DRD2

Functionⁱ

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	114	AgonistBy similarity	1
Siteⁱ	194	Important for receptor activationBy similarity	1
Siteⁱ	197	Important for receptor activationBy similarity	1

GO - Molecular functionⁱ

dopamine binding Source: GO_Central
dopamine neurotransmitter receptor activity, coupled via Gi/Go
Source: BHF-UCL
Inferred from direct assayⁱ
- 8301582
- 2531656
drug binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 8413587
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18668123
ionotropic glutamate receptor binding Source: Ensembl
potassium channel regulator activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 12297500
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity Source: Ensembl
adenohypophysis development Source: BHF-UCL
adenylate cyclase-inhibiting dopamine receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
adrenergic receptor signaling pathway Source: GOC
adult walking behavior Source: BHF-UCL
arachidonic acid secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 8301582
associative learning Source: BHF-UCL
auditory behavior Source: Ensembl
autophagy Source: Ensembl
axonogenesis Source: BHF-UCL
behavioral response to cocaine Source: BHF-UCL
behavioral response to ethanol Source: BHF-UCL
branching morphogenesis of a nerve Source: BHF-UCL
cellular calcium ion homeostasis
Source: BHF-UCL
Inferred by curatorⁱ
- 7921596
cerebral cortex GABAergic interneuron migration Source: BHF-UCL
circadian regulation of gene expression Source: BHF-UCL
dopamine metabolic process
Source: BHF-UCL
Inferred by curatorⁱ
- 8301582
drinking behavior Source: Ensembl
excitatory postsynaptic potential
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 21711983
G-protein coupled receptor internalization Source: Ensembl
G-protein coupled receptor signaling pathway Source: Reactome
grooming behavior Source: Ensembl
intracellular signal transduction
Source: BHF-UCL
Inferred from direct assayⁱ
- 1331329
locomotory behavior Source: BHF-UCL
long-term memory Source: Ensembl
negative regulation of adenylate cyclase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 2531656
negative regulation of blood pressure Source: BHF-UCL
negative regulation of cell death Source: Ensembl
negative regulation of cell migration Source: BHF-UCL
negative regulation of cell proliferation Source: BHF-UCL
negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
negative regulation of cytosolic calcium ion concentration Source: GO_Central
negative regulation of dopamine receptor signaling pathway Source: BHF-UCL
negative regulation of dopamine secretion Source: Ensembl
negative regulation of innate immune response Source: Ensembl
negative regulation of insulin secretion Source: Ensembl
negative regulation of protein kinase B signaling Source: BHF-UCL
negative regulation of protein phosphorylation Source: Ensembl
negative regulation of protein secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 16839358
negative regulation of synaptic transmission, glutamatergic Source: BHF-UCL
negative regulation of voltage-gated calcium channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 7921596
neurological system process involved in regulation of systemic arterial blood pressure Source: BHF-UCL
neuron-neuron synaptic transmission Source: BHF-UCL
orbitofrontal cortex development Source: Ensembl
peristalsis Source: BHF-UCL
phospholipase C-activating dopamine receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 17194762
pigmentation Source: Ensembl
positive regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22888021
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1331329
positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of glial cell-derived neurotrophic factor secretion
Source: CACAO
Inferred from direct assayⁱ
- 23373701
positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
positive regulation of growth hormone secretion Source: BHF-UCL
positive regulation of long-term synaptic potentiation Source: Ensembl
positive regulation of multicellular organism growth Source: Ensembl
positive regulation of neuroblast proliferation Source: BHF-UCL
positive regulation of receptor internalization Source: Ensembl
positive regulation of renal sodium excretion Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of urine volume Source: Ensembl
postsynaptic modulation of chemical synaptic transmission Source: Ensembl
prepulse inhibition Source: BHF-UCL
protein localization Source: BHF-UCL
regulation of dopamine secretion Source: GO_Central
regulation of dopamine uptake involved in synaptic transmission
Source: BHF-UCL
Inferred by curatorⁱ
- 8301582
regulation of heart rate Source: BHF-UCL
regulation of locomotion involved in locomotory behavior Source: Ensembl
regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
regulation of phosphoprotein phosphatase activity Source: Ensembl
regulation of potassium ion transport Source: BHF-UCL
regulation of sodium ion transport Source: BHF-UCL
regulation of synapse structural plasticity Source: Ensembl
regulation of synaptic transmission, GABAergic Source: BHF-UCL
regulation of synaptic vesicle exocytosis Source: Ensembl
release of sequestered calcium ion into cytosol Source: BHF-UCL
response to amphetamine Source: BHF-UCL
response to axon injury Source: Ensembl
response to cocaine Source: BHF-UCL
response to drug Source: BHF-UCL
response to histamine
Source: BHF-UCL
Inferred from direct assayⁱ
- 16839358
response to hypoxia Source: Ensembl
response to inactivity Source: Ensembl
response to iron ion Source: Ensembl
response to light stimulus Source: BHF-UCL
response to morphine Source: BHF-UCL
response to nicotine Source: Ensembl
response to toxic substance Source: GO_Central
sensory perception of smell Source: BHF-UCL
striatum development Source: Ensembl
synapse assembly Source: BHF-UCL
synaptic transmission, dopaminergic Source: GO_Central
temperature homeostasis Source: BHF-UCL
visual learning Source: BHF-UCL
Wnt signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390651 Dopamine receptors R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	P14416
SIGNORⁱ	P14416

