UniProtKB - P14416 (DRD2_HUMAN)
D(2) dopamine receptor
DRD2
Functioni
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528).
Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 194 | Important for receptor activationBy similarity | 1 | |
Sitei | 197 | Important for receptor activationBy similarity | 1 |
GO - Molecular functioni
- dopamine binding Source: Ensembl
- dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
- heterocyclic compound binding Source: Ensembl
- identical protein binding Source: IntAct
- ionotropic glutamate receptor binding Source: Ensembl
- potassium channel regulator activity Source: BHF-UCL
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- acid secretion Source: Ensembl
- activation of protein kinase activity Source: Ensembl
- adenohypophysis development Source: BHF-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
- adult walking behavior Source: BHF-UCL
- arachidonic acid secretion Source: BHF-UCL
- associative learning Source: BHF-UCL
- auditory behavior Source: Ensembl
- autophagy Source: Ensembl
- axonogenesis Source: BHF-UCL
- behavioral response to cocaine Source: BHF-UCL
- behavioral response to ethanol Source: BHF-UCL
- branching morphogenesis of a nerve Source: BHF-UCL
- cellular calcium ion homeostasis Source: BHF-UCL
- cerebral cortex GABAergic interneuron migration Source: BHF-UCL
- circadian regulation of gene expression Source: BHF-UCL
- dopamine metabolic process Source: BHF-UCL
- drinking behavior Source: Ensembl
- excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- G protein-coupled receptor internalization Source: Ensembl
- grooming behavior Source: Ensembl
- hyaloid vascular plexus regression Source: UniProtKB
- intracellular signal transduction Source: BHF-UCL
- locomotory behavior Source: BHF-UCL
- long-term memory Source: Ensembl
- negative regulation of adenylate cyclase activity Source: BHF-UCL
- negative regulation of blood pressure Source: BHF-UCL
- negative regulation of cell death Source: Ensembl
- negative regulation of cell migration Source: BHF-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
- negative regulation of cytosolic calcium ion concentration Source: GO_Central
- negative regulation of dopamine receptor signaling pathway Source: BHF-UCL
- negative regulation of dopamine secretion Source: Ensembl
- negative regulation of innate immune response Source: Ensembl
- negative regulation of insulin secretion Source: Ensembl
- negative regulation of protein kinase B signaling Source: BHF-UCL
- negative regulation of protein phosphorylation Source: Ensembl
- negative regulation of protein secretion Source: BHF-UCL
- negative regulation of synaptic transmission, glutamatergic Source: BHF-UCL
- negative regulation of voltage-gated calcium channel activity Source: BHF-UCL
- nervous system process involved in regulation of systemic arterial blood pressure Source: BHF-UCL
- neuron-neuron synaptic transmission Source: BHF-UCL
- orbitofrontal cortex development Source: Ensembl
- peristalsis Source: BHF-UCL
- phospholipase C-activating dopamine receptor signaling pathway Source: MGI
- pigmentation Source: Ensembl
- positive regulation of cytokinesis Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: BHF-UCL
- positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of glial cell-derived neurotrophic factor production Source: CACAO
- positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
- positive regulation of growth hormone secretion Source: BHF-UCL
- positive regulation of long-term synaptic potentiation Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- positive regulation of neuroblast proliferation Source: BHF-UCL
- positive regulation of receptor internalization Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of urine volume Source: Ensembl
- postsynaptic modulation of chemical synaptic transmission Source: Ensembl
- prepulse inhibition Source: BHF-UCL
- protein localization Source: BHF-UCL
- regulation of dopamine secretion Source: GO_Central
- regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
- regulation of heart rate Source: BHF-UCL
