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Protein

Glucosidase 2 subunit beta

Gene

PRKCSH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: N-glycan metabolism

This protein is involved in the pathway N-glycan metabolism, which is part of Glycan metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-glycan metabolism and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei49Substrate; shared with catalytic subunitBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi50Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi53Calcium 1By similarity1
Binding sitei53Substrate; shared with catalytic subunitBy similarity1
Metal bindingi55Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi57Calcium 1By similarity1
Metal bindingi63Calcium 1By similarity1
Metal bindingi64Calcium 1By similarity1
Metal bindingi91Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi94Calcium 2By similarity1
Metal bindingi96Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi98Calcium 2By similarity1
Metal bindingi104Calcium 2By similarity1
Metal bindingi105Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi213 – 2361PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • ion channel binding Source: UniProtKB
  • phosphoprotein binding Source: UniProtKB
  • protein kinase C binding Source: UniProtKB

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • intracellular signal transduction Source: UniProtKB
  • N-glycan processing Source: UniProtKB
  • post-translational protein modification Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05346-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.84 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-901042 Calnexin/calreticulin cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P14314

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00957

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucosidase 2 subunit beta
Alternative name(s):
80K-H protein1 Publication
Glucosidase II subunit beta
Protein kinase C substrate 60.1 kDa protein heavy chain
Short name:
PKCSH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKCSH1 PublicationImported
Synonyms:G19P1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130175.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9411 PRKCSH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
177060 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14314

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polycystic liver disease 1 with or without kidney cysts (PCLD1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. A subset of patients may develop kidney cysts that usually do not result in clinically significant renal disease.
See also OMIM:174050
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08093918 – 528Missing in PCLD1. 1 PublicationAdd BLAST511
Natural variantiVAR_080940156 – 528Missing in PCLD1. 1 PublicationAdd BLAST373
Natural variantiVAR_080941198 – 528Missing in PCLD1. 1 PublicationAdd BLAST331
Natural variantiVAR_080942414 – 528Missing in PCLD1. 1 PublicationAdd BLAST115
Natural variantiVAR_080943423 – 528Missing in PCLD1. 1 PublicationAdd BLAST106

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5589

MalaCards human disease database

More...
MalaCardsi
PRKCSH
MIMi174050 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000130175

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2924 Isolated polycystic liver disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33774

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRKCSH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242499

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 141 PublicationAdd BLAST14
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000414315 – 528Glucosidase 2 subunit betaAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 58By similarity
Disulfide bondi56 ↔ 70By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 99By similarity
Modified residuei89Phosphoserine; by PKCSequence analysis1
Disulfide bondi97 ↔ 112By similarity
Disulfide bondi100 ↔ 116By similarity
Modified residuei166N6-succinyllysineBy similarity1
Modified residuei168Phosphoserine; by FAM20C1 Publication1
Modified residuei383Phosphoserine; by PKCSequence analysis1
Modified residuei390Phosphoserine; by PKCSequence analysis1
Modified residuei434Phosphoserine; by PKCSequence analysis1
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P14314

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P14314

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P14314

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14314

PeptideAtlas

More...
PeptideAtlasi
P14314

PRoteomics IDEntifications database

More...
PRIDEi
P14314

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53041
53042 [P14314-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P14314-1 [P14314-1]
P14314-2 [P14314-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1269

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14314

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P14314

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P14314

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P14314

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130175 Expressed in 237 organ(s), highest expression level in spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_PRKCSH

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P14314 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14314 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004465
HPA041940
HPA043560

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH) (PubMed:10929008). Binds glycosylated PTPRC (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111575, 66 interactors

Protein interaction database and analysis system

More...
IntActi
P14314, 25 interactors

Molecular INTeraction database

More...
MINTi
P14314

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P14314

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14314

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 71LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST35
Domaini72 – 113LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST42
Domaini209 – 244EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini245 – 290EF-hand 2PROSITE-ProRule annotationAdd BLAST46
Domaini413 – 468PRKCSHAdd BLAST56

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi525 – 528Prevents secretion from ERPROSITE-ProRule annotation1 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi313 – 336Glu-rich (acidic)Add BLAST24

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2397 Eukaryota
ENOG410XPE3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007805

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051738

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14314

KEGG Orthology (KO)

More...
KOi
K08288

Database of Orthologous Groups

More...
OrthoDBi
632472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14314

TreeFam database of animal gene trees

More...
TreeFami
TF329550

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR026874 Glucosidase_2_bsu
IPR039794 Gtb1-like
IPR036055 LDL_receptor-like_sf
IPR002172 LDrepeatLR_classA_rpt
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR036607 PRKCSH
IPR028146 PRKCSH_N