Protein family/group databases

TCDBⁱ

9.A.14.3.10 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: D(2) dopamine receptor Alternative name(s): Dopamine D2 receptor
Gene namesⁱ	Name:DRD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149295.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3023 DRD2
MIMⁱ	126450 gene
neXtProtⁱ	NX_P14416

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 37	ExtracellularBy similarityAdd BLAST	37
Transmembraneⁱ	38 – 60	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	61 – 70	CytoplasmicBy similarity	10
Transmembraneⁱ	71 – 93	Helical; Name=2By similarityAdd BLAST	23
Topological domainⁱ	94 – 108	ExtracellularBy similarityAdd BLAST	15
Transmembraneⁱ	109 – 130	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	131 – 151	CytoplasmicBy similarityAdd BLAST	21
Transmembraneⁱ	152 – 172	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	173 – 188	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	189 – 213	Helical; Name=5By similarityAdd BLAST	25
Topological domainⁱ	214 – 373	CytoplasmicBy similarityAdd BLAST	160
Transmembraneⁱ	374 – 395	Helical; Name=6By similarityAdd BLAST	22
Topological domainⁱ	396 – 409	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	410 – 431	Helical; Name=7By similarityAdd BLAST	22
Topological domainⁱ	432 – 443	CytoplasmicBy similarityAdd BLAST	12

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1813
MalaCards human disease database More...MalaCardsⁱ	DRD2
MIMⁱ	103780 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000149295
Orphanetⁱ	36899 Myoclonus-dystonia syndrome
PharmGKBⁱ	PA27478