- regulation of locomotion involved in locomotory behavior Source: Ensembl
- regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
- regulation of phosphoprotein phosphatase activity Source: Ensembl
- regulation of potassium ion transport Source: BHF-UCL
- regulation of sodium ion transport Source: BHF-UCL
- regulation of synapse structural plasticity Source: Ensembl
- regulation of synaptic transmission, GABAergic Source: BHF-UCL
- regulation of synaptic vesicle exocytosis Source: Ensembl
- release of sequestered calcium ion into cytosol Source: BHF-UCL
- response to amphetamine Source: BHF-UCL
- response to axon injury Source: Ensembl
- response to cocaine Source: BHF-UCL
- response to histamine Source: BHF-UCL
- response to hypoxia Source: Ensembl
- response to inactivity Source: Ensembl
- response to iron ion Source: Ensembl
- response to light stimulus Source: BHF-UCL
- response to morphine Source: BHF-UCL
- response to nicotine Source: Ensembl
- response to toxic substance Source: Ensembl
- response to xenobiotic stimulus Source: BHF-UCL
- sensory perception of smell Source: BHF-UCL
- striatum development Source: Ensembl
- synapse assembly Source: BHF-UCL
- temperature homeostasis Source: BHF-UCL
- visual learning Source: BHF-UCL
- Wnt signaling pathway Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P14416 |
Reactomei | R-HSA-390651, Dopamine receptors |
SignaLinki | P14416 |
SIGNORi | P14416 |
Protein family/group databases
TCDBi | 9.A.14.3.10, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: D(2) dopamine receptorAlternative name(s): Dopamine D2 receptor |
Gene namesi | Name:DRD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3023, DRD2 |
MIMi | 126450, gene |
neXtProti | NX_P14416 |
VEuPathDBi | HostDB:ENSG00000149295 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- ciliary membrane Source: SYSCILIA_CCNET
- integral component of plasma membrane Source: BHF-UCL
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: GO_Central
- lateral plasma membrane Source: Ensembl
- plasma membrane Source: WormBase
Other locations
- acrosomal vesicle Source: Ensembl
- axon Source: BHF-UCL
- axon terminus Source: Ensembl
- cilium Source: MGI
- dendrite Source: BHF-UCL
- dendritic spine Source: Ensembl
- dopaminergic synapse Source: Ensembl
- endocytic vesicle Source: Ensembl
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: GO_Central
- non-motile cilium Source: SYSCILIA_CCNET
- perikaryon Source: Ensembl
- postsynaptic density Source: Ensembl
- sperm flagellum Source: Ensembl
- synapse Source: GOC
- synaptic vesicle membrane Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | ExtracellularBy similarityAdd BLAST | 37 | |
Transmembranei | 38 – 60 | Helical; Name=1By similarityAdd BLAST | 23 | |
Topological domaini | 61 – 70 | CytoplasmicBy similarity | 10 | |
Transmembranei | 71 – 93 | Helical; Name=2By similarityAdd BLAST | 23 | |
Topological domaini | 94 – 108 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 109 – 130 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 131 – 151 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 152 – 172 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 173 – 188 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 189 – 213 | Helical; Name=5By similarityAdd BLAST | 25 | |
Topological domaini | 214 – 373 | CytoplasmicBy similarityAdd BLAST | 160 | |
Transmembranei | 374 – 395 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 396 – 409 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 410 – 431 | Helical; Name=7By similarityAdd BLAST | 22 | |
Topological domaini | 432 – 443 | CytoplasmicBy similarityAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 126 | C → S: No effect on palmitoylation; no effect on localization to the plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 244 | C → S: No effect on palmitoylation; no effect on localization to the plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 253 | C → S: No effect on palmitoylation; no effect on localization to the plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 443 | Missing : Decreased palmitoylation; decreased localization to the plasma membrane; decreased stability. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1813 |
