qacC

Functionⁱ

Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide.1 Publication2 Publications

Activity regulationⁱ

Ethidium export is inhibited by N-ethylmaleimide (NEM).1 Publication

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Protein family/group databases

TCDBⁱ	2.A.7.1.1 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.1.1 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Quaternary ammonium compound-resistance protein QacCCurated Alternative name(s): Ethidium bromide resistance protein Multidrug resistance protein Quaternary ammonium determinant C
Gene namesⁱ	Name:qacC1 Publication Synonyms:ebr2 Publications, smr1 Publication
Encoded onⁱ	Plasmid pTZ201 Publication Plasmid pWBG321 Publication Plasmid pSK891 Publication Plasmid pTZ221 Publication Plasmid pKH81 Publication
Organismⁱ	Staphylococcus aureus
Taxonomic identifierⁱ	1280 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Subcellular locationⁱ

Cell membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.8
  "Molecular characterization of the staphylococcal multidrug resistance export protein QacC."
  Paulsen I.T., Brown M.H., Dunstan S.J., Skurray R.A.
  J. Bacteriol. 177:2827-2833(1995) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF PRO-31; CYS-42; TYR-59 AND TRP-62.
; Multi-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.8
  "Molecular characterization of the staphylococcal multidrug resistance export protein QacC."
  Paulsen I.T., Brown M.H., Dunstan S.J., Skurray R.A.
  J. Bacteriol. 177:2827-2833(1995) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF PRO-31; CYS-42; TYR-59 AND TRP-62.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 2	Cytoplasmic1 Publication	2
Transmembraneⁱ	3 – 20	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	21 – 29	Extracellular1 Publication	9
Transmembraneⁱ	30 – 47	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	48 – 56	Cytoplasmic1 Publication	9
Transmembraneⁱ	57 – 75	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	76 – 85	Extracellular1 Publication	10
Transmembraneⁱ	86 – 103	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	104 – 107	Cytoplasmic1 Publication	4

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	31	P → A or G: Decrease in resistance to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication	1
Mutagenesisⁱ	42	C → A or G: Decrease in resistance to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication	1
Mutagenesisⁱ	42	C → D, E, I, K, L, P, R or V: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication	1
Mutagenesisⁱ	42	C → S: Confers sensitivity to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication	1
Mutagenesisⁱ	42	C → T: No change in activity. 1 Publication	1
Mutagenesisⁱ	59	Y → S or W: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication	1
Mutagenesisⁱ	62	W → F or Y: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000108083	1 – 107	Quaternary ammonium compound-resistance protein QacCAdd BLAST		107

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P14319
SMRⁱ	P14319
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small multidrug resistance (SMR) protein family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Family and domain databases

InterProⁱ	View protein in InterPro IPR000390 Small_multidrug_res
PANTHERⁱ	PTHR30561 PTHR30561, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00893 Multi_Drug_Res, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P14319-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPYIYLIIAI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM 
        60         70         80         90        100
QHLPLNITYA TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL 

NIFGTSH

Length:107

Mass (Da):11,673

Last modified:January 1, 1990 - v1

Checksum:ⁱ9A0155B54A052E1F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37888 Genomic DNA Translation: AAA26666.1 X15574 Genomic DNA Translation: CAA33598.1 M33479 Genomic DNA Translation: AAA26668.1 M37889 Genomic DNA Translation: AAB02114.1 X62587 Genomic DNA Translation: CAA44471.1 X62587 Genomic DNA Translation: CAA44472.1 U50077 Genomic DNA Translation: AAB07747.1 U15783 Genomic DNA Translation: AAA60379.1
PIRⁱ	JQ1439
NCBI Reference Sequences More...RefSeqⁱ	NP_863640.1, NC_005024.1 NP_878005.1, NC_005054.1 WP_001146389.1, NZ_QHCO01000001.1 YP_002790936.1, NC_012547.1 YP_006938404.1, NC_013339.1 YP_006938512.1, NC_013342.1 YP_006938611.1, NC_013344.1 YP_006938730.1, NC_013350.1 YP_534903.1, NC_007928.1