Chemistry databases

ChEMBLⁱ	CHEMBL217
Drug and drug target database More...DrugBankⁱ	DB01614 Acepromazine DB01063 Acetophenazine DB05766 ACP-104 DB01425 Alizapride DB00915 Amantadine DB06288 Amisulpride DB00543 Amoxapine DB00182 Amphetamine DB04599 Aniracetam DB00714 Apomorphine DB01238 Aripiprazole DB09207 AS-8112 DB06216 Asenapine DB04889 Bicifadine DB04888 Bifeprunox DB05687 BL-1020 DB04857 Brasofensine DB09128 Brexpiprazole DB01200 Bromocriptine DB09018 Bromopride DB00490 Buspirone DB00248 Cabergoline DB06016 Cariprazine DB01038 Carphenazine DB00477 Chlorpromazine DB01239 Chlorprothixene DB00568 Cinnarizine DB00363 Clozapine DB01151 Desipramine DB01184 Domperidone DB00988 Dopamine DB01142 Doxepin DB00450 Droperidol DB01049 Ergoloid mesylate DB00696 Ergotamine DB00875 Flupentixol DB00623 Fluphenazine DB04842 Fluspirilene DB00502 Haloperidol DB04946 Iloperidone DB00458 Imipramine DB05816 intranasal apomorphine DB04924 Itopride DB01221 Ketamine DB01235 Levodopa DB00589 Lisuride DB00408 Loxapine DB06077 Lumateperone DB08815 Lurasidone DB00934 Maprotiline DB01043 Memantine DB00933 Mesoridazine DB01403 Methotrimeprazine DB01233 Metoclopramide DB06148 Mianserin DB00805 Minaprine DB00370 Mirtazapine DB01618 Molindone DB00540 Nortriptyline DB00334 Olanzapine DB01267 Paliperidone DB01186 Pergolide DB00850 Perphenazine DB05316 Pimavanserin DB01100 Pimozide DB01621 Pipotiazine DB00413 Pramipexole DB00433 Prochlorperazine DB00420 Promazine DB01069 Promethazine DB00777 Propiomazine DB01224 Quetiapine DB00409 Remoxipride DB00734 Risperidone DB01549 Rolicyclidine DB00268 Ropinirole DB05271 Rotigotine DB06144 Sertindole DB05280 SLV 308 DB00391 Sulpiride DB04844 Tetrabenazine DB00372 Thiethylperazine DB01622 Thioproperazine DB00679 Thioridazine DB01623 Thiothixene DB13025 Tiapride DB00831 Trifluoperazine DB00508 Triflupromazine DB00726 Trimipramine DB01392 Yohimbine DB00246 Ziprasidone DB01624 Zuclopenthixol
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	215

Polymorphism and mutation databases

BioMutaⁱ	DRD2
DMDMⁱ	118206

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069387	1 – 443	D(2) dopamine receptorAdd BLAST		443

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	17	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	23	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	107 ↔ 182	PROSITE-ProRule annotation
Disulfide bondⁱ	399 ↔ 401	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P14416
PeptideAtlas More...PeptideAtlasⁱ	P14416
PRIDEⁱ	P14416
ProteomicsDBⁱ	53053 53054 [P14416-2] 53055 [P14416-3]

PTM databases

iPTMnetⁱ	P14416
PhosphoSitePlusⁱ	P14416
SwissPalmⁱ	P14416

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000149295 Expressed in 106 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_DRD2
ExpressionAtlasⁱ	P14416 baseline and differential
Genevisibleⁱ	P14416 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015139 HPA015691

HPAⁱ

HPA015139
HPA015691

Interactionⁱ

Subunit structureⁱ

Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-2928178,EBI-2928178
ADORA2A	P29274	2	EBI-2928178,EBI-2902702
DRD4	P21917	4	EBI-11686358,EBI-8592297
SLC6A3	Q01959	4	EBI-2928178,EBI-6661445

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18668123
ionotropic glutamate receptor binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108147, 18 interactors
Database of interacting proteins More...DIPⁱ	DIP-5977N
IntActⁱ	P14416, 6 interactors
Molecular INTeraction database More...MINTⁱ	P14416
STRINGⁱ	9606.ENSP00000354859

Chemistry databases

BindingDBⁱ

P14416

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	36 – 61	Combined sources	26
Helixⁱ	63 – 65	Combined sources	3
Helixⁱ	68 – 86	Combined sources	19
Helixⁱ	88 – 97	Combined sources	10
Helixⁱ	104 – 137	Combined sources	34
Helixⁱ	147 – 167	Combined sources	21
Helixⁱ	168 – 175	Combined sources	8
Helixⁱ	183 – 185	Combined sources	3
Helixⁱ	189 – 195	Combined sources	7
Turnⁱ	196 – 198	Combined sources	3
Helixⁱ	199 – 222	Combined sources	24
Helixⁱ	369 – 398	Combined sources	30
Helixⁱ	405 – 417	Combined sources	13
Helixⁱ	418 – 420	Combined sources	3
Helixⁱ	422 – 429	Combined sources	8
Helixⁱ	431 – 442	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P14416
SMRⁱ	P14416
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P14416

