HGF

Functionⁱ

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.2 Publications

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

GO - Molecular functionⁱ

chemoattractant activity
Source: BHF-UCL
Inferred from direct assayⁱ
- "Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells."
  Evans I.M., Yamaji M., Britton G., Pellet-Many C., Lockie C., Zachary I.C., Frankel P.
  Mol Cell Biol 31:1174-1185(2011) [PubMed] [Europe PMC] [Abstract]
growth factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- Ref.2
  "Molecular cloning and expression of human hepatocyte growth factor."
  Nakamura T., Nishizawa T., Hagiya M., Seki T., Shimonishi M., Sugimura A., Tashiro K., Shimizu S.
  Nature 342:440-443(1989) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 55-73 AND 495-520.
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- "A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist."
  Tolbert W.D., Daugherty J., Gao C., Xie Q., Miranti C., Gherardi E., Woude G.V., Xu H.E.
  Proc. Natl. Acad. Sci. U.S.A. 104:14592-14597(2007) [PubMed] [Europe PMC] [Abstract]
- Ref.24
  "Structural basis for agonism and antagonism of hepatocyte growth factor."
  Tolbert W.D., Daugherty-Holtrop J., Gherardi E., Vande Woude G., Xu H.E.
  Proc. Natl. Acad. Sci. U.S.A. 107:13264-13269(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 28-289, DISULFIDE BONDS, FUNCTION.
- "Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling."
  Cecchi F., Pajalunga D., Fowler C.A., Uren A., Rabe D.C., Peruzzi B., Macdonald N.J., Blackman D.K., Stahl S.J., Byrd R.A., Bottaro D.P.
  Cancer Cell 22:250-262(2012) [PubMed] [Europe PMC] [Abstract]
protein-containing complex binding Source: Ensembl
serine-type endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor, Serine protease homolog

Molecular function

Growth factor, Serine protease homolog

Enzyme and pathway databases

PathwayCommonsⁱ	P14210
Reactomeⁱ	R-HSA-114608, Platelet degranulation R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1266695, Interleukin-7 signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6806942, MET Receptor Activation R-HSA-6807004, Negative regulation of MET activity R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8851805, MET activates RAS signaling R-HSA-8851907, MET activates PI3K/AKT signaling R-HSA-8865999, MET activates PTPN11 R-HSA-8874081, MET activates PTK2 signaling R-HSA-8875513, MET interacts with TNS proteins R-HSA-8875555, MET activates RAP1 and RAC1 R-HSA-8875656, MET receptor recycling R-HSA-8875791, MET activates STAT3
SignaLinkⁱ	P14210
SIGNORⁱ	P14210

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.976

MEROPSⁱ

S01.976

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte growth factor Alternative name(s): Hepatopoietin-A Scatter factor Short name: SF Cleaved into the following 2 chains: Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Gene namesⁱ	Name:HGF Synonyms:HPTA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4893, HGF
MIMⁱ	142409, gene
neXtProtⁱ	NX_P14210
VEuPathDBⁱ	HostDB:ENSG00000019991.15

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Deafness, autosomal recessive, 39 (DFNB39)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Related information in OMIM

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	494	R → Q: Loss of activity due to absence of proteolytic cleavage. 1 Publication		1

Keywords - Diseaseⁱ

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3082
GeneReviewsⁱ	HGF
MalaCards human disease database More...MalaCardsⁱ	HGF
MIMⁱ	608265, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000019991
Orphanetⁱ	90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBⁱ	PA29269

Miscellaneous databases

Pharosⁱ	P14210, Tchem

Pharosⁱ

P14210, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL5479
Drug and drug target database More...DrugBankⁱ	DB05434, ABT-510 DB12307, Foretinib DB01109, Heparin DB03959, N,O6-Disulfo-Glucosamine DB02264, O2-Sulfo-Glucuronic Acid

Genetic variation databases

BioMutaⁱ	HGF
DMDMⁱ	123116

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 31	1 PublicationAdd BLAST	31
ChainⁱPRO_0000028091	32 – 494	Hepatocyte growth factor alpha chainAdd BLAST	463
ChainⁱPRO_0000028092	495 – 728	Hepatocyte growth factor beta chainAdd BLAST	234

