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Protein

DNA polymerase zeta catalytic subunit

Gene

REV3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=543 µM for dGTP (insertion opposite abasic site)1 Publication
  2. KM=81 µM for dATP (insertion opposite abasic site)1 Publication
  3. KM=125 µM for dTTP (insertion opposite abasic site)1 Publication
  4. KM=113 µM for dCTP (insertion opposite abasic site)1 Publication
  5. KM=0.11 µM for dGTP (insertion opposite C)1 Publication
  6. KM=267 µM for dATP (insertion opposite C)1 Publication
  7. KM=552 µM for dTTP (insertion opposite C)1 Publication
  8. KM=321 µM for dCTP (insertion opposite C)1 Publication
  9. KM=344 µM for dGTP (insertion opposite G)1 Publication
  10. KM=118 µM for dATP (insertion opposite G)1 Publication
  11. KM=428 µM for dTTP (insertion opposite G)1 Publication
  12. KM=0.14 µM for dCTP (insertion opposite G)1 Publication
  13. KM=6.5 µM for dTTP (extension from G, A, T, or C opposite abasic site)1 Publication
  14. KM=2.3 µM for dTTP (extension from G, A, T, or C opposite abasic site)1 Publication
  15. KM=49 µM for dTTP (extension from G, A, T, or C opposite abasic site)1 Publication
  16. KM=21 µM for dTTP (extension from G, A, T, or C opposite abasic site)1 Publication
  17. KM=0.35 µM for dTTP (extension from G, A, T, or C opposite C)1 Publication
  18. KM=2.3 µM for dTTP (extension from G, A, T, or C opposite C)1 Publication
  19. KM=15 µM for dTTP (extension from G, A, T, or C opposite C)1 Publication
  20. KM=26 µM for dTTP (extension from G, A, T, or C opposite C)1 Publication
  21. KM=6.9 µM for dTTP (extension from G, A, T, or C opposite G)1 Publication
  22. KM=2.1 µM for dTTP (extension from G, A, T, or C opposite G)1 Publication
  23. KM=28.8 µM for dTTP (extension from G, A, T, or C opposite G)1 Publication
  24. KM=0.23 µM for dTTP (extension from G, A, T, or C opposite G)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1398ZincBy similarity1
    Metal bindingi1401ZincBy similarity1
    Metal bindingi1414ZincBy similarity1
    Metal bindingi1417ZincBy similarity1
    Metal bindingi1446Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi1449Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi1468Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi1473Iron-sulfur (4Fe-4S)By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1398 – 1417CysA-typeAdd BLAST20

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
    Biological processDNA damage, DNA repair, DNA replication
    Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    YEAST:G3O-34063-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-SCE-5655862 Translesion synthesis by POLK
    R-SCE-5656121 Translesion synthesis by POLI

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    DNA polymerase zeta catalytic subunit (EC:2.7.7.7)
    Alternative name(s):
    Protein reversionless 3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:REV3
    Synonyms:PSO1
    Ordered Locus Names:YPL167C
    ORF Names:P2535
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

    Organism-specific databases

    Saccharomyces Genome Database

    More...
    SGDi
    S000006088 REV3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion, Nucleus

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000464701 – 1504DNA polymerase zeta catalytic subunitAdd BLAST1504

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P14284

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P14284

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Forms DNA polymerase zeta with REV7.

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    REV7P389273EBI-6155,EBI-14960

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    36016, 135 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-1091 DNA polymerase zeta complex

    Database of interacting proteins

    More...
    DIPi
    DIP-8024N

    Protein interaction database and analysis system

    More...
    IntActi
    P14284, 3 interactors

    Molecular INTeraction database

    More...
    MINTi
    P14284

    STRING: functional protein association networks

    More...
    STRINGi
    4932.YPL167C

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P14284

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P14284

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1446 – 1473CysB motifAdd BLAST28

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri1398 – 1417CysA-typeAdd BLAST20

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000169521

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000194392

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P14284

    KEGG Orthology (KO)