MalaCardsi | DRD2 |
MIMi | 103780, phenotype |
OpenTargetsi | ENSG00000149295 |
Orphaneti | 36899, Myoclonus-dystonia syndrome |
PharmGKBi | PA27478 |
Miscellaneous databases
Pharosi | P14416, Tclin |
Chemistry databases
ChEMBLi | CHEMBL217 |
DrugBanki | DB01614, Acepromazine DB01063, Acetophenazine DB05766, ACP-104 DB01425, Alizapride DB00915, Amantadine DB06288, Amisulpride DB05964, Amitifadine DB00543, Amoxapine DB00182, Amphetamine DB04599, Aniracetam DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09207, AS-8112 DB06216, Asenapine DB04889, Bicifadine DB04888, Bifeprunox DB05687, BL-1020 DB09223, Blonanserin DB04857, Brasofensine DB09128, Brexpiprazole DB01200, Bromocriptine DB09018, Bromopride DB00490, Buspirone DB00248, Cabergoline DB06016, Cariprazine DB01038, Carphenazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB00568, Cinnarizine DB00363, Clozapine DB01151, Desipramine DB11274, Dihydro-alpha-ergocryptine DB13345, Dihydroergocristine DB01184, Domperidone DB00988, Dopamine DB00450, Droperidol DB11275, Epicriptine DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB09194, Etoperidone DB00875, Flupentixol DB00623, Fluphenazine DB04842, Fluspirilene DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB04924, Itopride DB12579, JNJ-37822681 DB01221, Ketamine DB00555, Lamotrigine DB01235, Levodopa DB00589, Lisuride DB00408, Loxapine DB06077, Lumateperone DB08815, Lurasidone DB00934, Maprotiline DB09224, Melperone DB01043, Memantine DB00933, Mesoridazine DB01403, Methotrimeprazine DB01233, Metoclopramide DB06148, Mianserin DB00805, Minaprine DB01618, Molindone DB00540, Nortriptyline DB06229, Ocaperidone DB00334, Olanzapine DB01267, Paliperidone DB12061, Pardoprunox DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB00850, Perphenazine DB05316, Pimavanserin DB01100, Pimozide DB09286, Pipamperone DB01621, Pipotiazine DB12478, Piribedil DB00413, Pramipexole DB00433, Prochlorperazine DB00420, Promazine DB01069, Promethazine DB00777, Propiomazine DB01224, Quetiapine DB09097, Quinagolide DB12518, Raclopride DB00409, Remoxipride DB00734, Risperidone DB01549, Rolicyclidine DB00268, Ropinirole DB05271, Rotigotine DB06454, Sarizotan DB06144, Sertindole DB00391, Sulpiride DB06477, Sumanirole DB04844, Tetrabenazine DB12093, Tetrahydropalmatine DB00372, Thiethylperazine DB01622, Thioproperazine DB00679, Thioridazine DB01623, Thiothixene DB13025, Tiapride DB00831, Trifluoperazine DB00508, Triflupromazine DB00726, Trimipramine DB06109, YKP-1358 DB01392, Yohimbine DB00246, Ziprasidone DB09225, Zotepine DB01624, Zuclopenthixol |
DrugCentrali | P14416 |
GuidetoPHARMACOLOGYi | 215 |
Genetic variation databases
BioMutai | DRD2 |
DMDMi | 118206 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069387 | 1 – 443 | D(2) dopamine receptorAdd BLAST | 443 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 107 ↔ 182 | Combined sources1 Publication | ||
Disulfide bondi | 399 ↔ 401 | Combined sources1 Publication | ||
Lipidationi | 443 | S-palmitoyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P14416 |
PeptideAtlasi | P14416 |
PRIDEi | P14416 |
ProteomicsDBi | 53053 [P14416-1] 53054 [P14416-2] 53055 [P14416-3] |
PTM databases
GlyGeni | P14416, 3 sites |
iPTMneti | P14416 |
PhosphoSitePlusi | P14416 |
SwissPalmi | P14416 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000149295, Expressed in adenohypophysis and 135 other tissues |
ExpressionAtlasi | P14416, baseline and differential |
Genevisiblei | P14416, HS |
Organism-specific databases
HPAi | ENSG00000149295, Group enriched (brain, pituitary gland) |
Interactioni
Subunit structurei
Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734).
Interacts with CADPS and CADPS2 (PubMed:15857609).
Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity).
Interacts with ARRB2 (By similarity).
Interacts with HTR2A (PubMed:21645528).
Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964).
Interacts with DRD1 (By similarity).