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	190 – 197	Agonist bindingBy similarity	8
Regionⁱ	211 – 373	Interaction with PPP1R9BBy similarityAdd BLAST	163
Regionⁱ	386 – 394	Agonist bindingBy similarity	9

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOVERGENⁱ	HBG106962
InParanoidⁱ	P14416
KEGG Orthology (KO) More...KOⁱ	K04145
OMAⁱ	RNWSRPF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P14416
TreeFamⁱ	TF334382

Family and domain databases

InterProⁱ	View protein in InterPro IPR001922 Dopamine_D2_rcpt IPR000929 Dopamine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00567 DOPAMINED2R PR00242 DOPAMINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P14416-1) [UniParc]FASTA Add to basket

Also known as: D2(Long)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP 
       310        320        330        340        350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK 
       360        370        380        390        400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD 
       410        420        430        440 
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC

Length:443

Mass (Da):50,619

Last modified:April 1, 1990 - v2

Checksum:ⁱ9BF8EA36C988A2E2

GO

Isoform 2 (identifier: P14416-2) [UniParc]FASTA Add to basket

Also known as: D2(Short)

The sequence of this isoform differs from the canonical sequence as follows:
242-270: Missing.

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KEAARRAQEL 
       260        270        280        290        300
EMEMLSSTSP PERTRYSPIP PSHHQLTLPD PSHHGLHSTP DSPAKPEKNG 
       310        320        330        340        350
HAKDHPKIAK IFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL 
       360        370        380        390        400
GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF 
       410 
NIEFRKAFLK ILHC

Show »

Length:414

Mass (Da):47,347

Checksum:ⁱBFC25AC601DFDC7F

GO

Isoform 3 (identifier: P14416-3) [UniParc]FASTA Add to basket

Also known as: D2(Longer)

The sequence of this isoform differs from the canonical sequence as follows:
270-270: V → VVQ

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRV VQEAARRAQE LEMEMLSSTS PPERTRYSPI 
       310        320        330        340        350
PPSHHQLTLP DPSHHGLHST PDSPAKPEKN GHAKDHPKIA KIFEIQTMPN 
       360        370        380        390        400
GKTRTSLKTM SRRKLSQQKE KKATQMLAIV LGVFIICWLP FFITHILNIH 
       410        420        430        440 
CDCNIPPVLY SAFTWLGYVN SAVNPIIYTT FNIEFRKAFL KILHC

Show »

Length:445

Mass (Da):50,847

Checksum:ⁱ111674E96E087FD6

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VUV1	F8VUV1_HUMAN	D(2) dopamine receptor D(2) dopamine receptor	DRD2	442	Annotation score:
Q6LDH7	Q6LDH7_HUMAN	D(2) dopamine receptor D(2) dopamine receptor (Dopamine D2 receptor)	DRD2	177	Annotation score:
A0A1Y8EK52	A0A1Y8EK52_HUMAN	D(2) dopamine receptor D(2) dopamine receptor	DRD2	7	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	40	L → R in AAB26819 (PubMed:1363862).Curated		1

