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Protein

Fructose-bisphosphate aldolase

Gene
N/A
Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (GGI.R1)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (P41), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62Substrate1
Binding sitei152Substrate1
Active sitei195Proton acceptorBy similarity1
Active sitei237Schiff-base intermediate with dihydroxyacetone-P1
Sitei369Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

SABIO-RKiP14223
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Alternative name(s):
41 kDa antigen
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169301 – 369Fructose-bisphosphate aldolaseAdd BLAST369

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-60915N
IntActiP14223, 1 interactor

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 29Combined sources14
Beta strandi35 – 39Combined sources5
Helixi43 – 52Combined sources10
Helixi59 – 70Combined sources12
Turni76 – 78Combined sources3
Beta strandi79 – 84Combined sources6
Helixi86 – 89Combined sources4
Helixi99 – 106Combined sources8
Beta strandi109 – 113Combined sources5
Beta strandi118 – 120Combined sources3
Beta strandi124 – 126Combined sources3
Beta strandi128 – 130Combined sources3
Turni133 – 135Combined sources3
Helixi136 – 146Combined sources11
Beta strandi150 – 157Combined sources8
Helixi161 – 163Combined sources3
Helixi168 – 187Combined sources20
Beta strandi191 – 198Combined sources8
Helixi206 – 226Combined sources21
Helixi231 – 233Combined sources3
Helixi253 – 267Combined sources15
Beta strandi274 – 277Combined sources4
Helixi284 – 296Combined sources13
Beta strandi301 – 309Combined sources9
Helixi310 – 318Combined sources9
Turni319 – 322Combined sources4
Turni324 – 326Combined sources3
Helixi327 – 346Combined sources20

3D structure databases

ProteinModelPortaliP14223
SMRiP14223
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14223

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

P14223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHCTEYMNA PKKLPADVAE ELATTAQKLV QAGKGILAAD ESTQTIKKRF
60 70 80 90 100
DNIKLENTIE NRASYRDLLF GTKGLGKFIS GAILFEETLF QKNEAGVPMV
110 120 130 140 150
NLLHNENIIP GIKVDKGLVN IPCTDEEKST QGLDGLAERC KEYYKAGARF
160 170 180 190 200
AKWRTVLVID TAKGKPTDLS IHETAWGLAR YASICQQNRL VPIVEPEILA
210 220 230 240 250
DGPHSIEVCA VVTQKVLSCV FKALQENGVL LEGALLKPNM VTAGYECTAK
260 270 280 290 300
TTTQDVGFLT VRTLRRTVPP ALPGVVFLSG GQSEEEASVN LNSINALGPH
310 320 330 340 350
PWALTFSYGR ALQASVLNTW QGKKENVAKA REVLLQRAEA NSLATYGKYK
360
GGAGGENAGA SLYEKKYVY
Length:369
Mass (Da):40,105
Last modified:January 1, 1990 - v1
Checksum:i2AE9CDED4F5C96A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28881 Genomic DNA Translation: AAA29473.1
A13461 Unassigned DNA Translation: CAA01107.1
A13481 Unassigned DNA Translation: CAA01117.1
PIRiA44942

Similar proteinsi

Entry informationi

Entry nameiALF_PLAFA
AccessioniPrimary (citable) accession number: P14223
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 31, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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