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UniProtKB - P14373 (TRI27_HUMAN)

Protein

Zinc finger protein RFP

Gene

TRIM27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri96 – 127B box-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • metal ion binding Source: ProtInc
  • nucleic acid binding Source: ProtInc
  • SUMO transferase activity Source: Reactome
  • ubiquitin protein ligase activity Source: Reactome
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, Transferase
Biological processTranscription, Transcription regulation, Transport, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-8948751 Regulation of PTEN stability and activity

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14373

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P14373 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein RFP (EC:2.3.2.27)
Alternative name(s):
RING finger protein 76
RING-type E3 ubiquitin transferase TRIM27Curated
Ret finger protein
Tripartite motif-containing protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM27
Synonyms:RFP, RNF76
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204713.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:9975 TRIM27

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602165 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14373

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei315 – 316Breakpoint for translocation to form the TRIM27/RET oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		5987

MalaCards human disease database

More...MalaCardsi		TRIM27

Open Targets

More...OpenTargetsi		ENSG00000204713

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		146 Differentiated thyroid carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162406956

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM27

Domain mapping of disease mutations (DMDM)

More...DMDMi		132517

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562401 – 513Zinc finger protein RFPAdd BLAST513

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14373

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14373

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14373

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14373

PeptideAtlas

More...PeptideAtlasi		P14373

PRoteomics IDEntifications database

More...PRIDEi		P14373

ProteomicsDB human proteome resource

More...ProteomicsDBi		53047
53048 [P14373-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14373

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14373

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis namely within the seminiferous tubules.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204713 Expressed in 223 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...CleanExi		HS_TRIM27

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14373 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14373 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA048684
HPA053408

