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Protein

Sodium/potassium-transporting ATPase subunit beta-2

Gene

Atp1b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-2
Alternative name(s):
Adhesion molecule in glia
Short name:
AMOG
Sodium/potassium-dependent ATPase subunit beta-2
Gene namesi
Name:Atp1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88109 Atp1b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 67Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini68 – 290ExtracellularSequence analysisAdd BLAST223

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191051 – 290Sodium/potassium-transporting ATPase subunit beta-2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi129 ↔ 150By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 177By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 261By similarity
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi250N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14231
PeptideAtlasiP14231
PRIDEiP14231

PTM databases

iPTMnetiP14231
PhosphoSitePlusiP14231
SwissPalmiP14231

Expressioni

Gene expression databases

BgeeiENSMUSG00000041329
CleanExiMM_ATP1B2
ExpressionAtlasiP14231 baseline and differential
GenevisibleiP14231 MM

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated

GO - Molecular functioni

Protein-protein interaction databases

IntActiP14231, 2 interactors
MINTiP14231
STRINGi10090.ENSMUSP00000047353

Structurei

3D structure databases

ProteinModelPortaliP14231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 290immunoglobulin-likeBy similarityAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP14231
KOiK01540
OMAiHKLNTIW
OrthoDBiEOG091G0DJ4
PhylomeDBiP14231
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P14231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF
60 70 80 90 100
LTAMFSLTMW VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNISDT
110 120 130 140 150
ESWGQHVQKL NKFLEPYNDS IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC
160 170 180 190 200
QFNRTQLGDC SGIGDPTHYG YSTGQPCVFI KMNRVINFYA GANQSMNVTC
210 220 230 240 250
VGKRDEDAEN LGHFVMFPAN GSIDLMYFPY YGKKFHVNYT QPLVAVKFLN
260 270 280 290
VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
Length:290
Mass (Da):33,344
Last modified:February 1, 1996 - v2
Checksum:i731836AFB23198D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16645 mRNA Translation: CAA34638.1
X56007 Genomic DNA Translation: CAA39482.1
M60897 Genomic DNA No translation available.
BC042467 mRNA Translation: AAH42467.1
BC058763 mRNA Translation: AAH58763.1
CCDSiCCDS24898.1
PIRiA34057
S14235
RefSeqiNP_038201.1, NM_013415.5
UniGeneiMm.235204

Genome annotation databases

EnsembliENSMUST00000047889; ENSMUSP00000047353; ENSMUSG00000041329
GeneIDi11932
KEGGimmu:11932
UCSCiuc007jqo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAT1B2_MOUSE
AccessioniPrimary (citable) accession number: P14231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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