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	32	Pyrrolidone carboxylic acid1 Publication	1
Disulfide bondⁱ	70 ↔ 96
Disulfide bondⁱ	74 ↔ 84
Disulfide bondⁱ	128 ↔ 206
Disulfide bondⁱ	149 ↔ 189
Disulfide bondⁱ	177 ↔ 201
Disulfide bondⁱ	211 ↔ 288	By similarity
Disulfide bondⁱ	232 ↔ 271	By similarity
Disulfide bondⁱ	260 ↔ 283	By similarity
GlycosylationⁱCAR_000021	294	N-linked (GlcNAc...) (complex) asparagine	1
Disulfide bondⁱ	305 ↔ 383	By similarity
Disulfide bondⁱ	326 ↔ 365	By similarity
Disulfide bondⁱ	354 ↔ 377	By similarity
Disulfide bondⁱ	391 ↔ 469	By similarity
GlycosylationⁱCAR_000022	402	N-linked (GlcNAc...) (complex) asparagine	1
Disulfide bondⁱ	412 ↔ 452	By similarity
Disulfide bondⁱ	440 ↔ 464	By similarity
GlycosylationⁱCAR_000023	476	O-linked (GalNAc...) threonine1 Publication	1
Disulfide bondⁱ	487 ↔ 604	Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondⁱ	519 ↔ 535	By similarity
GlycosylationⁱCAR_000024	566	N-linked (GlcNAc...) (complex) asparagine	1
Disulfide bondⁱ	612 ↔ 679	By similarity
Disulfide bondⁱ	642 ↔ 658	By similarity
GlycosylationⁱCAR_000025	653	N-linked (GlcNAc...) (complex) asparagine	1
Disulfide bondⁱ	669 ↔ 697	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDⁱ	P14210
MassIVEⁱ	P14210
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14210
PaxDbⁱ	P14210
PeptideAtlas More...PeptideAtlasⁱ	P14210
PRIDEⁱ	P14210
ProteomicsDBⁱ	53034 [P14210-1] 53035 [P14210-2] 53036 [P14210-3] 53037 [P14210-4] 53038 [P14210-5] 53039 [P14210-6]

PTM databases

GlyConnectⁱ	219, 8 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site)
GlyGenⁱ	P14210, 5 sites, 8 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
iPTMnetⁱ	P14210
PhosphoSitePlusⁱ	P14210

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000019991, Expressed in placenta and 194 other tissues
ExpressionAtlasⁱ	P14210, baseline and differential
Genevisibleⁱ	P14210, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000019991, Tissue enhanced (placenta)

HPAⁱ

ENSG00000019991, Tissue enhanced (placenta)

Interactionⁱ

Subunit structureⁱ

Dimer of an alpha chain and a beta chain linked by a disulfide bond.

Interacts with SRPX2; the interaction increases HGF mitogenic activity.

2 Publications

Binary interactionsⁱ

Hide details

P14210

With	#Exp.	IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]	3	EBI-1039104,EBI-10173507
itself	2	EBI-1039104,EBI-1039104
MEOX2 [P50222]	3	EBI-1039104,EBI-748397
MET [P08581]	7	EBI-1039104,EBI-1039152
Met [P16056] from Mus musculus.	2	EBI-1039104,EBI-1798780

HGF - isoform 6 [P14210-6]

With	#Exp.	IntAct
itself	3	EBI-6280319,EBI-6280319
MET [P08581]	3	EBI-6280319,EBI-1039152

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	109330, 33 interactors
CORUMⁱ	P14210
Database of interacting proteins More...DIPⁱ	DIP-37535N
IntActⁱ	P14210, 9 interactors
Molecular INTeraction database More...MINTⁱ	P14210
STRINGⁱ	9606.ENSP00000222390

