Protein RED1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin DNA binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation."
    Blat Y., Protacio R.U., Hunter N., Kleckner N.
    Cell 111:791-802(2002) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis."
    Lin F.M., Lai Y.J., Shen H.J., Cheng Y.H., Wang T.F.
    EMBO J 29:586-596(2010) [PubMed] [Europe PMC] [Abstract]
  • "Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1."
    Eichinger C.S., Jentsch S.
    Proc Natl Acad Sci U S A 107:11370-11375(2010) [PubMed] [Europe PMC] [Abstract]
• structural molecule activity Source: SGDInferred from direct assayⁱ
  • "A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae."
    de los Santos T., Loidl J., Larkin B., Hollingsworth N.M.
    Genetics 159:1511-1525(2001) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• meiotic recombination checkpoint signaling Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins."
    Bailis J.M., Smith A.V., Roeder G.S.
    Mol. Cell. Biol. 20:4838-4848(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of catalytic activity Source: SGDInferred from direct assayⁱ
  • "Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast."
    Wan L., de los Santos T., Zhang C., Shokat K., Hollingsworth N.M.
    Mol Biol Cell 15:11-23(2004) [PubMed] [Europe PMC] [Abstract]
• reciprocal meiotic recombination Source: InterPro
• sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
• synaptonemal complex assembly Source: SGDInferred from mutant phenotypeⁱ
  • "Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast."
    de los Santos T., Hollingsworth N.M.
    J Biol Chem 274:1783-1790(1999) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis."
    Lin F.M., Lai Y.J., Shen H.J., Cheng Y.H., Wang T.F.
    EMBO J 29:586-596(2010) [PubMed] [Europe PMC] [Abstract]
  • "Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1."
    Eichinger C.S., Jentsch S.
    Proc Natl Acad Sci U S A 107:11370-11375(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEGLKKKIFG VCLKNDLAQT RNETKGIHYG LMTLETSKQL QEFLHLLVIK 
        60         70         80         90        100
REVIQNFELL FHIINVAVKI TDSNLPSDDI WHFILKLRFS SEINIDEDSK 
       110        120        130        140        150
VLNYLLETGI AMENPVSWKC LAVISSILSS VPQSKKIITN LIETEHAKKI 
       160        170        180        190        200
GQLFDNIQDL QQGNFLVEIL SNCFKKSASN SKKVEKIPQL WQSRSKNKFF 
       210        220        230        240        250
FENEFYPFSS KNGSLQTCQF LCNNFMSTLS FTGILRQVSY SGSETLKNLR 
       260        270        280        290        300
IFKKKDDENS YFIQCIYNKI YLWLDEKAPL EFERKKIRIT KNLKNKIQIK 
       310        320        330        340        350
LRQPFHECVR TTADKTALLF NKTKGFQLEF EDEKLGETFF HNVNNIPKIS 
       360        370        380        390        400
EVQNFLVLDY IEEEPENEGE EEEQIGRADE QKEDEEEESL DELSTPMVYP 
       410        420        430        440        450
IKSSIPHNHN EKVQLVTPDR SVSIRSDEWD LKSNTEDEEG NVLADLKISS 
       460        470        480        490        500
TKETKRQTDY VHIDSEDQSP VVSAQMRKMR RESTKTLEIL RQEFKDKDVQ 
       510        520        530        540        550
NKEDQSEQIQ NPFVNTSSLV VGKSCLVNPK EKPNIDQTVV GITELKSNSS 
       560        570        580        590        600
IKKRDINILD TIFGQPPSKK QKQFHKKEKK KQQKKLTNFK PIIDVPSQDK 
       610        620        630        640        650
RNLRSNAPTK PKSIKVSKLR TDKKVTGEKS SPETAAEKVD DQTVRSNDEQ 
       660        670        680        690        700
AMSRATKEKC FPDVNEGKEI TKDDAKVSLE SKKNNETFVD SSVVEKHTPP 
       710        720        730        740        750
DKDCNNCNIT DILESTTVID LQSPHGLSAP GQNTFTNKLQ EQIYSSINHF 
       760        770        780        790        800
SNELVRKISI INQELNKKIL KELSEKYQKL FSELQDNFQN DTNEMLKFMG 
       810        820 
EIKDMMNLPE DQLVHAIRTR KFDNNKR                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XII
   Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names