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Protein

Quaternary ammonium compound-resistance protein QacC

Gene

qacC

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide.1 Publication2 Publications

Activity regulationi

Ethidium export is inhibited by N-ethylmaleimide (NEM).1 Publication

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.1.1 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Quaternary ammonium compound-resistance protein QacCCurated
Alternative name(s):
Ethidium bromide resistance protein
Multidrug resistance protein
Quaternary ammonium determinant C
Gene namesi
Name:qacC1 Publication
Synonyms:ebr2 Publications, smr1 Publication
Encoded oniPlasmid pTZ201 Publication
Plasmid pWBG321 Publication
Plasmid pSK891 Publication
Plasmid pTZ221 Publication
Plasmid pKH81 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2Cytoplasmic1 Publication2
Transmembranei3 – 20HelicalSequence analysisAdd BLAST18
Topological domaini21 – 29Extracellular1 Publication9
Transmembranei30 – 47HelicalSequence analysisAdd BLAST18
Topological domaini48 – 56Cytoplasmic1 Publication9
Transmembranei57 – 75HelicalSequence analysisAdd BLAST19
Topological domaini76 – 85Extracellular1 Publication10
Transmembranei86 – 103HelicalSequence analysisAdd BLAST18
Topological domaini104 – 107Cytoplasmic1 Publication4

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31P → A or G: Decrease in resistance to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication1
Mutagenesisi42C → A or G: Decrease in resistance to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication1
Mutagenesisi42C → D, E, I, K, L, P, R or V: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication1
Mutagenesisi42C → S: Confers sensitivity to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication1
Mutagenesisi42C → T: No change in activity. 1 Publication1
Mutagenesisi59Y → S or W: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication1
Mutagenesisi62W → F or Y: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080831 – 107Quaternary ammonium compound-resistance protein QacCAdd BLAST107

Structurei

3D structure databases

ProteinModelPortaliP14319
SMRiP14319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR000390 Small_multidrug_res
PANTHERiPTHR30561 PTHR30561, 1 hit
PfamiView protein in Pfam
PF00893 Multi_Drug_Res, 1 hit

Sequencei

Sequence statusi: Complete.

P14319-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYIYLIIAI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM
60 70 80 90 100
QHLPLNITYA TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL

NIFGTSH
Length:107
Mass (Da):11,673
Last modified:January 1, 1990 - v1
Checksum:i9A0155B54A052E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37888 Genomic DNA Translation: AAA26666.1
X15574 Genomic DNA Translation: CAA33598.1
M33479 Genomic DNA Translation: AAA26668.1
M37889 Genomic DNA Translation: AAB02114.1
X62587 Genomic DNA Translation: CAA44471.1
X62587 Genomic DNA Translation: CAA44472.1
U50077 Genomic DNA Translation: AAB07747.1
U15783 Genomic DNA Translation: AAA60379.1
PIRiJQ1439
RefSeqiNP_863640.1, NC_005024.1
NP_878005.1, NC_005054.1
WP_001146389.1, NZ_QHCO01000001.1
YP_002790936.1, NC_012547.1
YP_006938404.1, NC_013339.1
YP_006938512.1, NC_013342.1
YP_006938611.1, NC_013344.1
YP_006938730.1, NC_013350.1
YP_534903.1, NC_007928.1

Genome annotation databases

GeneIDi13875573
13875683
13875784
13875911
2598266
2598368
3978602
7751503

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37888 Genomic DNA Translation: AAA26666.1
X15574 Genomic DNA Translation: CAA33598.1
M33479 Genomic DNA Translation: AAA26668.1
M37889 Genomic DNA Translation: AAB02114.1
X62587 Genomic DNA Translation: CAA44471.1
X62587 Genomic DNA Translation: CAA44472.1
U50077 Genomic DNA Translation: AAB07747.1
U15783 Genomic DNA Translation: AAA60379.1
PIRiJQ1439
RefSeqiNP_863640.1, NC_005024.1
NP_878005.1, NC_005054.1
WP_001146389.1, NZ_QHCO01000001.1
YP_002790936.1, NC_012547.1
YP_006938404.1, NC_013339.1
YP_006938512.1, NC_013342.1
YP_006938611.1, NC_013344.1
YP_006938730.1, NC_013350.1
YP_534903.1, NC_007928.1

3D structure databases

ProteinModelPortaliP14319
SMRiP14319
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.7.1.1 the drug/metabolite transporter (dmt) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13875573
13875683
13875784
13875911
2598266
2598368
3978602
7751503

Family and domain databases

InterProiView protein in InterPro
IPR000390 Small_multidrug_res
PANTHERiPTHR30561 PTHR30561, 1 hit
PfamiView protein in Pfam
PF00893 Multi_Drug_Res, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQACC_STAAU
AccessioniPrimary (citable) accession number: P14319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 10, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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