UniProtKB - P14210 (HGF_HUMAN)
Hepatocyte growth factor
HGF
Functioni
Caution
GO - Molecular functioni
- chemoattractant activity Source: BHF-UCL
- growth factor activity Source: UniProtKB
- identical protein binding Source: IntAct
- protein-containing complex binding Source: Ensembl
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- animal organ regeneration Source: Ensembl
- cell chemotaxis Source: BHF-UCL
- cell morphogenesis Source: Ensembl
- cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
- cytokine-mediated signaling pathway Source: Reactome
- epithelial cell proliferation Source: Ensembl
- epithelial to mesenchymal transition Source: HGNC-UCL
- hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
- hyaluronan metabolic process Source: Ensembl
- liver development Source: Ensembl
- MAPK cascade Source: Reactome
- mitotic cell cycle Source: UniProtKB
- myoblast proliferation Source: Ensembl
- negative regulation of apoptotic process Source: GO_Central
- negative regulation of autophagy Source: ParkinsonsUK-UCL
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- negative regulation of hydrogen peroxide-mediated programmed cell death Source: BHF-UCL
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of peptidyl-serine phosphorylation Source: Ensembl
- negative regulation of release of cytochrome c from mitochondria Source: BHF-UCL
- platelet degranulation Source: Reactome
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of DNA biosynthetic process Source: UniProtKB
- positive regulation of interleukin-10 production Source: Ensembl
- positive regulation of myelination Source: Ensembl
- positive regulation of neuron projection regeneration Source: Ensembl
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of protein phosphorylation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
- regulation of p38MAPK cascade Source: Ensembl
- regulation of tau-protein kinase activity Source: Ensembl
Keywordsi
Molecular function | Growth factor, Serine protease homolog |
Enzyme and pathway databases
PathwayCommonsi | P14210 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1266695, Interleukin-7 signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6806942, MET Receptor Activation R-HSA-6807004, Negative regulation of MET activity R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8851805, MET activates RAS signaling R-HSA-8851907, MET activates PI3K/AKT signaling R-HSA-8865999, MET activates PTPN11 R-HSA-8874081, MET activates PTK2 signaling R-HSA-8875513, MET interacts with TNS proteins R-HSA-8875555, MET activates RAP1 and RAC1 R-HSA-8875656, MET receptor recycling R-HSA-8875791, MET activates STAT3 |
SignaLinki | P14210 |
SIGNORi | P14210 |
Protein family/group databases
MEROPSi | S01.976 |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatocyte growth factorAlternative name(s): Hepatopoietin-A Scatter factor Short name: SF Cleaved into the following 2 chains: |
Gene namesi | Name:HGF Synonyms:HPTA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4893, HGF |
MIMi | 142409, gene |
neXtProti | NX_P14210 |
VEuPathDBi | HostDB:ENSG00000019991.15 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: Ensembl
Other locations
- membrane Source: UniProtKB
- platelet alpha granule lumen Source: Reactome
Pathology & Biotechi
Involvement in diseasei
Deafness, autosomal recessive, 39 (DFNB39)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 494 | R → Q: Loss of activity due to absence of proteolytic cleavage. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 3082 |
GeneReviewsi | HGF |
MalaCardsi | HGF |
MIMi | 608265, phenotype |
OpenTargetsi | ENSG00000019991 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA29269 |
Miscellaneous databases
Pharosi | P14210, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5479 |
DrugBanki | DB05434, ABT-510 DB12307, Foretinib DB01109, Heparin DB03959, N,O6-Disulfo-Glucosamine DB02264, O2-Sulfo-Glucuronic Acid |
Genetic variation databases
BioMutai | HGF |
DMDMi | 123116 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | 1 PublicationAdd BLAST | 31 | |
ChainiPRO_0000028091 | 32 – 494 | Hepatocyte growth factor alpha chainAdd BLAST | 463 | |
ChainiPRO_0000028092 | 495 – 728 | Hepatocyte growth factor beta chainAdd BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 32 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 70 ↔ 96 | |||
Disulfide bondi | 74 ↔ 84 | |||
Disulfide bondi | 128 ↔ 206 | |||
Disulfide bondi | 149 ↔ 189 | |||
Disulfide bondi | 177 ↔ 201 | |||
Disulfide bondi | 211 ↔ 288 | By similarity | ||
Disulfide bondi | 232 ↔ 271 | By similarity | ||
Disulfide bondi | 260 ↔ 283 | By similarity | ||
