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UniProtKB - P14210 (HGF_HUMAN)

Protein

Hepatocyte growth factor

Gene

HGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.2 Publications

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • growth factor activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • protein heterodimerization activity Source: Ensembl
  • protein tyrosine kinase activity Source: Reactome
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • serine-type endopeptidase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Serine protease homolog

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6806942 MET Receptor Activation
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8865999 MET activates PTPN11
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8875513 MET interacts with TNS proteins
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-8875791 MET activates STAT3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14210

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14210

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.976

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatocyte growth factor
Alternative name(s):
Hepatopoietin-A
Scatter factor
Short name:
SF
Cleaved into the following 2 chains:
Hepatocyte growth factor alpha chain
Hepatocyte growth factor beta chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HGF
Synonyms:HPTA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000019991.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:4893 HGF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142409 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 39 (DFNB39)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:608265

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi494R → Q: Loss of activity due to absence of proteolytic cleavage. 1 Publication1

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		3082

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		HGF

MalaCards human disease database

More...MalaCardsi		HGF
MIMi608265 phenotype

Open Targets

More...OpenTargetsi		ENSG00000019991

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29269

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5479

Drug and drug target database

More...DrugBanki		DB05434 ABT-510
DB02264 O2-Sulfo-Glucuronic Acid
DB05030 XL880

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HGF

Domain mapping of disease mutations (DMDM)

More...DMDMi		123116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 311 PublicationAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002809132 – 494Hepatocyte growth factor alpha chainAdd BLAST463
ChainiPRO_0000028092495 – 728Hepatocyte growth factor beta chainAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 96
Disulfide bondi74 ↔ 84
Disulfide bondi128 ↔ 206
Disulfide bondi149 ↔ 189
Disulfide bondi177 ↔ 201
Disulfide bondi211 ↔ 288By similarity
Disulfide bondi232 ↔ 271By similarity
Disulfide bondi260 ↔ 283By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000021294N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi305 ↔ 383By similarity
Disulfide bondi326 ↔ 365By similarity
Disulfide bondi354 ↔ 377By similarity
Disulfide bondi391 ↔ 469By similarity
GlycosylationiCAR_000022402N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi412 ↔ 452By similarity
Disulfide bondi440 ↔ 464By similarity
GlycosylationiCAR_000023476O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi487 ↔ 604Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi519 ↔ 535By similarity
GlycosylationiCAR_000024566N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi612 ↔ 679By similarity
Disulfide bondi642 ↔ 658By similarity
GlycosylationiCAR_000025653N-linked (GlcNAc...) (complex) asparagine1
Disulfide bondi669 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14210

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14210

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14210

PeptideAtlas

More...PeptideAtlasi		P14210

PRoteomics IDEntifications database

More...PRIDEi		P14210

ProteomicsDB human proteome resource

More...ProteomicsDBi		53034
53035 [P14210-2]
53036 [P14210-3]
53037 [P14210-4]
53038 [P14210-5]
53039 [P14210-6]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		219

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14210

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14210

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P14210

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P14210

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000019991 Expressed in 183 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14210 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14210 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB010333
HPA040360
HPA044088

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109330, 31 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14210

Database of interacting proteins

More...DIPi		DIP-37535N

Protein interaction database and analysis system

More...IntActi		P14210, 8 interactors

Molecular INTeraction database

More...MINTi		P14210

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222390

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14210

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHTX-ray2.00A/B35-210[»]
1GMNX-ray2.30A/B28-210[»]
1GMOX-ray3.00A/B/C/D/E/F/G/H28-210[»]
1GP9X-ray2.50A/B/C/D40-210[»]
1NK1X-ray2.50A/B28-210[»]
1SHYX-ray3.22A495-728[»]
1SI5X-ray2.53H495-728[»]
2HGFNMR-A31-127[»]
2QJ2X-ray1.81A/B28-209[»]
3HMSX-ray1.70A28-126[»]
3HMTX-ray2.00A/B28-126[»]
3HN4X-ray2.60A28-289[»]
3MKPX-ray2.81A/B/C/D28-210[»]
3SP8X-ray1.86A/B28-288[»]
4D3CX-ray2.62A32-210[»]
4K3JX-ray2.80A495-721[»]
4O3TX-ray2.99A495-728[»]
4O3UX-ray3.04A495-728[»]
5COEX-ray2.18A/B28-210[»]
5CP9X-ray1.90A/B28-210[»]
5CS1X-ray2.00A/B28-210[»]
5CS3X-ray2.50A/B28-210[»]
5CS5X-ray1.90A/B28-210[»]
5CS9X-ray2.00A/B28-210[»]
5CSQX-ray1.95A/B28-210[»]
5CT1X-ray2.00A/B28-210[»]
5CT2X-ray2.00A/B28-210[»]
5CT3X-ray2.00A/B28-210[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P14210