The PANTHER Classification System

More...
PANTHERi
PTHR12630 PTHR12630, 1 hit
PTHR12630:SF1 PTHR12630:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13202 EF-hand_5, 1 hit
PF12999 PRKCSH-like, 1 hit
PF13015 PRKCSH_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF57424 SSF57424, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00014 ER_TARGET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPLLLLLP MCWAVEVKRP RGVSLTNHHF YDESKPFTCL DGSATIPFDQ
60 70 80 90 100
VNDDYCDCKD GSDEPGTAAC PNGSFHCTNT GYKPLYIPSN RVNDGVCDCC
110 120 130 140 150
DGTDEYNSGV ICENTCKEKG RKERESLQQM AEVTREGFRL KKILIEDWKK
160 170 180 190 200
AREEKQKKLI ELQAGKKSLE DQVEMLRTVK EEAEKPEREA KEQHQKLWEE
210 220 230 240 250
QLAAAKAQQE QELAADAFKE LDDDMDGTVS VTELQTHPEL DTDGDGALSE
260 270 280 290 300
AEAQALLSGD TQTDATSFYD RVWAAIRDKY RSEALPTDLP APSAPDLTEP
310 320 330 340 350
KEEQPPVPSS PTEEEEEEEE EEEEEAEEEE EEEDSEEAPP PLSPPQPASP
360 370 380 390 400
AEEDKMPPYD EQTQAFIDAA QEARNKFEEA ERSLKDMEES IRNLEQEISF
410 420 430 440 450
DFGPNGEFAY LYSQCYELTT NEYVYRLCPF KLVSQKPKLG GSPTSLGTWG
460 470 480 490 500
SWIGPDHDKF SAMKYEQGTG CWQGPNRSTT VRLLCGKETM VTSTTEPSRC
510 520
EYLMELMTPA ACPEPPPEAP TEDDHDEL
Length:528
Mass (Da):59,425
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DAD9776037E878E
GO
Isoform 2 (identifier: P14314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-346: EAPPPLSPPQ → VQGEQPK

Show »
Length:525
Mass (Da):59,178
Checksum:iABACF156C534F30E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELL7K7ELL7_HUMAN
Glucosidase 2 subunit beta
PRKCSH
535Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPW7K7EPW7_HUMAN
Glucosidase 2 subunit beta
PRKCSH
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGP4A0A0C4DGP4_HUMAN
Glucosidase 2 subunit beta
PRKCSH
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKX1K7EKX1_HUMAN
Glucosidase 2 subunit beta
PRKCSH
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ70K7EJ70_HUMAN
Glucosidase 2 subunit beta
PRKCSH
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL27K7EL27_HUMAN
Glucosidase 2 subunit beta
PRKCSH
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIP3K7EIP3_HUMAN
Glucosidase 2 subunit beta
PRKCSH
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15154 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti325Missing in AAA52493 (PubMed:2793184).Curated1
Sequence conflicti325Missing in AAA98668 (PubMed:9043864).Curated1
Sequence conflicti325Missing in AAP88860 (Ref. 4) Curated1
Sequence conflicti325Missing in AAH13586 (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08093918 – 528Missing in PCLD1. 1 PublicationAdd BLAST511
Natural variantiVAR_02876174S → N. Corresponds to variant dbSNP:rs10406672Ensembl.1
Natural variantiVAR_080940156 – 528Missing in PCLD1. 1 PublicationAdd BLAST373
Natural variantiVAR_080941198 – 528Missing in PCLD1. 1 PublicationAdd BLAST331
Natural variantiVAR_028762291A → T2 PublicationsCorresponds to variant dbSNP:rs11557488EnsemblClinVar.1
Natural variantiVAR_048658338A → G. Corresponds to variant dbSNP:rs35847588Ensembl.1
Natural variantiVAR_080942414 – 528Missing in PCLD1. 1 PublicationAdd BLAST115
Natural variantiVAR_080943423 – 528Missing in PCLD1. 1 PublicationAdd BLAST106

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043749337 – 346EAPPPLSPPQ → VQGEQPK in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03075 mRNA Translation: AAA52493.1
U50326
, U50317, U50318, U50319, U50320, U50321, U50322, U50323, U50324, U50325 Genomic DNA Translation: AAA98668.1
AF144075 mRNA Translation: AAF66686.1
BT009858 mRNA Translation: AAP88860.1
AK290433 mRNA Translation: BAF83122.1
AC008481 Genomic DNA No translation available.
AC024575 Genomic DNA No translation available.
BC013586 mRNA Translation: AAH13586.2
BC015154 mRNA Translation: AAH15154.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32911.1 [P14314-1]
CCDS45977.1 [P14314-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A32469

