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Protein

Pertactin autotransporter

Gene

prn

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.

Miscellaneous

Synthesized only in the presence of low Mg2+ concentration.

GO - Biological processi

Keywordsi

Biological processCell adhesion, Virulence

Enzyme and pathway databases

BioCyciBPER257313:BP1054-MONOMER

Protein family/group databases

TCDBi1.B.12.2.1 the autotransporter-1 (at-1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pertactin autotransporter
Alternative name(s):
P.93
Cleaved into the following 2 chains:
Gene namesi
Name:prn
Synonyms:omp69A
Ordered Locus Names:BP1054
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

Pertactin translocator :

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000000270535 – 910Pertactin autotransporterAdd BLAST876
ChainiPRO_000000270635 – 631Outer membrane protein P.69Add BLAST597
ChainiPRO_0000002707632 – 910Pertactin translocatorAdd BLAST279

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei631 – 632CleavageBy similarity2

Proteomic databases

PRIDEiP14283

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi257313.BP1054

Structurei

Secondary structure

1910
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14283
SMRiP14283
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14283

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati266 – 27015
Repeati271 – 27525
Repeati276 – 28035
Repeati281 – 2854; approximate5
Repeati286 – 2905; approximate5
Domaini642 – 910AutotransporterPROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni266 – 2905 X 5 AA tandem repeats of G-G-A-V-PAdd BLAST25
Regioni579 – 5935 X 3 AA tandem repeats of P-Q-PAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi260 – 262Cell attachment site; involved in adhesion to various eukaryotic cell lines3

Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108P8G Bacteria
COG3468 LUCA
HOGENOMiHOG000115499
KOiK12681
OMAiKAGERQH

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR006315 OM_autotransptr_brl
IPR012332 P22_tailspike-like_C_sf
IPR011050 Pectin_lyase_fold/virulence
IPR003992 Pertactin
IPR004899 Pertactin_central
IPR003991 Pertactin_virulence_factor
PfamiView protein in Pfam
PF03797 Autotransporter, 1 hit
PF03212 Pertactin, 1 hit
PRINTSiPR01482 PERTACTIN
PR01484 PRTACTNFAMLY
SMARTiView protein in SMART
SM00869 Autotransporter, 1 hit
SUPFAMiSSF103515 SSF103515, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01414 autotrans_barl, 1 hit
PROSITEiView protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14283-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMSLSRIVK AAPLRRTTLA MALGALGAAP AAHADWNNQS IVKTGERQHG
60 70 80 90 100
IHIQGSDPGG VRTASGTTIK VSGRQAQGIL LENPAAELQF RNGSVTSSGQ
110 120 130 140 150
LSDDGIRRFL GTVTVKAGKL VADHATLANV GDTWDDDGIA LYVAGEQAQA
160 170 180 190 200
SIADSTLQGA GGVQIERGAN VTVQRSAIVD GGLHIGALQS LQPEDLPPSR
210 220 230 240 250
VVLRDTNVTA VPASGAPAAV SVLGASELTL DGGHITGGRA AGVAAMQGAV
260 270 280 290 300
VHLQRATIRR GDAPAGGAVP GGAVPGGAVP GGFGPGGFGP VLDGWYGVDV
310 320 330 340 350
SGSSVELAQS IVEAPELGAA IRVGRGARVT VSGGSLSAPH GNVIETGGAR
360 370 380 390 400
RFAPQAAPLS ITLQAGAHAQ GKALLYRVLP EPVKLTLTGG ADAQGDIVAT
410 420 430 440 450
ELPSIPGTSI GPLDVALASQ ARWTGATRAV DSLSIDNATW VMTDNSNVGA
460 470 480 490 500
LRLASDGSVD FQQPAEAGRF KVLTVNTLAG SGLFRMNVFA DLGLSDKLVV
510 520 530 540 550
MQDASGQHRL WVRNSGSEPA SANTLLLVQT PLGSAATFTL ANKDGKVDIG
560 570 580 590 600
TYRYRLAANG NGQWSLVGAK APPAPKPAPQ PGPQPPQPPQ PQPEAPAPQP
610 620 630 640 650
PAGRELSAAA NAAVNTGGVG LASTLWYAES NALSKRLGEL RLNPDAGGAW
660 670 680 690 700
GRGFAQRQQL DNRAGRRFDQ KVAGFELGAD HAVAVAGGRW HLGGLAGYTR
710 720 730 740 750
GDRGFTGDGG GHTDSVHVGG YATYIADSGF YLDATLRASR LENDFKVAGS
760 770 780 790 800
DGYAVKGKYR THGVGASLEA GRRFTHADGW FLEPQAELAV FRAGGGAYRA
810 820 830 840 850
ANGLRVRDEG GSSVLGRLGL EVGKRIELAG GRQVQPYIKA SVLQEFDGAG
860 870 880 890 900
TVHTNGIAHR TELRGTRAEL GLGMAAALGR GHSLYASYEY SKGPKLAMPW
910
TFHAGYRYSW
Length:910
Mass (Da):93,453
Last modified:February 1, 1994 - v3
Checksum:iA169871E20A2E7DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04560 Genomic DNA Translation: AAA22980.1 Sequence problems.
BX640414 Genomic DNA Translation: CAE41353.1
RefSeqiNP_879839.1, NC_002929.2
WP_010930159.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE41353; CAE41353; BP1054
GeneIDi2664290
KEGGibpe:BP1054
PATRICifig|257313.5.peg.1126

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04560 Genomic DNA Translation: AAA22980.1 Sequence problems.
BX640414 Genomic DNA Translation: CAE41353.1
RefSeqiNP_879839.1, NC_002929.2
WP_010930159.1, NC_002929.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DABX-ray2.50A35-573[»]
ProteinModelPortaliP14283
SMRiP14283
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP1054

Protein family/group databases

TCDBi1.B.12.2.1 the autotransporter-1 (at-1) family

Proteomic databases

PRIDEiP14283

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE41353; CAE41353; BP1054
GeneIDi2664290
KEGGibpe:BP1054
PATRICifig|257313.5.peg.1126

Phylogenomic databases

eggNOGiENOG4108P8G Bacteria
COG3468 LUCA
HOGENOMiHOG000115499
KOiK12681
OMAiKAGERQH

Enzyme and pathway databases

BioCyciBPER257313:BP1054-MONOMER

Miscellaneous databases

EvolutionaryTraceiP14283

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR006315 OM_autotransptr_brl
IPR012332 P22_tailspike-like_C_sf
IPR011050 Pectin_lyase_fold/virulence
IPR003992 Pertactin
IPR004899 Pertactin_central
IPR003991 Pertactin_virulence_factor
PfamiView protein in Pfam
PF03797 Autotransporter, 1 hit
PF03212 Pertactin, 1 hit
PRINTSiPR01482 PERTACTIN
PR01484 PRTACTNFAMLY
SMARTiView protein in SMART
SM00869 Autotransporter, 1 hit
SUPFAMiSSF103515 SSF103515, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01414 autotrans_barl, 1 hit
PROSITEiView protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPERT_BORPE
AccessioniPrimary (citable) accession number: P14283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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