Genome annotation databases

GeneIDⁱ	13875573 13875683 13875784 13875911 2598266 2598368 3978602 7751503

GeneIDⁱ

13875573
13875683
13875784
13875911
2598266
2598368
3978602
7751503

Protein	Similar proteins		Species	Score	Length	Source
P14319	Quaternary ammonium compound efflux SMR transporter		STAAG		107	UniRef100_P14319
Multidrug resistance efflux protein Smr		STAWA		107
Quaternary ammonium compound efflux SMR transporter QacC		STALU		107
Quarternary ammonium compound efflux system, multidrug transporter		Staphylococcus petrasii subsp. petrasii		107
Quaternary ammonium compound efflux SMR transporter QacC		Staphylococcus petrasii subsp. croceilyticus		107
+25

Protein	Similar proteins		Species	Score	Length	Source
P14319	Quaternary ammonium compound-resistance protein QacC		STASS		107	UniRef90_P14319
Quaternary ammonium compound efflux SMR transporter		STAAG		107
Multidrug resistance efflux protein Smr		STAWA		107
Quaternary ammonium compound efflux SMR transporter QacC		STALU		107
Quarternary ammonium compound efflux system, multidrug transporter		Staphylococcus petrasii subsp. petrasii		107
+58

Protein	Similar proteins		Species	Score	Length	Source
P14319	Quaternary ammonium compound-resistance protein QacC		STASS		107	UniRef50_P14319
Quaternary ammonium compound efflux SMR transporter		STAAG		107
Multidrug resistance efflux protein Smr		STAWA		107
Quaternary ammonium compound efflux SMR transporter QacC		STALU		107
Quarternary ammonium compound efflux system, multidrug transporter		Staphylococcus petrasii subsp. petrasii		107
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37888 Genomic DNA Translation: AAA26666.1 X15574 Genomic DNA Translation: CAA33598.1 M33479 Genomic DNA Translation: AAA26668.1 M37889 Genomic DNA Translation: AAB02114.1 X62587 Genomic DNA Translation: CAA44471.1 X62587 Genomic DNA Translation: CAA44472.1 U50077 Genomic DNA Translation: AAB07747.1 U15783 Genomic DNA Translation: AAA60379.1
PIRⁱ	JQ1439
RefSeqⁱ	NP_863640.1, NC_005024.1 NP_878005.1, NC_005054.1 WP_001146389.1, NZ_QHCO01000001.1 YP_002790936.1, NC_012547.1 YP_006938404.1, NC_013339.1 YP_006938512.1, NC_013342.1 YP_006938611.1, NC_013344.1 YP_006938730.1, NC_013350.1 YP_534903.1, NC_007928.1

3D structure databases

ProteinModelPortalⁱ	P14319
SMRⁱ	P14319
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

TCDBⁱ	2.A.7.1.1 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.1.1 the drug/metabolite transporter (dmt) superfamily

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	13875573 13875683 13875784 13875911 2598266 2598368 3978602 7751503

GeneIDⁱ

13875573
13875683
13875784
13875911
2598266
2598368
3978602
7751503

Family and domain databases

InterProⁱ	View protein in InterPro IPR000390 Small_multidrug_res
PANTHERⁱ	PTHR30561 PTHR30561, 1 hit
Pfamⁱ	View protein in Pfam PF00893 Multi_Drug_Res, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	QACC_STAAU
Accessionⁱ	P14319Primary (citable) accession number: P14319
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	October 10, 2018
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - P14319 (QACC_STAAU)

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Quaternary ammonium compound-resistance protein QacC

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Functionⁱ

Activity regulationⁱ

Keywordsⁱ

Protein family/group databases

Names & Taxonomyⁱ

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Mutagenesis

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

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Supporting data

UniProtKB - P14319 (QACC_STAAU)

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Quaternary ammonium compound-resistance protein QacC

qacC

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