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Protein

MDS1 and EVI1 complex locus protein

Gene

Mecom

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 238C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 344C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri350 – 372C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri914 – 936C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri942 – 965C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri971 – 993C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processApoptosis, Differentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
MDS1 and EVI1 complex locus proteinBy similarity
Alternative name(s):
Ecotropic virus integration site 1 protein
Short name:
EVI-1
Myelodysplasia syndrome 1 protein homolog
Gene namesi
Name:MecomImported
Synonyms:Evi1, Mds1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95457 Mecom

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop until 9.5 dpc but die before 11.5 dpc. At 10.5 dpc embryos display multiple malformations associated with hypocellularity and reduced body size. Required for neural, heart and paraxial mesenchyme.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472741 – 1232MDS1 and EVI1 complex locus proteinAdd BLAST1232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki369Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki432Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki525Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki545Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki557Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki624Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei626PhosphoserineCombined sources1
Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki665Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki687Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki723Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei728PhosphoserineBy similarity1
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki737Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei742PhosphoserineCombined sources1
Cross-linki751Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki754Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki762Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki789Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki802Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki803Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki837Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki848Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1020Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1039PhosphoserineBy similarity1
Modified residuei1041PhosphoserineCombined sources1
Cross-linki1055Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1058Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

May be acetylated by CREBBP and KAT2B.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP14404
PRIDEiP14404

PTM databases

iPTMnetiP14404
PhosphoSitePlusiP14404

Expressioni

Developmental stagei

Expressed at 8.5 dpc in the anterior section of the primary head folds. Ubiquitously expressed at 9.5 dpc with higher expression in forebrain, mesenchyme of the branchial arches, nasal pits, limb buds and mesonephric ducts. Also detected at 10.5 dpc in hindbrain and lateral region of the neural tube.1 Publication

Gene expression databases

BgeeiENSMUSG00000027684 Expressed in 279 organ(s), highest expression level in pes
CleanExiMM_EVI1
MM_MDS1
ExpressionAtlasiP14404 baseline and differential
GenevisibleiP14404 MM

Interactioni

Subunit structurei

Isoform 1: Homooligomer. Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and MAPK9; inhibits JNK signaling (By similarity). Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199542, 2 interactors
DIPiDIP-46516N
IntActiP14404, 5 interactors
STRINGi10090.ENSMUSP00000134303

Structurei

3D structure databases

ProteinModelPortaliP14404
SMRiP14404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 192SETPROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 442Interaction with SUV39H1 and probably MAPK9 and SMAD31 PublicationAdd BLAST252

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi611 – 624Nuclear localization signalSequence analysisAdd BLAST14
Motifi743 – 747CTBP-binding motif 1By similarity5
Motifi774 – 778CTBP-binding motif 2By similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1067 – 1118Asp/Glu-rich (acidic)Add BLAST52

Domaini

Both zinc finger regions are required for the transcriptional activation of PBX1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 238C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 344C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri350 – 372C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri914 – 936C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri942 – 965C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri971 – 993C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140928
HOGENOMiHOG000231144
HOVERGENiHBG031707
InParanoidiP14404
KOiK04462
PhylomeDBiP14404
TreeFamiTF315309

Family and domain databases

InterProiView protein in InterPro
IPR036970 MECOM
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24393:SF11 PTHR24393:SF11, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3Curated (identifier: P14404-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSKGRARKL ATSNECAYGN YPEIPLEEMP DADADGITSV PSLHIQEPCS
60 70 80 90 100
PATSSESFTP KEGSPYKAPI YIPDDIPIPD EFELRESTMP GAGLGIWTKR
110 120 130 140 150
KIEIGEKFGP YMGEQRSDLK DSSYGWEILD EFCNVKFCID ASQPDVGSWL
160 170 180 190 200
KYIRFAGCYD QHNLVACQIN DQIFYRVVAD IAPGEELLLF MKSEEDPHEP
210 220 230 240 250
MAPDIHEERQ HRCEDCDQLF ESKAELADHQ KFPCSTPHSA FSMVEEDLQQ
260 270 280 290 300
NLESESDLRE IHGNQDCKEC DRVFPDLQSL EKHMLSHTEE REYKCDQCPK
310 320 330 340 350
AFNWKSNLIR HQMSHDSGKH YECENCAKVF TDPSNLQRHI RSQHVGARAH
360 370 380 390 400
ACPECGKTFA TSSGLKQHKH IHSSVKPFIC EVCHKSYTQF SNLCRHKRMH
410 420 430 440 450
ADCRTQIKCK DCGQMFSTTS SLNKHRRFCE GKNHFAAGGF FGQGISLPGT
460 470 480 490 500
PAMDKTSMVN MSHANPGLAD YFGTNRHPAG LTFPTAPGFS FSFPGLFPSG
510 520 530 540 550
LYHRPPLIPA SPPVKGLSST EQSNKCQSPL LTHPQILPAT QDILKALSKH
560 570 580 590 600
PPVGDNKPVE LLPERSSEER PLEKISDQSE SSDLDDVSTP SGSDLETTSG
610 620 630 640 650
SDLESDLESD KEKCKENGKM FKDKVSPLQN LASITNKKEH NNHSVFSASV
660 670 680 690 700
EEQSAVSGAV NDSIKAIASI AEKYFGSTGL VGLQDKKVGA LPYPSMFPLP
710 720 730 740 750
FFPAFSQSMY PFPDRDLRSL PLKMEPQSPS EVKKLQKGSS ESPFDLTTKR
760 770 780 790 800
KDEKPLTSGP SKPSGTPATS QDQPLDLSMG SRGRASGTKL TEPRKNHVFG
810 820 830 840 850
EKKGSNMDTR PSSDGSLQHA RPTPFFMDPI YRVEKRKLTD PLEALKEKYL
860 870 880 890 900
RPSPGFLFHP QMSAIENMAE KLESFSALKP EASELLQSVP SMFSFRAPPN
910 920 930 940 950
TLPENLLRKG KERYTCRYCG KIFPRSANLT RHLRTHTGEQ PYRCKYCDRS
960 970 980 990 1000
FSISSNLQRH VRNIHNKEKP FKCHLCDRCF GQQTNLDRHL KKHENGNMSG
1010 1020 1030 1040 1050
TATSSPHSEL ESAGAILDDK EDAYFTEIRN FIGNSNHGSQ SPRNMEERMN
1060 1070 1080 1090 1100
GSHFKDKKAL ATSQNSDLLD DEEVEDEVLL DEEDEDNDIP GKPRKELGVT
1110 1120 1130 1140 1150
RLDEEIPEDD YEEAGALEMS CKASPVRYKE EDYKSGLSAL DHIRHFTDSL
1160 1170 1180 1190 1200
KMREMEENQY TDAELSSISS SHVPEELKQT LHRKSKSQAY AMMLSLSDKD
1210 1220 1230
SLHPTSHSSS NVWHSMARAA AESSAIQSIS HV
Length:1,232
Mass (Da):138,100
Last modified:March 28, 2018 - v2
Checksum:i044BB6F19DBD1403
GO
Isoform 1Curated (identifier: P14404-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Show »
Length:1,042
Mass (Da):116,848
Checksum:i8DEDF164F536D2FE
GO
Isoform 4Curated (identifier: P14404-3) [UniParc]FASTAAdd to basket
Also known as: Mds1