    More...
    KOi
    K02350

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GAFPYLY

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG092C0C07

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.420.10, 1 hit
    3.90.1600.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006172 DNA-dir_DNA_pol_B
    IPR017964 DNA-dir_DNA_pol_B_CS
    IPR006133 DNA-dir_DNA_pol_B_exonuc
    IPR006134 DNA-dir_DNA_pol_B_multi_dom
    IPR023211 DNA_pol_palm_dom_sf
    IPR030559 PolZ_Rev3
    IPR012337 RNaseH-like_sf
    IPR036397 RNaseH_sf
    IPR025687 Znf-C4pol

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10322:SF5 PTHR10322:SF5, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00136 DNA_pol_B, 1 hit
    PF03104 DNA_pol_B_exo1, 2 hits
    PF14260 zf-C4pol, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00106 DNAPOLB

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00486 POLBc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53098 SSF53098, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00116 DNA_POLYMERASE_B, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P14284-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSRESNDTIQ SDTVRSSSKS DYFRIQLNNQ DYYMSKPTFL DPSHGESLPL
    60 70 80 90 100
    NQFSQVPNIR VFGALPTGHQ VLCHVHGILP YMFIKYDGQI TDTSTLRHQR
    110 120 130 140 150
    CAQVHKTLEV KIRASFKRKK DDKHDLAGDK LGNLNFVADV SVVKGIPFYG
    160 170 180 190 200
    YHVGWNLFYK ISLLNPSCLS RISELIRDGK IFGKKFEIYE SHIPYLLQWT
    210 220 230 240 250
    ADFNLFGCSW INVDRCYFRS PVLNSILDID KLTINDDLQL LLDRFCDFKC
    260 270 280 290 300
    NVLSRRDFPR VGNGLIEIDI LPQFIKNREK LQHRDIHHDF LEKLGDISDI
    310 320 330 340 350
    PVKPYVSSAR DMINELTMQR EELSLKEYKE PPETKRHVSG HQWQSSGEFE
    360 370 380 390 400
    AFYKKAQHKT STFDGQIPNF ENFIDKNQKF SAINTPYEAL PQLWPRLPQI
    410 420 430 440 450
    EINNNSMQDK KNDDQVNASF TEYEICGVDN ENEGVKGSNI KSRSYSWLPE
    460 470 480 490 500
    SIASPKDSTI LLDHQTKYHN TINFSMDCAM TQNMASKRKL RSSVSANKTS
    510 520 530 540 550
    LLSRKRKKVM AAGLRYGKRA FVYGEPPFGY QDILNKLEDE GFPKIDYKDP
    560 570 580 590 600
    FFSNPVDLEN KPYAYAGKRF EISSTHVSTR IPVQFGGETV SVYNKPTFDM
    610 620 630 640 650
    FSSWKYALKP PTYDAVQKWY NKVPSMGNKK TESQISMHTP HSKFLYKFAS
    660 670 680 690 700
    DVSGKQKRKK SSVHDSLTHL TLEIHANTRS DKIPDPAIDE VSMIIWCLEE
    710 720 730 740 750
    ETFPLDLDIA YEGIMIVHKA SEDSTFPTKI QHCINEIPVM FYESEFEMFE
    760 770 780 790 800
    ALTDLVLLLD PDILSGFEIH NFSWGYIIER CQKIHQFDIV RELARVKCQI
    810 820 830 840 850
    KTKLSDTWGY AHSSGIMITG RHMINIWRAL RSDVNLTQYT IESAAFNILH
    860 870 880 890 900
    KRLPHFSFES LTNMWNAKKS TTELKTVLNY WLSRAQINIQ LLRKQDYIAR
    910 920 930 940 950
    NIEQARLIGI DFHSVYYRGS QFKVESFLIR ICKSESFILL SPGKKDVRKQ
    960 970 980 990 1000
    KALECVPLVM EPESAFYKSP LIVLDFQSLY PSIMIGYNYC YSTMIGRVRE
    1010 1020 1030 1040 1050
    INLTENNLGV SKFSLPRNIL ALLKNDVTIA PNGVVYAKTS VRKSTLSKML
    1060 1070 1080 1090 1100
    TDILDVRVMI KKTMNEIGDD NTTLKRLLNN KQLALKLLAN VTYGYTSASF
    1110 1120 1130 1140 1150
    SGRMPCSDLA DSIVQTGRET LEKAIDIIEK DETWNAKVVY GDTDSLFVYL
    1160 1170 1180 1190 1200
    PGKTAIEAFS IGHAMAERVT QNNPKPIFLK FEKVYHPSIL ISKKRYVGFS
    1210 1220 1230 1240 1250
    YESPSQTLPI FDAKGIETVR RDGIPAQQKI IEKCIRLLFQ TKDLSKIKKY
    1260 1270 1280 1290 1300
    LQNEFFKIQI GKVSAQDFCF AKEVKLGAYK SEKTAPAGAV VVKRRINEDH
    1310 1320 1330 1340 1350
    RAEPQYKERI PYLVVKGKQG QLLRERCVSP EEFLEGENLE LDSEYYINKI
    1360 1370 1380 1390 1400
    LIPPLDRLFN LIGINVGNWA QEIVKSKRAS TTTTKVENIT RVGTSATCCN
    1410 1420 1430 1440 1450
    CGEELTKICS LQLCDDCLEK RSTTTLSFLI KKLKRQKEYQ TLKTVCRTCS
    1460 1470 1480 1490 1500
    YRYTSDAGIE NDHIASKCNS YDCPVFYSRV KAERYLRDNQ SVQREEALIS

