UniProtKB - P14415 (AT1B2_HUMAN)
Sodium/potassium-transporting ATPase subunit beta-2
ATP1B2
Functioni
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
By similarityGO - Molecular functioni
- ATPase activator activity Source: BHF-UCL
- ATPase binding Source: BHF-UCL
- protein heterodimerization activity Source: ARUK-UCL
- protein-macromolecule adaptor activity Source: BHF-UCL
GO - Biological processi
- cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
- cell-substrate adhesion Source: ARUK-UCL
- cellular potassium ion homeostasis Source: BHF-UCL
- cellular sodium ion homeostasis Source: BHF-UCL
- lateral ventricle development Source: ARUK-UCL
- membrane repolarization Source: BHF-UCL
- motor behavior Source: ARUK-UCL
- negative regulation of glial cell migration Source: ARUK-UCL
- neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration Source: ARUK-UCL
- photoreceptor cell maintenance Source: ARUK-UCL
- plasma membrane bounded cell projection organization Source: ARUK-UCL
- positive regulation of ATPase activity Source: BHF-UCL
- positive regulation of neuron projection development Source: ARUK-UCL
- positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
- positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
- positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
- potassium ion import across plasma membrane Source: BHF-UCL
- protein stabilization Source: BHF-UCL
- retina homeostasis Source: ARUK-UCL
- sodium ion export across plasma membrane Source: BHF-UCL
- third ventricle development Source: ARUK-UCL
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Cell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | Potassium, Sodium |
Enzyme and pathway databases
PathwayCommonsi | P14415 |
Reactomei | R-HSA-210991, Basigin interactions R-HSA-5578775, Ion homeostasis R-HSA-936837, Ion transport by P-type ATPases R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P14415 |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit beta-2Alternative name(s): Adhesion molecule in glia Short name: AMOG Sodium/potassium-dependent ATPase subunit beta-2 |
Gene namesi | Name:ATP1B2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:805, ATP1B2 |
MIMi | 182331, gene |
neXtProti | NX_P14415 |
VEuPathDBi | HostDB:ENSG00000129244 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- cell body membrane Source: ARUK-UCL
- cell projection membrane Source: ARUK-UCL
- external side of plasma membrane Source: ARUK-UCL
- lateral plasma membrane Source: ARUK-UCL
- plasma membrane Source: ARUK-UCL
- sodium:potassium-exchanging ATPase complex Source: BHF-UCL
Other locations
- astrocyte end-foot Source: ARUK-UCL
- astrocyte projection Source: ARUK-UCL
- cell periphery Source: ARUK-UCL
- cytoplasm Source: Ensembl
- membrane Source: ARUK-UCL
- neuron to neuron synapse Source: ARUK-UCL
- photoreceptor inner segment Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 67 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 28 | |
Topological domaini | 68 – 290 | ExtracellularSequence analysisAdd BLAST | 223 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 482 |
OpenTargetsi | ENSG00000129244 |
PharmGKBi | PA67 |
Miscellaneous databases
Pharosi | P14415, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2095186 |
DrugBanki | DB09479, Rubidium Rb-82 |
DrugCentrali | P14415 |
Genetic variation databases
BioMutai | ATP1B2 |
DMDMi | 125987795 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219104 | 1 – 290 | Sodium/potassium-transporting ATPase subunit beta-2Add BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 129 ↔ 150 | By similarity | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 177 | By similarity | ||
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 200 ↔ 261 | By similarity | ||
Glycosylationi | 238 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P14415 |
jPOSTi | P14415 |
MassIVEi | P14415 |
MaxQBi | P14415 |
PaxDbi | P14415 |
PeptideAtlasi | P14415 |
PRIDEi | P14415 |
ProteomicsDBi | 53052 |
PTM databases
GlyConnecti | 1758, 1 N-Linked glycan (1 site) |
GlyGeni | P14415, 7 sites, 1 N-linked glycan (1 site) |
iPTMneti | P14415 |
PhosphoSitePlusi | P14415 |
Expressioni
Gene expression databases
Bgeei | ENSG00000129244, Expressed in right hemisphere of cerebellum and 175 other tissues |
ExpressionAtlasi | P14415, baseline and differential |
Genevisiblei | P14415, HS |
Organism-specific databases
HPAi | ENSG00000129244, Group enriched (brain, retina) |
Interactioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
Interacts with isoform 2 of BSG (By similarity).
