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UniProtKB - P14416 (DRD2_HUMAN)

Entry version 231 (07 Apr 2021)
Sequence version 2 (01 Apr 1990)
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Protein

D(2) dopamine receptor

Gene

DRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei114AgonistBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei194Important for receptor activationBy similarity1
Sitei197Important for receptor activationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14416

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390651, Dopamine receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14416

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14416

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.3.10, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D(2) dopamine receptor
Alternative name(s):
Dopamine D2 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3023, DRD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		126450, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14416

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149295.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37ExtracellularBy similarityAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 60Helical; Name=1By similarityAdd BLAST23
Topological domaini61 – 70CytoplasmicBy similarity10
Transmembranei71 – 93Helical; Name=2By similarityAdd BLAST23
Topological domaini94 – 108ExtracellularBy similarityAdd BLAST15
Transmembranei109 – 130Helical; Name=3By similarityAdd BLAST22
Topological domaini131 – 151CytoplasmicBy similarityAdd BLAST21
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 188ExtracellularBy similarityAdd BLAST16
Transmembranei189 – 213Helical; Name=5By similarityAdd BLAST25
Topological domaini214 – 373CytoplasmicBy similarityAdd BLAST160
Transmembranei374 – 395Helical; Name=6By similarityAdd BLAST22
Topological domaini396 – 409ExtracellularBy similarityAdd BLAST14
Transmembranei410 – 431Helical; Name=7By similarityAdd BLAST22
Topological domaini432 – 443CytoplasmicBy similarityAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi126C → S: No effect on palmitoylation; no effect on localization to the plasma membrane. 1 Publication1
Mutagenesisi244C → S: No effect on palmitoylation; no effect on localization to the plasma membrane. 1 Publication1
Mutagenesisi253C → S: No effect on palmitoylation; no effect on localization to the plasma membrane. 1 Publication1
Mutagenesisi443Missing : Decreased palmitoylation; decreased localization to the plasma membrane; decreased stability. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		1813

MalaCards human disease database

More...MalaCardsi		DRD2
MIMi103780, phenotype

Open Targets

More...OpenTargetsi		ENSG00000149295

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		36899, Myoclonus-dystonia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27478

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14416, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL217

Drug and drug target database

More...DrugBanki		DB01614, Acepromazine
DB01063, Acetophenazine
DB05766, ACP-104
DB01425, Alizapride
DB00915, Amantadine
DB06288, Amisulpride
DB05964, Amitifadine
DB00543, Amoxapine
DB00182, Amphetamine
DB04599, Aniracetam
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB09207, AS-8112
DB06216, Asenapine
DB04889, Bicifadine
DB04888, Bifeprunox
DB05687, BL-1020
DB09223, Blonanserin
DB04857, Brasofensine
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB09018, Bromopride
DB00490, Buspirone
DB00248, Cabergoline
DB06016, Cariprazine
DB01038, Carphenazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00568, Cinnarizine
DB00363, Clozapine
DB01151, Desipramine
DB11274, Dihydro-alpha-ergocryptine
DB13345, Dihydroergocristine
DB01184, Domperidone
DB00988, Dopamine
DB00450, Droperidol
DB11275, Epicriptine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB09194, Etoperidone
DB00875, Flupentixol
DB00623, Fluphenazine
DB04842, Fluspirilene
DB00502, Haloperidol
DB04946, Iloperidone
DB00458, Imipramine
DB04924, Itopride
DB12579, JNJ-37822681
DB01221, Ketamine
DB00555, Lamotrigine
DB01235, Levodopa
DB00589, Lisuride
DB00408, Loxapine
DB06077, Lumateperone
DB08815, Lurasidone
DB00934, Maprotiline
DB09224, Melperone
DB01043, Memantine
DB00933, Mesoridazine
DB01403, Methotrimeprazine
DB01233, Metoclopramide
DB06148, Mianserin
DB00805, Minaprine
DB01618, Molindone
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00334, Olanzapine
DB01267, Paliperidone
DB12061, Pardoprunox
DB00715, Paroxetine
DB01186, Pergolide
DB08922, Perospirone
DB00850, Perphenazine
DB05316, Pimavanserin
DB01100, Pimozide
DB09286, Pipamperone
DB01621, Pipotiazine
DB12478, Piribedil
DB00413, Pramipexole
DB00433, Prochlorperazine
DB00420, Promazine
DB01069, Promethazine
DB00777, Propiomazine
DB01224, Quetiapine
DB09097, Quinagolide
DB12518, Raclopride
DB00409, Remoxipride
DB00734, Risperidone
DB01549, Rolicyclidine
DB00268, Ropinirole
DB05271, Rotigotine
DB06454, Sarizotan
DB06144, Sertindole
DB00391, Sulpiride
DB06477, Sumanirole
DB04844, Tetrabenazine
DB12093, Tetrahydropalmatine
DB00372, Thiethylperazine
DB01622, Thioproperazine
DB00679, Thioridazine
DB01623, Thiothixene
DB13025, Tiapride
DB00831, Trifluoperazine
DB00508, Triflupromazine
DB00726, Trimipramine
DB06109, YKP-1358
DB01392, Yohimbine
DB00246, Ziprasidone
DB09225, Zotepine
DB01624, Zuclopenthixol

