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UniProtKB - P14415 (AT1B2_HUMAN)

Entry version 191 (23 Feb 2022)
Sequence version 3 (06 Feb 2007)
Previous versions | rss
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Protein

Sodium/potassium-transporting ATPase subunit beta-2

Gene

ATP1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.

Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14415

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-210991, Basigin interactions
R-HSA-5578775, Ion homeostasis
R-HSA-936837, Ion transport by P-type ATPases
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14415

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-2
Alternative name(s):
Adhesion molecule in glia
Short name:
AMOG
Sodium/potassium-dependent ATPase subunit beta-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP1B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:805, ATP1B2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182331, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14415

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000129244

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 67Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini68 – 290ExtracellularSequence analysisAdd BLAST223

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		482

Open Targets

More...OpenTargetsi		ENSG00000129244

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA67

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14415, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2095186

Drug and drug target database

More...DrugBanki		DB09479, Rubidium Rb-82

DrugCentral

More...DrugCentrali		P14415

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP1B2

Domain mapping of disease mutations (DMDM)

More...DMDMi		125987795

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002191041 – 290Sodium/potassium-transporting ATPase subunit beta-2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi129 ↔ 150By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 177By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 261By similarity
Glycosylationi238N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14415

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14415

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14415

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14415

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14415

PeptideAtlas

More...PeptideAtlasi		P14415

PRoteomics IDEntifications database

More...PRIDEi		P14415

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53052

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1758, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14415, 7 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14415

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14415

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129244, Expressed in right hemisphere of cerebellum and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14415, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14415, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129244, Group enriched (brain, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Interacts with isoform 2 of BSG (By similarity).

By similarityCurated

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106972, 14 interactors

Protein interaction database and analysis system

More...IntActi		P14415, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000250111

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14415

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14415, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14415

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni193 – 290immunoglobulin-likeAdd BLAST98

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the X(+)/potassium ATPases subunit beta family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3927, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234579

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_057702_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14415

Identification of Orthologs from Complete Genome Data

More...OMAi		VCRPGHY

Database of Orthologous Groups

More...OrthoDBi		998086at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14415

TreeFam database of animal gene trees

More...TreeFami		TF314618

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1660, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000402, Na/K_ATPase_sub_beta
IPR038702, Na/K_ATPase_sub_beta_sf

The PANTHER Classification System

More...PANTHERi		PTHR11523, PTHR11523, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00287, Na_K-ATPase, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01107, Na_K_ATPase_bet, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00390, ATPASE_NA_K_BETA_1, 1 hit
PS00391, ATPASE_NA_K_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P14415-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF 
        60         70         80         90        100
LTAMFTLTMW VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT 
       110        120        130        140        150
ESWDQHVQKL NKFLEPYNDS IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC 
       160        170        180        190        200
QFNRTQLGNC SGIGDSTHYG YSTGQPCVFI KMNRVINFYA GANQSMNVTC 
       210        220        230        240        250
AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT QPLVAVKFLN 
       260        270        280        290
VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
Length:290
Mass (Da):33,367
Last modified:February 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC5BFBB6D01347F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1V9I3L1V9_HUMAN
Sodium/potassium-transporting ATPas...
ATP1B2
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3J8I3L3J8_HUMAN
Sodium/potassium-transporting ATPas...
ATP1B2
172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51L → P in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti51L → P no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti121I → M in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti121I → M no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti148R → L in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti148R → L no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti248F → L in AAC50873 (PubMed:8918259).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061031124Q → L. Corresponds to variant dbSNP:rs34745087Ensembl.1
Natural variantiVAR_030339199T → A. Corresponds to variant dbSNP:rs2227866Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M81181 mRNA Translation: AAA51805.1
U45945 mRNA Translation: AAC50873.1
AF007876 Genomic DNA Translation: AAC39686.1
AK290143 mRNA Translation: BAF82832.1
CH471108 Genomic DNA Translation: EAW90148.1
BC126175 mRNA Translation: AAI26176.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32550.1

Protein sequence database of the Protein Information Resource

More...PIRi		B32459
JC5107

NCBI Reference Sequences

More...RefSeqi		NP_001290192.1, NM_001303263.1
NP_001669.3, NM_001678.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000250111; ENSP00000250111; ENSG00000129244

Database of genes from NCBI RefSeq genomes

More...GeneIDi		482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:482

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000250111.9; ENSP00000250111.4; NM_001678.5; NP_001669.3

UCSC genome browser

More...UCSCi		uc002gif.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81181 mRNA Translation: AAA51805.1
U45945 mRNA Translation: AAC50873.1
AF007876 Genomic DNA Translation: AAC39686.1
AK290143 mRNA Translation: BAF82832.1
CH471108 Genomic DNA Translation: EAW90148.1
BC126175 mRNA Translation: AAI26176.1
CCDSiCCDS32550.1
PIRiB32459
JC5107
RefSeqiNP_001290192.1, NM_001303263.1
NP_001669.3, NM_001678.4

3D structure databases

SMRiP14415
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106972, 14 interactors
IntActiP14415, 3 interactors
STRINGi9606.ENSP00000250111

Chemistry databases

BindingDBiP14415
ChEMBLiCHEMBL2095186
DrugBankiDB09479, Rubidium Rb-82
DrugCentraliP14415

PTM databases

GlyConnecti1758, 1 N-Linked glycan (1 site)
GlyGeniP14415, 7 sites, 1 N-linked glycan (1 site)
iPTMnetiP14415
PhosphoSitePlusiP14415

Genetic variation databases

BioMutaiATP1B2
DMDMi125987795

Proteomic databases

EPDiP14415
jPOSTiP14415
MassIVEiP14415
MaxQBiP14415
PaxDbiP14415
PeptideAtlasiP14415
PRIDEiP14415
ProteomicsDBi53052

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2415, 251 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		482

Genome annotation databases

EnsembliENST00000250111; ENSP00000250111; ENSG00000129244
GeneIDi482
KEGGihsa:482
MANE-SelectiENST00000250111.9; ENSP00000250111.4; NM_001678.5; NP_001669.3
UCSCiuc002gif.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		482
DisGeNETi482

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP1B2
HGNCiHGNC:805, ATP1B2
HPAiENSG00000129244, Group enriched (brain, retina)
MIMi182331, gene
neXtProtiNX_P14415
OpenTargetsiENSG00000129244
PharmGKBiPA67
VEuPathDBiHostDB:ENSG00000129244

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3927, Eukaryota
GeneTreeiENSGT01030000234579
HOGENOMiCLU_057702_1_1_1
InParanoidiP14415
OMAiVCRPGHY
OrthoDBi998086at2759
PhylomeDBiP14415
TreeFamiTF314618

Enzyme and pathway databases

PathwayCommonsiP14415
ReactomeiR-HSA-210991, Basigin interactions
R-HSA-5578775, Ion homeostasis
R-HSA-936837, Ion transport by P-type ATPases
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiP14415

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		482, 3 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP1B2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		482
PharosiP14415, Tclin

Protein Ontology

More...PROi		PR:P14415
RNActiP14415, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000129244, Expressed in right hemisphere of cerebellum and 175 other tissues
ExpressionAtlasiP14415, baseline and differential
GenevisibleiP14415, HS

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402, Na/K_ATPase_sub_beta
IPR038702, Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523, PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287, Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107, Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390, ATPASE_NA_K_BETA_1, 1 hit
PS00391, ATPASE_NA_K_BETA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT1B2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14415
Secondary accession number(s): A0AV17
, A8K278, D3DTQ2, O60444
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 6, 2007
Last modified: February 23, 2022
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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