Chemistry databases

BindingDBⁱ

P14210

Miscellaneous databases

RNActⁱ	P14210, protein

RNActⁱ

P14210, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	39 – 41	Combined sources	3
Beta strandⁱ	42 – 52	Combined sources	11
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	60 – 63	Combined sources	4
Helixⁱ	67 – 76	Combined sources	10
Turnⁱ	77 – 79	Combined sources	3
Beta strandⁱ	80 – 82	Combined sources	3
Beta strandⁱ	86 – 90	Combined sources	5
Turnⁱ	91 – 94	Combined sources	4
Beta strandⁱ	95 – 100	Combined sources	6
Beta strandⁱ	105 – 107	Combined sources	3
Beta strandⁱ	108 – 121	Combined sources	14
Helixⁱ	122 – 124	Combined sources	3
Beta strandⁱ	128 – 132	Combined sources	5
Beta strandⁱ	148 – 150	Combined sources	3
Beta strandⁱ	156 – 158	Combined sources	3
Helixⁱ	164 – 167	Combined sources	4
Turnⁱ	168 – 171	Combined sources	4
Beta strandⁱ	187 – 193	Combined sources	7
Beta strandⁱ	198 – 200	Combined sources	3
Helixⁱ	206 – 209	Combined sources	4
Beta strandⁱ	211 – 213	Combined sources	3
Beta strandⁱ	239 – 241	Combined sources	3
Turnⁱ	247 – 249	Combined sources	3
Turnⁱ	251 – 254	Combined sources	4
Beta strandⁱ	270 – 274	Combined sources	5
Beta strandⁱ	279 – 282	Combined sources	4
Beta strandⁱ	508 – 525	Combined sources	18
Beta strandⁱ	528 – 532	Combined sources	5
Helixⁱ	533 – 535	Combined sources	3
Beta strandⁱ	537 – 539	Combined sources	3
Helixⁱ	541 – 543	Combined sources	3
Beta strandⁱ	544 – 549	Combined sources	6
Beta strandⁱ	551 – 554	Combined sources	4
Turnⁱ	557 – 561	Combined sources	5
Beta strandⁱ	563 – 572	Combined sources	10
Beta strandⁱ	579 – 586	Combined sources	8
Beta strandⁱ	591 – 593	Combined sources	3
Beta strandⁱ	611 – 618	Combined sources	8
Beta strandⁱ	630 – 637	Combined sources	8
Helixⁱ	639 – 641	Combined sources	3
Turnⁱ	646 – 648	Combined sources	3
Beta strandⁱ	656 – 660	Combined sources	5
Beta strandⁱ	662 – 664	Combined sources	3
Turnⁱ	670 – 674	Combined sources	5
Beta strandⁱ	676 – 680	Combined sources	5
Beta strandⁱ	682 – 691	Combined sources	10
Beta strandⁱ	695 – 697	Combined sources	3
Beta strandⁱ	704 – 708	Combined sources	5
Helixⁱ	709 – 712	Combined sources	4
Helixⁱ	713 – 720	Combined sources	8

Show more details

3D structure databases

SMRⁱ	P14210
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14210

EvolutionaryTraceⁱ

P14210

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	37 – 123	PANPROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	128 – 206	Kringle 1PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	211 – 288	Kringle 2PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	305 – 383	Kringle 3PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	391 – 469	Kringle 4PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	495 – 721	Peptidase S1PROSITE-ProRule annotationAdd BLAST	227

Sequence similaritiesⁱ

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG502QR40, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156019
HOGENOMⁱ	CLU_017565_1_0_1
InParanoidⁱ	P14210
OMAⁱ	TNIPQCG
Database of Orthologous Groups More...OrthoDBⁱ	164039at2759
PhylomeDBⁱ	P14210
TreeFamⁱ	TF329901

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit
Gene3Dⁱ	2.40.10.10, 2 hits 2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00051, Kringle, 4 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit
PIRSFⁱ	PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit
PRINTSⁱ	PR00722, CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits
PROSITEⁱ	View protein in PROSITE PS00021, KRINGLE_1, 4 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P14210-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV 
       210        220        230        240        250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY 
       260        270        280        290        300
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL 
       310        320        330        340        350
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR 
       360        370        380        390        400
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM 
       410        420        430        440        450
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP 
       460        470        480        490        500
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP 
       510        520        530        540        550
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI 
       560        570        580        590        600
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP 
       610        620        630        640        650
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV 
       660        670        680        690        700
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP 
       710        720 
NRPGIFVRVA YYAKWIHKII LTYKVPQS

