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Protein

Hepatocyte growth factor

Gene

HGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.2 Publications

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • growth factor activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • protein heterodimerization activity Source: Ensembl
  • protein tyrosine kinase activity Source: Reactome
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Serine protease homolog

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6806942 MET Receptor Activation
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8865999 MET activates PTPN11
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8875513 MET interacts with TNS proteins
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-8875791 MET activates STAT3
SignaLinkiP14210
SIGNORiP14210

Protein family/group databases

MEROPSiS01.976

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor
Alternative name(s):
Hepatopoietin-A
Scatter factor
Short name:
SF
Cleaved into the following 2 chains:
Gene namesi
Name:HGF
Synonyms:HPTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000019991.15
HGNCiHGNC:4893 HGF
MIMi142409 gene
neXtProtiNX_P14210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 39 (DFNB39)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:608265

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi494R → Q: Loss of activity due to absence of proteolytic cleavage. 1 Publication1

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNETi3082
GeneReviewsiHGF
MalaCardsiHGF
MIMi608265 phenotype
OpenTargetsiENSG00000019991
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA29269

Chemistry databases

ChEMBLiCHEMBL5479
DrugBankiDB05434 ABT-510
DB02264 O2-Sulfo-Glucuronic Acid
DB05030 XL880

Polymorphism and mutation databases

BioMutaiHGF
DMDMi123116

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000002809132 – 494Hepatocyte growth factor alpha chainAdd BLAST463
ChainiPRO_0000028092495 – 728Hepatocyte growth factor beta chainAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi70 ↔ 96
Disulfide bondi74 ↔ 84
Disulfide bondi128 ↔ 206
Disulfide bondi149 ↔ 189
Disulfide bondi177 ↔ 201
Disulfide bondi211 ↔ 288By similarity
Disulfide bondi232 ↔ 271By similarity
Disulfide bondi260 ↔ 283By similarity
GlycosylationiCAR_000021294N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi305 ↔ 383By similarity
Disulfide bondi326 ↔ 365By similarity
Disulfide bondi354 ↔ 377By similarity
Disulfide bondi391 ↔ 469By similarity
GlycosylationiCAR_000022402N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi412 ↔ 452By similarity
Disulfide bondi440 ↔ 464By similarity
GlycosylationiCAR_000023476O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi487 ↔ 604Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi519 ↔ 535By similarity
GlycosylationiCAR_000024566N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi612 ↔ 679By similarity
Disulfide bondi642 ↔ 658By similarity
GlycosylationiCAR_000025653N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi669 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP14210
MaxQBiP14210
PaxDbiP14210
PeptideAtlasiP14210
PRIDEiP14210
ProteomicsDBi53034
53035 [P14210-2]
53036 [P14210-3]
53037 [P14210-4]
53038 [P14210-5]
53039 [P14210-6]

PTM databases

GlyConnecti219
iPTMnetiP14210
PhosphoSitePlusiP14210
UniCarbKBiP14210

Miscellaneous databases

PMAP-CutDBiP14210

Expressioni

Gene expression databases

BgeeiENSG00000019991 Expressed in 183 organ(s), highest expression level in placenta
ExpressionAtlasiP14210 baseline and differential
GenevisibleiP14210 HS

Organism-specific databases

HPAiCAB010333
HPA040360
HPA044088

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109330, 10 interactors
CORUMiP14210
DIPiDIP-37535N
IntActiP14210, 8 interactors
MINTiP14210
STRINGi9606.ENSP00000222390

Chemistry databases

BindingDBiP14210

Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14210
SMRiP14210
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14210

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 123PANPROSITE-ProRule annotationAdd BLAST87
Domaini128 – 206Kringle 1PROSITE-ProRule annotationAdd BLAST79
Domaini211 – 288Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini305 – 383Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini391 – 469Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini495 – 721Peptidase S1PROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOVERGENiHBG004381
InParanoidiP14210
KOiK05460
OMAiYCAIKMC
OrthoDBiEOG091G0AH5
PhylomeDBiP14210
TreeFamiTF329901