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with herpes simplex virus protein ICP0.10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself17EBI-719493,EBI-719493
A8K9323EBI-719493,EBI-10174671
E5KN553EBI-719493,EBI-10176944
ABCF3Q9NUQ87EBI-719493,EBI-717672
AENQ8WTP83EBI-719493,EBI-8637627
AESQ081173EBI-719493,EBI-717810
AMMECR1Q9Y4X03EBI-719493,EBI-8583355
AMOTL2Q9Y2J4-43EBI-719493,EBI-10187270
ARHGEF3Q9NR815EBI-719493,EBI-10312733
ARHGEF5Q127745EBI-719493,EBI-602199
ARMC7Q9H6L45EBI-719493,EBI-742909
ARPINQ7Z6K53EBI-719493,EBI-10258086
ATPAF2Q8N5M16EBI-719493,EBI-1166928
AXIN1A0A0S2Z4M13EBI-719493,EBI-16429430
AXIN1O151693EBI-719493,EBI-710484
BABAM1Q9NWV85EBI-719493,EBI-745725
BAG1Q999336EBI-719493,EBI-1030678
BAG5Q9UL155EBI-719493,EBI-356517
BEX2Q9BXY83EBI-719493,EBI-745073
BMP7A8K5713EBI-719493,EBI-10174327
BYSLQ138955EBI-719493,EBI-358049
CCDC102BQ68D865EBI-719493,EBI-10171570
CCDC198Q9NVL83EBI-719493,EBI-10238351
CCDC87Q9NVE43EBI-719493,EBI-749261
CCDC92Q53HC03EBI-719493,EBI-719994
CCHCR1Q8TD31-33EBI-719493,EBI-10175300
CDC20BQ86Y333EBI-719493,EBI-10260504
CDC23Q9UJX24EBI-719493,EBI-396137
CDK18Q070023EBI-719493,EBI-746238
CDKL3Q8IVW45EBI-719493,EBI-3919850
CHCHD3Q9NX633EBI-719493,EBI-743375
CKS1BP610243EBI-719493,EBI-456371
CLK2P497603EBI-719493,EBI-750020
CPNE2Q96FN45EBI-719493,EBI-7097057
CSRP2Q165273EBI-719493,EBI-2959737
CWF19L2Q2TBE05EBI-719493,EBI-5453285
DCXO436023EBI-719493,EBI-8646694
DDX6P261965EBI-719493,EBI-351257
DMRT3Q9NQL95EBI-719493,EBI-9679045
DTNBP1Q96EV83EBI-719493,EBI-465804
EHHADHQ084265EBI-719493,EBI-2339219
EIF3DO153715EBI-719493,EBI-353818
EIF3EP602287EBI-719493,EBI-347740
EIF4EP067303EBI-719493,EBI-73440
EIF4E2O605733EBI-719493,EBI-398610
FAM110AQ9BQ893EBI-719493,EBI-1752811
FAM126AA0A0S2Z6M93EBI-719493,EBI-16428876
FAM126AQ9BYI36EBI-719493,EBI-11065686
FAM126BQ8IXS83EBI-719493,EBI-8787606
FAM193BQ96PV7-23EBI-719493,EBI-10292648
FAM214AQ32MH53EBI-719493,EBI-2866142
FAM214BQ7L5A35EBI-719493,EBI-745689
FAM83AQ86UY53EBI-719493,EBI-1384254
FANCMQ8IYD83EBI-719493,EBI-3957237
FARS2O953633EBI-719493,EBI-2513774
FBF1Q8TES7-63EBI-719493,EBI-10244131
FBXW5Q969U65EBI-719493,EBI-741068
FHL3Q96C983EBI-719493,EBI-10229248
FLJ38668C0H5X23EBI-719493,EBI-10176227
FNDC11Q9BVV23EBI-719493,EBI-744935
FOXB1Q998533EBI-719493,EBI-3916225
FOXC2Q999583EBI-719493,EBI-3956892
GATAD2BQ8WXI93EBI-719493,EBI-923440
GEMP550405EBI-719493,EBI-744104
GFAPP141366EBI-719493,EBI-744302
GFM2Q969S93EBI-719493,EBI-2371750
GLYCTKQ8IVS83EBI-719493,EBI-748515
GNPDA2Q8TDQ73EBI-719493,EBI-10275006
GPANK1O958725EBI-719493,EBI-751540
GRB2P629933EBI-719493,EBI-401755
HAUS1Q96CS23EBI-719493,EBI-2514791
HGSA0A0S2Z4Q43EBI-719493,EBI-16429135
ILKQ134183EBI-719493,EBI-747644
INPP5JQ157353EBI-719493,EBI-10236940
IQCNQ9H0B33EBI-719493,EBI-745878
IQUBQ8NA543EBI-719493,EBI-10220600
JOSD1Q150404EBI-719493,EBI-2510602
KANSL1Q7Z3B33EBI-719493,EBI-740244
KAT14Q9H8E85EBI-719493,EBI-750907
KAT5Q929933EBI-719493,EBI-399080
KCTD9Q7L2735EBI-719493,EBI-4397613
KIFC3Q9BVG83EBI-719493,EBI-2125614
KRT1P042644EBI-719493,EBI-298429
LASP1Q148473EBI-719493,EBI-742828
LENG1Q96BZ83EBI-719493,EBI-726510
LGALS14Q8TCE95EBI-719493,EBI-10274069
LINC00526Q96FQ73EBI-719493,EBI-10286106
LINGO1Q96FE53EBI-719493,EBI-719955
LMO1P258003EBI-719493,EBI-8639312
MAD2L2Q9UI953EBI-719493,EBI-77889
MAPKBP1O603363EBI-719493,EBI-947402
MAT2BQ9NZL93EBI-719493,EBI-10317491
MCM7P339933EBI-719493,EBI-355924
MEMO1Q9Y3163EBI-719493,EBI-1104564
MIA3Q5JRA6-23EBI-719493,EBI-10244342
MID2Q9UJV3-23EBI-719493,EBI-10172526
MOSP005403EBI-719493,EBI-1757866
MRPL40Q9NQ503EBI-719493,EBI-1053902
MTMR6Q9Y2173EBI-719493,EBI-766064
NCK2O436395EBI-719493,EBI-713635
NDEL1Q9GZM86EBI-719493,EBI-928842
NEBLO760413EBI-719493,EBI-2880203
NEDD9Q145114EBI-719493,EBI-2108053
NEIL2Q969S25EBI-719493,EBI-10281234
NEK6Q9HC983EBI-719493,EBI-740364
NELFEP186153EBI-719493,EBI-348444
NIF3L1Q9GZT83EBI-719493,EBI-740897
NME7Q9Y5B83EBI-719493,EBI-744782
NOD2Q9HC2910EBI-719493,EBI-7445625
NOTCH2NLAQ7Z3S93EBI-719493,EBI-945833
NR1D2Q6NSM05EBI-719493,EBI-10250949
NUDT21O438095EBI-719493,EBI-355720
OAS1P009733EBI-719493,EBI-3932815
OAS1P00973-25EBI-719493,EBI-12081862
PIK3C2BO007505EBI-719493,EBI-641107
PIMREGQ9BSJ69EBI-719493,EBI-2568609
PLEKHN1Q494U13EBI-719493,EBI-10241513
POLE2P562825EBI-719493,EBI-713847
POLR1CO151605EBI-719493,EBI-1055079
POLR3CQ9BUI45EBI-719493,EBI-5452779
PPLO604373EBI-719493,EBI-368321
PPP1R18Q6NYC86EBI-719493,EBI-2557469
PRAM1Q96QH23EBI-719493,EBI-2860740
PRKAA1Q131313EBI-719493,EBI-1181405
PRPF31Q8WWY38EBI-719493,EBI-1567797
PSMA1P257865EBI-719493,EBI-359352
PSMB1P206185EBI-719493,EBI-372273
PSMB3P497205EBI-719493,EBI-603340
PTPMT1Q8WUK03EBI-719493,EBI-7199479
PTPN23Q9H3S73EBI-719493,EBI-724478
PUS7LQ9H0K65EBI-719493,EBI-5464419
RAB7L1Q6FGU73EBI-719493,EBI-10249635
RAMACQ9BTL33EBI-719493,EBI-744023
RBM23Q86U063EBI-719493,EBI-780319
RBM41Q96IZ53EBI-719493,EBI-740773
RCOR3Q9P2K33EBI-719493,EBI-743428
RHPN1Q8TCX53EBI-719493,EBI-746325
RIBC1Q8N4433EBI-719493,EBI-10265323
RNF213Q63HN8-63EBI-719493,EBI-10248548
RNF6A0A0S2Z4G93EBI-719493,EBI-16428950
RXRBP28702-33EBI-719493,EBI-16429492
SCNM1Q9BWG65EBI-719493,EBI-748391
SDCBPO005603EBI-719493,EBI-727004
SFRS2Q6NXQ03EBI-719493,EBI-10251550
SH2D4AQ9H7883EBI-719493,EBI-747035
SH2D4AQ9H788-23EBI-719493,EBI-10308083
SIAH1Q8IUQ43EBI-719493,EBI-747107
SLC15A3Q05CH43EBI-719493,EBI-10223741
SNRPAP090125EBI-719493,EBI-607085
SNRPB2P085795EBI-719493,EBI-1053651
SORBS3O605043EBI-719493,EBI-741237
SPATA2Q9UM823EBI-719493,EBI-744066
SPATC1LQ9H0A93EBI-719493,EBI-372911
STAMBPL1Q96FJ05EBI-719493,EBI-745021
STK16O757163EBI-719493,EBI-749295
STK25O005066EBI-719493,EBI-618295
TBC1D22BQ9NU193EBI-719493,EBI-8787464
TCEA2Q155605EBI-719493,EBI-710310
TCHPQ9BT923EBI-719493,EBI-740781
TEAD4D3DUQ63EBI-719493,EBI-10176734
TEAD4Q155615EBI-719493,EBI-747736
TMSB4XQ0P5Q03EBI-719493,EBI-10226570
TPM3Q5VU623EBI-719493,EBI-10184033
TPRKBQ9Y3C43EBI-719493,EBI-750123
TRIM42Q8IWZ53EBI-719493,EBI-5235829
TSGA10IPQ3SY003EBI-719493,EBI-10241197
TSHZ3Q63HK53EBI-719493,EBI-9053916
TTLL10Q6ZVT03EBI-719493,EBI-7844656
TUFT1Q9NNX14EBI-719493,EBI-2557363
TXNDC9O145303EBI-719493,EBI-707554
UBE2KP610868EBI-719493,EBI-473850
USE1Q9NZ433EBI-719493,EBI-742842
USP2O756045EBI-719493,EBI-743272
UTP23Q9BRU93EBI-719493,EBI-5457544
VPS25Q9BRG15EBI-719493,EBI-741945
VPS28Q548N13EBI-719493,EBI-10243107
VPS28Q9UK413EBI-719493,EBI-727424
WDYHV1Q96HA85EBI-719493,EBI-741158
WT1-ASQ062503EBI-719493,EBI-10223946
XPAP230255EBI-719493,EBI-295222
YJU2Q9BW853EBI-719493,EBI-10300345
ZBTB16Q055165EBI-719493,EBI-711925
ZC2HC1CQ53FD03EBI-719493,EBI-740767
ZFC3H1G3V1X13EBI-719493,EBI-6448783
ZFYVE21Q9BQ243EBI-719493,EBI-2849569
ZGPATA0A0S2Z6H03EBI-719493,EBI-16428984
ZGPATQ8N5A53EBI-719493,EBI-3439227
ZGPATQ8N5A5-28EBI-719493,EBI-10183064
ZMYND19Q96E353EBI-719493,EBI-746595
ZNF250P15622-33EBI-719493,EBI-10177272
ZNF417Q8TAU36EBI-719493,EBI-740727
ZNF446Q9NWS9-23EBI-719493,EBI-740232
ZNF572Q7Z3I76EBI-719493,EBI-10172590
ZNF581Q9P0T45EBI-719493,EBI-745520
ZNF688A0A0S2Z5X46EBI-719493,EBI-16429014
ZNF688A0A0S2Z6P06EBI-719493,EBI-16429989
ZNF79Q159373EBI-719493,EBI-10237274

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111919, 360 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14373

Protein interaction database and analysis system

More...IntActi		P14373, 378 interactors

Molecular INTeraction database

More...MINTi		P14373

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366404

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P14373

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14373

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini298 – 492B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili132 – 172Sequence analysisAdd BLAST41
Coiled coili282 – 311Sequence analysisAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri96 – 127B box-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITF0 Eukaryota
ENOG410Z5PW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158537

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG001357

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14373

KEGG Orthology (KO)

More...KOi		K12009

Identification of Orthologs from Complete Genome Data

More...OMAi		XSLTQME

Database of Orthologous Groups

More...OrthoDBi		423686at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14373

TreeFam database of animal gene trees

More...TreeFami		TF350411

Family and domain databases

Conserved Domains Database

More...CDDi		cd00021 BBOX, 1 hit
cd15814 SPRY_PRY_TRIM27, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035791 SPRY/PRY_TRIM27
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR020457 Znf_B-box_chordata
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01406 BBOXZNFINGER
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P14373-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN 
        60         70         80         90        100
VSCPQCRETF PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR 
       110        120        130        140        150
EPLKLYCEED QMPICVVCDR SREHRGHSVL PLEEAVEGFK EQIQNQLDHL 
       160        170        180        190        200
KRVKDLKKRR RAQGEQARAE LLSLTQMERE KIVWEFEQLY HSLKEHEYRL 
       210        220        230        240        250
LARLEELDLA IYNSINGAIT QFSCNISHLS SLIAQLEEKQ QQPTRELLQD 
       260        270        280        290        300
IGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS 
       310        320        330        340        350
DMEKIQELRE AQLYSVDVTL DPDTAYPSLI LSDNLRQVRY SYLQQDLPDN 
       360        370        380        390        400
PERFNLFPCV LGSPCFIAGR HYWEVEVGDK AKWTIGVCED SVCRKGGVTS 
       410        420        430        440        450
APQNGFWAVS LWYGKEYWAL TSPMTALPLR TPLQRVGIFL DYDAGEVSFY 
       460        470        480        490        500
NVTERCHTFT FSHATFCGPV RPYFSLSYSG GKSAAPLIIC PMSGIDGFSG 
       510 
HVGNHGHSME TSP
Length:513
Mass (Da):58,490
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F963D9048D8A731
GO
Isoform Beta (identifier: P14373-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-358: FNLFP → SPSTT
     359-513: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):41,439
Checksum:iD722163761427340
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JIZ4A0A0G2JIZ4_HUMAN
Zinc finger protein RFP
TRIM27
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y551H0Y551_HUMAN
Zinc finger protein RFP
TRIM27
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9N6A0A140T9N6_HUMAN
Zinc finger protein RFP
TRIM27
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9V9A0A140T9V9_HUMAN
Zinc finger protein RFP
TRIM27
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9B9A0A140T9B9_HUMAN
Zinc finger protein RFP
TRIM27
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9Q6A0A140T9Q6_HUMAN
Zinc finger protein RFP
TRIM27
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti446E → K in AAH66924 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010896354 – 358FNLFP → SPSTT in isoform Beta. 1 Publication5
Alternative sequenceiVSP_010897359 – 513Missing in isoform Beta. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03407 mRNA Translation: AAA36564.1
AF230393 mRNA Translation: AAG50172.1
AF230394 mRNA Translation: AAG50173.1
AL662859 Genomic DNA No translation available.
AL662871 Genomic DNA No translation available.
BX000360 Genomic DNA No translation available.
BX537153 Genomic DNA No translation available.
BX005144 Genomic DNA No translation available.
BX119924 Genomic DNA No translation available.
CR759942 Genomic DNA No translation available.
Z84474, Z84476 Genomic DNA Translation: CAB06480.2
Z84476, Z84474 Genomic DNA Translation: CAI19959.1
CH471081 Genomic DNA Translation: EAX03176.1
CH471081 Genomic DNA Translation: EAX03177.1
BC013580 mRNA Translation: AAH13580.1
BC066924 mRNA Translation: AAH66924.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4654.1 [P14373-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A28101 TVHURF

NCBI Reference Sequences

More...RefSeqi		NP_006501.1, NM_006510.4 [P14373-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.440382

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377194; ENSP00000366399; ENSG00000204713 [P14373-2]
ENST00000377199; ENSP00000366404; ENSG00000204713 [P14373-1]
ENST00000400720; ENSP00000383555; ENSG00000215641 [P14373-1]
ENST00000412687; ENSP00000416281; ENSG00000234495 [P14373-2]
ENST00000417660; ENSP00000411026; ENSG00000215641 [P14373-2]
ENST00000427689; ENSP00000388622; ENSG00000237071 [P14373-2]
ENST00000431123; ENSP00000414793; ENSG00000229006 [P14373-1]
ENST00000435528; ENSP00000405229; ENSG00000237071 [P14373-1]
ENST00000437160; ENSP00000392787; ENSG00000234495 [P14373-1]
ENST00000452265; ENSP00000412445; ENSG00000229006 [P14373-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5987

UCSC genome browser

More...UCSCi		uc003nlr.4 human [P14373-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03407 mRNA Translation: AAA36564.1
AF230393 mRNA Translation: AAG50172.1
AF230394 mRNA Translation: AAG50173.1
AL662859 Genomic DNA No translation available.
AL662871 Genomic DNA No translation available.
BX000360 Genomic DNA No translation available.
BX537153 Genomic DNA No translation available.
BX005144 Genomic DNA No translation available.
BX119924 Genomic DNA No translation available.
CR759942 Genomic DNA No translation available.
Z84474, Z84476 Genomic DNA Translation: CAB06480.2
Z84476, Z84474 Genomic DNA Translation: CAI19959.1
CH471081 Genomic DNA Translation: EAX03176.1
CH471081 Genomic DNA Translation: EAX03177.1
BC013580 mRNA Translation: AAH13580.1
BC066924 mRNA Translation: AAH66924.1
CCDSiCCDS4654.1 [P14373-1]
PIRiA28101 TVHURF
RefSeqiNP_006501.1, NM_006510.4 [P14373-1]
UniGeneiHs.440382

3D structure databases

ProteinModelPortaliP14373
SMRiP14373
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111919, 360 interactors
CORUMiP14373
IntActiP14373, 378 interactors
MINTiP14373
STRINGi9606.ENSP00000366404

Protein family/group databases

MoonDBiP14373 Predicted

PTM databases

iPTMnetiP14373
PhosphoSitePlusiP14373

Polymorphism and mutation databases

BioMutaiTRIM27
DMDMi132517

Proteomic databases

EPDiP14373
jPOSTiP14373
MaxQBiP14373
PaxDbiP14373
PeptideAtlasiP14373
PRIDEiP14373
ProteomicsDBi53047
53048 [P14373-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5987
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377194; ENSP00000366399; ENSG00000204713 [P14373-2]
ENST00000377199; ENSP00000366404; ENSG00000204713 [P14373-1]
ENST00000400720; ENSP00000383555; ENSG00000215641 [P14373-1]
ENST00000412687; ENSP00000416281; ENSG00000234495 [P14373-2]
ENST00000417660; ENSP00000411026; ENSG00000215641 [P14373-2]
ENST00000427689; ENSP00000388622; ENSG00000237071 [P14373-2]
ENST00000431123; ENSP00000414793; ENSG00000229006 [P14373-1]
ENST00000435528; ENSP00000405229; ENSG00000237071 [P14373-1]
ENST00000437160; ENSP00000392787; ENSG00000234495 [P14373-1]
ENST00000452265; ENSP00000412445; ENSG00000229006 [P14373-2]
GeneIDi5987
KEGGihsa:5987
UCSCiuc003nlr.4 human [P14373-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5987
DisGeNETi5987
EuPathDBiHostDB:ENSG00000204713.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM27
HGNCiHGNC:9975 TRIM27
HPAiHPA048684
HPA053408
MalaCardsiTRIM27
MIMi602165 gene
neXtProtiNX_P14373
OpenTargetsiENSG00000204713
Orphaneti146 Differentiated thyroid carcinoma
PharmGKBiPA162406956

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITF0 Eukaryota
ENOG410Z5PW LUCA
GeneTreeiENSGT00940000158537
HOVERGENiHBG001357
InParanoidiP14373
KOiK12009
OMAiXSLTQME
OrthoDBi423686at2759
PhylomeDBiP14373
TreeFamiTF350411

Enzyme and pathway databases

ReactomeiR-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-8948751 Regulation of PTEN stability and activity
SIGNORiP14373

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM27 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIM27

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5987

Protein Ontology

More...PROi		PR:P14373

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204713 Expressed in 223 organ(s), highest expression level in right lobe of liver
CleanExiHS_TRIM27
ExpressionAtlasiP14373 baseline and differential
GenevisibleiP14373 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15814 SPRY_PRY_TRIM27, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035791 SPRY/PRY_TRIM27
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR020457 Znf_B-box_chordata
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01406 BBOXZNFINGER
PR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14373
Secondary accession number(s): A2BE15
, Q5RJA8, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 16, 2019
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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