Length:728

Mass (Da):83,134

Last modified:August 1, 1991 - v2

Checksum:ⁱ2D997938295ADD2F

GO

Isoform 2 (identifier: P14210-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
289-290: AD → ET
291-728: Missing.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV 
       210        220        230        240        250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY 
       260        270        280        290
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCET

Show »

Length:290

Mass (Da):33,766

Checksum:ⁱC8A18A6F0D63200A

GO

Isoform 3 (identifier: P14210-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
161-165: Missing.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SYRGKDLQEN YCRNPRGEEG GPWCFTSNPE VRYEVCDIPQ 
       210        220        230        240        250
CSEVECMTCN GESYRGLMDH TESGKICQRW DHQTPHRHKF LPERYPDKGF 
       260        270        280        290        300
DDNYCRNPDG QPRPWCYTLD PHTRWEYCAI KTCADNTMND TDVPLETTEC 
       310        320        330        340        350
IQGQGEGYRG TVNTIWNGIP CQRWDSQYPH EHDMTPENFK CKDLRENYCR 
       360        370        380        390        400
NPDGSESPWC FTTDPNIRVG YCSQIPNCDM SHGQDCYRGN GKNYMGNLSQ 
       410        420        430        440        450
TRSGLTCSMW DKNMEDLHRH IFWEPDASKL NENYCRNPDD DAHGPWCYTG 
       460        470        480        490        500
NPLIPWDYCP ISRCEGDTTP TIVNLDHPVI SCAKTKQLRV VNGIPTRTNI 
       510        520        530        540        550
GWMVSLRYRN KHICGGSLIK ESWVLTARQC FPSRDLKDYE AWLGIHDVHG 
       560        570        580        590        600
RGDEKCKQVL NVSQLVYGPE GSDLVLMKLA RPAVLDDFVS TIDLPNYGCT 
       610        620        630        640        650
IPEKTSCSVY GWGYTGLINY DGLLRVAHLY IMGNEKCSQH HRGKVTLNES 
       660        670        680        690        700
EICAGAEKIG SGPCEGDYGG PLVCEQHKMR MVLGVIVPGR GCAIPNRPGI 
       710        720 
FVRVAYYAKW IHKIILTYKV PQS

Show »

Length:723

Mass (Da):82,602

Checksum:ⁱ627B1EF99FAD931B

GO

Isoform 4 (identifier: P14210-4) [UniParc]FASTA Add to basket

Also known as: HGF/NK2

The sequence of this isoform differs from the canonical sequence as follows:
287-296: TCADNTMNDT → NMRDITWALN
297-728: Missing.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV 
       210        220        230        240        250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY 
       260        270        280        290 
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKNMRD ITWALN

Note: Acts as a competitive antagonist in MET-signaling.Curated

Show »

Length:296

Mass (Da):34,547

Checksum:ⁱA45E456B87AE03BE

GO

Isoform 5 (identifier: P14210-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.
     289-290: AD → ET
     291-728: Missing.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SYRGKDLQEN YCRNPRGEEG GPWCFTSNPE VRYEVCDIPQ 
       210        220        230        240        250
CSEVECMTCN GESYRGLMDH TESGKICQRW DHQTPHRHKF LPERYPDKGF 
       260        270        280 
DDNYCRNPDG QPRPWCYTLD PHTRWEYCAI KTCET

Show »

Length:285

Mass (Da):33,234

Checksum:ⁱ0A93B073EA86EA61

GO

Isoform 6 (identifier: P14210-6) [UniParc]FASTA Add to basket

Also known as: HGF/NK1

The sequence of this isoform differs from the canonical sequence as follows:
209-210: VE → GK
211-728: Missing.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV 
       210
CDIPQCSEGK

Show »

