Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 202 (29 Sep 2021)
Sequence version 3 (11 Jul 2006)
Previous versions | rss
Add a publicationFeedback
Protein

DNA mismatch repair protein PMS1

Gene

PMS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.

3 Publications

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.5 mM for ATP1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase Source: SGD
  • ATP binding Source: SGD
  • mismatched DNA binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33111-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA mismatch repair protein PMS1
Alternative name(s):
Postmeiotic segregation protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PMS1
Ordered Locus Names:YNL082W
ORF Names:N2317
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005026, PMS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL082W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30E → A: Reduces ATPase activity by 62%. Displays 60-fold increase in spontaneous mutation accumulation. 2 Publications1
Mutagenesisi34N → A: Reduces ATPase activity by 84%. Displays 11000-fold increase in spontaneous mutation accumulation. 1 Publication1
Mutagenesisi95F → A: Displays an increase in spontaneous mutation accumulation. Does not impair heterodimer formation. 1 Publication1
Mutagenesisi97G → A: Displays an increase in spontaneous mutation accumulation. 1 Publication1
Mutagenesisi297K → E: Displays a 60-fold increase in spontaneous mutation accumulation. 1 Publication1
Mutagenesisi851G → E: Confers a strong defect in the repair of primer strand-specific 1-bp loops during DNA replication, but not during meoitic recombination. Does not impair heterodimer formation. 1 Publication1
Mutagenesisi857H → R: Confers a strong defect in the repair of primer strand-specific 1-bp loops during DNA replication, but not during meoitic recombination. Does not impair heterodimer formation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455711 – 873DNA mismatch repair protein PMS1Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei393PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P14242

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14242

PRoteomics IDEntifications database

More...
PRIDEi
P14242

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14242

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of MLH1 and PMS1, called MutLalpha, which is the major MMR MutL activity correcting base-base mismatches as well as IDLs. The heterodimer binds double strand DNA independently of a mismatch with positive cooperativity and has more than one DNA binding site.

Forms a ternary complex with either the MSH2-MSH6 (MutSalpha) or the MSH2-MSH3 heterodimer (MutSbeta), which recognize and bind to mismatch DNA. Ternary complex formation is promoted by ATP binding.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35741, 244 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1666, MutLalpha endonuclease complex

Database of interacting proteins

More...
DIPi
DIP-2416N

Protein interaction database and analysis system

More...
IntActi
P14242, 8 interactors

Molecular INTeraction database

More...
MINTi
P14242

STRING: functional protein association networks

More...
STRINGi
4932.YNL082W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P14242, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1873
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14242

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P14242

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 357DNA- and ATP-bindingAdd BLAST357
Regioni379 – 423DisorderedSequence analysisAdd BLAST45
Regioni661 – 873Interaction with MLH1Add BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi379 – 399Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi400 – 423Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1978, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155381

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004131_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14242

Identification of Orthologs from Complete Genome Data

More...
OMAi
SFNNVQY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.100, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014762, DNA_mismatch_repair_CS
IPR002099, DNA_mismatch_repair_N
IPR013507, DNA_mismatch_S5_2-like
IPR036890, HATPase_C_sf
IPR038973, MutL/Mlh/Pms
IPR014790, MutL_C
IPR042121, MutL_C_regsub
IPR037198, MutL_C_sf
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr

The PANTHER Classification System

More...
PANTHERi
PTHR10073, PTHR10073, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01119, DNA_mis_repair, 1 hit
PF08676, MutL_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01340, DNA_mis_repair, 1 hit
SM00853, MutL_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118116, SSF118116, 1 hit
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00585, mutl, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00058, DNA_MISMATCH_REPAIR_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P14242-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQIHQINDI DVHRITSGQV ITDLTTAVKE LVDNSIDANA NQIEIIFKDY
60 70 80 90 100
GLESIECSDN GDGIDPSNYE FLALKHYTSK IAKFQDVAKV QTLGFRGEAL
110 120 130 140 150
SSLCGIAKLS VITTTSPPKA DKLEYDMVGH ITSKTTTSRN KGTTVLVSQL
160 170 180 190 200
FHNLPVRQKE FSKTFKRQFT KCLTVIQGYA IINAAIKFSV WNITPKGKKN
210 220 230 240 250
LILSTMRNSS MRKNISSVFG AGGMRGLEEV DLVLDLNPFK NRMLGKYTDD
260 270 280 290 300
PDFLDLDYKI RVKGYISQNS FGCGRNSKDR QFIYVNKRPV EYSTLLKCCN
310 320 330 340 350
EVYKTFNNVQ FPAVFLNLEL PMSLIDVNVT PDKRVILLHN ERAVIDIFKT
360 370 380 390 400
TLSDYYNRQE LALPKRMCSQ SEQQAQKRLK TEVFDDRSTT HESDNENYHT
410 420 430 440 450
ARSESNQSNH AHFNSTTGVI DKSNGTELTS VMDGNYTNVT DVIGSECEVS
460 470 480 490 500
VDSSVVLDEG NSSTPTKKLP SIKTDSQNLS DLNLNNFSNP EFQNITSPDK
510 520 530 540 550
ARSLEKVVEE PVYFDIDGEK FQEKAVLSQA DGLVFVDNEC HEHTNDCCHQ
560 570 580 590 600
ERRGSTDTEQ DDEADSIYAE IEPVEINVRT PLKNSRKSIS KDNYRSLSDG
610 620 630 640 650
LTHRKFEDEI LEYNLSTKNF KEISKNGKQM SSIISKRKSE AQENIIKNKD
660 670 680 690 700
ELEDFEQGEK YLTLTVSKND FKKMEVVGQF NLGFIIVTRK VDNKYDLFIV
710 720 730 740 750
DQHASDEKYN FETLQAVTVF KSQKLIIPQP VELSVIDELV VLDNLPVFEK
760 770 780 790 800
NGFKLKIDEE EEFGSRVKLL SLPTSKQTLF DLGDFNELIH LIKEDGGLRR
810 820 830 840 850
DNIRCSKIRS MFAMRACRSS IMIGKPLNKK TMTRVVHNLS ELDKPWNCPH
860 870
GRPTMRHLME LRDWSSFSKD YEI
Length:873
Mass (Da):99,355
Last modified:July 11, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E0FFBC59B718854
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA34885 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM00521 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM00533 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM00545 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM00551 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM00563 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM00569 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA60176 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA61428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA95956 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA95957 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti695Y → S in AAA34885 (PubMed:2676974).Curated1
Sequence conflicti861L → I in AAA34885 (PubMed:2676974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti41N → S in strain: SK1 and YJM421. 2 Publications1
Natural varianti112I → T in strain: SK1 and YJM421. 2 Publications1
Natural varianti384F → V in strain: SK1, YJM320, YJM339 and YJM421. 2 Publications1
Natural varianti392E → V in strain: YJM320. 1 Publication1
Natural varianti400T → S in strain: SK1, YJM320, YJM339 and YJM421. 2 Publications1
Natural varianti401A → S in strain: YJM320 and YJM421. 1 Publication1
Natural varianti416T → TCEGT in strain: SK1, YJM320, YJM339 and YJM421. 1
Natural varianti458D → Y in strain: EAY1068. 1 Publication1
Natural varianti475D → N in strain: YJM339. 1 Publication1
Natural varianti513Y → F in strain: SK1. 1 Publication1
Natural varianti564A → V in strain: YJM320. 1 Publication1
Natural varianti768K → R in strain: YJM320. 1 Publication1
Natural varianti818R → K in strain: SK1 and YJM320; forms a non-functional heterodimer with MHL1 from strain S288c, resulting in an accumulation of mutations in spore progeny of crosses between these strains. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M29688 Genomic DNA Translation: AAA34885.1 Different initiation.
AF458969 Genomic DNA Translation: AAM00521.1 Different initiation.
AF458971 Genomic DNA Translation: AAM00533.1 Different initiation.
AF458973 Genomic DNA Translation: AAM00545.1 Different initiation.
AF458974 Genomic DNA Translation: AAM00551.1 Different initiation.
AF458976 Genomic DNA Translation: AAM00563.1 Different initiation.
AF458977 Genomic DNA Translation: AAM00569.1 Different initiation.
DQ115393 Genomic DNA Translation: AAZ22526.1
DQ356628 Genomic DNA Translation: ABC86932.1
DQ356629 Genomic DNA Translation: ABC86933.1
DQ356630 Genomic DNA Translation: ABC86934.1
DQ356631 Genomic DNA Translation: ABC86935.1
DQ356632 Genomic DNA Translation: ABC86936.1
X86470 Genomic DNA Translation: CAA60176.1 Different initiation.
Z71357 Genomic DNA Translation: CAA95956.1 Different initiation.
Z71358 Genomic DNA Translation: CAA95957.1 Different initiation.
X89016 Genomic DNA Translation: CAA61428.1 Different initiation.
BK006947 Genomic DNA Translation: DAA10463.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53896

