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Protein

H-2 class II histocompatibility antigen, A-B alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-202424 Downstream TCR signaling
R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
R-MMU-202430 Translocation of ZAP-70 to Immunological synapse
R-MMU-202433 Generation of second messenger molecules
R-MMU-2132295 MHC class II antigen presentation
R-MMU-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-B alpha chain
Short name:
IAalpha
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95895 H2-Aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 218ExtracellularSequence analysisAdd BLAST195
Transmembranei219 – 244HelicalSequence analysisAdd BLAST26
Topological domaini245 – 256CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001897524 – 256H-2 class II histocompatibility antigen, A-B alpha chainAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi134 ↔ 190PROSITE-ProRule annotation1 Publication
Glycosylationi145N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14434
MaxQBiP14434
PaxDbiP14434
PeptideAtlasiP14434
PRIDEiP14434

PTM databases

iPTMnetiP14434

Expressioni

Gene expression databases

BgeeiENSMUSG00000036594 Expressed in 192 organ(s), highest expression level in spleen
CleanExiMM_H2-AA
ExpressionAtlasiP14434 baseline and differential
GenevisibleiP14434 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200146, 2 interactors
IntActiP14434, 1 interactor
MINTiP14434
STRINGi10090.ENSMUSP00000046105

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14434
SMRiP14434
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14434

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 206Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 111Alpha-1Add BLAST88
Regioni112 – 205Alpha-2Add BLAST94
Regioni206 – 218Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZMF Eukaryota
ENOG410YHX9 LUCA
GeneTreeiENSGT00900000140882
HOGENOMiHOG000112076
HOVERGENiHBG006862
KOiK06752
OMAiLKHWEPD
OrthoDBiEOG091G0IC9
PhylomeDBiP14434
TreeFamiTF333797

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P14434-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSRALILG VLALTTMLSL CGGEDDIEAD HVGTYGISVY QSPGDIGQYT
60 70 80 90 100
FEFDGDELFY VDLDKKETVW MLPEFGQLAS FDPQGGLQNI AVVKHNLGVL
110 120 130 140 150
TKRSNSTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR
160 170 180 190 200
NSKSVADGVY ETSFFVNRDY SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP
210 220 230 240 250
VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS

RHPGPL
Length:256
Mass (Da):28,093
Last modified:May 30, 2000 - v2
Checksum:iC9DD084F6179B41F
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P01910HA2K_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P23150HA2J_MOUSE
H-2 class II histocompatibility ant...
254Annotation score:
P04228HA2D_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P14438HA2U_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
227Annotation score:
P14435HA2F_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P04227HA2Q_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
221Annotation score:
P14437HA2S_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P14436HA2R_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
G3UWR9G3UWR9_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
173Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027865 Genomic DNA Translation: AAB81529.1
AF050157 Genomic DNA Translation: AAC05285.1
BC019721 mRNA Translation: AAH19721.1
BC031711 mRNA Translation: AAH31711.1
K01922 mRNA Translation: AAA39614.1
CCDSiCCDS28645.1
RefSeqiNP_034508.2, NM_010378.2
UniGeneiMm.235338

Genome annotation databases

EnsembliENSMUST00000040655; ENSMUSP00000046105; ENSMUSG00000036594
GeneIDi14960
KEGGimmu:14960
UCSCiuc008ccd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027865 Genomic DNA Translation: AAB81529.1
AF050157 Genomic DNA Translation: AAC05285.1
BC019721 mRNA Translation: AAH19721.1
BC031711 mRNA Translation: AAH31711.1
K01922 mRNA Translation: AAA39614.1
CCDSiCCDS28645.1
RefSeqiNP_034508.2, NM_010378.2
UniGeneiMm.235338

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50A/C/E/G27-208[»]
1MUJX-ray2.15A24-205[»]
3C5ZX-ray2.55C/G27-208[»]
3C60X-ray3.05C/G27-208[»]
3C6LX-ray3.40C/G27-208[»]
3RDTX-ray2.70C27-208[»]
4P23X-ray2.25C27-205[»]
4P46X-ray2.85C27-205[»]
4P5TX-ray3.26C/G27-208[»]
ProteinModelPortaliP14434
SMRiP14434
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200146, 2 interactors
IntActiP14434, 1 interactor
MINTiP14434
STRINGi10090.ENSMUSP00000046105

PTM databases

iPTMnetiP14434

Proteomic databases

EPDiP14434
MaxQBiP14434
PaxDbiP14434
PeptideAtlasiP14434
PRIDEiP14434

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040655; ENSMUSP00000046105; ENSMUSG00000036594
GeneIDi14960
KEGGimmu:14960
UCSCiuc008ccd.1 mouse

Organism-specific databases

CTDi14960
MGIiMGI:95895 H2-Aa

Phylogenomic databases

eggNOGiENOG410IZMF Eukaryota
ENOG410YHX9 LUCA
GeneTreeiENSGT00900000140882
HOGENOMiHOG000112076
HOVERGENiHBG006862
KOiK06752
OMAiLKHWEPD
OrthoDBiEOG091G0IC9
PhylomeDBiP14434
TreeFamiTF333797

Enzyme and pathway databases

ReactomeiR-MMU-202424 Downstream TCR signaling
R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
R-MMU-202430 Translocation of ZAP-70 to Immunological synapse
R-MMU-202433 Generation of second messenger molecules
R-MMU-2132295 MHC class II antigen presentation
R-MMU-389948 PD-1 signaling

Miscellaneous databases

EvolutionaryTraceiP14434
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036594 Expressed in 192 organ(s), highest expression level in spleen
CleanExiMM_H2-AA
ExpressionAtlasiP14434 baseline and differential
GenevisibleiP14434 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA2B_MOUSE
AccessioniPrimary (citable) accession number: P14434
Secondary accession number(s): O78195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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