Interacts with KCNA2 (By similarity).
By similarityBinary interactionsi
P14416
With | #Exp. | IntAct |
---|---|---|
DISC1 [Q9NRI5] | 3 | EBI-2928178,EBI-529989 |
itself | 9 | EBI-2928178,EBI-2928178 |
SLC6A3 [Q01959] | 4 | EBI-2928178,EBI-6661445 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- ionotropic glutamate receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108147, 95 interactors |
CORUMi | P14416 |
DIPi | DIP-5977N |
IntActi | P14416, 77 interactors |
MINTi | P14416 |
STRINGi | 9606.ENSP00000354859 |
Chemistry databases
BindingDBi | P14416 |
Miscellaneous databases
RNActi | P14416, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P14416 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14416 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 211 – 373 | Interaction with PPP1R9BBy similarityAdd BLAST | 163 | |
Regioni | 281 – 332 | DisorderedSequence analysisAdd BLAST | 52 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155539 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P14416 |
OMAi | HGLHSTA |
PhylomeDBi | P14416 |
TreeFami | TF334382 |
Family and domain databases
InterProi | View protein in InterPro IPR001922, Dopamine_D2_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00567, DOPAMINED2R PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF
60 70 80 90 100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW
110 120 130 140 150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR
160 170 180 190 200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV
210 220 230 240 250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM
260 270 280 290 300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP
310 320 330 340 350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK
360 370 380 390 400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD
410 420 430 440
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VUV1 | F8VUV1_HUMAN | D(2) dopamine receptor | DRD2 | 442 | Annotation score: | ||
Q6LDH7 | Q6LDH7_HUMAN | D(2) dopamine receptor | DRD2 | 177 | Annotation score: | ||
A0A1Y8EK52 | A0A1Y8EK52_HUMAN | D(2) dopamine receptor | DRD2 | 7 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | L → R in AAB26819 (PubMed:1363862).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017143 | 154 | V → I Found in patients with alcohol-responsive myoclonus-dystonia; unknown pathological significance; the mutation does not affect functional properties. 2 PublicationsCorresponds to variant dbSNP:rs104894220EnsemblClinVar. | 1 | |
Natural variantiVAR_014674 | 310 | P → S. Corresponds to variant dbSNP:rs1800496EnsemblClinVar. | 1 | |
Natural variantiVAR_003462 | 311 | S → C May be associated with a higher risk for schizophrenia. 1 PublicationCorresponds to variant dbSNP:rs1801028EnsemblClinVar. | 1 | |
Natural variantiVAR_064579 | 327 | K → E1 PublicationCorresponds to variant dbSNP:rs71653614EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001870 | 242 – 270 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_026455 | 270 | V → VVQ in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30625 mRNA Translation: AAA88024.1 X51645 mRNA Translation: CAB56463.1 X51646 Genomic DNA Translation: CAB37869.1 X51362 mRNA Translation: CAA35746.1 M29066 mRNA Translation: AAA52761.1 S62137 mRNA Translation: AAB26819.1 S69899 mRNA Translation: AAB20571.1 S58589 , S58577, S58584, S58586, S58588 Genomic DNA Translation: AAB26274.1 AF176812 mRNA Translation: AAF61479.1 AB065860 Genomic DNA Translation: BAC06078.1 AF050737 Genomic DNA Translation: AAC78779.1 BC021195 mRNA Translation: AAH21195.1 |