Family and domain databases

CDDicd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR027284 Hepatocyte_GF
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF500183 Hepatocyte_GF, 1 hit
PIRSF001152 HGF_MST1, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14210-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL
60 70 80 90 100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP
110 120 130 140 150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ
160 170 180 190 200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV
210 220 230 240 250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY
260 270 280 290 300
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL
310 320 330 340 350
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR
360 370 380 390 400
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM
410 420 430 440 450
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP
460 470 480 490 500
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP
510 520 530 540 550
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI
560 570 580 590 600
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP
610 620 630 640 650
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV
660 670 680 690 700
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP
710 720
NRPGIFVRVA YYAKWIHKII LTYKVPQS
Length:728
Mass (Da):83,134
Last modified:August 1, 1991 - v2
Checksum:i2D997938295ADD2F
GO
Isoform 2 (identifier: P14210-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-290: AD → ET
     291-728: Missing.

Show »
Length:290
Mass (Da):33,766
Checksum:iC8A18A6F0D63200A
GO
Isoform 3 (identifier: P14210-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.

Show »
Length:723
Mass (Da):82,602
Checksum:i627B1EF99FAD931B
GO
Isoform 4 (identifier: P14210-4) [UniParc]FASTAAdd to basket
Also known as: HGF/NK2

The sequence of this isoform differs from the canonical sequence as follows:
     287-296: TCADNTMNDT → NMRDITWALN
     297-728: Missing.

Note: Acts as a competitive antagonist in MET-signaling.
Show »
Length:296
Mass (Da):34,547
Checksum:iA45E456B87AE03BE
GO
Isoform 5 (identifier: P14210-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.
     289-290: AD → ET
     291-728: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):33,234
Checksum:i0A93B073EA86EA61
GO
Isoform 6 (identifier: P14210-6) [UniParc]FASTAAdd to basket
Also known as: HGF/NK1

The sequence of this isoform differs from the canonical sequence as follows:
     209-210: VE → GK
     211-728: Missing.

Show »
Length:210
Mass (Da):24,116
Checksum:i94A6EE9C50DE5A86
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9WSJ3C9WSJ3_HUMAN
Hepatocyte growth factor isoform 6
HGF
184Annotation score:
C9WSJ4C9WSJ4_HUMAN
Hepatocyte growth factor isoform 6
HGF
161Annotation score:
A0A2R8YEI1A0A2R8YEI1_HUMAN
Hepatocyte growth factor
HGF
205Annotation score:
C9JDP4C9JDP4_HUMAN
Hepatocyte growth factor
HGF
141Annotation score:
C9JS80C9JS80_HUMAN
Hepatocyte growth factor
HGF
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 33QR → HK in CAA34387 (PubMed:2531289).Curated2
Sequence conflicti78K → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti180P → T AA sequence (PubMed:1824873).Curated1
Sequence conflicti293M → V in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti300L → M in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti317V → A in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti336E → K in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti387H → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti416D → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti505I → V in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti509V → I in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti558D → E in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti561C → R in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti592D → N AA sequence (PubMed:1824873).Curated1
Sequence conflicti595S → N in CAA34387 (PubMed:2531289).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019199304E → K1 PublicationCorresponds to variant dbSNP:rs5745687EnsemblClinVar.1
Natural variantiVAR_019200330D → Y1 PublicationCorresponds to variant dbSNP:rs5745688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009617161 – 165Missing in isoform 3 and isoform 5. 2 Publications5
Alternative sequenceiVSP_009618209 – 210VE → GK in isoform 6. 2 Publications2
Alternative sequenceiVSP_009619211 – 728Missing in isoform 6. 2 PublicationsAdd BLAST518
Alternative sequenceiVSP_009620287 – 296TCADNTMNDT → NMRDITWALN in isoform 4. 1 Publication10
Alternative sequenceiVSP_009622289 – 290AD → ET in isoform 2 and isoform 5. 3 Publications2
Alternative sequenceiVSP_009623291 – 728Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST438
Alternative sequenceiVSP_009621297 – 728Missing in isoform 4. 1 PublicationAdd BLAST432