DrugCentral

More...DrugCentrali		P14416

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		215

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DRD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		118206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693871 – 443D(2) dopamine receptorAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi107 ↔ 182Combined sources1 Publication
Disulfide bondi399 ↔ 401Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi443S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14416

PeptideAtlas

More...PeptideAtlasi		P14416

PRoteomics IDEntifications database

More...PRIDEi		P14416

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53053 [P14416-1]
53054 [P14416-2]
53055 [P14416-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14416, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14416

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14416

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P14416

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the anterior pituitary gland.1 Publication
Expressed in the anterior pituitary gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149295, Expressed in adenohypophysis and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14416, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14416, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149295, Group enriched (adrenal gland, brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734).

Interacts with CADPS and CADPS2 (PubMed:15857609).

Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity).

Interacts with ARRB2 (By similarity).

Interacts with HTR2A (PubMed:21645528).

Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964).

Interacts with DRD1 (By similarity).

Interacts with KCNA2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108147, 84 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14416

Database of interacting proteins

More...DIPi		DIP-5977N

Protein interaction database and analysis system

More...IntActi		P14416, 74 interactors

Molecular INTeraction database

More...MINTi		P14416

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354859

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14416

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14416, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14416

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14416

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni190 – 197Agonist bindingBy similarity8
Regioni211 – 373Interaction with PPP1R9BBy similarityAdd BLAST163
Regioni386 – 394Agonist bindingBy similarity9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14416

Identification of Orthologs from Complete Genome Data

More...OMAi		MLFGLNN

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14416

TreeFam database of animal gene trees

More...TreeFami		TF334382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001922, Dopamine_D2_rcpt
IPR000929, Dopamine_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00567, DOPAMINED2R
PR00242, DOPAMINER
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14416-1) [UniParc]FASTAAdd to basket
Also known as: D2(Long), D2A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF 
        60         70         80         90        100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 
       110        120        130        140        150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 
       160        170        180        190        200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 
       210        220        230        240        250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM 
       260        270        280        290        300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP 
       310        320        330        340        350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK 
       360        370        380        390        400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD 
       410        420        430        440 
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC
Length:443
Mass (Da):50,619
Last modified:April 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BF8EA36C988A2E2
GO
Isoform 2 (identifier: P14416-2) [UniParc]FASTAAdd to basket
Also known as: D2(Short), D2B

The sequence of this isoform differs from the canonical sequence as follows:
     242-270: Missing.

Show »
Length:414
Mass (Da):47,347
Checksum:iBFC25AC601DFDC7F
GO
Isoform 3 (identifier: P14416-3) [UniParc]FASTAAdd to basket
Also known as: D2(Longer)

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: V → VVQ

Show »
Length:445
Mass (Da):50,847
Checksum:i111674E96E087FD6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VUV1F8VUV1_HUMAN
D(2) dopamine receptor
DRD2
442Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6LDH7Q6LDH7_HUMAN
D(2) dopamine receptor
DRD2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y8EK52A0A1Y8EK52_HUMAN
D(2) dopamine receptor
DRD2
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40L → R in AAB26819 (PubMed:1363862).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIMi:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017143154V → I Found in patients with alcohol-responsive myoclonus-dystonia; unknown pathological significance; the mutation does not affect functional properties. 2 PublicationsCorresponds to variant dbSNP:rs104894220EnsemblClinVar.1
Natural variantiVAR_014674310P → S. Corresponds to variant dbSNP:rs1800496EnsemblClinVar.1
Natural variantiVAR_003462311S → C May be associated with a higher risk for schizophrenia. 1 PublicationCorresponds to variant dbSNP:rs1801028EnsemblClinVar.1
Natural variantiVAR_064579327K → E1 PublicationCorresponds to variant dbSNP:rs71653614EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001870242 – 270Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_026455270V → VVQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M30625 mRNA Translation: AAA88024.1
X51645 mRNA Translation: CAB56463.1
X51646 Genomic DNA Translation: CAB37869.1
X51362 mRNA Translation: CAA35746.1
M29066 mRNA Translation: AAA52761.1
S62137 mRNA Translation: AAB26819.1
S69899 mRNA Translation: AAB20571.1
S58589 S58588 Genomic DNA Translation: AAB26274.1
AF176812 mRNA Translation: AAF61479.1
AB065860 Genomic DNA Translation: BAC06078.1
AF050737 Genomic DNA Translation: AAC78779.1
BC021195 mRNA Translation: AAH21195.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8361.1 [P14416-1]
CCDS8362.1 [P14416-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S08417, DYHUD2