Length:210

Mass (Da):24,116

Checksum:ⁱ94A6EE9C50DE5A86

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9WSJ3	C9WSJ3_HUMAN	Hepatocyte growth factor Hepatocyte growth factor (Hepatocyte growth factor isoform 6)	HGF	184	Annotation score:
C9WSJ4	C9WSJ4_HUMAN	Hepatocyte growth factor Hepatocyte growth factor (Hepatocyte growth factor isoform 6)	HGF	161	Annotation score:
A0A2R8YEI1	A0A2R8YEI1_HUMAN	Hepatocyte growth factor Hepatocyte growth factor	HGF	205	Annotation score:
C9JDP4	C9JDP4_HUMAN	Hepatocyte growth factor Hepatocyte growth factor	HGF	141	Annotation score:
C9JS80	C9JS80_HUMAN	Hepatocyte growth factor Hepatocyte growth factor	HGF	118	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	32 – 33	QR → HK in CAA34387 (PubMed:2531289).Curated	2
Sequence conflictⁱ	78	K → N in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	180	P → T AA sequence (PubMed:1824873).Curated	1
Sequence conflictⁱ	293	M → V in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	300	L → M in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	317	V → A in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	336	E → K in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	387	H → N in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	416	D → N in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	505	I → V in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	509	V → I in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	558	D → E in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	561	C → R in CAA34387 (PubMed:2531289).Curated	1
Sequence conflictⁱ	592	D → N AA sequence (PubMed:1824873).Curated	1
Sequence conflictⁱ	595	S → N in CAA34387 (PubMed:2531289).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019199	304	E → K1 PublicationCorresponds to variant dbSNP:rs5745687EnsemblClinVar.		1
Natural variantⁱVAR_019200	330	D → Y1 PublicationCorresponds to variant dbSNP:rs5745688Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_009617	161 – 165	Missing in isoform 3 and isoform 5. 2 Publications	5
Alternative sequenceⁱVSP_009618	209 – 210	VE → GK in isoform 6. 2 Publications	2
Alternative sequenceⁱVSP_009619	211 – 728	Missing in isoform 6. 2 PublicationsAdd BLAST	518
Alternative sequenceⁱVSP_009620	287 – 296	TCADNTMNDT → NMRDITWALN in isoform 4. 1 Publication	10
Alternative sequenceⁱVSP_009622	289 – 290	AD → ET in isoform 2 and isoform 5. 3 Publications	2
Alternative sequenceⁱVSP_009623	291 – 728	Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST	438
Alternative sequenceⁱVSP_009621	297 – 728	Missing in isoform 4. 1 PublicationAdd BLAST	432

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29145 mRNA Translation: AAA52650.1 X16323 mRNA Translation: CAA34387.1 M60718 mRNA Translation: AAA52648.1 D90334 Genomic DNA Translation: BAA14348.1 X57574 mRNA Translation: CAA40802.1 M55379 mRNA No translation available. M73239 mRNA Translation: AAA64239.1 M73240 mRNA Translation: AAA64297.1 M77227 mRNA Translation: AAA35980.1 L02931 mRNA Translation: AAA52649.1 U46010 mRNA Translation: AAC50539.1 AY246560 Genomic DNA Translation: AAO61091.1 AC004960 Genomic DNA Translation: AAC71655.1 CH236949 Genomic DNA Translation: EAL24189.1 BC022308 mRNA Translation: AAH22308.1 BC063485 mRNA Translation: AAH63485.1 BC105797 mRNA Translation: AAI05798.1 BC130284 mRNA Translation: AAI30285.1 BC130286 mRNA Translation: AAI30287.1 M75971 M75969 Genomic DNA Translation: AAG53459.1 M75983 M75982 Genomic DNA Translation: AAG53460.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47626.1 [P14210-3] CCDS47627.1 [P14210-2] CCDS47628.1 [P14210-5] CCDS47629.1 [P14210-6] CCDS5597.1 [P14210-1]
PIRⁱ	JH0579
NCBI Reference Sequences More...RefSeqⁱ	NP_000592.3, NM_000601.5 [P14210-1] NP_001010931.1, NM_001010931.2 [P14210-2] NP_001010932.1, NM_001010932.2 [P14210-3] NP_001010933.1, NM_001010933.2 [P14210-5] NP_001010934.1, NM_001010934.2 [P14210-6] XP_006716019.1, XM_006715956.2 [P14210-1] XP_011514417.1, XM_011516115.2 [P14210-3] XP_016867586.1, XM_017012097.1 [P14210-2] XP_016867587.1, XM_017012098.1 [P14210-5]