The sequence of this isoform differs from the canonical sequence as follows:
     128-129: IL → NR
     130-1232: Missing.

Note: Produced by alternative promoter usage. May be due to intron retention.
Show »
Length:129
Mass (Da):14,329
Checksum:i812CD5EB59C36A6E
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ13G3UZ13_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
718Annotation score:
O35700O35700_MOUSE
Evi1delta 105
Mecom evi-1, Evi1
949Annotation score:
Q8CCA6Q8CCA6_MOUSE
MDS1 and EVI1 complex locus protein
Mecom Evi1
795Annotation score:
G3UZT5G3UZT5_MOUSE
Ecotropic viral integration site 1,...
Mecom Evi1, mCG_140922
1,051Annotation score:
G3UYY9G3UYY9_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
606Annotation score:
G3UWJ0G3UWJ0_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
843Annotation score:
G3UYK2G3UYK2_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
949Annotation score:
G3UY46G3UY46_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
52Annotation score:
F6SZX1F6SZX1_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
116Annotation score:
G3UYN3G3UYN3_MOUSE
MDS1 and EVI1 complex locus protein
Mecom
45Annotation score:

Sequence cautioni

The sequence AAA40581 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594871 – 190Missing in isoform 1. Add BLAST190
Alternative sequenceiVSP_059488128 – 129IL → NR in isoform 4. 2
Alternative sequenceiVSP_059489130 – 1232Missing in isoform 4. Add BLAST1103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010015 mRNA Translation: CAA08971.1
M21829 Genomic DNA Translation: AAA40581.1 Different initiation.
AC119995 Genomic DNA No translation available.
AL683891 Genomic DNA No translation available.
AL691419 Genomic DNA No translation available.
AL772145 Genomic DNA No translation available.
AL929377 Genomic DNA No translation available.
PIRiA31591
RefSeqiNP_067417.1, NM_021442.2 [P14404-3]
UniGeneiMm.426829
Mm.56965

Genome annotation databases

EnsembliENSMUST00000108270; ENSMUSP00000103905; ENSMUSG00000027684 [P14404-1]
GeneIDi14013
KEGGimmu:14013
UCSCiuc033hsp.1 mouse [P14404-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010015 mRNA Translation: CAA08971.1
M21829 Genomic DNA Translation: AAA40581.1 Different initiation.
AC119995 Genomic DNA No translation available.
AL683891 Genomic DNA No translation available.
AL691419 Genomic DNA No translation available.
AL772145 Genomic DNA No translation available.
AL929377 Genomic DNA No translation available.
PIRiA31591
RefSeqiNP_067417.1, NM_021442.2 [P14404-3]
UniGeneiMm.426829
Mm.56965

3D structure databases

ProteinModelPortaliP14404
SMRiP14404
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199542, 2 interactors
DIPiDIP-46516N
IntActiP14404, 5 interactors
STRINGi10090.ENSMUSP00000134303

PTM databases

iPTMnetiP14404
PhosphoSitePlusiP14404

Proteomic databases

PaxDbiP14404
PRIDEiP14404

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108270; ENSMUSP00000103905; ENSMUSG00000027684 [P14404-1]
GeneIDi14013
KEGGimmu:14013
UCSCiuc033hsp.1 mouse [P14404-2]

Organism-specific databases

CTDi2122
MGIiMGI:95457 Mecom

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140928
HOGENOMiHOG000231144
HOVERGENiHBG031707
InParanoidiP14404
KOiK04462
PhylomeDBiP14404
TreeFamiTF315309

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

ChiTaRSiMecom mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027684 Expressed in 279 organ(s), highest expression level in pes
CleanExiMM_EVI1
MM_MDS1
ExpressionAtlasiP14404 baseline and differential
GenevisibleiP14404 MM

Family and domain databases

InterProiView protein in InterPro
IPR036970 MECOM
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24393:SF11 PTHR24393:SF11, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMECOM_MOUSE
AccessioniPrimary (citable) accession number: P14404
Secondary accession number(s): G3UWT0, Q9Z1L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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