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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.By similarity

Activity regulationi

Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1Curated
Short name:
UCP 1Curated
Alternative name(s):
Solute carrier family 25 member 7By similarity
ThermogeninBy similarity
Gene namesi
Name:UCP1By similarity
Synonyms:SLC25A7By similarity, UCP1 Publication
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembraneBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 73Mitochondrial matrixBy similarityAdd BLAST41
Transmembranei74 – 96Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini97 – 115Mitochondrial intermembraneBy similarityAdd BLAST19
Transmembranei116 – 132Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini133 – 177Mitochondrial matrixBy similarityAdd BLAST45
Transmembranei178 – 194Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini195 – 211Mitochondrial intermembraneBy similarityAdd BLAST17
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 265Mitochondrial matrixBy similarityAdd BLAST34
Transmembranei266 – 288Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini289 – 306Mitochondrial intermembraneBy similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906611 – 306Mitochondrial brown fat uncoupling protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253Cysteine sulfenic acid (-SOH)By similarity1

Post-translational modificationi

May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.By similarity
May undergo ubiquitin-mediated proteasomal degradation.By similarity

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiP14271

Expressioni

Tissue specificityi

Brown adipose tissue.1 Publication

Interactioni

Subunit structurei

Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001977

Structurei

3D structure databases

ProteinModelPortaliP14271
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 102Solcar 1Add BLAST92
Repeati110 – 200Solcar 2Add BLAST91
Repeati209 – 294Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiP14271
KOiK08769

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P14271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGTTTTDVP PTMGVKIFSA GVAACLADVI TFPLDTAKVR QQIQGEFPIT
60 70 80 90 100
SGIRYKGVLG TITTLAKTEG PLKLYSGLPA GLQRQISFAS LRIGLYDTVQ
110 120 130 140 150
EFFTSGEETP SLGSKISAGL TTGGVAVFIG QPTEVVKVRL QAQSHLHGLK
160 170 180 190 200
PRYTGTYNAY RIIATTESLT SLWKGTTPNL LRNVIINCTE LVTYDLMKGA
210 220 230 240 250
LVRNEILADD VPCHFVSALI AGFCTTLLSS PVDVVKTRFI NSPPGQYASV
260 270 280 290 300
PNCAMTMFTK EGPTAFFKGF VPSFLRLGSW NVIMFVCFEK LKGELMRSRQ

TVDCAT
Length:306
Mass (Da):33,083
Last modified:January 1, 1990 - v1
Checksum:i58343CAD94C910F1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1SH82G1SH82_RABIT
Mitochondrial brown fat uncoupling ...
UCP1
307Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14696 mRNA Translation: CAA32826.1
PIRiA32446
RefSeqiNP_001164548.1, NM_001171077.1
UniGeneiOcu.2093

Genome annotation databases

GeneIDi100328618
KEGGiocu:100328618

Similar proteinsi

Entry informationi

Entry nameiUCP1_RABIT
AccessioniPrimary (citable) accession number: P14271
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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