 1130 1140 1150
RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ PSRRKALEGL
1160 1170 1180 1190 1200
QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT
1210 1220 1230 1240
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK
Length:1,247
Mass (Da):136,377
Last modified:July 7, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCC839416525CD48
GO
Isoform 2 (identifier: P14543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Show »
Length:1,114
Mass (Da):122,017
Checksum:i177A25689611C3BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33 – 34EL → SS in CAA57709 (PubMed:7557988).Curated2
Sequence conflicti37 – 42FGPGQG → SAPDR in CAA57709 (PubMed:7557988).Curated6
Sequence conflicti653L → F in AAA59932 (PubMed:2574658).Curated1
Sequence conflicti653L → F in CAA57709 (PubMed:7557988).Curated1
Sequence conflicti1115T → H in AAA59932 (PubMed:2574658).Curated1
Sequence conflicti1115T → H in CAA57709 (PubMed:7557988).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05576031R → L. Corresponds to variant dbSNP:rs2071529Ensembl.1
Natural variantiVAR_05812360S → R1 PublicationCorresponds to variant dbSNP:rs17857302Ensembl.1
Natural variantiVAR_024264246V → I4 PublicationsCorresponds to variant dbSNP:rs10733133Ensembl.1
Natural variantiVAR_055761302R → H. Corresponds to variant dbSNP:rs16833183Ensembl.1
Natural variantiVAR_055762335R → H. Corresponds to variant dbSNP:rs34406281Ensembl.1
Natural variantiVAR_055763387R → H. Corresponds to variant dbSNP:rs16833154Ensembl.1
Natural variantiVAR_021904669Q → R. Corresponds to variant dbSNP:rs3738534Ensembl.1
Natural variantiVAR_058124807Q → H1 PublicationCorresponds to variant dbSNP:rs3738531Ensembl.1
Natural variantiVAR_055764970K → E. Corresponds to variant dbSNP:rs16833060Ensembl.1
Natural variantiVAR_0358351036F → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0557651163L → V. Corresponds to variant dbSNP:rs16833032Ensembl.1
Natural variantiVAR_0557661226T → I. Corresponds to variant dbSNP:rs6662744Ensembl.1
Natural variantiVAR_0581251246Q → R3 PublicationsCorresponds to variant dbSNP:rs3213190Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017254710 – 842Missing in isoform 2. 2 PublicationsAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M30269 mRNA Translation: AAA59932.1
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA Translation: CAA57709.1
AL122018 Genomic DNA No translation available.
AL139161 Genomic DNA No translation available.
BC045606 mRNA Translation: AAH45606.1
AB209448 mRNA Translation: BAD92685.1
M27445 mRNA Translation: AAA57261.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1608.1 [P14543-1]

Protein sequence database of the Protein Information Resource

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PIRi
A33322 MMHUND

NCBI Reference Sequences

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RefSeqi
NP_002499.2, NM_002508.2 [P14543-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264187; ENSP00000264187; ENSG00000116962 [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962 [P14543-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4811

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4811

UCSC genome browser

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UCSCi
uc001hxo.4 human [P14543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30269 mRNA Translation: AAA59932.1
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA Translation: CAA57709.1
AL122018 Genomic DNA No translation available.
AL139161 Genomic DNA No translation available.
BC045606 mRNA Translation: AAH45606.1
AB209448 mRNA Translation: BAD92685.1
M27445 mRNA Translation: AAA57261.1
CCDSiCCDS1608.1 [P14543-1]
PIRiA33322 MMHUND
RefSeqiNP_002499.2, NM_002508.2 [P14543-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
SMRiP14543
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110876, 20 interactors
ComplexPortaliCPX-1265 Laminin111-nidogen complex
CPX-1282 Laminin211-nidogen complex
CPX-1285 Laminin221-nidogen complex
IntActiP14543, 17 interactors
MINTiP14543
STRINGi9606.ENSP00000264187

Chemistry databases

DrugBankiDB00013 Urokinase

PTM databases

iPTMnetiP14543
PhosphoSitePlusiP14543

Polymorphism and mutation databases

BioMutaiNID1
DMDMi251757450

Proteomic databases

EPDiP14543
jPOSTiP14543
MassIVEiP14543
MaxQBiP14543
PaxDbiP14543
PeptideAtlasiP14543
PRIDEiP14543
ProteomicsDBi53056 [P14543-1]
53057 [P14543-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4811

Genome annotation databases

EnsembliENST00000264187; ENSP00000264187; ENSG00000116962 [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962 [P14543-2]
GeneIDi4811
KEGGihsa:4811
UCSCiuc001hxo.4 human [P14543-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4811
DisGeNETi4811

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NID1
HGNCiHGNC:7821 NID1
HPAiCAB010044
MIMi131390 gene
neXtProtiNX_P14543
OpenTargetsiENSG00000116962
Orphaneti217 Isolated Dandy-Walker malformation
PharmGKBiPA31625

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1214 Eukaryota
ENOG410XR8N LUCA
GeneTreeiENSGT00940000156318
HOGENOMiHOG000072712
InParanoidiP14543
KOiK06826
OMAiTFRCECE
OrthoDBi95286at2759
PhylomeDBiP14543
TreeFamiTF320666

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-3000157 Laminin interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NID1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Entactin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4811
PharosiP14543

Protein Ontology

More...
PROi
PR:P14543

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116962 Expressed in 208 organ(s), highest expression level in endometrium
GenevisibleiP14543 HS

Family and domain databases

CDDicd00255 nidG2, 1 hit
cd00191 TY, 1 hit
Gene3Di2.120.10.30, 1 hit
4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
IPR003886 NIDO_dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
PF07474 G2F, 1 hit
PF00058 Ldl_recept_b, 3 hits
PF06119 NIDO, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00682 G2F, 1 hit
SM00135 LY, 5 hits
SM00539 NIDO, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 2 hits
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 2 hits
PS51120 LDLRB, 4 hits
PS51220 NIDO, 1 hit
PS50993 NIDOGEN_G2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNID1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14543
Secondary accession number(s): Q14942
, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: November 13, 2019
This is version 213 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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