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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

Slc2a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei348MonosaccharideBy similarity1
Binding sitei419MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport
R-MMU-422356 Regulation of insulin secretion
R-MMU-8981373 Intestinal hexose absorption

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1095438 Slc2a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 97ExtracellularSequence analysisAdd BLAST66
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicSequence analysis8
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 157ExtracellularSequence analysis10
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 186CytoplasmicSequence analysis8
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 216ExtracellularSequence analysis9
Transmembranei217 – 237Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini238 – 302CytoplasmicSequence analysisAdd BLAST65
Transmembranei303 – 323Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini324 – 337ExtracellularSequence analysisAdd BLAST14
Transmembranei338 – 358Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini359 – 367CytoplasmicSequence analysis9
Transmembranei368 – 388Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini389 – 401ExtracellularSequence analysisAdd BLAST13
Transmembranei402 – 422Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini423 – 432CytoplasmicSequence analysis10
Transmembranei433 – 453Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini454 – 460ExtracellularSequence analysis7
Transmembranei461 – 481Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini482 – 523CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503471 – 523Solute carrier family 2, facilitated glucose transporter member 2Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei522PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14246
PaxDbiP14246
PeptideAtlasiP14246
PRIDEiP14246

PTM databases

iPTMnetiP14246
PhosphoSitePlusiP14246

Expressioni

Tissue specificityi

In embryo, expressed in endoderm layer of yolk sac and liver primordium.1 Publication

Gene expression databases

BgeeiENSMUSG00000027690 Expressed in 68 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiP14246 baseline and differential
GenevisibleiP14246 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029240

Structurei

3D structure databases

ProteinModelPortaliP14246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni313 – 319Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP14246
KOiK07593
OMAiAVEMKFL
OrthoDBiEOG091G0A9K
PhylomeDBiP14246
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002440 Glc_transpt_2
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01191 GLUCTRSPORT2
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEDKITGTL AFTVFTAVLS SFQFGYDIGV INAPQEVIIS HYRHVLGVPL
60 70 80 90 100
DDRKAAINYD VNGTDTPLTV TPAYTTPAPW DEEETEGSAH IVTMLWSLSV
110 120 130 140 150
SSFAVGGMVA SFFGGWLGDK LGRIKAMLAA NSLSLTGALL MGCSKFGPAH
160 170 180 190 200
ALIIAGRSVS GLYCGLISGL VPMYIGEIAP TTLRGALGTL HQLALVTGIL
210 220 230 240 250
ISQIAGLSFI LGNQDHWHIL LGLSAVPALL QCLLLLFCPE SPRYLYIKLE
260 270 280 290 300
EEVRAKKSLK RLRGTEDVTK DINEMKKEKE EASTEQKVSV IQLFTDANYR
310 320 330 340 350
QPILVALMLH MAQQFSGING IFYYSTSIFQ TAGISQPVYA TIGVGAINMI
360 370 380 390 400
FTAVSVLLVE KAGRRTLFLT GMIGMFFCTI FMSVGLVLLD KFAWMSYVSM
410 420 430 440 450
TAIFLFVSFF EIGPGPIPWF MVAEFFSQGP RPTALALAAF SNWVCNFVIA
460 470 480 490 500
LCFQYIADFL GPYVFFLFAG VVLVFTLFTF FKVPETKGKS FEEIAAEFRK
510 520
KSGSAPPRKA AVQMEFLASS ESV
Length:523
Mass (Da):57,107
Last modified:November 16, 2001 - v3
Checksum:iF12B5376CBDB5F63
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXR7E9PXR7_MOUSE
Solute carrier family 2, facilitate...
Slc2a2
159Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106G → D in CAA33719 (PubMed:2771649).Curated1
Sequence conflicti181T → N in CAA34855 (PubMed:2602116).Curated1
Sequence conflicti327S → T in CAA33719 (PubMed:2771649).Curated1
Sequence conflicti351F → L in CAA34855 (PubMed:2602116).Curated1
Sequence conflicti432P → S in CAA34855 (PubMed:2602116).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16986 mRNA Translation: CAA34855.1
X15684 mRNA Translation: CAA33719.1
S77926 mRNA Translation: AAB20847.1
AK005068 mRNA Translation: BAB23792.1
AK165430 mRNA Translation: BAE38184.1
BC034675 mRNA Translation: AAH34675.1
X78722 Genomic DNA Translation: CAA55368.1
CCDSiCCDS50880.1
PIRiS06920
RefSeqiNP_112474.2, NM_031197.2
UniGeneiMm.18443

Genome annotation databases

EnsembliENSMUST00000029240; ENSMUSP00000029240; ENSMUSG00000027690
GeneIDi20526
KEGGimmu:20526
UCSCiuc008oua.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16986 mRNA Translation: CAA34855.1
X15684 mRNA Translation: CAA33719.1
S77926 mRNA Translation: AAB20847.1
AK005068 mRNA Translation: BAB23792.1
AK165430 mRNA Translation: BAE38184.1
BC034675 mRNA Translation: AAH34675.1
X78722 Genomic DNA Translation: CAA55368.1
CCDSiCCDS50880.1
PIRiS06920
RefSeqiNP_112474.2, NM_031197.2
UniGeneiMm.18443

3D structure databases

ProteinModelPortaliP14246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029240

PTM databases

iPTMnetiP14246
PhosphoSitePlusiP14246

Proteomic databases

MaxQBiP14246
PaxDbiP14246
PeptideAtlasiP14246
PRIDEiP14246

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029240; ENSMUSP00000029240; ENSMUSG00000027690
GeneIDi20526
KEGGimmu:20526
UCSCiuc008oua.2 mouse

Organism-specific databases

CTDi6514
MGIiMGI:1095438 Slc2a2

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP14246
KOiK07593
OMAiAVEMKFL
OrthoDBiEOG091G0A9K
PhylomeDBiP14246
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport
R-MMU-422356 Regulation of insulin secretion
R-MMU-8981373 Intestinal hexose absorption

Miscellaneous databases

ChiTaRSiSlc2a2 mouse
PROiPR:P14246
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027690 Expressed in 68 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiP14246 baseline and differential
GenevisibleiP14246 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002440 Glc_transpt_2
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01191 GLUCTRSPORT2
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR2_MOUSE
AccessioniPrimary (citable) accession number: P14246
Secondary accession number(s): Q3TNA5, Q9DBA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 16, 2001
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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