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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Pennisetum americanum (Pearl millet) (Pennisetum glaucum)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1By similarity)
Alternative name(s):
ADH slow-allele
Gene namesi
Name:ADH1
OrganismiPennisetum americanum (Pearl millet) (Pennisetum glaucum)
Taxonomic identifieri4543 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaePanicodaePaniceaeCenchrinaeCenchrus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607101 – 379Alcohol dehydrogenase 1Add BLAST379

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP14219
SMRiP14219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P14219-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTSLCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRIFGHE AGGIIESVGE GVTDVAPGDH VLPVFTGECK
110 120 130 140 150
ECPHCKSAES NMCDLLRINT VRGVMIGDGK SRFSINGKPI YHFVGTSTFS
160 170 180 190 200
EYTVMHVGCV AKINPEAPLD KVCVLSCGIS TGLGASINVA KPPKGSTVAI
210 220 230 240 250
FGLGAVGLAA AEGARIAGAS RIIGVDLNPS RFEEAKKFGC TEFVNPKDHN
260 270 280 290 300
KPVQEVLADM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK
310 320 330 340 350
DAEFKTHPMN FLNERTLKGT FFGNFKPRTD LPNVVELYMK KELEVEKFIT
360 370
HSVPFSEINK AFDLMAKGEG IRCIIRMEN
Length:379
Mass (Da):40,916
Last modified:January 1, 1990 - v1
Checksum:iE4FB72DE7A2C3EC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16547 mRNA Translation: CAA34547.1
PIRiS14905 DEILSP

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16547 mRNA Translation: CAA34547.1
PIRiS14905 DEILSP

3D structure databases

ProteinModelPortaliP14219
SMRiP14219
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_PENAM
AccessioniPrimary (citable) accession number: P14219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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