NCBI Reference Sequences

More...RefSeqi		NP_000786.1, NM_000795.3 [P14416-1]
NP_057658.2, NM_016574.3 [P14416-2]
XP_016872785.1, XM_017017296.1 [P14416-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346454; ENSP00000278597; ENSG00000149295 [P14416-2]
ENST00000362072; ENSP00000354859; ENSG00000149295 [P14416-1]
ENST00000538967; ENSP00000438215; ENSG00000149295 [P14416-3]
ENST00000542968; ENSP00000442172; ENSG00000149295 [P14416-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1813

UCSC genome browser

More...UCSCi		uc001pnz.4, human [P14416-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30625 mRNA Translation: AAA88024.1
X51645 mRNA Translation: CAB56463.1
X51646 Genomic DNA Translation: CAB37869.1
X51362 mRNA Translation: CAA35746.1
M29066 mRNA Translation: AAA52761.1
S62137 mRNA Translation: AAB26819.1
S69899 mRNA Translation: AAB20571.1
S58589 S58588 Genomic DNA Translation: AAB26274.1
AF176812 mRNA Translation: AAF61479.1
AB065860 Genomic DNA Translation: BAC06078.1
AF050737 Genomic DNA Translation: AAC78779.1
BC021195 mRNA Translation: AAH21195.1
CCDSiCCDS8361.1 [P14416-1]
CCDS8362.1 [P14416-2]
PIRiS08417, DYHUD2
RefSeqiNP_000786.1, NM_000795.3 [P14416-1]
NP_057658.2, NM_016574.3 [P14416-2]
XP_016872785.1, XM_017017296.1 [P14416-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I15model-A34-58[»]
B72-97[»]
C108-129[»]
D153-172[»]
E190-210[»]
F371-396[»]
G403-426[»]
5AERX-ray2.19B/C430-443[»]
6CM4X-ray2.87A35-222[»]
A363-443[»]
6LUQX-ray3.10A35-222[»]
A367-443[»]
6VMSelectron microscopy3.80R29-443[»]
SMRiP14416
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108147, 84 interactors
CORUMiP14416
DIPiDIP-5977N
IntActiP14416, 74 interactors
MINTiP14416
STRINGi9606.ENSP00000354859