Polymorphismⁱ

Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIMⁱ:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017143	154	V → I Found in patients with alcohol-responsive myoclonus-dystonia; unknown pathological significance; the mutation does not affect functional properties. 2 PublicationsCorresponds to variant dbSNP:rs104894220EnsemblClinVar.	1
Natural variantⁱVAR_014674	310	P → S. Corresponds to variant dbSNP:rs1800496EnsemblClinVar.	1
Natural variantⁱVAR_003462	311	S → C May be associated with a higher risk for schizophrenia. 1 PublicationCorresponds to variant dbSNP:rs1801028EnsemblClinVar.	1
Natural variantⁱVAR_064579	327	K → E1 PublicationCorresponds to variant dbSNP:rs71653614EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001870	242 – 270	Missing in isoform 2. 1 PublicationAdd BLAST		29
Alternative sequenceⁱVSP_026455	270	V → VVQ in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30625 mRNA Translation: AAA88024.1 X51645 mRNA Translation: CAB56463.1 X51646 Genomic DNA Translation: CAB37869.1 X51362 mRNA Translation: CAA35746.1 M29066 mRNA Translation: AAA52761.1 S62137 mRNA Translation: AAB26819.1 S69899 mRNA Translation: AAB20571.1 S58589 , S58577, S58584, S58586, S58588 Genomic DNA Translation: AAB26274.1 AF176812 mRNA Translation: AAF61479.1 AB065860 Genomic DNA Translation: BAC06078.1 AF050737 Genomic DNA Translation: AAC78779.1 BC021195 mRNA Translation: AAH21195.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8361.1 [P14416-1] CCDS8362.1 [P14416-2]
PIRⁱ	S08417 DYHUD2
NCBI Reference Sequences More...RefSeqⁱ	NP_000786.1, NM_000795.3 [P14416-1] NP_057658.2, NM_016574.3 [P14416-2] XP_016872785.1, XM_017017296.1 [P14416-1]
UniGeneⁱ	Hs.73893

Genome annotation databases

Ensemblⁱ	ENST00000346454; ENSP00000278597; ENSG00000149295 [P14416-2] ENST00000362072; ENSP00000354859; ENSG00000149295 [P14416-1] ENST00000538967; ENSP00000438215; ENSG00000149295 [P14416-3] ENST00000542968; ENSP00000442172; ENSG00000149295 [P14416-1]
GeneIDⁱ	1813
KEGGⁱ	hsa:1813
UCSC genome browser More...UCSCⁱ	uc001pnz.4 human [P14416-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14416	D(2) dopamine receptor		PANTR		443	UniRef100_P14416
Uncharacterized protein		PANPA		490
D2 dopamine receptor (Fragment)		MACFA		37
D(2) dopamine receptor (Fragment)		HUMAN		177
Dopamine receptor D2		GORGO		443
+10
P14416-2	Dopamine receptor D2, isoform CRA_b		HUMAN		414	UniRef100_A0A024R3I6
D(2) dopamine receptor		PANTR		414
Uncharacterized protein		PANPA		414
Dopamine receptor D2		GORGO		414
P14416-3	D(2) dopamine receptor		PANTR		445	UniRef100_H2R3M5
Dopamine receptor D2		GORGO		445

Protein	Similar proteins		Species	Score	Length	Source
P14416	D(2) dopamine receptor		PANTR		443	UniRef90_P14416
D(2) dopamine receptor		CHLAE		443
Uncharacterized protein		PANPA		490
D2 dopamine receptor (Fragment)		MACFA		37
D(2) dopamine receptor (Fragment)		HUMAN		177
+16
P14416-2	Isoform Short of D(2) dopamine receptor		RAT		415	UniRef90_P61169-2
Isoform Short of D(2) dopamine receptor		BOVIN		415
Isoform 2 of D(2) dopamine receptor		MOUSE		415
Uncharacterized protein		CALJA		414
D(2) dopamine receptor isoform X1		Yangtze finless porpoise		414
+75
P14416-3	D(2) dopamine receptor		RAT		444	UniRef90_P61169
D(2) dopamine receptor		MOUSE		444
D(2) dopamine receptor		BOVIN		444
D(2) dopamine receptor		CANLF		443
D(2) dopamine receptor		MUSPF		443
+122