Genome annotation databases

Ensemblⁱ	ENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1] ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6] ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2] ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5] ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3]
GeneIDⁱ	3082
KEGGⁱ	hsa:3082
UCSC genome browser More...UCSCⁱ	uc003uhl.4, human [P14210-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14210-2	Hepatocyte growth factor		PANTR		290	UniRef100_K7CWX4
HGF isoform 3		PANTR		290
P14210-5	HGF isoform 4		PANTR		285	UniRef100_A0A2J8LGB0
P14210-6	HGF isoform 5		PANTR		210	UniRef100_K7AMD5
Hepatocyte growth factor isoform 1 preproprotein variant (Fragment)		HUMAN		245
HGF isoform 5		PONAB		210

Protein	Similar proteins		Species	Score	Length	Source
P14210	Hepatocyte growth factor		PANTR		812	UniRef90_P14210
Hepatocyte growth factor (Fragment)		HUMAN		141
HGF isoform 9 (Fragment)		PONAB		141
Hepatocyte growth factor		PANPA		812
Hepatocyte growth factor		MACNE		788
+42
P14210-2	Isoform 4 of Hepatocyte growth factor		HUMAN		296	UniRef90_P14210-4
Hepatocyte growth factor		SAIBB		311
Uncharacterized protein		MANLE		290
Uncharacterized protein		RHIRO		290
Uncharacterized protein		RHIBE		290
+29
P14210-3	Hepatocyte growth factor		BOVIN		730	UniRef90_P14210-3
Hepatocyte growth factor		CANLF		730
Hepatocyte growth factor	)	MOUSE		728
Hepatocyte growth factor		FELCA		728
Hepatocyte growth factor		RAT		728
+230
P14210-6	Hepatocyte growth factor		HUMAN		205	UniRef90_A0A2R8YEI1
HGF isoform 5		PANTR		210
HGF isoform 5		PONAB		210
HGF		CEREH		210
Hepatocyte growth factor		CASCN		210
+9

Protein	Similar proteins		Species	Score	Length	Source
P14210	Hepatocyte growth factor		CANLF		730	UniRef50_P14210
Hepatocyte growth factor		BOVIN		730
Hepatocyte growth factor		FELCA		728
Hepatocyte growth factor	)	MOUSE		728
Hepatocyte growth factor		RAT		728
+740
P14210-2	Isoform 4 of Hepatocyte growth factor		HUMAN		296	UniRef50_P14210-4
Hepatocyte growth factor		SAIBB		311
Uncharacterized protein		NOMLE		290
Uncharacterized protein		CEBIM		290
HGF isoform 3		PONAB		290
+50
P14210-6	Hepatocyte growth factor		HUMAN		205	UniRef50_A0A2R8YEI1
Hepatocyte growth factor		CASCN		210
HGF		CEREH		210
Hepatocyte growth factor		PIG		210
Hepatocyte growth factor		RHIFE		210
+13

