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UniProtKB - P14378 (GC_BHV1C)
Protein
Envelope glycoprotein C homolog
Gene
gC
Organism
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Functioni
Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans (By similarity).
Plays also a role in host immune evasion by inhibiting the host complement cascade activation.
By similarityGO - Biological processi
- adhesion receptor-mediated virion attachment to host cell Source: UniProtKB-KW
- suppression by virus of host complement activation Source: UniProtKB-KW
- viral entry into host cell Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Envelope glycoprotein C homologAlternative name(s): Glycoprotein GIII |
Gene namesi | Name:gC ORF Names:GIII |
Organismi | Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus) |
Taxonomic identifieri | 10323 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Subcellular locationi
Other locations
- Virion membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- virion membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 475 | Virion surfaceSequence analysisAdd BLAST | 454 | |
Transmembranei | 476 – 496 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 497 – 521 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000038205 | 22 – 521 | Envelope glycoprotein C homologAdd BLAST | 500 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 111 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 159 | PROSITE-ProRule annotation | ||
Glycosylationi | 164 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 208 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Disulfide bondi | 290 ↔ 351 | PROSITE-ProRule annotation | ||
Disulfide bondi | 390 ↔ 447 | PROSITE-ProRule annotation | ||
Disulfide bondi | 394 ↔ 421 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Interacts with host complement component C3; this interaction inhibits host immune response by disregulating complement cascade.
1 PublicationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 227 | Ig-like V-typeAdd BLAST | 73 | |
Domaini | 386 – 451 | Ig-like C2-typeAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 138 | DisorderedSequence analysisAdd BLAST | 115 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 57 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 64 – 80 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 82 – 104 | Pro residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the herpesviridae glycoprotein C family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR001038, GA_GC IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF02124, Marek_A, 1 hit |
PRINTSi | PR00668, GLYCPROTEINC |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P14378-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPLGRAWLI AAIFAWALLS ARRGLAEEAE ASPSPPPSPC PTETESSAGT
60 70 80 90 100
TGATPPTPNS PDATPEDSTP GATTPVGTPE PPSVSEHDPP VTNSTPPPAP
110 120 130 140 150
PEDGRPGGAG NASRDGRPSG GGRPRPPRPS KAPPKERKWM LCEREAVAAS
160 170 180 190 200
YAEPLYVHCG VADNATGGAR LELWFQRVGR FRSTRGDDEA VRNPFPRAPP
210 220 230 240 250
VLLFVAQNGS IAYRSAELGD NYIFPSPADP RNLPLTVRSL TAATEGVYTW
260 270 280 290 300
RRDMGTKSQR KVVTVTTHRA PAVSVEPQPA LEGAGYAAVC RAAEYYPPRS
310 320 330 340 350
TRLHWFRNGY PVEARHARDV FTVDDSGLFS RTSVLTLEDA TPTAHPPNLR
360 370 380 390 400
CDVSWFQSAN MERRFYAAGT PAVYRPPELR VYFEGGEAVC EARCVPEGRV
410 420 430 440 450
SLRWTVRDGI APSRTEQTGV CAERPGLVNL RGVRLLSTTD GPVDYTCTAT
460 470 480 490 500
GYPAPLPEFS ATATYDASPG LIGSPVLVSV VAVACGLGAV GLLLVAASCL
510 520
RRKARVIQPG LTRARALGSA P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27491 Genomic DNA Translation: AAA46054.1 |
PIRi | A32593, VGBEHB |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27491 Genomic DNA Translation: AAA46054.1 |
PIRi | A32593, VGBEHB |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR001038, GA_GC IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF02124, Marek_A, 1 hit |
PRINTSi | PR00668, GLYCPROTEINC |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GC_BHV1C | |
Accessioni | P14378Primary (citable) accession number: P14378 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | June 2, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |