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UniProtKB - P14373 (TRI27_HUMAN)

Entry version 232 (23 Feb 2022)
Sequence version 1 (01 Jan 1990)
Previous versions | rss
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Protein

Zinc finger protein RFP

Gene

TRIM27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi96ZincPROSITE-ProRule annotation1
Metal bindingi99ZincPROSITE-ProRule annotation1
Metal bindingi118ZincPROSITE-ProRule annotation1
Metal bindingi124ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri96 – 127B box-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, Transferase
Biological processTranscription, Transcription regulation, Transport, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14373

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-9635465, Suppression of apoptosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14373

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14373

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P14373, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein RFP (EC:2.3.2.27)
Alternative name(s):
RING finger protein 76
RING-type E3 ubiquitin transferase TRIM27Curated
Ret finger protein
Tripartite motif-containing protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM27
Synonyms:RFP, RNF76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9975, TRIM27

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602165, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14373

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204713

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei315 – 316Breakpoint for translocation to form the TRIM27/RET oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		5987

MalaCards human disease database

More...MalaCardsi		TRIM27

Open Targets

More...OpenTargetsi		ENSG00000204713

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		146, Differentiated thyroid carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162406956

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14373, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM27

Domain mapping of disease mutations (DMDM)

More...DMDMi		132517

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562401 – 513Zinc finger protein RFPAdd BLAST513

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14373

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14373

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14373

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14373

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14373

PeptideAtlas

More...PeptideAtlasi		P14373

PRoteomics IDEntifications database

More...PRIDEi		P14373

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53047 [P14373-1]
53048 [P14373-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14373, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14373

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P14373

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14373

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis namely within the seminiferous tubules.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204713, Expressed in right lobe of liver and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14373, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14373, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204713, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimerizes.

Interacts with PML, EIF3S6, EPC1, CHD4 and EID1.

Interacts with MAGED4, MAGEF1 and MAGEL2.

Interacts with herpes simplex virus protein ICP0.

10 Publications

(Microbial infection) Interacts with M.tuberculosis PtpA, whick blocks TRIM27-promoted JNK/p38 MAPK pathway activation and cell apoptosis.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P14373
With#Exp.IntAct
ABCF3 [Q9NUQ8]7EBI-719493,EBI-717672
ACSF3 [Q4G176]3EBI-719493,EBI-10714818
AEN [Q8WTP8]3EBI-719493,EBI-8637627
AMMECR1 [Q9Y4X0]3EBI-719493,EBI-8583355
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-719493,EBI-10187270
AP1M1 [Q9BXS5]3EBI-719493,EBI-541426
ARHGEF3 [Q9NR81]8EBI-719493,EBI-10312733
ARHGEF5 [Q12774]6EBI-719493,EBI-602199
ARID5A [Q03989]3EBI-719493,EBI-948603
ARMC7 [Q9H6L4]6EBI-719493,EBI-742909
ARPIN [Q7Z6K5]3EBI-719493,EBI-10258086
ATPAF2 [Q8N5M1]6EBI-719493,EBI-1166928
AXIN1 [A0A0S2Z4M1]3EBI-719493,EBI-16429430
AXIN1 [O15169]3EBI-719493,EBI-710484
BABAM1 [Q9NWV8]7EBI-719493,EBI-745725
BAG1 [Q99933]7EBI-719493,EBI-1030678
BAG3 [O95817]3EBI-719493,EBI-747185
BAG5 [Q9UL15]6EBI-719493,EBI-356517
BEX2 [Q9BXY8]3EBI-719493,EBI-745073
BMP7 [A8K571]3EBI-719493,EBI-10174327
BMP7 [P18075]4EBI-719493,EBI-1035195
BYSL [Q13895]6EBI-719493,EBI-358049
CAPN7 [Q9Y6W3]3EBI-719493,EBI-1765641
CARD10 [Q9BWT7]3EBI-719493,EBI-3866279
CATSPER1 [Q8NEC5]3EBI-719493,EBI-744545
CBX8 [Q9HC52]3EBI-719493,EBI-712912
CCDC102B [Q68D86]6EBI-719493,EBI-10171570
CCDC185 [Q8N715]3EBI-719493,EBI-740814
CCDC198 [Q9NVL8]3EBI-719493,EBI-10238351
CCDC87 [Q9NVE4]3EBI-719493,EBI-749261
CCDC92 [Q53HC0]3EBI-719493,EBI-719994
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-719493,EBI-10175300
CDC20B [Q86Y33]3EBI-719493,EBI-10260504
CDC20B - isoform 5 [Q86Y33-5]3EBI-719493,EBI-11983537
CDC23 [Q9UJX2]4EBI-719493,EBI-396137
CDC7 [O00311]3EBI-719493,EBI-374980
CDK18 [Q07002]3EBI-719493,EBI-746238
CDKL3 [Q8IVW4]6EBI-719493,EBI-3919850
CFAP206 [Q8IYR0]3EBI-719493,EBI-749051
CHCHD3 [Q9NX63]3EBI-719493,EBI-743375
CKS1B [P61024]3EBI-719493,EBI-456371
CLK2 [P49760]3EBI-719493,EBI-750020
CNNM3 [Q8NE01]3EBI-719493,EBI-741032
COX5B [P10606]3EBI-719493,EBI-1053725
CPNE2 [Q96FN4]6EBI-719493,EBI-7097057
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-719493,EBI-12012272
CREB5 - isoform 3 [Q02930-3]3EBI-719493,EBI-10192698
CSRP2 [Q16527]3EBI-719493,EBI-2959737
CWF19L2 [Q2TBE0]6EBI-719493,EBI-5453285
DBF4B - isoform 2 [Q8NFT6-2]3EBI-719493,EBI-12205861
DCX [O43602]3EBI-719493,EBI-8646694
DDX6 [P26196]6EBI-719493,EBI-351257
DMRT3 [Q9NQL9]6EBI-719493,EBI-9679045
DTNB - isoform 5 [O60941-5]3EBI-719493,EBI-11984733
DTNBP1 [Q96EV8]3EBI-719493,EBI-465804
EHHADH [Q08426]6EBI-719493,EBI-2339219
EIF3D [O15371]6EBI-719493,EBI-353818
EIF3E [P60228]7EBI-719493,EBI-347740
EIF4A3 [P38919]3EBI-719493,EBI-299104
EIF4E [P06730]5EBI-719493,EBI-73440
EIF4E2 [O60573]3EBI-719493,EBI-398610
ENKD1 [Q9H0I2]3EBI-719493,EBI-744099
ERCC3 [P19447]4EBI-719493,EBI-1183307
EXOC8 [Q8IYI6]3EBI-719493,EBI-742102
FAM110A [Q9BQ89]3EBI-719493,EBI-1752811
FAM126A [A0A0S2Z6M9]3EBI-719493,EBI-16428876
FAM126A [Q9BYI3]6EBI-719493,EBI-11065686
FAM126B [Q8IXS8]3EBI-719493,EBI-8787606
FAM161A [Q3B820]3EBI-719493,EBI-719941
FAM193B - isoform 2 [Q96PV7-2]3EBI-719493,EBI-10292648
FAM214A [Q32MH5]3EBI-719493,EBI-2866142
FAM214B [Q7L5A3]7EBI-719493,EBI-745689
FAM83A [Q86UY5]3EBI-719493,EBI-1384254
FAM90A1 [Q86YD7]3EBI-719493,EBI-6658203
FANCM [Q8IYD8]3EBI-719493,EBI-3957237
FARS2 [O95363]3EBI-719493,EBI-2513774
FASTKD5 [Q7L8L6]3EBI-719493,EBI-747570
FBF1 - isoform 6 [Q8TES7-6]3EBI-719493,EBI-10244131
FBXW5 [Q969U6]6EBI-719493,EBI-741068
FHL3 [Q96C98]3EBI-719493,EBI-10229248
FLJ38668 [C0H5X2]3EBI-719493,EBI-10176227
FNDC11 [Q9BVV2]3EBI-719493,EBI-744935
FOXB1 [Q99853]3EBI-719493,EBI-3916225
FOXC2 [Q99958]3EBI-719493,EBI-3956892
GADD45GIP1 [Q8TAE8]3EBI-719493,EBI-372506
GAS2L2 [Q8NHY3]3EBI-719493,EBI-7960826
GATAD2B [Q8WXI9]3EBI-719493,EBI-923440
GEM [P55040]6EBI-719493,EBI-744104
GFAP [P14136]6EBI-719493,EBI-744302
GFM2 [Q969S9]3EBI-719493,EBI-2371750
GLYCTK [Q8IVS8]3EBI-719493,EBI-748515
GNE - isoform 2 [Q9Y223-2]3EBI-719493,EBI-11975289
GNPDA2 [Q8TDQ7]4EBI-719493,EBI-10275006
GNPDA2 - isoform 2 [Q8TDQ7-2]3EBI-719493,EBI-12197555
GPANK1 [O95872]7EBI-719493,EBI-751540
GPKOW [Q92917]3EBI-719493,EBI-746309
GRB14 [Q14449]3EBI-719493,EBI-2680889
GRB2 [P62993]3EBI-719493,EBI-401755
GSE1 [Q14687]5EBI-719493,EBI-372619
HAPLN2 [Q9GZV7]3EBI-719493,EBI-11956675
HAUS1 [Q96CS2]3EBI-719493,EBI-2514791
hCG_1987119 [A0A024R8L2]3EBI-719493,EBI-14103818
HCK - isoform 2 [P08631-2]3EBI-719493,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-719493,EBI-11953488
HGS [A0A0S2Z4Q4]3EBI-719493,EBI-16429135
HGS [O14964]3EBI-719493,EBI-740220
HIP1R - isoform 2 [O75146-2]3EBI-719493,EBI-12292427
HOXB5 [P09067]3EBI-719493,EBI-3893317
HOXB9 [P17482]3EBI-719493,EBI-745290
HOXC8 [P31273]3EBI-719493,EBI-1752118
IGFN1 - isoform 5 [Q86VF2-5]3EBI-719493,EBI-11955401
IL16 - isoform 2 [Q14005-2]3EBI-719493,EBI-17178971
ILF2 [Q12905]3EBI-719493,EBI-357925
ILK [Q13418]4EBI-719493,EBI-747644
INO80B [Q9C086]3EBI-719493,EBI-715611
INPP5J [Q15735]3EBI-719493,EBI-10236940
IP6K3 [Q96PC2]3EBI-719493,EBI-10990676
IQCN [Q9H0B3]3EBI-719493,EBI-745878
IQUB [Q8NA54]3EBI-719493,EBI-10220600
JOSD1 [Q15040]4EBI-719493,EBI-2510602
KANSL1 [Q7Z3B3]4EBI-719493,EBI-740244
KAT14 [Q9H8E8]6EBI-719493,EBI-750907
KAT5 [Q92993]3EBI-719493,EBI-399080
KCTD9 [Q7L273]6EBI-719493,EBI-4397613
KIFC3 [Q9BVG8]3EBI-719493,EBI-2125614
KRT1 [P04264]4EBI-719493,EBI-298429
KRT3 [P12035]3EBI-719493,EBI-2430095
KRT75 [O95678]3EBI-719493,EBI-2949715
KRT76 [Q01546]3EBI-719493,EBI-2952745
LAGE3 [Q14657]3EBI-719493,EBI-1052105
LASP1 [Q14847]3EBI-719493,EBI-742828
LENG1 [Q96BZ8]3EBI-719493,EBI-726510
LGALS14 [Q8TCE9]6EBI-719493,EBI-10274069
LINC00526 [Q96FQ7]3EBI-719493,EBI-10286106
LINGO1 [Q96FE5]3EBI-719493,EBI-719955
LMNB2 [Q03252]3EBI-719493,EBI-2830427
LMO1 [P25800]3EBI-719493,EBI-8639312
LMO4 [P61968]3EBI-719493,EBI-2798728
LNX1 [Q8TBB1]3EBI-719493,EBI-739832
LONRF1 [Q17RB8]3EBI-719493,EBI-2341787
MAD2L2 [Q9UI95]3EBI-719493,EBI-77889
MAGOHB [Q96A72]3EBI-719493,EBI-746778
MAPKBP1 [O60336]3EBI-719493,EBI-947402
MAT2B [Q9NZL9]3EBI-719493,EBI-10317491
MCM7 [P33993]3EBI-719493,EBI-355924
MEMO1 [Q9Y316]3EBI-719493,EBI-1104564
MGC50722 [Q8IVT4]3EBI-719493,EBI-14086479
MIA3 - isoform 2 [Q5JRA6-2]3EBI-719493,EBI-10244342
MID2 - isoform 2 [Q9UJV3-2]3EBI-719493,EBI-10172526
MOS [P00540]3EBI-719493,EBI-1757866
MRPL40 [Q9NQ50]3EBI-719493,EBI-1053902
MSRB1 [Q9NZV6]3EBI-719493,EBI-12330065
MTMR6 [Q9Y217]3EBI-719493,EBI-766064
NCK2 [O43639]6EBI-719493,EBI-713635
NCOA1 [Q15788]3EBI-719493,EBI-455189
NDEL1 [Q9GZM8]7EBI-719493,EBI-928842
NEBL [O76041]3EBI-719493,EBI-2880203
NEDD9 [Q14511]4EBI-719493,EBI-2108053
NEIL2 [Q969S2]6EBI-719493,EBI-10281234
NEK6 [Q9HC98]3EBI-719493,EBI-740364
NEK6 - isoform 4 [Q9HC98-4]3EBI-719493,EBI-11750983
NELFE [P18615]3EBI-719493,EBI-348444
NIF3L1 [Q9GZT8]5EBI-719493,EBI-740897
NME7 [Q9Y5B8]3EBI-719493,EBI-744782
NOD2 [Q9HC29]10EBI-719493,EBI-7445625
NOTCH2NLA [Q7Z3S9]3EBI-719493,EBI-945833
NR1D2 [Q6NSM0]7EBI-719493,EBI-10250949
NTAQ1 [Q96HA8]6EBI-719493,EBI-741158
NUDT21 [O43809]6EBI-719493,EBI-355720
OAS1 [P00973]5EBI-719493,EBI-3932815
OAS1 - isoform p42 [P00973-2]6EBI-719493,EBI-12081862
P2RX7 [Q99572]3EBI-719493,EBI-1753251
PIBF1 [Q4G0R1]3EBI-719493,EBI-14066006
PIK3C2B [O00750]5EBI-719493,EBI-641107
PIMREG [Q9BSJ6]9EBI-719493,EBI-2568609
PIN1 [Q13526]3EBI-719493,EBI-714158
PKN1 [Q16512]3EBI-719493,EBI-602382
PLEKHN1 [Q494U1]3EBI-719493,EBI-10241513
POLE2 [P56282]7EBI-719493,EBI-713847
POLR1C [O15160]6EBI-719493,EBI-1055079
POLR3C [Q9BUI4]6EBI-719493,EBI-5452779
POM121 - isoform 2 [Q96HA1-2]3EBI-719493,EBI-11956563
PPL [O60437]3EBI-719493,EBI-368321
PPP1R18 [Q6NYC8]7EBI-719493,EBI-2557469
PRAM1 [Q96QH2]3EBI-719493,EBI-2860740
PRKAA1 [Q13131]3EBI-719493,EBI-1181405
PRPF18 [Q99633]3EBI-719493,EBI-2798416
PRPF31 [Q8WWY3]8EBI-719493,EBI-1567797
PRR35 [P0CG20]3EBI-719493,EBI-11986293
PSMA1 [P25786]6EBI-719493,EBI-359352
PSMB1 [P20618]8EBI-719493,EBI-372273
PSMB3 [P49720]6EBI-719493,EBI-603340
PTPMT1 [Q8WUK0]3EBI-719493,EBI-7199479
PTPN23 [Q9H3S7]3EBI-719493,EBI-724478
PUS7L [Q9H0K6]7EBI-719493,EBI-5464419
QARS1 [P47897]3EBI-719493,EBI-347462
RAB29 [O14966]3EBI-719493,EBI-372165
RAB7L1 [Q6FGU7]3EBI-719493,EBI-10249635
RAMAC [Q9BTL3]3EBI-719493,EBI-744023
RBM23 [Q86U06]3EBI-719493,EBI-780319
RBM41 [Q96IZ5]3EBI-719493,EBI-740773
RCOR3 [Q9P2K3]3EBI-719493,EBI-743428
RHPN1 [Q8TCX5]3EBI-719493,EBI-746325
RIBC1 [Q8N443]3EBI-719493,EBI-10265323
RIN1 [Q13671]3EBI-719493,EBI-366017
RNF213 - isoform 4 [Q63HN8-6]3EBI-719493,EBI-10248548
RNF6 [A0A0S2Z4G9]3EBI-719493,EBI-16428950
RSPH14 [Q9UHP6]3EBI-719493,EBI-748350
RXRB - isoform 2 [P28702-3]3EBI-719493,EBI-16429492
SCNM1 [Q9BWG6]6EBI-719493,EBI-748391
SDCBP [O00560]3EBI-719493,EBI-727004
SFRS2 [Q6NXQ0]3EBI-719493,EBI-10251550
SH2D4A [Q9H788]3EBI-719493,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-719493,EBI-10308083
SIAH1 [Q8IUQ4]3EBI-719493,EBI-747107
SLC15A3 [Q05CH4]3EBI-719493,EBI-10223741
SMARCD1 [Q96GM5]3EBI-719493,EBI-358489
SMG9 [Q9H0W8]3EBI-719493,EBI-2872322
SNRPA [P09012]6EBI-719493,EBI-607085
SNRPB2 [P08579]6EBI-719493,EBI-1053651
SORBS3 [O60504]3EBI-719493,EBI-741237
SPATA2 [Q9UM82]4EBI-719493,EBI-744066
SPATC1L [Q9H0A9]3EBI-719493,EBI-372911
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-719493,EBI-11995806
STAMBPL1 [Q96FJ0]6EBI-719493,EBI-745021
STK16 [O75716]3EBI-719493,EBI-749295
STK25 [O00506]6EBI-719493,EBI-618295
SYNGAP1 [Q96PV0]3EBI-719493,EBI-2682386
SYT17 [Q9BSW7]3EBI-719493,EBI-745392
SYT6 - isoform 2 [Q5T7P8-2]3EBI-719493,EBI-10246152
TACO1 [Q9BSH4]3EBI-719493,EBI-747797
TBC1D22B [Q9NU19]4EBI-719493,EBI-8787464
TCEA2 [Q15560]6EBI-719493,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]5EBI-719493,EBI-11955057
TCHP [Q9BT92]4EBI-719493,EBI-740781
TEAD4 [D3DUQ6]3EBI-719493,EBI-10176734
TEAD4 [Q15561]6EBI-719493,EBI-747736
TEX33 - isoform 2 [O43247-2]3EBI-719493,EBI-12093053
THOC1 [Q96FV9]3EBI-719493,EBI-1765605
TLE5 [Q08117]4EBI-719493,EBI-717810
TMSB4X [Q0P5Q0]3EBI-719493,EBI-10226570
TNS4 [Q8IZW8]3EBI-719493,EBI-7543499
TPM3 [Q5VU62]3EBI-719493,EBI-10184033
TPRKB [Q9Y3C4]3EBI-719493,EBI-750123
TRAF4 [Q9BUZ4]3EBI-719493,EBI-3650647
itself17EBI-719493,EBI-719493
TRIM42 [Q8IWZ5]3EBI-719493,EBI-5235829
TRIM50 [Q86XT4]3EBI-719493,EBI-9867283
TSGA10IP [Q3SY00]3EBI-719493,EBI-10241197
TSHZ3 [Q63HK5]3EBI-719493,EBI-9053916
TTLL10 [Q6ZVT0]3EBI-719493,EBI-7844656
TUFT1 [Q9NNX1]4EBI-719493,EBI-2557363
TXNDC9 [O14530]3EBI-719493,EBI-707554
UBASH3A - isoform 2 [P57075-2]3EBI-719493,EBI-7353612
UBE2K [P61086]12EBI-719493,EBI-473850
USE1 [Q9NZ43]3EBI-719493,EBI-742842
USP2 [O75604]6EBI-719493,EBI-743272
UTP14C [Q5TAP6]3EBI-719493,EBI-11737646
UTP23 [Q9BRU9]3EBI-719493,EBI-5457544
VEZF1 [Q14119]3EBI-719493,EBI-11980193
VPS25 [Q9BRG1]7EBI-719493,EBI-741945
VPS28 [Q548N1]3EBI-719493,EBI-10243107
VPS28 [Q9UK41]3EBI-719493,EBI-727424
VPS9D1 [Q9Y2B5]3EBI-719493,EBI-9031083
WT1-AS [Q06250]3EBI-719493,EBI-10223946
XPA [P23025]6EBI-719493,EBI-295222
YJU2 [Q9BW85]3EBI-719493,EBI-10300345
ZBTB16 [Q05516]5EBI-719493,EBI-711925
ZC2HC1C [Q53FD0]3EBI-719493,EBI-740767
ZFC3H1 [G3V1X1]3EBI-719493,EBI-6448783
ZFHX3 - isoform B [Q15911-2]3EBI-719493,EBI-10237226
ZFYVE21 [Q9BQ24]3EBI-719493,EBI-2849569
ZGPAT [A0A0S2Z6H0]3EBI-719493,EBI-16428984
ZGPAT [Q8N5A5]4EBI-719493,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]9EBI-719493,EBI-10183064
ZMYND19 [Q96E35]3EBI-719493,EBI-746595
ZNF250 - isoform 3 [P15622-3]3EBI-719493,EBI-10177272
ZNF414 [Q96IQ9]3EBI-719493,EBI-744257
ZNF417 [Q8TAU3]7EBI-719493,EBI-740727
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-719493,EBI-740232
ZNF572 [Q7Z3I7]6EBI-719493,EBI-10172590
ZNF580 [Q9UK33]3EBI-719493,EBI-746277
ZNF581 [Q9P0T4]6EBI-719493,EBI-745520
ZNF587 [Q96SQ5]3EBI-719493,EBI-6427977
ZNF688 [A0A0S2Z5X4]6EBI-719493,EBI-16429014
ZNF688 [A0A0S2Z6P0]6EBI-719493,EBI-16429989
ZNF79 [Q15937]3EBI-719493,EBI-10237274
A8K9323EBI-719493,EBI-10174671
E5KN553EBI-719493,EBI-10176944
Proofreading exoribonuclease nsp14 (PRO_0000449631) from Severe acute respiratory syndrome coronavirus 2.3EBI-719493,EBI-25475920
2'-O-methyltransferase nsp16 (PRO_0000449633) from Severe acute respiratory syndrome coronavirus 2.3EBI-719493,EBI-25492395

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111919, 508 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14373

Protein interaction database and analysis system

More...IntActi		P14373, 418 interactors

Molecular INTeraction database

More...MINTi		P14373

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366404

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14373, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14373

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini298 – 492B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili132 – 172Sequence analysisAdd BLAST41
Coiled coili282 – 311Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri96 – 127B box-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013137_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14373

Identification of Orthologs from Complete Genome Data

More...OMAi		ICCACLT

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14373

TreeFam database of animal gene trees

More...TreeFami		TF350411

Family and domain databases

Conserved Domains Database

More...CDDi		cd15814, SPRY_PRY_TRIM27, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR035791, SPRY/PRY_TRIM27
IPR003877, SPRY_dom
IPR000315, Znf_B-box
IPR020457, Znf_B-box_chordata
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01406, BBOXZNFINGER
PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P14373-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN 
        60         70         80         90        100
VSCPQCRETF PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR 
       110        120        130        140        150
EPLKLYCEED QMPICVVCDR SREHRGHSVL PLEEAVEGFK EQIQNQLDHL 
       160        170        180        190        200
KRVKDLKKRR RAQGEQARAE LLSLTQMERE KIVWEFEQLY HSLKEHEYRL 
       210        220        230        240        250
LARLEELDLA IYNSINGAIT QFSCNISHLS SLIAQLEEKQ QQPTRELLQD 
       260        270        280        290        300
IGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS 
       310        320        330        340        350
DMEKIQELRE AQLYSVDVTL DPDTAYPSLI LSDNLRQVRY SYLQQDLPDN 
       360        370        380        390        400
PERFNLFPCV LGSPCFIAGR HYWEVEVGDK AKWTIGVCED SVCRKGGVTS 
       410        420        430        440        450
APQNGFWAVS LWYGKEYWAL TSPMTALPLR TPLQRVGIFL DYDAGEVSFY 
       460        470        480        490        500
NVTERCHTFT FSHATFCGPV RPYFSLSYSG GKSAAPLIIC PMSGIDGFSG 
       510 
HVGNHGHSME TSP
Length:513
Mass (Da):58,490
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F963D9048D8A731
GO
Isoform Beta (identifier: P14373-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-358: FNLFP → SPSTT
     359-513: Missing.

Show »
Length:358
Mass (Da):41,439
Checksum:iD722163761427340
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JIZ4A0A0G2JIZ4_HUMAN
RING-type E3 ubiquitin transferase
TRIM27
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y551H0Y551_HUMAN
Zinc finger protein RFP
TRIM27
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9V9A0A140T9V9_HUMAN
Zinc finger protein RFP
TRIM27
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9B9A0A140T9B9_HUMAN
Zinc finger protein RFP
TRIM27
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9N6A0A140T9N6_HUMAN
Zinc finger protein RFP
TRIM27
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9Q6A0A140T9Q6_HUMAN
Zinc finger protein RFP
TRIM27
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti446E → K in AAH66924 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010896354 – 358FNLFP → SPSTT in isoform Beta. 1 Publication5
Alternative sequenceiVSP_010897359 – 513Missing in isoform Beta. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03407 mRNA Translation: AAA36564.1
AF230393 mRNA Translation: AAG50172.1
AF230394 mRNA Translation: AAG50173.1
AL662859 Genomic DNA No translation available.
AL662871 Genomic DNA No translation available.
BX000360 Genomic DNA No translation available.
BX537153 Genomic DNA No translation available.
BX005144 Genomic DNA No translation available.
BX119924 Genomic DNA No translation available.
CR759942 Genomic DNA No translation available.
Z84474, Z84476 Genomic DNA Translation: CAB06480.2
Z84476, Z84474 Genomic DNA Translation: CAI19959.1
CH471081 Genomic DNA Translation: EAX03176.1
CH471081 Genomic DNA Translation: EAX03177.1
BC013580 mRNA Translation: AAH13580.1
BC066924 mRNA Translation: AAH66924.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4654.1 [P14373-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A28101, TVHURF

NCBI Reference Sequences

More...RefSeqi		NP_006501.1, NM_006510.4 [P14373-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377194; ENSP00000366399; ENSG00000204713 [P14373-2]
ENST00000377199; ENSP00000366404; ENSG00000204713
ENST00000400720; ENSP00000383555; ENSG00000215641
ENST00000412687; ENSP00000416281; ENSG00000234495 [P14373-2]
ENST00000417660; ENSP00000411026; ENSG00000215641 [P14373-2]
ENST00000427689; ENSP00000388622; ENSG00000237071 [P14373-2]
ENST00000431123; ENSP00000414793; ENSG00000229006
ENST00000435528; ENSP00000405229; ENSG00000237071
ENST00000437160; ENSP00000392787; ENSG00000234495
ENST00000452265; ENSP00000412445; ENSG00000229006 [P14373-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5987

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000377199.4; ENSP00000366404.3; NM_006510.5; NP_006501.1