Protein	Similar proteins		Species	Score	Length	Source
P14416	Isoform Short of D(2) dopamine receptor		RAT		415	UniRef50_P61169-2
D(2) dopamine receptor		MELGA		436
D(2) dopamine receptor		CHLAE		443
D(2) dopamine receptor		PANTR		443
Isoform 2 of D(2) dopamine receptor		MOUSE		415
+299
P14416-3	D(2) dopamine receptor		RAT		444	UniRef50_P61169
D(2) dopamine receptor		BOVIN		444
D(2) dopamine receptor		MOUSE		444
D(2) dopamine receptor		MUSPF		443
D(2) dopamine receptor		CANLF		443
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30625 mRNA Translation: AAA88024.1 X51645 mRNA Translation: CAB56463.1 X51646 Genomic DNA Translation: CAB37869.1 X51362 mRNA Translation: CAA35746.1 M29066 mRNA Translation: AAA52761.1 S62137 mRNA Translation: AAB26819.1 S69899 mRNA Translation: AAB20571.1 S58589 , S58577, S58584, S58586, S58588 Genomic DNA Translation: AAB26274.1 AF176812 mRNA Translation: AAF61479.1 AB065860 Genomic DNA Translation: BAC06078.1 AF050737 Genomic DNA Translation: AAC78779.1 BC021195 mRNA Translation: AAH21195.1
CCDSⁱ	CCDS8361.1 [P14416-1] CCDS8362.1 [P14416-2]
PIRⁱ	S08417 DYHUD2
RefSeqⁱ	NP_000786.1, NM_000795.3 [P14416-1] NP_057658.2, NM_016574.3 [P14416-2] XP_016872785.1, XM_017017296.1 [P14416-1]
UniGeneⁱ	Hs.73893

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1I15	model	-	A	34-58	[»]
				B	72-97	[»]
				C	108-129	[»]
				D	153-172	[»]
				E	190-210	[»]
				F	371-396	[»]
				G	403-426	[»]
	5AER	X-ray	2.19	B/C	430-443	[»]
	6CM4	X-ray	2.87	A	35-222	[»]
				A	363-443	[»]
ProteinModelPortalⁱ	P14416
SMRⁱ	P14416
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108147, 18 interactors
DIPⁱ	DIP-5977N
IntActⁱ	P14416, 6 interactors
MINTⁱ	P14416
STRINGⁱ	9606.ENSP00000354859

Chemistry databases

BindingDBⁱ	P14416
ChEMBLⁱ	CHEMBL217
DrugBankⁱ	DB01614 Acepromazine DB01063 Acetophenazine DB05766 ACP-104 DB01425 Alizapride DB00915 Amantadine DB06288 Amisulpride DB00543 Amoxapine DB00182 Amphetamine DB04599 Aniracetam DB00714 Apomorphine DB01238 Aripiprazole DB09207 AS-8112 DB06216 Asenapine DB04889 Bicifadine DB04888 Bifeprunox DB05687 BL-1020 DB04857 Brasofensine DB09128 Brexpiprazole DB01200 Bromocriptine DB09018 Bromopride DB00490 Buspirone DB00248 Cabergoline DB06016 Cariprazine DB01038 Carphenazine DB00477 Chlorpromazine DB01239 Chlorprothixene DB00568 Cinnarizine DB00363 Clozapine DB01151 Desipramine DB01184 Domperidone DB00988 Dopamine DB01142 Doxepin DB00450 Droperidol DB01049 Ergoloid mesylate DB00696 Ergotamine DB00875 Flupentixol DB00623 Fluphenazine DB04842 Fluspirilene DB00502 Haloperidol DB04946 Iloperidone DB00458 Imipramine DB05816 intranasal apomorphine DB04924 Itopride DB01221 Ketamine DB01235 Levodopa DB00589 Lisuride DB00408 Loxapine DB06077 Lumateperone DB08815 Lurasidone DB00934 Maprotiline DB01043 Memantine DB00933 Mesoridazine DB01403 Methotrimeprazine DB01233 Metoclopramide DB06148 Mianserin DB00805 Minaprine DB00370 Mirtazapine DB01618 Molindone DB00540 Nortriptyline DB00334 Olanzapine DB01267 Paliperidone DB01186 Pergolide DB00850 Perphenazine DB05316 Pimavanserin DB01100 Pimozide DB01621 Pipotiazine DB00413 Pramipexole DB00433 Prochlorperazine DB00420 Promazine DB01069 Promethazine DB00777 Propiomazine DB01224 Quetiapine DB00409 Remoxipride DB00734 Risperidone DB01549 Rolicyclidine DB00268 Ropinirole DB05271 Rotigotine DB06144 Sertindole DB05280 SLV 308 DB00391 Sulpiride DB04844 Tetrabenazine DB00372 Thiethylperazine DB01622 Thioproperazine DB00679 Thioridazine DB01623 Thiothixene DB13025 Tiapride DB00831 Trifluoperazine DB00508 Triflupromazine DB00726 Trimipramine DB01392 Yohimbine DB00246 Ziprasidone DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYⁱ	215