CCDSi | CCDS8361.1 [P14416-1] CCDS8362.1 [P14416-2] |
PIRi | S08417, DYHUD2 |
RefSeqi | NP_000786.1, NM_000795.3 [P14416-1] NP_057658.2, NM_016574.3 [P14416-2] XP_016872785.1, XM_017017296.1 [P14416-1] |
Genome annotation databases
Ensembli | ENST00000346454; ENSP00000278597; ENSG00000149295 [P14416-2] ENST00000362072; ENSP00000354859; ENSG00000149295 ENST00000538967; ENSP00000438215; ENSG00000149295 [P14416-3] ENST00000542968; ENSP00000442172; ENSG00000149295 |
GeneIDi | 1813 |
KEGGi | hsa:1813 |
MANE-Selecti | ENST00000362072.8; ENSP00000354859.3; NM_000795.4; NP_000786.1 |
UCSCi | uc001pnz.4, human [P14416-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30625 mRNA Translation: AAA88024.1 X51645 mRNA Translation: CAB56463.1 X51646 Genomic DNA Translation: CAB37869.1 X51362 mRNA Translation: CAA35746.1 M29066 mRNA Translation: AAA52761.1 S62137 mRNA Translation: AAB26819.1 S69899 mRNA Translation: AAB20571.1 S58589 , S58577, S58584, S58586, S58588 Genomic DNA Translation: AAB26274.1 AF176812 mRNA Translation: AAF61479.1 AB065860 Genomic DNA Translation: BAC06078.1 AF050737 Genomic DNA Translation: AAC78779.1 BC021195 mRNA Translation: AAH21195.1 |
CCDSi | CCDS8361.1 [P14416-1] CCDS8362.1 [P14416-2] |
PIRi | S08417, DYHUD2 |
RefSeqi | NP_000786.1, NM_000795.3 [P14416-1] NP_057658.2, NM_016574.3 [P14416-2] XP_016872785.1, XM_017017296.1 [P14416-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5AER | X-ray | 2.19 | B/C | 430-443 | [»] | |
6CM4 | X-ray | 2.87 | A | 35-222 | [»] | |
A | 363-443 | [»] | ||||
6LUQ | X-ray | 3.10 | A | 35-222 | [»] | |
A | 367-443 | [»] | ||||
6VMS | electron microscopy | 3.80 | R | 29-443 | [»] | |
7JVR | electron microscopy | 2.80 | R | 1-443 | [»] | |
SMRi | P14416 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108147, 95 interactors |
CORUMi | P14416 |
DIPi | DIP-5977N |
IntActi | P14416, 77 interactors |
MINTi | P14416 |
STRINGi | 9606.ENSP00000354859 |
Chemistry databases
BindingDBi | P14416 |
ChEMBLi | CHEMBL217 |
DrugBanki | DB01614, Acepromazine DB01063, Acetophenazine DB05766, ACP-104 DB01425, Alizapride DB00915, Amantadine DB06288, Amisulpride DB05964, Amitifadine DB00543, Amoxapine DB00182, Amphetamine DB04599, Aniracetam DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09207, AS-8112 DB06216, Asenapine DB04889, Bicifadine DB04888, Bifeprunox DB05687, BL-1020 DB09223, Blonanserin DB04857, Brasofensine DB09128, Brexpiprazole DB01200, Bromocriptine DB09018, Bromopride DB00490, Buspirone DB00248, Cabergoline DB06016, Cariprazine DB01038, Carphenazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB00568, Cinnarizine DB00363, Clozapine DB01151, Desipramine DB11274, Dihydro-alpha-ergocryptine DB13345, Dihydroergocristine DB01184, Domperidone DB00988, Dopamine DB00450, Droperidol DB11275, Epicriptine DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB09194, Etoperidone DB00875, Flupentixol DB00623, Fluphenazine DB04842, Fluspirilene DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB04924, Itopride DB12579, JNJ-37822681 DB01221, Ketamine DB00555, Lamotrigine DB01235, Levodopa DB00589, Lisuride DB00408, Loxapine DB06077, Lumateperone DB08815, Lurasidone DB00934, Maprotiline DB09224, Melperone DB01043, Memantine DB00933, Mesoridazine DB01403, Methotrimeprazine DB01233, Metoclopramide DB06148, Mianserin DB00805, Minaprine DB01618, Molindone DB00540, Nortriptyline DB06229, Ocaperidone DB00334, Olanzapine