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Protein

Sucrase-isomaltase, intestinal

Gene

SI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.1 Publication

Miscellaneous

There is a high degree of homology between the isomaltase and sucrase portions (41% of amino acid identity) indicating that this protein is evolved by partial gene duplication.

Catalytic activityi

Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action.
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei264Substrate1
Binding sitei388Substrate1
Active sitei505Nucleophile; for isomaltase activityPROSITE-ProRule annotation1 Publication1
Binding sitei588Substrate1
Active sitei604For isomaltase activity1 Publication1
Binding sitei662Substrate1
Active sitei1394Nucleophile; for sucrase activityPROSITE-ProRule annotation1 Publication1
Active sitei1397For sucrase activityBy similarity1
Active sitei1500Proton donor; for isomaltase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Multifunctional enzyme

Enzyme and pathway databases

BioCyciMetaCyc:HS01688-MONOMER
BRENDAi3.2.1.10 2681
3.2.1.48 2681
ReactomeiR-HSA-189085 Digestion of dietary carbohydrate
R-HSA-5659898 Intestinal saccharidase deficiencies

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Sucrase-isomaltase, intestinal
Cleaved into the following 2 chains:
Gene namesi
Name:SI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000090402.7
HGNCiHGNC:10856 SI
MIMi609845 gene
neXtProtiNX_P14410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicAdd BLAST11
Transmembranei13 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini33 – 1827LumenalAdd BLAST1795

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital sucrase-isomaltase deficiency (CSID)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
See also OMIM:222900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025368117Q → R in CSID; missorting of the enzyme to the basolateral membrane. 1 PublicationCorresponds to variant dbSNP:rs121912612EnsemblClinVar.1
Natural variantiVAR_025370341L → P in CSID; causes loss of anchored SI from the membrane. 1 PublicationCorresponds to variant dbSNP:rs267607049EnsemblClinVar.1
Natural variantiVAR_025371577V → G in CSID. 1 PublicationCorresponds to variant dbSNP:rs121912615EnsemblClinVar.1
Natural variantiVAR_025372594S → P in CSID. 1 PublicationCorresponds to variant dbSNP:rs765433197Ensembl.1
Natural variantiVAR_025373620L → P in CSID; SI accumulates predominantly in the ER. 1 PublicationCorresponds to variant dbSNP:rs121912613EnsemblClinVar.1
Natural variantiVAR_025374694T → P in CSID. 1 Publication1
Natural variantiVAR_0253751073G → D in CSID. 1 PublicationCorresponds to variant dbSNP:rs121912616EnsemblClinVar.1
Natural variantiVAR_0078541098Q → P in CSID; exhibits intracellular accumulation of mannose-rich SI in the Golgi. 1 PublicationCorresponds to variant dbSNP:rs121912611EnsemblClinVar.1
Natural variantiVAR_0253761229C → Y in CSID. 1 PublicationCorresponds to variant dbSNP:rs121912614EnsemblClinVar.1
Natural variantiVAR_0253771367R → G in CSID. 1 PublicationCorresponds to variant dbSNP:rs143388292EnsemblClinVar.1
Natural variantiVAR_0253791745F → C in CSID. 1 PublicationCorresponds to variant dbSNP:rs79717168EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6476
MalaCardsiSI
MIMi222900 phenotype
OpenTargetsiENSG00000090402
Orphaneti306446 Congenital sucrase-isomaltase deficiency with minimal starch tolerance
306474 Congenital sucrase-isomaltase deficiency with starch and lactose intolerance
306436 Congenital sucrase-isomaltase deficiency with starch intolerance
306462 Congenital sucrase-isomaltase deficiency without starch intolerance
306486 Congenital sucrase-isomaltase deficiency without sucrose intolerance
PharmGKBiPA35758