By similarityCuratedGO - Molecular functioni
- ATPase binding Source: BHF-UCL
- protein heterodimerization activity Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 106972, 14 interactors |
IntActi | P14415, 3 interactors |
STRINGi | 9606.ENSP00000250111 |
Chemistry databases
BindingDBi | P14415 |
Miscellaneous databases
RNActi | P14415, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 193 – 290 | immunoglobulin-likeAdd BLAST | 98 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3927, Eukaryota |
GeneTreei | ENSGT01030000234579 |
HOGENOMi | CLU_057702_1_1_1 |
InParanoidi | P14415 |
OMAi | VCRPGHY |
OrthoDBi | 998086at2759 |
PhylomeDBi | P14415 |
TreeFami | TF314618 |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
TIGRFAMsi | TIGR01107, Na_K_ATPase_bet, 1 hit |
PROSITEi | View protein in PROSITE PS00390, ATPASE_NA_K_BETA_1, 1 hit PS00391, ATPASE_NA_K_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF
60 70 80 90 100
LTAMFTLTMW VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT
110 120 130 140 150
ESWDQHVQKL NKFLEPYNDS IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC
160 170 180 190 200
QFNRTQLGNC SGIGDSTHYG YSTGQPCVFI KMNRVINFYA GANQSMNVTC
210 220 230 240 250
AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT QPLVAVKFLN
260 270 280 290
VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L1V9 | I3L1V9_HUMAN | Sodium/potassium-transporting ATPas... | ATP1B2 | 166 | Annotation score: | ||
I3L3J8 | I3L3J8_HUMAN | Sodium/potassium-transporting ATPas... | ATP1B2 | 172 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 51 | L → P in AAA51805 (PubMed:8305453).Curated | 1 | |
Sequence conflicti | 51 | L → P no nucleotide entry (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 121 | I → M in AAA51805 (PubMed:8305453).Curated | 1 | |
Sequence conflicti | 121 | I → M no nucleotide entry (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 148 | R → L in AAA51805 (PubMed:8305453).Curated | 1 | |
Sequence conflicti | 148 | R → L no nucleotide entry (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 248 | F → L in AAC50873 (PubMed:8918259).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061031 | 124 | Q → L. Corresponds to variant dbSNP:rs34745087Ensembl. | 1 | |
Natural variantiVAR_030339 | 199 | T → A. Corresponds to variant dbSNP:rs2227866Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81181 mRNA Translation: AAA51805.1 U45945 mRNA Translation: AAC50873.1 AF007876 Genomic DNA Translation: AAC39686.1 AK290143 mRNA Translation: BAF82832.1 CH471108 Genomic DNA Translation: EAW90148.1 BC126175 mRNA Translation: AAI26176.1 |
CCDSi | CCDS32550.1 |
PIRi | B32459 JC5107 |
RefSeqi | NP_001290192.1, NM_001303263.1 NP_001669.3, NM_001678.4 |
Genome annotation databases
Ensembli | ENST00000250111; ENSP00000250111; ENSG00000129244 |
GeneIDi | 482 |
KEGGi | hsa:482 |
MANE-Selecti | ENST00000250111.9; ENSP00000250111.4; NM_001678.5; NP_001669.3 |
UCSCi | uc002gif.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81181 mRNA Translation: AAA51805.1 U45945 mRNA Translation: AAC50873.1 AF007876 Genomic DNA Translation: AAC39686.1 AK290143 mRNA Translation: BAF82832.1 CH471108 Genomic DNA Translation: EAW90148.1 BC126175 mRNA Translation: AAI26176.1 |
CCDSi | CCDS32550.1 |
PIRi | B32459 JC5107 |
RefSeqi | NP_001290192.1, NM_001303263.1 NP_001669.3, NM_001678.4 |
3D structure databases
SMRi | P14415 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106972, 14 interactors |
IntActi | P14415, 3 interactors |
STRINGi | 9606.ENSP00000250111 |
Chemistry databases
BindingDBi | P14415 |
ChEMBLi | CHEMBL2095186 |
DrugBanki | DB09479, Rubidium Rb-82 |
DrugCentrali | P14415 |
PTM databases
GlyConnecti | 1758, 1 N-Linked glycan (1 site) |
GlyGeni | P14415, 7 sites, 1 N-linked glycan (1 site) |
iPTMneti | P14415 |
PhosphoSitePlusi | P14415 |
Genetic variation databases
BioMutai | ATP1B2 |
DMDMi | 125987795 |
Proteomic databases
EPDi | P14415 |
jPOSTi | P14415 |
MassIVEi | P14415 |
MaxQBi | P14415 |
PaxDbi | P14415 |
PeptideAtlasi | P14415 |
PRIDEi | P14415 |
ProteomicsDBi | 53052 |
Protocols and materials databases
Antibodypediai | 2415, 251 antibodies from 31 providers |
DNASUi | 482 |
Genome annotation databases
Ensembli | ENST00000250111; ENSP00000250111; ENSG00000129244 |
GeneIDi | 482 |
KEGGi | hsa:482 |
MANE-Selecti | ENST00000250111.9; ENSP00000250111.4; NM_001678.5; NP_001669.3 |
UCSCi | uc002gif.2, human |
Organism-specific databases
CTDi | 482 |
DisGeNETi | 482 |
GeneCardsi | ATP1B2 |
HGNCi | HGNC:805, ATP1B2 |
HPAi | ENSG00000129244, Group enriched (brain, retina) |
MIMi | 182331, gene |
neXtProti | NX_P14415 |
OpenTargetsi | ENSG00000129244 |
PharmGKBi | PA67 |
VEuPathDBi | HostDB:ENSG00000129244 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3927, Eukaryota |
GeneTreei | ENSGT01030000234579 |
HOGENOMi | CLU_057702_1_1_1 |
InParanoidi | P14415 |
OMAi | VCRPGHY |
OrthoDBi | 998086at2759 |
PhylomeDBi | P14415 |
TreeFami | TF314618 |
Enzyme and pathway databases
PathwayCommonsi | P14415 |
Reactomei | R-HSA-210991, Basigin interactions R-HSA-5578775, Ion homeostasis R-HSA-936837, Ion transport by P-type ATPases R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P14415 |
Miscellaneous databases
BioGRID-ORCSi | 482, 3 hits in 1042 CRISPR screens |
ChiTaRSi | ATP1B2, human |
GenomeRNAii | 482 |
Pharosi | P14415, Tclin |
PROi | PR:P14415 |
RNActi | P14415, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129244, Expressed in right hemisphere of cerebellum and 175 other tissues |
ExpressionAtlasi | P14415, baseline and differential |
Genevisiblei | P14415, HS |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
TIGRFAMsi | TIGR01107, Na_K_ATPase_bet, 1 hit |
PROSITEi | View protein in PROSITE PS00390, ATPASE_NA_K_BETA_1, 1 hit PS00391, ATPASE_NA_K_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1B2_HUMAN | |
Accessioni | P14415Primary (citable) accession number: P14415 Secondary accession number(s): A0AV17 O60444 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families