Protein family/group databases

TCDBⁱ	9.A.14.3.10 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	P14416
PhosphoSitePlusⁱ	P14416
SwissPalmⁱ	P14416

Polymorphism and mutation databases

BioMutaⁱ	DRD2
DMDMⁱ	118206

Proteomic databases

PaxDbⁱ	P14416
PeptideAtlasⁱ	P14416
PRIDEⁱ	P14416
ProteomicsDBⁱ	53053 53054 [P14416-2] 53055 [P14416-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1813
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000346454; ENSP00000278597; ENSG00000149295 [P14416-2] ENST00000362072; ENSP00000354859; ENSG00000149295 [P14416-1] ENST00000538967; ENSP00000438215; ENSG00000149295 [P14416-3] ENST00000542968; ENSP00000442172; ENSG00000149295 [P14416-1]
GeneIDⁱ	1813
KEGGⁱ	hsa:1813
UCSCⁱ	uc001pnz.4 human [P14416-1]

Organism-specific databases

CTDⁱ	1813
DisGeNETⁱ	1813
EuPathDBⁱ	HostDB:ENSG00000149295.13
GeneCardsⁱ	DRD2
HGNCⁱ	HGNC:3023 DRD2
HPAⁱ	HPA015139 HPA015691
MalaCardsⁱ	DRD2
MIMⁱ	103780 phenotype 126450 gene
neXtProtⁱ	NX_P14416
OpenTargetsⁱ	ENSG00000149295
Orphanetⁱ	36899 Myoclonus-dystonia syndrome
PharmGKBⁱ	PA27478
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOVERGENⁱ	HBG106962
InParanoidⁱ	P14416
KOⁱ	K04145
OMAⁱ	RNWSRPF
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P14416
TreeFamⁱ	TF334382

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390651 Dopamine receptors R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	P14416
SIGNORⁱ	P14416

Miscellaneous databases

EvolutionaryTraceⁱ	P14416
GeneWikiⁱ	Dopamine_receptor_D2
GenomeRNAiⁱ	1813
Protein Ontology More...PROⁱ	PR:P14416
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149295 Expressed in 106 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_DRD2
ExpressionAtlasⁱ	P14416 baseline and differential
Genevisibleⁱ	P14416 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001922 Dopamine_D2_rcpt IPR000929 Dopamine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00567 DOPAMINED2R PR00242 DOPAMINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DRD2_HUMAN
Accessionⁱ	P14416Primary (citable) accession number: P14416 Secondary accession number(s): Q9NZR3, Q9UPA9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	October 10, 2018
	This is version 213 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - P14416 (DRD2_HUMAN)

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D(2) dopamine receptor

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GO - Molecular functionⁱ

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Keywords - Cellular componentⁱ

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Keywords - Diseaseⁱ

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Keywords - PTMⁱ

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Keywords - Domainⁱ

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Keywords - Technical termⁱ