Chemistry databases

ChEMBLiCHEMBL2748
DrugBankiDB00284 Acarbose
DB00747 Scopolamine

Polymorphism and mutation databases

BioMutaiSI
DMDMi317373594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000185512 – 1827Sucrase-isomaltase, intestinalAdd BLAST1826
ChainiPRO_00000185522 – 1007IsomaltaseAdd BLAST1006
ChainiPRO_00000185531008 – 1827SucraseAdd BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphoserine; by PKA1 Publication1
Disulfide bondi63 ↔ 94PROSITE-ProRule annotation1 Publication
Disulfide bondi77 ↔ 93PROSITE-ProRule annotation1 Publication
Disulfide bondi88 ↔ 106PROSITE-ProRule annotation1 Publication
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei237SulfotyrosineSequence analysis1
Modified residuei239SulfotyrosineSequence analysis1
Modified residuei391SulfotyrosineSequence analysis1
Modified residuei400SulfotyrosineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi520 ↔ 545PROSITE-ProRule annotation1 Publication
Disulfide bondi635 ↔ 646PROSITE-ProRule annotation1 Publication
Modified residuei667SulfotyrosineSequence analysis1
Modified residuei763SulfotyrosineSequence analysis1
Modified residuei765SulfotyrosineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi855N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi904N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1675N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1763N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1815N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiP14410
PaxDbiP14410
PeptideAtlasiP14410
PRIDEiP14410
ProteomicsDBi53051

PTM databases

iPTMnetiP14410
PhosphoSitePlusiP14410

Expressioni

Tissue specificityi

Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.1 Publication

Gene expression databases

BgeeiENSG00000090402 Expressed in 41 organ(s), highest expression level in jejunal mucosa
CleanExiHS_SI
ExpressionAtlasiP14410 baseline and differential
GenevisibleiP14410 HS

Organism-specific databases

HPAiHPA011897

Interactioni

Subunit structurei

The resulting sucrase and isomaltase subunits stay associated with one another in a complex by non-covalent linkages.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000264382

Chemistry databases

BindingDBiP14410

Structurei

Secondary structure

11827
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14410
SMRiP14410
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14410

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 110P-type 1PROSITE-ProRule annotationAdd BLAST50
Domaini932 – 978P-type 2PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 1007IsomaltaseAdd BLAST898
Regioni1008 – 1827SucraseAdd BLAST820

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 60Ser/Thr-richAdd BLAST18

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1065 Eukaryota
COG1501 LUCA
GeneTreeiENSGT00760000119229
HOGENOMiHOG000067936
HOVERGENiHBG080721
InParanoidiP14410
KOiK01203
OMAiFHPYYMA
OrthoDBiEOG091G01E3
PhylomeDBiP14410
TreeFamiTF314577