GlycosylationiCAR_000021 | 294 | N-linked (GlcNAc...) (complex) asparagine | 1 | |
Disulfide bondi | 305 ↔ 383 | By similarity | ||
Disulfide bondi | 326 ↔ 365 | By similarity | ||
Disulfide bondi | 354 ↔ 377 | By similarity | ||
Disulfide bondi | 391 ↔ 469 | By similarity | ||
GlycosylationiCAR_000022 | 402 | N-linked (GlcNAc...) (complex) asparagine | 1 | |
Disulfide bondi | 412 ↔ 452 | By similarity | ||
Disulfide bondi | 440 ↔ 464 | By similarity | ||
GlycosylationiCAR_000023 | 476 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 487 ↔ 604 | Interchain (between alpha and beta chains)PROSITE-ProRule annotation | ||
Disulfide bondi | 519 ↔ 535 | By similarity | ||
GlycosylationiCAR_000024 | 566 | N-linked (GlcNAc...) (complex) asparagine | 1 | |
Disulfide bondi | 612 ↔ 679 | By similarity | ||
Disulfide bondi | 642 ↔ 658 | By similarity | ||
GlycosylationiCAR_000025 | 653 | N-linked (GlcNAc...) (complex) asparagine | 1 | |
Disulfide bondi | 669 ↔ 697 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
EPDi | P14210 |
MassIVEi | P14210 |
MaxQBi | P14210 |
PaxDbi | P14210 |
PeptideAtlasi | P14210 |
PRIDEi | P14210 |
ProteomicsDBi | 53034 [P14210-1] 53035 [P14210-2] 53036 [P14210-3] 53037 [P14210-4] 53038 [P14210-5] 53039 [P14210-6] |
PTM databases
GlyConnecti | 219, 8 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P14210, 5 sites, 8 N-linked glycans (4 sites), 1 O-linked glycan (1 site) |
iPTMneti | P14210 |
PhosphoSitePlusi | P14210 |
Expressioni
Gene expression databases
Bgeei | ENSG00000019991, Expressed in placenta and 194 other tissues |
ExpressionAtlasi | P14210, baseline and differential |
Genevisiblei | P14210, HS |
Organism-specific databases
HPAi | ENSG00000019991, Tissue enhanced (placenta) |
Interactioni
Subunit structurei
Dimer of an alpha chain and a beta chain linked by a disulfide bond.
Interacts with SRPX2; the interaction increases HGF mitogenic activity.
2 PublicationsBinary interactionsi
Hide detailsP14210
HGF - isoform 6 [P14210-6]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-6280319,EBI-6280319 |
MET [P08581] | 3 | EBI-6280319,EBI-1039152 |
GO - Molecular functioni
- chemoattractant activity Source: BHF-UCL
- growth factor activity Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 109330, 33 interactors |
CORUMi | P14210 |
DIPi | DIP-37535N |
IntActi | P14210, 9 interactors |
MINTi | P14210 |
STRINGi | 9606.ENSP00000222390 |
Chemistry databases
BindingDBi | P14210 |
Miscellaneous databases
RNActi | P14210, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P14210 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14210 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 123 | PANPROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 128 – 206 | Kringle 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 211 – 288 | Kringle 2PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 305 – 383 | Kringle 3PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 391 – 469 | Kringle 4PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 495 – 721 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 227 |
Sequence similaritiesi
Keywords - Domaini
Kringle, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QR40, Eukaryota |
GeneTreei | ENSGT00940000156019 |
HOGENOMi | CLU_017565_1_0_1 |
InParanoidi | P14210 |
OMAi | TNIPQCG |
OrthoDBi | 164039at2759 |
PhylomeDBi | P14210 |
TreeFami | TF329901 |
Family and domain databases
CDDi | cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom |
Pfami | View protein in Pfam PF00051, Kringle, 4 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 4 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL
60 70 80 90 100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP
110 120 130 140 150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ
160 170 180 190 200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV
210 220 230 240 250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY
260 270 280 290 300
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL
310 320 330 340 350
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR
360 370 380 390 400
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM
410 420 430 440 450
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP
460 470 480 490 500
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP
510 520 530 540 550
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI
560 570 580 590 600
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP
610 620 630 640 650
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV
660 670 680 690 700
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP
710 720