Chemistry databases

BindingDBiP14416
ChEMBLiCHEMBL217
DrugBankiDB01614, Acepromazine
DB01063, Acetophenazine
DB05766, ACP-104
DB01425, Alizapride
DB00915, Amantadine
DB06288, Amisulpride
DB05964, Amitifadine
DB00543, Amoxapine
DB00182, Amphetamine
DB04599, Aniracetam
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB09207, AS-8112
DB06216, Asenapine
DB04889, Bicifadine
DB04888, Bifeprunox
DB05687, BL-1020
DB09223, Blonanserin
DB04857, Brasofensine
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB09018, Bromopride
DB00490, Buspirone
DB00248, Cabergoline
DB06016, Cariprazine
DB01038, Carphenazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00568, Cinnarizine
DB00363, Clozapine
DB01151, Desipramine
DB11274, Dihydro-alpha-ergocryptine
DB13345, Dihydroergocristine
DB01184, Domperidone
DB00988, Dopamine
DB00450, Droperidol
DB11275, Epicriptine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB09194, Etoperidone
DB00875, Flupentixol
DB00623, Fluphenazine
DB04842, Fluspirilene
DB00502, Haloperidol
DB04946, Iloperidone
DB00458, Imipramine
DB04924, Itopride
DB12579, JNJ-37822681
DB01221, Ketamine
DB00555, Lamotrigine
DB01235, Levodopa
DB00589, Lisuride
DB00408, Loxapine
DB06077, Lumateperone
DB08815, Lurasidone
DB00934, Maprotiline
DB09224, Melperone
DB01043, Memantine
DB00933, Mesoridazine
DB01403, Methotrimeprazine
DB01233, Metoclopramide
DB06148, Mianserin
DB00805, Minaprine
DB01618, Molindone
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00334, Olanzapine
DB01267, Paliperidone
DB12061, Pardoprunox
DB00715, Paroxetine
DB01186, Pergolide
DB08922, Perospirone
DB00850, Perphenazine
DB05316, Pimavanserin
DB01100, Pimozide
DB09286, Pipamperone
DB01621, Pipotiazine
DB12478, Piribedil
DB00413, Pramipexole
DB00433, Prochlorperazine
DB00420, Promazine
DB01069, Promethazine
DB00777, Propiomazine
DB01224, Quetiapine
DB09097, Quinagolide
DB12518, Raclopride
DB00409, Remoxipride
DB00734, Risperidone
DB01549, Rolicyclidine
DB00268, Ropinirole
DB05271, Rotigotine
DB06454, Sarizotan
DB06144, Sertindole
DB00391, Sulpiride
DB06477, Sumanirole
DB04844, Tetrabenazine
DB12093, Tetrahydropalmatine
DB00372, Thiethylperazine
DB01622, Thioproperazine
DB00679, Thioridazine
DB01623, Thiothixene
DB13025, Tiapride
DB00831, Trifluoperazine
DB00508, Triflupromazine
DB00726, Trimipramine
DB06109, YKP-1358
DB01392, Yohimbine
DB00246, Ziprasidone
DB09225, Zotepine
DB01624, Zuclopenthixol
DrugCentraliP14416
GuidetoPHARMACOLOGYi215

Protein family/group databases

TCDBi9.A.14.3.10, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP14416, 3 sites
iPTMnetiP14416
PhosphoSitePlusiP14416
SwissPalmiP14416

Genetic variation databases

BioMutaiDRD2
DMDMi118206

Proteomic databases

PaxDbiP14416
PeptideAtlasiP14416
PRIDEiP14416
ProteomicsDBi53053 [P14416-1]
53054 [P14416-2]
53055 [P14416-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2801, 363 antibodies

The DNASU plasmid repository

More...DNASUi		1813

Genome annotation databases

EnsembliENST00000346454; ENSP00000278597; ENSG00000149295 [P14416-2]
ENST00000362072; ENSP00000354859; ENSG00000149295 [P14416-1]
ENST00000538967; ENSP00000438215; ENSG00000149295 [P14416-3]
ENST00000542968; ENSP00000442172; ENSG00000149295 [P14416-1]
GeneIDi1813
KEGGihsa:1813
UCSCiuc001pnz.4, human [P14416-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1813
DisGeNETi1813

GeneCards: human genes, protein and diseases

More...GeneCardsi		DRD2
HGNCiHGNC:3023, DRD2
HPAiENSG00000149295, Group enriched (adrenal gland, brain, pituitary gland)
MalaCardsiDRD2
MIMi103780, phenotype
126450, gene
neXtProtiNX_P14416
OpenTargetsiENSG00000149295
Orphaneti36899, Myoclonus-dystonia syndrome
PharmGKBiPA27478
VEuPathDBiHostDB:ENSG00000149295.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000155539
HOGENOMiCLU_009579_11_1_1
InParanoidiP14416
OMAiMLFGLNN
PhylomeDBiP14416
TreeFamiTF334382

Enzyme and pathway databases

PathwayCommonsiP14416
ReactomeiR-HSA-390651, Dopamine receptors
SignaLinkiP14416
SIGNORiP14416

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1813, 8 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DRD2, human
EvolutionaryTraceiP14416

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Dopamine_receptor_D2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1813
PharosiP14416, Tclin

Protein Ontology

More...PROi		PR:P14416
RNActiP14416, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149295, Expressed in adenohypophysis and 134 other tissues
ExpressionAtlasiP14416, baseline and differential
GenevisibleiP14416, HS

Family and domain databases

InterProiView protein in InterPro
IPR001922, Dopamine_D2_rcpt
IPR000929, Dopamine_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00567, DOPAMINED2R
PR00242, DOPAMINER
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14416
Secondary accession number(s): Q9NZR3, Q9UPA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: April 7, 2021
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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