    LNDW
    Length:1,504
    Mass (Da):172,957
    Last modified:January 1, 1990 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54C2C6B664F734F5
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M29683 Genomic DNA Translation: AAA34968.1
    X96770 Genomic DNA Translation: CAA65554.1
    Z73523 Genomic DNA Translation: CAA97873.1
    BK006949 Genomic DNA Translation: DAA11267.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A33602

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_015158.1, NM_001183981.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    YPL167C_mRNA; YPL167C_mRNA; YPL167C

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    855936

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    sce:YPL167C

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M29683 Genomic DNA Translation: AAA34968.1
    X96770 Genomic DNA Translation: CAA65554.1
    Z73523 Genomic DNA Translation: CAA97873.1
    BK006949 Genomic DNA Translation: DAA11267.1
    PIRiA33602
    RefSeqiNP_015158.1, NM_001183981.1

    3D structure databases

    ProteinModelPortaliP14284
    SMRiP14284
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi36016, 135 interactors
    ComplexPortaliCPX-1091 DNA polymerase zeta complex
    DIPiDIP-8024N
    IntActiP14284, 3 interactors
    MINTiP14284
    STRINGi4932.YPL167C

    Proteomic databases

    PaxDbiP14284
    PRIDEiP14284

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblFungiiYPL167C_mRNA; YPL167C_mRNA; YPL167C
    GeneIDi855936
    KEGGisce:YPL167C

    Organism-specific databases

    SGDiS000006088 REV3

    Phylogenomic databases

    GeneTreeiENSGT00940000169521
    HOGENOMiHOG000194392
    InParanoidiP14284
    KOiK02350
    OMAiGAFPYLY
    OrthoDBiEOG092C0C07

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34063-MONOMER
    ReactomeiR-SCE-5655862 Translesion synthesis by POLK
    R-SCE-5656121 Translesion synthesis by POLI

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P14284

    Family and domain databases

    Gene3Di3.30.420.10, 1 hit
    3.90.1600.10, 1 hit
    InterProiView protein in InterPro
    IPR006172 DNA-dir_DNA_pol_B
    IPR017964 DNA-dir_DNA_pol_B_CS
    IPR006133 DNA-dir_DNA_pol_B_exonuc
    IPR006134 DNA-dir_DNA_pol_B_multi_dom
    IPR023211 DNA_pol_palm_dom_sf
    IPR030559 PolZ_Rev3
    IPR012337 RNaseH-like_sf
    IPR036397 RNaseH_sf
    IPR025687 Znf-C4pol
    PANTHERiPTHR10322:SF5 PTHR10322:SF5, 1 hit
    PfamiView protein in Pfam
    PF00136 DNA_pol_B, 1 hit
    PF03104 DNA_pol_B_exo1, 2 hits
    PF14260 zf-C4pol, 1 hit
    PRINTSiPR00106 DNAPOLB
    SMARTiView protein in SMART
    SM00486 POLBc, 1 hit
    SUPFAMiSSF53098 SSF53098, 1 hit
    PROSITEiView protein in PROSITE
    PS00116 DNA_POLYMERASE_B, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOZ_YEAST
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14284
    Secondary accession number(s): D6W3K1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: December 5, 2018
    This is version 175 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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