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14210

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14210

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 123PANPROSITE-ProRule annotationAdd BLAST87
Domaini128 – 206Kringle 1PROSITE-ProRule annotationAdd BLAST79
Domaini211 – 288Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini305 – 383Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini391 – 469Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini495 – 721Peptidase S1PROSITE-ProRule annotationAdd BLAST227

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IDXR Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156019

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004381

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14210

KEGG Orthology (KO)

More...KOi		K05460

Identification of Orthologs from Complete Genome Data

More...OMAi		YCAIKMC

Database of Orthologous Groups

More...OrthoDBi		153834at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14210

TreeFam database of animal gene trees

More...TreeFami		TF329901

Family and domain databases

Conserved Domains Database

More...CDDi		cd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.20.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027284 Hepatocyte_GF
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF500183 Hepatocyte_GF, 1 hit
PIRSF001152 HGF_MST1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14210-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV 
       210        220        230        240        250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY 
       260        270        280        290        300
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL 
       310        320        330        340        350
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR 
       360        370        380        390        400
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM 
       410        420        430        440        450
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP 
       460        470        480        490        500
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP 
       510        520        530        540        550
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI 
       560        570        580        590        600
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP 
       610        620        630        640        650
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV 
       660        670        680        690        700
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP 
       710        720 
NRPGIFVRVA YYAKWIHKII LTYKVPQS
Length:728
Mass (Da):83,134
Last modified:August 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D997938295ADD2F
GO
Isoform 2 (identifier: P14210-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-290: AD → ET
     291-728: Missing.

Show »
Length:290
Mass (Da):33,766
Checksum:iC8A18A6F0D63200A
GO
Isoform 3 (identifier: P14210-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.

Show »
Length:723
Mass (Da):82,602
Checksum:i627B1EF99FAD931B
GO
Isoform 4 (identifier: P14210-4) [UniParc]FASTAAdd to basket
Also known as: HGF/NK2

The sequence of this isoform differs from the canonical sequence as follows:
     287-296: TCADNTMNDT → NMRDITWALN
     297-728: Missing.

Note: Acts as a competitive antagonist in MET-signaling.
Show »
Length:296
Mass (Da):34,547
Checksum:iA45E456B87AE03BE
GO
Isoform 5 (identifier: P14210-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.
     289-290: AD → ET
     291-728: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):33,234
Checksum:i0A93B073EA86EA61
GO
Isoform 6 (identifier: P14210-6) [UniParc]FASTAAdd to basket
Also known as: HGF/NK1

The sequence of this isoform differs from the canonical sequence as follows:
     209-210: VE → GK
     211-728: Missing.

Show »
Length:210
Mass (Da):24,116
Checksum:i94A6EE9C50DE5A86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9WSJ3C9WSJ3_HUMAN
Hepatocyte growth factor isoform 6
HGF
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9WSJ4C9WSJ4_HUMAN
Hepatocyte growth factor isoform 6
HGF
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEI1A0A2R8YEI1_HUMAN
Hepatocyte growth factor
HGF
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDP4C9JDP4_HUMAN
Hepatocyte growth factor
HGF
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JS80C9JS80_HUMAN
Hepatocyte growth factor
HGF
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32 – 33QR → HK in CAA34387 (PubMed:2531289).Curated2
Sequence conflicti78K → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti180P → T AA sequence (PubMed:1824873).Curated1
Sequence conflicti293M → V in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti300L → M in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti317V → A in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti336E → K in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti387H → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti416D → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti505I → V in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti509V → I in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti558D → E in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti561C → R in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti592D → N AA sequence (PubMed:1824873).Curated1
Sequence conflicti595S → N in CAA34387 (PubMed:2531289).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019199304E → K1 PublicationCorresponds to variant dbSNP:rs5745687EnsemblClinVar.1
Natural variantiVAR_019200330D → Y1 PublicationCorresponds to variant dbSNP:rs5745688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009617161 – 165Missing in isoform 3 and isoform 5. 2 Publications5
Alternative sequenceiVSP_009618209 – 210VE → GK in isoform 6. 2 Publications2
Alternative sequenceiVSP_009619211 – 728Missing in isoform 6. 2 PublicationsAdd BLAST518
Alternative sequenceiVSP_009620287 – 296TCADNTMNDT → NMRDITWALN in isoform 4. 1 Publication10
Alternative sequenceiVSP_009622289 – 290AD → ET in isoform 2 and isoform 5. 3 Publications2
Alternative sequenceiVSP_009623291 – 728Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST438
Alternative sequenceiVSP_009621297 – 728Missing in isoform 4. 1 PublicationAdd BLAST432