Family and domain databases

CDDicd00111 Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits
SMARTiView protein in SMART
SM00018 PD, 2 hits
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707 GLYCOSYL_HYDROL_F31_2, 2 hits
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14410-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKKFSGLE ISLIVLFVIV TIIAIALIVV LATKTPAVDE ISDSTSTPAT
60 70 80 90 100
TRVTTNPSDS GKCPNVLNDP VNVRINCIPE QFPTEGICAQ RGCCWRPWND
110 120 130 140 150
SLIPWCFFVD NHGYNVQDMT TTSIGVEAKL NRIPSPTLFG NDINSVLFTT
160 170 180 190 200
QNQTPNRFRF KITDPNNRRY EVPHQYVKEF TGPTVSDTLY DVKVAQNPFS
210 220 230 240 250
IQVIRKSNGK TLFDTSIGPL VYSDQYLQIS TRLPSDYIYG IGEQVHKRFR
260 270 280 290 300
HDLSWKTWPI FTRDQLPGDN NNNLYGHQTF FMCIEDTSGK SFGVFLMNSN
310 320 330 340 350
AMEIFIQPTP IVTYRVTGGI LDFYILLGDT PEQVVQQYQQ LVGLPAMPAY
360 370 380 390 400
WNLGFQLSRW NYKSLDVVKE VVRRNREAGI PFDTQVTDID YMEDKKDFTY
410 420 430 440 450
DQVAFNGLPQ FVQDLHDHGQ KYVIILDPAI SIGRRANGTT YATYERGNTQ
460 470 480 490 500
HVWINESDGS TPIIGEVWPG LTVYPDFTNP NCIDWWANEC SIFHQEVQYD
510 520 530 540 550
GLWIDMNEVS SFIQGSTKGC NVNKLNYPPF TPDILDKLMY SKTICMDAVQ
560 570 580 590 600
NWGKQYDVHS LYGYSMAIAT EQAVQKVFPN KRSFILTRST FAGSGRHAAH
610 620 630 640 650
WLGDNTASWE QMEWSITGML EFSLFGIPLV GADICGFVAE TTEELCRRWM
660 670 680 690 700
QLGAFYPFSR NHNSDGYEHQ DPAFFGQNSL LVKSSRQYLT IRYTLLPFLY
710 720 730 740 750
TLFYKAHVFG ETVARPVLHE FYEDTNSWIE DTEFLWGPAL LITPVLKQGA
760 770 780 790 800
DTVSAYIPDA IWYDYESGAK RPWRKQRVDM YLPADKIGLH LRGGYIIPIQ
810 820 830 840 850
EPDVTTTASR KNPLGLIVAL GENNTAKGDF FWDDGETKDT IQNGNYILYT
860 870 880 890 900
FSVSNNTLDI VCTHSSYQEG TTLAFQTVKI LGLTDSVTEV RVAENNQPMN
910 920 930 940 950
AHSNFTYDAS NQVLLIADLK LNLGRNFSVQ WNQIFSENER FNCYPDADLA
960 970 980 990 1000
TEQKCTQRGC VWRTGSSLSK APECYFPRQD NSYSVNSARY SSMGITADLQ
1010 1020 1030 1040 1050
LNTANARIKL PSDPISTLRV EVKYHKNDML QFKIYDPQKK RYEVPVPLNI
1060 1070 1080 1090 1100
PTTPISTYED RLYDVEIKEN PFGIQIRRRS SGRVIWDSWL PGFAFNDQFI
1110 1120 1130 1140 1150
QISTRLPSEY IYGFGEVEHT AFKRDLNWNT WGMFTRDQPP GYKLNSYGFH
1160 1170 1180 1190 1200
PYYMALEEEG NAHGVFLLNS NAMDVTFQPT PALTYRTVGG ILDFYMFLGP
1210 1220 1230 1240 1250
TPEVATKQYH EVIGHPVMPA YWALGFQLCR YGYANTSEVR ELYDAMVAAN
1260 1270 1280 1290 1300
IPYDVQYTDI DYMERQLDFT IGEAFQDLPQ FVDKIRGEGM RYIIILDPAI
1310 1320 1330 1340 1350
SGNETKTYPA FERGQQNDVF VKWPNTNDIC WAKVWPDLPN ITIDKTLTED
1360 1370 1380 1390 1400
EAVNASRAHV AFPDFFRTST AEWWAREIVD FYNEKMKFDG LWIDMNEPSS
1410 1420 1430 1440 1450
FVNGTTTNQC RNDELNYPPY FPELTKRTDG LHFRTICMEA EQILSDGTSV
1460 1470 1480 1490 1500
LHYDVHNLYG WSQMKPTHDA LQKTTGKRGI VISRSTYPTS GRWGGHWLGD
1510 1520 1530 1540 1550
NYARWDNMDK SIIGMMEFSL FGMSYTGADI CGFFNNSEYH LCTRWMQLGA
1560 1570 1580 1590 1600
FYPYSRNHNI ANTRRQDPAS WNETFAEMSR NILNIRYTLL PYFYTQMHEI
1610 1620 1630 1640 1650
HANGGTVIRP LLHEFFDEKP TWDIFKQFLW GPAFMVTPVL EPYVQTVNAY
1660 1670 1680 1690 1700
VPNARWFDYH TGKDIGVRGQ FQTFNASYDT INLHVRGGHI LPCQEPAQNT
1710 1720 1730 1740 1750
FYSRQKHMKL IVAADDNQMA QGSLFWDDGE SIDTYERDLY LSVQFNLNQT
1760 1770 1780 1790 1800
TLTSTILKRG YINKSETRLG SLHVWGKGTT PVNAVTLTYN GNKNSLPFNE
1810 1820
DTTNMILRID LTTHNVTLEE PIEINWS
Length:1,827
Mass (Da):209,453
Last modified:January 11, 2011 - v6
Checksum:iDCB93F068AEEF83E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF21F8WF21_HUMAN
Sucrase-isomaltase, intestinal