NCBI Reference Sequences

More...
RefSeqi
NP_001001329.1, NM_001001329.2 [P14314-2]
NP_001276031.1, NM_001289102.1 [P14314-2]
NP_002734.2, NM_002743.3 [P14314-1]
XP_011526433.1, XM_011528131.1 [P14314-1]
XP_011526434.1, XM_011528132.1 [P14314-2]
XP_016882466.1, XM_017026977.1 [P14314-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.610830

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000587327; ENSP00000466012; ENSG00000130175 [P14314-2]
ENST00000589838; ENSP00000465461; ENSG00000130175 [P14314-1]
ENST00000591462; ENSP00000465489; ENSG00000130175 [P14314-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5589

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5589

UCSC genome browser

More...
UCSCi
uc010dyb.5 human [P14314-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03075 mRNA Translation: AAA52493.1
U50326
, U50317, U50318, U50319, U50320, U50321, U50322, U50323, U50324, U50325 Genomic DNA Translation: AAA98668.1
AF144075 mRNA Translation: AAF66686.1
BT009858 mRNA Translation: AAP88860.1
AK290433 mRNA Translation: BAF83122.1
AC008481 Genomic DNA No translation available.
AC024575 Genomic DNA No translation available.
BC013586 mRNA Translation: AAH13586.2
BC015154 mRNA Translation: AAH15154.1 Different initiation.
CCDSiCCDS32911.1 [P14314-1]
CCDS45977.1 [P14314-2]
PIRiA32469
RefSeqiNP_001001329.1, NM_001001329.2 [P14314-2]
NP_001276031.1, NM_001289102.1 [P14314-2]
NP_002734.2, NM_002743.3 [P14314-1]
XP_011526433.1, XM_011528131.1 [P14314-1]
XP_011526434.1, XM_011528132.1 [P14314-2]
XP_016882466.1, XM_017026977.1 [P14314-1]
UniGeneiHs.610830

3D structure databases

ProteinModelPortaliP14314
SMRiP14314
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111575, 66 interactors
IntActiP14314, 25 interactors
MINTiP14314
STRINGi9606.ENSP00000252455

PTM databases

GlyConnecti1269
iPTMnetiP14314
PhosphoSitePlusiP14314
SwissPalmiP14314

Polymorphism and mutation databases

BioMutaiPRKCSH
DMDMi116242499

Proteomic databases

EPDiP14314
jPOSTiP14314
MaxQBiP14314
PaxDbiP14314
PeptideAtlasiP14314
PRIDEiP14314
ProteomicsDBi53041
53042 [P14314-2]
TopDownProteomicsiP14314-1 [P14314-1]
P14314-2 [P14314-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5589
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587327; ENSP00000466012; ENSG00000130175 [P14314-2]
ENST00000589838; ENSP00000465461; ENSG00000130175 [P14314-1]
ENST00000591462; ENSP00000465489; ENSG00000130175 [P14314-2]
GeneIDi5589
KEGGihsa:5589
UCSCiuc010dyb.5 human [P14314-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5589
DisGeNETi5589
EuPathDBiHostDB:ENSG00000130175.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRKCSH
HGNCiHGNC:9411 PRKCSH
HPAiCAB004465
HPA041940
HPA043560
MalaCardsiPRKCSH
MIMi174050 phenotype
177060 gene
neXtProtiNX_P14314
OpenTargetsiENSG00000130175
Orphaneti2924 Isolated polycystic liver disease
PharmGKBiPA33774

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2397 Eukaryota
ENOG410XPE3 LUCA
GeneTreeiENSGT00510000047770
HOGENOMiHOG000007805
HOVERGENiHBG051738
InParanoidiP14314
KOiK08288
OrthoDBi632472at2759
PhylomeDBiP14314
TreeFamiTF329550

Enzyme and pathway databases

UniPathwayi
UPA00957

BioCyciMetaCyc:HS05346-MONOMER
BRENDAi3.2.1.84 2681
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-901042 Calnexin/calreticulin cycle
SignaLinkiP14314

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRKCSH human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PRKCSH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5589
PMAP-CutDBiP14314

Protein Ontology

More...
PROi
PR:P14314

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130175 Expressed in 237 organ(s), highest expression level in spinal cord
CleanExiHS_PRKCSH
ExpressionAtlasiP14314 baseline and differential
GenevisibleiP14314 HS

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR026874 Glucosidase_2_bsu
IPR039794 Gtb1-like
IPR036055 LDL_receptor-like_sf
IPR002172 LDrepeatLR_classA_rpt
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR036607 PRKCSH
IPR028146 PRKCSH_N
PANTHERiPTHR12630 PTHR12630, 1 hit
PTHR12630:SF1 PTHR12630:SF1, 1 hit
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF12999 PRKCSH-like, 1 hit
PF13015 PRKCSH_1, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00014 ER_TARGET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLU2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14314
Secondary accession number(s): A8K318
, Q96BU9, Q96D06, Q9P0W9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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