DB01267, Paliperidone DB12061, Pardoprunox DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB00850, Perphenazine DB05316, Pimavanserin DB01100, Pimozide DB09286, Pipamperone DB01621, Pipotiazine DB12478, Piribedil DB00413, Pramipexole DB00433, Prochlorperazine DB00420, Promazine DB01069, Promethazine DB00777, Propiomazine DB01224, Quetiapine DB09097, Quinagolide DB12518, Raclopride DB00409, Remoxipride DB00734, Risperidone DB01549, Rolicyclidine DB00268, Ropinirole DB05271, Rotigotine DB06454, Sarizotan DB06144, Sertindole DB00391, Sulpiride DB06477, Sumanirole DB04844, Tetrabenazine DB12093, Tetrahydropalmatine DB00372, Thiethylperazine DB01622, Thioproperazine DB00679, Thioridazine DB01623, Thiothixene DB13025, Tiapride DB00831, Trifluoperazine DB00508, Triflupromazine DB00726, Trimipramine DB06109, YKP-1358 DB01392, Yohimbine DB00246, Ziprasidone DB09225, Zotepine DB01624, Zuclopenthixol |
DrugCentrali | P14416 |
GuidetoPHARMACOLOGYi | 215 |
Protein family/group databases
TCDBi | 9.A.14.3.10, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P14416, 3 sites |
iPTMneti | P14416 |
PhosphoSitePlusi | P14416 |
SwissPalmi | P14416 |
Genetic variation databases
BioMutai | DRD2 |
DMDMi | 118206 |
Proteomic databases
PaxDbi | P14416 |
PeptideAtlasi | P14416 |
PRIDEi | P14416 |
ProteomicsDBi | 53053 [P14416-1] 53054 [P14416-2] 53055 [P14416-3] |
Protocols and materials databases
Antibodypediai | 2801, 366 antibodies from 40 providers |
DNASUi | 1813 |
Genome annotation databases
Ensembli | ENST00000346454; ENSP00000278597; ENSG00000149295 [P14416-2] ENST00000362072; ENSP00000354859; ENSG00000149295 ENST00000538967; ENSP00000438215; ENSG00000149295 [P14416-3] ENST00000542968; ENSP00000442172; ENSG00000149295 |
GeneIDi | 1813 |
KEGGi | hsa:1813 |
MANE-Selecti | ENST00000362072.8; ENSP00000354859.3; NM_000795.4; NP_000786.1 |
UCSCi | uc001pnz.4, human [P14416-1] |
Organism-specific databases
CTDi | 1813 |
DisGeNETi | 1813 |
GeneCardsi | DRD2 |
HGNCi | HGNC:3023, DRD2 |
HPAi | ENSG00000149295, Group enriched (brain, pituitary gland) |
MalaCardsi | DRD2 |
MIMi | 103780, phenotype 126450, gene |
neXtProti | NX_P14416 |
OpenTargetsi | ENSG00000149295 |
Orphaneti | 36899, Myoclonus-dystonia syndrome |
PharmGKBi | PA27478 |
VEuPathDBi | HostDB:ENSG00000149295 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155539 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P14416 |
OMAi | HGLHSTA |
PhylomeDBi | P14416 |
TreeFami | TF334382 |
Enzyme and pathway databases
PathwayCommonsi | P14416 |
Reactomei | R-HSA-390651, Dopamine receptors |
SignaLinki | P14416 |
SIGNORi | P14416 |
Miscellaneous databases
BioGRID-ORCSi | 1813, 9 hits in 1046 CRISPR screens |
ChiTaRSi | DRD2, human |
EvolutionaryTracei | P14416 |
GeneWikii | Dopamine_receptor_D2 |
GenomeRNAii | 1813 |
Pharosi | P14416, Tclin |
PROi | PR:P14416 |
RNActi | P14416, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149295, Expressed in adenohypophysis and 135 other tissues |
ExpressionAtlasi | P14416, baseline and differential |
Genevisiblei | P14416, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001922, Dopamine_D2_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00567, DOPAMINED2R PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DRD2_HUMAN | |
Accessioni | P14416Primary (citable) accession number: P14416 Secondary accession number(s): Q9NZR3, Q9UPA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 234 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families