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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

COX7A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Short name:
Cytochrome c oxidase subunit VIIaL
Gene namesi
Name:COX7A2
Synonyms:COX7AL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2288 COX7A2
MIMi123996 gene
neXtProtiNX_P14406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1347
PharmGKBiPA26806

Polymorphism and mutation databases

BioMutaiCOX7A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23Mitochondrion1 PublicationAdd BLAST23
ChainiPRO_000000614524 – 83Cytochrome c oxidase subunit 7A2, mitochondrialAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP14406
MaxQBiP14406
PaxDbiP14406
PeptideAtlasiP14406
PRIDEiP14406
ProteomicsDBi53050
TopDownProteomicsiP14406

PTM databases

iPTMnetiP14406
PhosphoSitePlusiP14406

Expressioni

Gene expression databases

CleanExiHS_COX7A2

Interactioni

Subunit structurei

Interacts with PET100.1 Publication

Protein-protein interaction databases

BioGridi107740, 23 interactors
IntActiP14406, 7 interactors
MINTiP14406
STRINGi9606.ENSP00000359098

Structurei

3D structure databases

ProteinModelPortaliP14406
SMRiP14406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9 Eukaryota
ENOG41124EQ LUCA
HOGENOMiHOG000264231
HOVERGENiHBG051095
InParanoidiP14406
KOiK02270
PhylomeDBiP14406

Family and domain databases

CDDicd00928 Cyt_c_Oxidase_VIIa, 1 hit
Gene3Di4.10.91.10, 1 hit
InterProiView protein in InterPro
IPR039297 COX7a
IPR036539 Cyt_c_oxidase_su7a_sf
IPR003177 Cytc_oxidase_su7a_met
PANTHERiPTHR10510 PTHR10510, 1 hit
PfamiView protein in Pfam
PF02238 COX7a, 1 hit
SUPFAMiSSF81419 SSF81419, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA
60 70 80
DALLYRATMI LTVGGTAYAI YELAVASFPK KQE
Length:83
Mass (Da):9,396
Last modified:January 1, 1990 - v1
Checksum:i490F45059CAF971F
GO

Sequence cautioni

The sequence CAI19899 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01231940E → D1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15822 mRNA Translation: CAA33820.1
AF134406 Genomic DNA Translation: AAF61396.1
CR407646 mRNA Translation: CAG28574.1
CR542125 mRNA Translation: CAG46922.1
AK312154 mRNA Translation: BAG35088.1
AL080250 Genomic DNA Translation: CAI19899.1 Different initiation.
BC101826 mRNA Translation: AAI01827.1
BC101828 mRNA Translation: AAI01829.1
PIRiS06897 OSHU7L
RefSeqiNP_001856.2, NM_001865.3
UniGeneiHs.70312

Genome annotation databases

EnsembliENST00000230459; ENSP00000230459; ENSG00000112695
GeneIDi1347
KEGGihsa:1347

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCX7A2_HUMAN
AccessioniPrimary (citable) accession number: P14406
Secondary accession number(s): B2R5E1
, Q3MIH5, Q5TF59, Q6FGI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 18, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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