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Protein

H-2 class II histocompatibility antigen, A-R alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-R alpha chain
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95895 H2-Aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 195ExtracellularSequence analysisAdd BLAST195
Transmembranei196 – 221HelicalSequence analysisAdd BLAST26
Topological domaini222 – 233CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807471 – 233H-2 class II histocompatibility antigen, A-R alpha chainAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi111 ↔ 167PROSITE-ProRule annotation
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP14436
PRIDEiP14436

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP14436
SMRiP14436
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 183Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 88Alpha-1Add BLAST88
Regioni89 – 182Alpha-2Add BLAST94
Regioni183 – 195Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P14436-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EDDIEADHVG VYGTTVYQSP GDIGQFTHEF DGDEWFYVDL DKKETVWMLP
60 70 80 90 100
EFGQLTSFDP QGGLQNIAVV KHNLEILTKR SNFTPAANEA PQATVFPKSP
110 120 130 140 150
VLLGQPNTLI CFVDNIFPPV INITWLRNSK SVTDGVYETS FLVNRDHSFH
160 170 180 190 200
KLSYLTFIPS DDDIYDCKVE HWGLEEPVLK HWEPEIPAPM SELTETVVCA
210 220 230
LGLSVGLVGI VVGTIFIIQG LRSGGTSRHP GPL
Length:233
Mass (Da):25,900
Last modified:January 1, 1990 - v1
Checksum:i918167E08F164DA9
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14434HA2B_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P01910HA2K_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P23150HA2J_MOUSE
H-2 class II histocompatibility ant...
254Annotation score:
P04228HA2D_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P14438HA2U_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
227Annotation score:
P14435HA2F_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P04227HA2Q_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
221Annotation score:
P14437HA2S_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
G3UWR9G3UWR9_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
173Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11356 mRNA Translation: AAA39621.1
PIRiI79357
UniGeneiMm.235338

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11356 mRNA Translation: AAA39621.1
PIRiI79357
UniGeneiMm.235338

3D structure databases

ProteinModelPortaliP14436
SMRiP14436
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiP14436
PRIDEiP14436

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95895 H2-Aa

Phylogenomic databases

HOVERGENiHBG006862

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA2R_MOUSE
AccessioniPrimary (citable) accession number: P14436
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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