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UniProtKB - P14319 (QACC_STAAU)
Protein
Quaternary ammonium compound-resistance protein QacC
Gene
qacC
Organism
Staphylococcus aureus
Status
Functioni
Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide.
1 Publication2 PublicationsActivity regulationi
Ethidium export is inhibited by N-ethylmaleimide (NEM).1 Publication
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.7.1.1, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Quaternary ammonium compound-resistance protein QacCCuratedAlternative name(s): Ethidium bromide resistance protein Multidrug resistance protein Quaternary ammonium determinant C |
Gene namesi | Name:qacC1 Publication Synonyms:ebr2 Publications, smr1 Publication |
Encoded oni | Plasmid pTZ201 Publication Plasmid pWBG321 Publication Plasmid pSK891 Publication Plasmid pTZ221 Publication Plasmid pKH81 Publication |
Organismi | Staphylococcus aureus |
Taxonomic identifieri | 1280 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2 | Cytoplasmic1 Publication | 2 | |
Transmembranei | 3 – 20 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 21 – 29 | Extracellular1 Publication | 9 | |
Transmembranei | 30 – 47 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 48 – 56 | Cytoplasmic1 Publication | 9 | |
Transmembranei | 57 – 75 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 76 – 85 | Extracellular1 Publication | 10 | |
Transmembranei | 86 – 103 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 104 – 107 | Cytoplasmic1 Publication | 4 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 31 | P → A or G: Decrease in resistance to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication | 1 | |
Mutagenesisi | 42 | C → A or G: Decrease in resistance to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication | 1 | |
Mutagenesisi | 42 | C → D, E, I, K, L, P, R or V: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication | 1 | |
Mutagenesisi | 42 | C → S: Confers sensitivity to ethidium bromide, but does not affect resistance to quaternary ammonium compounds. 1 Publication | 1 | |
Mutagenesisi | 42 | C → T: No change in activity. 1 Publication | 1 | |
Mutagenesisi | 59 | Y → S or W: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication | 1 | |
Mutagenesisi | 62 | W → F or Y: Confers sensitivity to ethidium bromide and quaternary ammonium compounds. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000108083 | 1 – 107 | Quaternary ammonium compound-resistance protein QacCAdd BLAST | 107 |
Family & Domainsi
Sequence similaritiesi
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR000390, Small_drug/metabolite_transptr IPR045324, Small_multidrug_res |
PANTHERi | PTHR30561, PTHR30561, 1 hit |
Pfami | View protein in Pfam PF00893, Multi_Drug_Res, 1 hit |
i Sequence
Sequence statusi: Complete.
P14319-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPYIYLIIAI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM
60 70 80 90 100
QHLPLNITYA TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL
NIFGTSH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37888 Genomic DNA Translation: AAA26666.1 X15574 Genomic DNA Translation: CAA33598.1 M33479 Genomic DNA Translation: AAA26668.1 M37889 Genomic DNA Translation: AAB02114.1 X62587 Genomic DNA Translation: CAA44471.1 X62587 Genomic DNA Translation: CAA44472.1 U50077 Genomic DNA Translation: AAB07747.1 U15783 Genomic DNA Translation: AAA60379.1 |
PIRi | JQ1439 |
RefSeqi | NP_863640.1, NC_005024.1 NP_878005.1, NC_005054.1 WP_001146389.1, NZ_WWCF01000015.1 YP_002790936.1, NC_012547.1 YP_006938404.1, NC_013339.1 YP_006938512.1, NC_013342.1 YP_006938611.1, NC_013344.1 YP_006938730.1, NC_013350.1 YP_534903.1, NC_007928.1 |
Genome annotation databases
GeneIDi | 66852236 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37888 Genomic DNA Translation: AAA26666.1 X15574 Genomic DNA Translation: CAA33598.1 M33479 Genomic DNA Translation: AAA26668.1 M37889 Genomic DNA Translation: AAB02114.1 X62587 Genomic DNA Translation: CAA44471.1 X62587 Genomic DNA Translation: CAA44472.1 U50077 Genomic DNA Translation: AAB07747.1 U15783 Genomic DNA Translation: AAA60379.1 |
PIRi | JQ1439 |
RefSeqi | NP_863640.1, NC_005024.1 NP_878005.1, NC_005054.1 WP_001146389.1, NZ_WWCF01000015.1 YP_002790936.1, NC_012547.1 YP_006938404.1, NC_013339.1 YP_006938512.1, NC_013342.1 YP_006938611.1, NC_013344.1 YP_006938730.1, NC_013350.1 YP_534903.1, NC_007928.1 |
3D structure databases
BMRBi | P14319 |
SMRi | P14319 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 2.A.7.1.1, the drug/metabolite transporter (dmt) superfamily |
Genome annotation databases
GeneIDi | 66852236 |
Family and domain databases
InterProi | View protein in InterPro IPR000390, Small_drug/metabolite_transptr IPR045324, Small_multidrug_res |
PANTHERi | PTHR30561, PTHR30561, 1 hit |
Pfami | View protein in Pfam PF00893, Multi_Drug_Res, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QACC_STAAU | |
Accessioni | P14319Primary (citable) accession number: P14319 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
PlasmidDocuments
- SIMILARITY comments
Index of protein domains and families