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Hepatocyte growth factor entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29145 mRNA Translation: AAA52650.1 X16323 mRNA Translation: CAA34387.1 M60718 mRNA Translation: AAA52648.1 D90334 Genomic DNA Translation: BAA14348.1 X57574 mRNA Translation: CAA40802.1 M55379 mRNA No translation available. M73239 mRNA Translation: AAA64239.1 M73240 mRNA Translation: AAA64297.1 M77227 mRNA Translation: AAA35980.1 L02931 mRNA Translation: AAA52649.1 U46010 mRNA Translation: AAC50539.1 AY246560 Genomic DNA Translation: AAO61091.1 AC004960 Genomic DNA Translation: AAC71655.1 CH236949 Genomic DNA Translation: EAL24189.1 BC022308 mRNA Translation: AAH22308.1 BC063485 mRNA Translation: AAH63485.1 BC105797 mRNA Translation: AAI05798.1 BC130284 mRNA Translation: AAI30285.1 BC130286 mRNA Translation: AAI30287.1 M75971 M75969 Genomic DNA Translation: AAG53459.1 M75983 M75982 Genomic DNA Translation: AAG53460.1
CCDSⁱ	CCDS47626.1 [P14210-3] CCDS47627.1 [P14210-2] CCDS47628.1 [P14210-5] CCDS47629.1 [P14210-6] CCDS5597.1 [P14210-1]
PIRⁱ	JH0579
RefSeqⁱ	NP_000592.3, NM_000601.5 [P14210-1] NP_001010931.1, NM_001010931.2 [P14210-2] NP_001010932.1, NM_001010932.2 [P14210-3] NP_001010933.1, NM_001010933.2 [P14210-5] NP_001010934.1, NM_001010934.2 [P14210-6] XP_006716019.1, XM_006715956.2 [P14210-1] XP_011514417.1, XM_011516115.2 [P14210-3] XP_016867586.1, XM_017012097.1 [P14210-2] XP_016867587.1, XM_017012098.1 [P14210-5]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BHT	X-ray	2.00	A/B	35-210	[»]
	1GMN	X-ray	2.30	A/B	28-210	[»]
	1GMO	X-ray	3.00	A/B/C/D/E/F/G/H	28-210	[»]
	1GP9	X-ray	2.50	A/B/C/D	40-210	[»]
	1NK1	X-ray	2.50	A/B	28-210	[»]
	1SHY	X-ray	3.22	A	495-728	[»]
	1SI5	X-ray	2.53	H	495-728	[»]
	2HGF	NMR	-	A	31-127	[»]
	2QJ2	X-ray	1.81	A/B	28-209	[»]
	3HMS	X-ray	1.70	A	28-126	[»]
	3HMT	X-ray	2.00	A/B	28-126	[»]
	3HN4	X-ray	2.60	A	28-289	[»]
	3MKP	X-ray	2.81	A/B/C/D	28-210	[»]
	3SP8	X-ray	1.86	A/B	28-288	[»]
	4D3C	X-ray	2.62	A	32-210	[»]
	4K3J	X-ray	2.80	A	495-721	[»]
	4O3T	X-ray	2.99	A	495-728	[»]
	4O3U	X-ray	3.04	A	495-728	[»]
	5COE	X-ray	2.18	A/B	28-210	[»]
	5CP9	X-ray	1.90	A/B	28-210	[»]
	5CS1	X-ray	2.00	A/B	28-210	[»]
	5CS3	X-ray	2.50	A/B	28-210	[»]
	5CS5	X-ray	1.90	A/B	28-210	[»]
	5CS9	X-ray	2.00	A/B	28-210	[»]
	5CSQ	X-ray	1.95	A/B	28-210	[»]
	5CT1	X-ray	2.00	A/B	28-210	[»]
	5CT2	X-ray	2.00	A/B	28-210	[»]
	5CT3	X-ray	2.00	A/B	28-210	[»]
SMRⁱ	P14210
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109330, 33 interactors
CORUMⁱ	P14210
DIPⁱ	DIP-37535N
IntActⁱ	P14210, 9 interactors
MINTⁱ	P14210
STRINGⁱ	9606.ENSP00000222390

Chemistry databases

BindingDBⁱ	P14210
ChEMBLⁱ	CHEMBL5479
DrugBankⁱ	DB05434, ABT-510 DB12307, Foretinib DB01109, Heparin DB03959, N,O6-Disulfo-Glucosamine DB02264, O2-Sulfo-Glucuronic Acid

Protein family/group databases

MEROPSⁱ	S01.976

MEROPSⁱ

S01.976

PTM databases

GlyConnectⁱ	219, 8 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site)
GlyGenⁱ	P14210, 5 sites, 8 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
iPTMnetⁱ	P14210
PhosphoSitePlusⁱ	P14210