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29145 mRNA Translation: AAA52650.1
X16323 mRNA Translation: CAA34387.1
M60718 mRNA Translation: AAA52648.1
D90334 Genomic DNA Translation: BAA14348.1
X57574 mRNA Translation: CAA40802.1
M55379 mRNA No translation available.
M73239 mRNA Translation: AAA64239.1
M73240 mRNA Translation: AAA64297.1
M77227 mRNA Translation: AAA35980.1
L02931 mRNA Translation: AAA52649.1
U46010 mRNA Translation: AAC50539.1
AY246560 Genomic DNA Translation: AAO61091.1
AC004960 Genomic DNA Translation: AAC71655.1
CH236949 Genomic DNA Translation: EAL24189.1
BC022308 mRNA Translation: AAH22308.1
BC063485 mRNA Translation: AAH63485.1
BC105797 mRNA Translation: AAI05798.1
BC130284 mRNA Translation: AAI30285.1
BC130286 mRNA Translation: AAI30287.1
M75971
, M75967, M75966, M75968, M75969 Genomic DNA Translation: AAG53459.1
M75983
, M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA Translation: AAG53460.1
CCDSiCCDS47626.1 [P14210-3]
CCDS47627.1 [P14210-2]
CCDS47628.1 [P14210-5]
CCDS47629.1 [P14210-6]
CCDS5597.1 [P14210-1]
PIRiJH0579
RefSeqiNP_000592.3, NM_000601.5 [P14210-1]
NP_001010931.1, NM_001010931.2 [P14210-2]
NP_001010932.1, NM_001010932.2 [P14210-3]
NP_001010933.1, NM_001010933.2 [P14210-5]
NP_001010934.1, NM_001010934.2 [P14210-6]
XP_006716019.1, XM_006715956.2 [P14210-1]
XP_011514417.1, XM_011516115.2 [P14210-3]
XP_016867586.1, XM_017012097.1 [P14210-2]
XP_016867587.1, XM_017012098.1 [P14210-5]
UniGeneiHs.396530
Hs.561679

Genome annotation databases

EnsembliENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1]
ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6]
ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2]
ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5]
ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3]
ENST00000644543; ENSP00000494899; ENSG00000019991 [P14210-1]
GeneIDi3082
KEGGihsa:3082
UCSCiuc003uhl.4 human [P14210-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Hepatocyte growth factor entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29145 mRNA Translation: AAA52650.1
X16323 mRNA Translation: CAA34387.1
M60718 mRNA Translation: AAA52648.1
D90334 Genomic DNA Translation: BAA14348.1
X57574 mRNA Translation: CAA40802.1
M55379 mRNA No translation available.
M73239 mRNA Translation: AAA64239.1
M73240 mRNA Translation: AAA64297.1
M77227 mRNA Translation: AAA35980.1
L02931 mRNA Translation: AAA52649.1
U46010 mRNA Translation: AAC50539.1
AY246560 Genomic DNA Translation: AAO61091.1
AC004960 Genomic DNA Translation: AAC71655.1
CH236949 Genomic DNA Translation: EAL24189.1
BC022308 mRNA Translation: AAH22308.1
BC063485 mRNA Translation: AAH63485.1
BC105797 mRNA Translation: AAI05798.1
BC130284 mRNA Translation: AAI30285.1
BC130286 mRNA Translation: AAI30287.1
M75971
, M75967, M75966, M75968, M75969 Genomic DNA Translation: AAG53459.1
M75983
, M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA Translation: AAG53460.1
CCDSiCCDS47626.1 [P14210-3]
CCDS47627.1 [P14210-2]
CCDS47628.1 [P14210-5]
CCDS47629.1 [P14210-6]
CCDS5597.1 [P14210-1]
PIRiJH0579
RefSeqiNP_000592.3, NM_000601.5 [P14210-1]
NP_001010931.1, NM_001010931.2 [P14210-2]
NP_001010932.1, NM_001010932.2 [P14210-3]
NP_001010933.1, NM_001010933.2 [P14210-5]
NP_001010934.1, NM_001010934.2 [P14210-6]
XP_006716019.1, XM_006715956.2 [P14210-1]
XP_011514417.1, XM_011516115.2 [P14210-3]
XP_016867586.1, XM_017012097.1 [P14210-2]
XP_016867587.1, XM_017012098.1 [P14210-5]
UniGeneiHs.396530
Hs.561679