UCSC genome browser

More...UCSCi		uc003nlr.4, human [P14373-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03407 mRNA Translation: AAA36564.1
AF230393 mRNA Translation: AAG50172.1
AF230394 mRNA Translation: AAG50173.1
AL662859 Genomic DNA No translation available.
AL662871 Genomic DNA No translation available.
BX000360 Genomic DNA No translation available.
BX537153 Genomic DNA No translation available.
BX005144 Genomic DNA No translation available.
BX119924 Genomic DNA No translation available.
CR759942 Genomic DNA No translation available.
Z84474, Z84476 Genomic DNA Translation: CAB06480.2
Z84476, Z84474 Genomic DNA Translation: CAI19959.1
CH471081 Genomic DNA Translation: EAX03176.1
CH471081 Genomic DNA Translation: EAX03177.1
BC013580 mRNA Translation: AAH13580.1
BC066924 mRNA Translation: AAH66924.1
CCDSiCCDS4654.1 [P14373-1]
PIRiA28101, TVHURF
RefSeqiNP_006501.1, NM_006510.4 [P14373-1]

3D structure databases

SMRiP14373
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111919, 508 interactors
CORUMiP14373
IntActiP14373, 418 interactors
MINTiP14373
STRINGi9606.ENSP00000366404

Protein family/group databases

MoonDBiP14373, Predicted

PTM databases

GlyGeniP14373, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP14373
MetOSiteiP14373
PhosphoSitePlusiP14373

Genetic variation databases

BioMutaiTRIM27
DMDMi132517

Proteomic databases

EPDiP14373
jPOSTiP14373
MassIVEiP14373
MaxQBiP14373
PaxDbiP14373
PeptideAtlasiP14373
PRIDEiP14373
ProteomicsDBi53047 [P14373-1]
53048 [P14373-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25916, 279 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		5987

Genome annotation databases

EnsembliENST00000377194; ENSP00000366399; ENSG00000204713 [P14373-2]
ENST00000377199; ENSP00000366404; ENSG00000204713
ENST00000400720; ENSP00000383555; ENSG00000215641
ENST00000412687; ENSP00000416281; ENSG00000234495 [P14373-2]
ENST00000417660; ENSP00000411026; ENSG00000215641 [P14373-2]
ENST00000427689; ENSP00000388622; ENSG00000237071 [P14373-2]
ENST00000431123; ENSP00000414793; ENSG00000229006
ENST00000435528; ENSP00000405229; ENSG00000237071
ENST00000437160; ENSP00000392787; ENSG00000234495
ENST00000452265; ENSP00000412445; ENSG00000229006 [P14373-2]
GeneIDi5987
KEGGihsa:5987
MANE-SelectiENST00000377199.4; ENSP00000366404.3; NM_006510.5; NP_006501.1
UCSCiuc003nlr.4, human [P14373-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5987
DisGeNETi5987

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM27
HGNCiHGNC:9975, TRIM27
HPAiENSG00000204713, Low tissue specificity
MalaCardsiTRIM27
MIMi602165, gene
neXtProtiNX_P14373
OpenTargetsiENSG00000204713
Orphaneti146, Differentiated thyroid carcinoma
PharmGKBiPA162406956
VEuPathDBiHostDB:ENSG00000204713

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000158537
HOGENOMiCLU_013137_6_1_1
InParanoidiP14373
OMAiICCACLT
PhylomeDBiP14373
TreeFamiTF350411

Enzyme and pathway databases

PathwayCommonsiP14373
ReactomeiR-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-9635465, Suppression of apoptosis
SignaLinkiP14373
SIGNORiP14373

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5987, 10 hits in 1090 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM27, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIM27

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5987
PharosiP14373, Tbio

Protein Ontology

More...PROi		PR:P14373
RNActiP14373, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204713, Expressed in right lobe of liver and 235 other tissues
ExpressionAtlasiP14373, baseline and differential
GenevisibleiP14373, HS

Family and domain databases

CDDicd15814, SPRY_PRY_TRIM27, 1 hit
Gene3Di2.60.120.920, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR035791, SPRY/PRY_TRIM27
IPR003877, SPRY_dom
IPR000315, Znf_B-box
IPR020457, Znf_B-box_chordata
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PRINTSiPR01406, BBOXZNFINGER
PR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI27_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14373
Secondary accession number(s): A2BE15
, Q5RJA8, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: February 23, 2022
This is version 232 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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