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M29145 mRNA Translation: AAA52650.1
X16323 mRNA Translation: CAA34387.1
M60718 mRNA Translation: AAA52648.1
D90334 Genomic DNA Translation: BAA14348.1
X57574 mRNA Translation: CAA40802.1
M55379 mRNA No translation available.
M73239 mRNA Translation: AAA64239.1
M73240 mRNA Translation: AAA64297.1
M77227 mRNA Translation: AAA35980.1
L02931 mRNA Translation: AAA52649.1
U46010 mRNA Translation: AAC50539.1
AY246560 Genomic DNA Translation: AAO61091.1
AC004960 Genomic DNA Translation: AAC71655.1
CH236949 Genomic DNA Translation: EAL24189.1
BC022308 mRNA Translation: AAH22308.1
BC063485 mRNA Translation: AAH63485.1
BC105797 mRNA Translation: AAI05798.1
BC130284 mRNA Translation: AAI30285.1
BC130286 mRNA Translation: AAI30287.1
M75971
, M75967, M75966, M75968, M75969 Genomic DNA Translation: AAG53459.1
M75983
, M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA Translation: AAG53460.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47626.1 [P14210-3]
CCDS47627.1 [P14210-2]
CCDS47628.1 [P14210-5]
CCDS47629.1 [P14210-6]
CCDS5597.1 [P14210-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JH0579

NCBI Reference Sequences

More...RefSeqi		NP_000592.3, NM_000601.5 [P14210-1]
NP_001010931.1, NM_001010931.2 [P14210-2]
NP_001010932.1, NM_001010932.2 [P14210-3]
NP_001010933.1, NM_001010933.2 [P14210-5]
NP_001010934.1, NM_001010934.2 [P14210-6]
XP_006716019.1, XM_006715956.2 [P14210-1]
XP_011514417.1, XM_011516115.2 [P14210-3]
XP_016867586.1, XM_017012097.1 [P14210-2]
XP_016867587.1, XM_017012098.1 [P14210-5]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.396530
Hs.561679

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1]
ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6]
ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2]
ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5]
ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3]
ENST00000644543; ENSP00000494899; ENSG00000019991 [P14210-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3082

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3082

UCSC genome browser

More...UCSCi		uc003uhl.4 human [P14210-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Hepatocyte growth factor entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29145 mRNA Translation: AAA52650.1
X16323 mRNA Translation: CAA34387.1
M60718 mRNA Translation: AAA52648.1
D90334 Genomic DNA Translation: BAA14348.1
X57574 mRNA Translation: CAA40802.1
M55379 mRNA No translation available.
M73239 mRNA Translation: AAA64239.1
M73240 mRNA Translation: AAA64297.1
M77227 mRNA Translation: AAA35980.1
L02931 mRNA Translation: AAA52649.1
U46010 mRNA Translation: AAC50539.1
AY246560 Genomic DNA Translation: AAO61091.1
AC004960 Genomic DNA Translation: AAC71655.1
CH236949 Genomic DNA Translation: EAL24189.1
BC022308 mRNA Translation: AAH22308.1
BC063485 mRNA Translation: AAH63485.1
BC105797 mRNA Translation: AAI05798.1
BC130284 mRNA Translation: AAI30285.1
BC130286 mRNA Translation: AAI30287.1
M75971
, M75967, M75966, M75968, M75969 Genomic DNA Translation: AAG53459.1
M75983
, M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA Translation: AAG53460.1
CCDSiCCDS47626.1 [P14210-3]
CCDS47627.1 [P14210-2]
CCDS47628.1 [P14210-5]
CCDS47629.1 [P14210-6]
CCDS5597.1 [P14210-1]
PIRiJH0579
RefSeqiNP_000592.3, NM_000601.5 [P14210-1]
NP_001010931.1, NM_001010931.2 [P14210-2]
NP_001010932.1, NM_001010932.2 [P14210-3]
NP_001010933.1, NM_001010933.2 [P14210-5]
NP_001010934.1, NM_001010934.2 [P14210-6]
XP_006716019.1, XM_006715956.2 [P14210-1]
XP_011514417.1, XM_011516115.2 [P14210-3]
XP_016867586.1, XM_017012097.1 [P14210-2]
XP_016867587.1, XM_017012098.1 [P14210-5]
UniGeneiHs.396530
Hs.561679