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHTX-ray2.00A/B35-210[»]
1GMNX-ray2.30A/B28-210[»]
1GMOX-ray3.00A/B/C/D/E/F/G/H28-210[»]
1GP9X-ray2.50A/B/C/D40-210[»]
1NK1X-ray2.50A/B28-210[»]
1SHYX-ray3.22A495-728[»]
1SI5X-ray2.53H495-728[»]
2HGFNMR-A31-127[»]
2QJ2X-ray1.81A/B28-209[»]
3HMSX-ray1.70A28-126[»]
3HMTX-ray2.00A/B28-126[»]
3HN4X-ray2.60A28-289[»]
3MKPX-ray2.81A/B/C/D28-210[»]
3SP8X-ray1.86A/B28-288[»]
4D3CX-ray2.62A32-210[»]
4K3JX-ray2.80A495-721[»]
4O3TX-ray2.99A495-728[»]
4O3UX-ray3.04A495-728[»]
5COEX-ray2.18A/B28-210[»]
5CP9X-ray1.90A/B28-210[»]
5CS1X-ray2.00A/B28-210[»]
5CS3X-ray2.50A/B28-210[»]
5CS5X-ray1.90A/B28-210[»]
5CS9X-ray2.00A/B28-210[»]
5CSQX-ray1.95A/B28-210[»]
5CT1X-ray2.00A/B28-210[»]
5CT2X-ray2.00A/B28-210[»]
5CT3X-ray2.00A/B28-210[»]
ProteinModelPortaliP14210
SMRiP14210
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109330, 10 interactors
CORUMiP14210
DIPiDIP-37535N
IntActiP14210, 8 interactors
MINTiP14210
STRINGi9606.ENSP00000222390

Chemistry databases

BindingDBiP14210
ChEMBLiCHEMBL5479
DrugBankiDB05434 ABT-510
DB02264 O2-Sulfo-Glucuronic Acid
DB05030 XL880

Protein family/group databases

MEROPSiS01.976

PTM databases

GlyConnecti219
iPTMnetiP14210
PhosphoSitePlusiP14210
UniCarbKBiP14210

Polymorphism and mutation databases

BioMutaiHGF
DMDMi123116

Proteomic databases

EPDiP14210
MaxQBiP14210
PaxDbiP14210
PeptideAtlasiP14210
PRIDEiP14210
ProteomicsDBi53034
53035 [P14210-2]
53036 [P14210-3]
53037 [P14210-4]
53038 [P14210-5]
53039 [P14210-6]

Protocols and materials databases

DNASUi3082
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1]
ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6]
ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2]
ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5]
ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3]
ENST00000644543; ENSP00000494899; ENSG00000019991 [P14210-1]
GeneIDi3082
KEGGihsa:3082
UCSCiuc003uhl.4 human [P14210-1]

Organism-specific databases

CTDi3082
DisGeNETi3082
EuPathDBiHostDB:ENSG00000019991.15
GeneCardsiHGF
GeneReviewsiHGF
HGNCiHGNC:4893 HGF
HPAiCAB010333
HPA040360
HPA044088
MalaCardsiHGF
MIMi142409 gene
608265 phenotype
neXtProtiNX_P14210
OpenTargetsiENSG00000019991
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA29269
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOVERGENiHBG004381
InParanoidiP14210
KOiK05460
OMAiYCAIKMC
OrthoDBiEOG091G0AH5
PhylomeDBiP14210
TreeFamiTF329901

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6806942 MET Receptor Activation
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8865999 MET activates PTPN11
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8875513 MET interacts with TNS proteins
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-8875791 MET activates STAT3
SignaLinkiP14210
SIGNORiP14210

Miscellaneous databases

ChiTaRSiHGF human
EvolutionaryTraceiP14210
GeneWikiiHepatocyte_growth_factor
GenomeRNAii3082
PMAP-CutDBiP14210
PROiPR:P14210
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000019991 Expressed in 183 organ(s), highest expression level in placenta
ExpressionAtlasiP14210 baseline and differential
GenevisibleiP14210 HS

Family and domain databases

CDDicd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR027284 Hepatocyte_GF
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF500183 Hepatocyte_GF, 1 hit
PIRSF001152 HGF_MST1, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHGF_HUMAN
AccessioniPrimary (citable) accession number: P14210
Secondary accession number(s): A1L3U6
, Q02935, Q13494, Q14519, Q3KRB2, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 1, 1991
Last modified: November 7, 2018
This is version 226 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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