Genetic variation databases

BioMutaⁱ	HGF
DMDMⁱ	123116

Proteomic databases

EPDⁱ	P14210
MassIVEⁱ	P14210
MaxQBⁱ	P14210
PaxDbⁱ	P14210
PeptideAtlasⁱ	P14210
PRIDEⁱ	P14210
ProteomicsDBⁱ	53034 [P14210-1] 53035 [P14210-2] 53036 [P14210-3] 53037 [P14210-4] 53038 [P14210-5] 53039 [P14210-6]

Protocols and materials databases

ABCDⁱ	P14210, 12 sequenced antibodies
Antibodypediaⁱ	4150, 1067 antibodies
The DNASU plasmid repository More...DNASUⁱ	3082

Genome annotation databases

Ensemblⁱ	ENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1] ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6] ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2] ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5] ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3]
GeneIDⁱ	3082
KEGGⁱ	hsa:3082
UCSCⁱ	uc003uhl.4, human [P14210-1]

Organism-specific databases

CTDⁱ	3082
DisGeNETⁱ	3082
GeneCardsⁱ	HGF
GeneReviewsⁱ	HGF
HGNCⁱ	HGNC:4893, HGF
HPAⁱ	ENSG00000019991, Tissue enhanced (placenta)
MalaCardsⁱ	HGF
MIMⁱ	142409, gene 608265, phenotype
neXtProtⁱ	NX_P14210
OpenTargetsⁱ	ENSG00000019991
Orphanetⁱ	90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBⁱ	PA29269
VEuPathDBⁱ	HostDB:ENSG00000019991.15
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QR40, Eukaryota
GeneTreeⁱ	ENSGT00940000156019
HOGENOMⁱ	CLU_017565_1_0_1
InParanoidⁱ	P14210
OMAⁱ	TNIPQCG
OrthoDBⁱ	164039at2759
PhylomeDBⁱ	P14210
TreeFamⁱ	TF329901

Enzyme and pathway databases

PathwayCommonsⁱ	P14210
Reactomeⁱ	R-HSA-114608, Platelet degranulation R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1266695, Interleukin-7 signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6806942, MET Receptor Activation R-HSA-6807004, Negative regulation of MET activity R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8851805, MET activates RAS signaling R-HSA-8851907, MET activates PI3K/AKT signaling R-HSA-8865999, MET activates PTPN11 R-HSA-8874081, MET activates PTK2 signaling R-HSA-8875513, MET interacts with TNS proteins R-HSA-8875555, MET activates RAP1 and RAC1 R-HSA-8875656, MET receptor recycling R-HSA-8875791, MET activates STAT3
SignaLinkⁱ	P14210
SIGNORⁱ	P14210

Miscellaneous databases

BioGRID-ORCSⁱ	3082, 32 hits in 994 CRISPR screens
ChiTaRSⁱ	HGF, human
EvolutionaryTraceⁱ	P14210
GeneWikiⁱ	Hepatocyte_growth_factor
GenomeRNAiⁱ	3082
Pharosⁱ	P14210, Tchem
Protein Ontology More...PROⁱ	PR:P14210
RNActⁱ	P14210, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000019991, Expressed in placenta and 194 other tissues
ExpressionAtlasⁱ	P14210, baseline and differential
Genevisibleⁱ	P14210, HS

Family and domain databases

CDDⁱ	cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit
Gene3Dⁱ	2.40.10.10, 2 hits 2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom
Pfamⁱ	View protein in Pfam PF00051, Kringle, 4 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit
PIRSFⁱ	PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit
PRINTSⁱ	PR00722, CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits
PROSITEⁱ	View protein in PROSITE PS00021, KRINGLE_1, 4 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HGF_HUMAN
Accessionⁱ	P14210Primary (citable) accession number: P14210 Secondary accession number(s): A1L3U6 Q9UDU6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	August 1, 1991
	Last modified:	April 7, 2021
	This is version 242 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Peptidase families
Classification of peptidase families and list of entries
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P14210 (HGF_HUMAN)

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Hepatocyte growth factor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P14210

HGF - isoform 6 [P14210-6]

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

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Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

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Protocols and materials databases

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