NCBI Reference Sequences

More...
RefSeqi
NP_014317.4, NM_001182920.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL082W_mRNA; YNL082W; YNL082W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855642

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL082W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29688 Genomic DNA Translation: AAA34885.1 Different initiation.
AF458969 Genomic DNA Translation: AAM00521.1 Different initiation.
AF458971 Genomic DNA Translation: AAM00533.1 Different initiation.
AF458973 Genomic DNA Translation: AAM00545.1 Different initiation.
AF458974 Genomic DNA Translation: AAM00551.1 Different initiation.
AF458976 Genomic DNA Translation: AAM00563.1 Different initiation.
AF458977 Genomic DNA Translation: AAM00569.1 Different initiation.
DQ115393 Genomic DNA Translation: AAZ22526.1
DQ356628 Genomic DNA Translation: ABC86932.1
DQ356629 Genomic DNA Translation: ABC86933.1
DQ356630 Genomic DNA Translation: ABC86934.1
DQ356631 Genomic DNA Translation: ABC86935.1
DQ356632 Genomic DNA Translation: ABC86936.1
X86470 Genomic DNA Translation: CAA60176.1 Different initiation.
Z71357 Genomic DNA Translation: CAA95956.1 Different initiation.
Z71358 Genomic DNA Translation: CAA95957.1 Different initiation.
X89016 Genomic DNA Translation: CAA61428.1 Different initiation.
BK006947 Genomic DNA Translation: DAA10463.1
PIRiS53896
RefSeqiNP_014317.4, NM_001182920.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H4LX-ray2.50A/B1-365[»]
4E4WX-ray2.50B635-873[»]
4FMNX-ray2.69B635-873[»]
4FMOX-ray3.04B635-873[»]
SMRiP14242
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35741, 244 interactors
ComplexPortaliCPX-1666, MutLalpha endonuclease complex
DIPiDIP-2416N
IntActiP14242, 8 interactors
MINTiP14242
STRINGi4932.YNL082W

PTM databases

iPTMnetiP14242

Proteomic databases

MaxQBiP14242
PaxDbiP14242
PRIDEiP14242

Genome annotation databases

EnsemblFungiiYNL082W_mRNA; YNL082W; YNL082W
GeneIDi855642
KEGGisce:YNL082W

Organism-specific databases

SGDiS000005026, PMS1
VEuPathDBiFungiDB:YNL082W

Phylogenomic databases

eggNOGiKOG1978, Eukaryota
GeneTreeiENSGT00940000155381
HOGENOMiCLU_004131_0_2_1
InParanoidiP14242
OMAiSFNNVQY

Enzyme and pathway databases

BioCyciYEAST:G3O-33111-MONOMER
ReactomeiR-SCE-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Miscellaneous databases

EvolutionaryTraceiP14242

Protein Ontology

More...
PROi
PR:P14242
RNActiP14242, protein

Family and domain databases

Gene3Di3.30.1370.100, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR014762, DNA_mismatch_repair_CS
IPR002099, DNA_mismatch_repair_N
IPR013507, DNA_mismatch_S5_2-like
IPR036890, HATPase_C_sf
IPR038973, MutL/Mlh/Pms
IPR014790, MutL_C
IPR042121, MutL_C_regsub
IPR037198, MutL_C_sf
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073, PTHR10073, 1 hit
PfamiView protein in Pfam
PF01119, DNA_mis_repair, 1 hit
PF08676, MutL_C, 1 hit
SMARTiView protein in SMART
SM01340, DNA_mis_repair, 1 hit
SM00853, MutL_C, 1 hit
SUPFAMiSSF118116, SSF118116, 1 hit
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit
TIGRFAMsiTIGR00585, mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058, DNA_MISMATCH_REPAIR_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPMS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14242
Secondary accession number(s): D6W197
, Q2I044, Q2I045, Q45TY4, Q8TG48, Q8TG50, Q8TG54, Q8TG57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 11, 2006
Last modified: September 29, 2021
This is version 202 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again