SI
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300N → D in AAI16453 (PubMed:15489334).Curated1
Sequence conflicti460S → I in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti475P → S in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti548A → V in AAI16453 (PubMed:15489334).Curated1
Sequence conflicti584F → L in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti588R → C in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti633D → A in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti687Q → R in AAI16453 (PubMed:15489334).Curated1
Sequence conflicti884T → A in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti1016S → E AA sequence (PubMed:1677636).Curated1
Sequence conflicti1022V → T AA sequence (PubMed:1677636).Curated1
Sequence conflicti1155A → V in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti1203E → Q in CAA45140 (PubMed:1353958).Curated1
Sequence conflicti1782V → I in AAI15035 (PubMed:15489334).Curated1
Sequence conflicti1825N → S in AAI16453 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02536715V → F4 PublicationsCorresponds to variant dbSNP:rs9290264EnsemblClinVar.1
Natural variantiVAR_025368117Q → R in CSID; missorting of the enzyme to the basolateral membrane. 1 PublicationCorresponds to variant dbSNP:rs121912612EnsemblClinVar.1
Natural variantiVAR_025369231T → A5 PublicationsCorresponds to variant dbSNP:rs9283633EnsemblClinVar.1
Natural variantiVAR_025370341L → P in CSID; causes loss of anchored SI from the membrane. 1 PublicationCorresponds to variant dbSNP:rs267607049EnsemblClinVar.1
Natural variantiVAR_025371577V → G in CSID. 1 PublicationCorresponds to variant dbSNP:rs121912615EnsemblClinVar.1
Natural variantiVAR_025372594S → P in CSID. 1 PublicationCorresponds to variant dbSNP:rs765433197Ensembl.1
Natural variantiVAR_025373620L → P in CSID; SI accumulates predominantly in the ER. 1 PublicationCorresponds to variant dbSNP:rs121912613EnsemblClinVar.1
Natural variantiVAR_025374694T → P in CSID. 1 Publication1
Natural variantiVAR_0253751073G → D in CSID. 1 PublicationCorresponds to variant dbSNP:rs121912616EnsemblClinVar.1
Natural variantiVAR_0078541098Q → P in CSID; exhibits intracellular accumulation of mannose-rich SI in the Golgi. 1 PublicationCorresponds to variant dbSNP:rs121912611EnsemblClinVar.1
Natural variantiVAR_0253761229C → Y in CSID. 1 PublicationCorresponds to variant dbSNP:rs121912614EnsemblClinVar.1
Natural variantiVAR_0253771367R → G in CSID. 1 PublicationCorresponds to variant dbSNP:rs143388292EnsemblClinVar.1
Natural variantiVAR_0253781523M → I3 PublicationsCorresponds to variant dbSNP:rs4855271EnsemblClinVar.1
Natural variantiVAR_0253791745F → C in CSID. 1 PublicationCorresponds to variant dbSNP:rs79717168EnsemblClinVar.1
Natural variantiVAR_0345221802T → S. Corresponds to variant dbSNP:rs9917722EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63597 mRNA Translation: CAA45140.1
AC092695 Genomic DNA No translation available.
AC140119 Genomic DNA No translation available.
AC144561 Genomic DNA No translation available.
BC115034 mRNA Translation: AAI15035.1
BC116452 mRNA Translation: AAI16453.1
BC132834 mRNA Translation: AAI32835.1
BC132860 mRNA Translation: AAI32861.1
M22616 mRNA Translation: AAA60551.1
CCDSiCCDS3196.1
PIRiS36082 UUHU
RefSeqiNP_001032.2, NM_001041.3
UniGeneiHs.429596