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHTX-ray2.00A/B35-210[»]
1GMNX-ray2.30A/B28-210[»]
1GMOX-ray3.00A/B/C/D/E/F/G/H28-210[»]
1GP9X-ray2.50A/B/C/D40-210[»]
1NK1X-ray2.50A/B28-210[»]
1SHYX-ray3.22A495-728[»]
1SI5X-ray2.53H495-728[»]
2HGFNMR-A31-127[»]
2QJ2X-ray1.81A/B28-209[»]
3HMSX-ray1.70A28-126[»]
3HMTX-ray2.00A/B28-126[»]
3HN4X-ray2.60A28-289[»]
3MKPX-ray2.81A/B/C/D28-210[»]
3SP8X-ray1.86A/B28-288[»]
4D3CX-ray2.62A32-210[»]
4K3JX-ray2.80A495-721[»]
4O3TX-ray2.99A495-728[»]
4O3UX-ray3.04A495-728[»]
5COEX-ray2.18A/B28-210[»]
5CP9X-ray1.90A/B28-210[»]
5CS1X-ray2.00A/B28-210[»]
5CS3X-ray2.50A/B28-210[»]
5CS5X-ray1.90A/B28-210[»]
5CS9X-ray2.00A/B28-210[»]
5CSQX-ray1.95A/B28-210[»]
5CT1X-ray2.00A/B28-210[»]
5CT2X-ray2.00A/B28-210[»]
5CT3X-ray2.00A/B28-210[»]
ProteinModelPortaliP14210
SMRiP14210
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109330, 31 interactors
CORUMiP14210
DIPiDIP-37535N
IntActiP14210, 8 interactors
MINTiP14210
STRINGi9606.ENSP00000222390

Chemistry databases

BindingDBiP14210
ChEMBLiCHEMBL5479
DrugBankiDB05434 ABT-510
DB02264 O2-Sulfo-Glucuronic Acid
DB05030 XL880

Protein family/group databases

MEROPSiS01.976

PTM databases

GlyConnecti219
iPTMnetiP14210
PhosphoSitePlusiP14210
UniCarbKBiP14210

Polymorphism and mutation databases

BioMutaiHGF
DMDMi123116

Proteomic databases

EPDiP14210
MaxQBiP14210
PaxDbiP14210
PeptideAtlasiP14210
PRIDEiP14210
ProteomicsDBi53034
53035 [P14210-2]
53036 [P14210-3]
53037 [P14210-4]
53038 [P14210-5]
53039 [P14210-6]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3082
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1]
ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6]
ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2]
ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5]
ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3]
ENST00000644543; ENSP00000494899; ENSG00000019991 [P14210-1]
GeneIDi3082
KEGGihsa:3082
UCSCiuc003uhl.4 human [P14210-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3082
DisGeNETi3082
EuPathDBiHostDB:ENSG00000019991.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		HGF
GeneReviewsiHGF
HGNCiHGNC:4893 HGF
HPAiCAB010333
HPA040360
HPA044088
MalaCardsiHGF
MIMi142409 gene
608265 phenotype
neXtProtiNX_P14210
OpenTargetsiENSG00000019991
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA29269

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000156019
HOVERGENiHBG004381
InParanoidiP14210
KOiK05460
OMAiYCAIKMC
OrthoDBi153834at2759
PhylomeDBiP14210
TreeFamiTF329901

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6806942 MET Receptor Activation
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8865999 MET activates PTPN11
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8875513 MET interacts with TNS proteins
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-8875791 MET activates STAT3
SignaLinkiP14210
SIGNORiP14210

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HGF human
EvolutionaryTraceiP14210

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Hepatocyte_growth_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3082
PMAP-CutDBiP14210

Protein Ontology

More...PROi		PR:P14210

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000019991 Expressed in 183 organ(s), highest expression level in placenta
ExpressionAtlasiP14210 baseline and differential
GenevisibleiP14210 HS

Family and domain databases

CDDicd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR027284 Hepatocyte_GF
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF500183 Hepatocyte_GF, 1 hit
PIRSF001152 HGF_MST1, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHGF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14210
Secondary accession number(s): A1L3U6
, Q02935, Q13494, Q14519, Q3KRB2, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 1, 1991
Last modified: January 16, 2019
This is version 228 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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