Genome annotation databases

EnsembliENST00000264382; ENSP00000264382; ENSG00000090402
GeneIDi6476
KEGGihsa:6476
UCSCiuc003fei.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63597 mRNA Translation: CAA45140.1
AC092695 Genomic DNA No translation available.
AC140119 Genomic DNA No translation available.
AC144561 Genomic DNA No translation available.
BC115034 mRNA Translation: AAI15035.1
BC116452 mRNA Translation: AAI16453.1
BC132834 mRNA Translation: AAI32835.1
BC132860 mRNA Translation: AAI32861.1
M22616 mRNA Translation: AAA60551.1
CCDSiCCDS3196.1
PIRiS36082 UUHU
RefSeqiNP_001032.2, NM_001041.3
UniGeneiHs.429596

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LPOX-ray3.20A/B/C/D62-931[»]
3LPPX-ray2.15A/B/C/D62-931[»]
ProteinModelPortaliP14410
SMRiP14410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264382

Chemistry databases

BindingDBiP14410
ChEMBLiCHEMBL2748
DrugBankiDB00284 Acarbose
DB00747 Scopolamine

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

PTM databases

iPTMnetiP14410
PhosphoSitePlusiP14410

Polymorphism and mutation databases

BioMutaiSI
DMDMi317373594

Proteomic databases

MaxQBiP14410
PaxDbiP14410
PeptideAtlasiP14410
PRIDEiP14410
ProteomicsDBi53051

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264382; ENSP00000264382; ENSG00000090402
GeneIDi6476
KEGGihsa:6476
UCSCiuc003fei.3 human

Organism-specific databases

CTDi6476
DisGeNETi6476
EuPathDBiHostDB:ENSG00000090402.7
GeneCardsiSI
H-InvDBiHIX0030867
HGNCiHGNC:10856 SI
HPAiHPA011897
MalaCardsiSI
MIMi222900 phenotype
609845 gene
neXtProtiNX_P14410
OpenTargetsiENSG00000090402
Orphaneti306446 Congenital sucrase-isomaltase deficiency with minimal starch tolerance
306474 Congenital sucrase-isomaltase deficiency with starch and lactose intolerance
306436 Congenital sucrase-isomaltase deficiency with starch intolerance
306462 Congenital sucrase-isomaltase deficiency without starch intolerance
306486 Congenital sucrase-isomaltase deficiency without sucrose intolerance
PharmGKBiPA35758
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1065 Eukaryota
COG1501 LUCA
GeneTreeiENSGT00760000119229
HOGENOMiHOG000067936
HOVERGENiHBG080721
InParanoidiP14410
KOiK01203
OMAiFHPYYMA
OrthoDBiEOG091G01E3
PhylomeDBiP14410
TreeFamiTF314577

Enzyme and pathway databases

BioCyciMetaCyc:HS01688-MONOMER
BRENDAi3.2.1.10 2681
3.2.1.48 2681
ReactomeiR-HSA-189085 Digestion of dietary carbohydrate
R-HSA-5659898 Intestinal saccharidase deficiencies

Miscellaneous databases

ChiTaRSiSI human
EvolutionaryTraceiP14410
GenomeRNAii6476
PROiPR:P14410
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090402 Expressed in 41 organ(s), highest expression level in jejunal mucosa
CleanExiHS_SI
ExpressionAtlasiP14410 baseline and differential
GenevisibleiP14410 HS

Family and domain databases

CDDicd00111 Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits
SMARTiView protein in SMART
SM00018 PD, 2 hits
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707 GLYCOSYL_HYDROL_F31_2, 2 hits
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSUIS_HUMAN
AccessioniPrimary (citable) accession number: P14410
Secondary accession number(s): A2RUC3, Q1JQ80, Q1RMC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 187 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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