NRPGIFVRVA YYAKWIHKII LTYKVPQS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9WSJ3 | C9WSJ3_HUMAN | Hepatocyte growth factor | HGF | 184 | Annotation score: | ||
C9WSJ4 | C9WSJ4_HUMAN | Hepatocyte growth factor | HGF | 161 | Annotation score: | ||
A0A2R8YEI1 | A0A2R8YEI1_HUMAN | Hepatocyte growth factor | HGF | 205 | Annotation score: | ||
C9JDP4 | C9JDP4_HUMAN | Hepatocyte growth factor | HGF | 141 | Annotation score: | ||
C9JS80 | C9JS80_HUMAN | Hepatocyte growth factor | HGF | 118 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 – 33 | QR → HK in CAA34387 (PubMed:2531289).Curated | 2 | |
Sequence conflicti | 78 | K → N in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 180 | P → T AA sequence (PubMed:1824873).Curated | 1 | |
Sequence conflicti | 293 | M → V in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 300 | L → M in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 317 | V → A in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 336 | E → K in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 387 | H → N in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 416 | D → N in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 505 | I → V in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 509 | V → I in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 558 | D → E in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 561 | C → R in CAA34387 (PubMed:2531289).Curated | 1 | |
Sequence conflicti | 592 | D → N AA sequence (PubMed:1824873).Curated | 1 | |
Sequence conflicti | 595 | S → N in CAA34387 (PubMed:2531289).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019199 | 304 | E → K1 PublicationCorresponds to variant dbSNP:rs5745687EnsemblClinVar. | 1 | |
Natural variantiVAR_019200 | 330 | D → Y1 PublicationCorresponds to variant dbSNP:rs5745688Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009617 | 161 – 165 | Missing in isoform 3 and isoform 5. 2 Publications | 5 | |
Alternative sequenceiVSP_009618 | 209 – 210 | VE → GK in isoform 6. 2 Publications | 2 | |
Alternative sequenceiVSP_009619 | 211 – 728 | Missing in isoform 6. 2 PublicationsAdd BLAST | 518 | |
Alternative sequenceiVSP_009620 | 287 – 296 | TCADNTMNDT → NMRDITWALN in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_009622 | 289 – 290 | AD → ET in isoform 2 and isoform 5. 3 Publications | 2 | |
Alternative sequenceiVSP_009623 | 291 – 728 | Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST | 438 | |
Alternative sequenceiVSP_009621 | 297 – 728 | Missing in isoform 4. 1 PublicationAdd BLAST | 432 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1] ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6] ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2] ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5] ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3] |
GeneIDi | 3082 |
KEGGi | hsa:3082 |
UCSCi | uc003uhl.4, human [P14210-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Hepatocyte growth factor entry |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BHT | X-ray | 2.00 | A/B | 35-210 | [»] | |
1GMN | X-ray | 2.30 | A/B | 28-210 | [»] | |
1GMO | X-ray | 3.00 | A/B/C/D/E/F/G/H | 28-210 | [»] | |
1GP9 | X-ray | 2.50 | A/B/C/D | 40-210 | [»] | |
1NK1 | X-ray | 2.50 | A/B | 28-210 | [»] | |
1SHY | X-ray | 3.22 | A | 495-728 | [»] | |
1SI5 | X-ray | 2.53 | H | 495-728 | [»] | |
2HGF | NMR | - | A | 31-127 | [»] | |
2QJ2 | X-ray | 1.81 | A/B | 28-209 | [»] | |
3HMS | X-ray | 1.70 | A | 28-126 | [»] | |
3HMT | X-ray | 2.00 | A/B | 28-126 | [»] | |
3HN4 | X-ray | 2.60 | A | 28-289 | [»] | |
3MKP | X-ray | 2.81 | A/B/C/D | 28-210 | [»] | |
3SP8 | X-ray | 1.86 | A/B | 28-288 | [»] | |
4D3C | X-ray | 2.62 | A | 32-210 | [»] | |
4K3J | X-ray | 2.80 | A | 495-721 | [»] | |
4O3T | X-ray | 2.99 | A | 495-728 | [»] | |
4O3U | X-ray | 3.04 | A | 495-728 | [»] | |
5COE | X-ray | 2.18 | A/B | 28-210 | [»] | |
5CP9 | X-ray | 1.90 | A/B | 28-210 | [»] | |
5CS1 | X-ray | 2.00 | A/B | 28-210 | [»] | |
5CS3 | X-ray | 2.50 | A/B | 28-210 | [»] | |
5CS5 | X-ray | 1.90 | A/B | 28-210 | [»] | |
5CS9 | X-ray | 2.00 | A/B | 28-210 | [»] | |
5CSQ | X-ray | 1.95 | A/B | 28-210 | [»] | |
5CT1 | X-ray | 2.00 | A/B | 28-210 | [»] | |
5CT2 | X-ray | 2.00 | A/B | 28-210 | [»] | |
5CT3 | X-ray | 2.00 | A/B | 28-210 | [»] | |
SMRi | P14210 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109330, 33 interactors |
CORUMi | P14210 |
DIPi | DIP-37535N |
IntActi | P14210, 9 interactors |
MINTi | P14210 |
STRINGi | 9606.ENSP00000222390 |
Chemistry databases
BindingDBi | P14210 |
ChEMBLi | CHEMBL5479 |
DrugBanki | DB05434, ABT-510 DB12307, Foretinib DB01109, Heparin DB03959, N,O6-Disulfo-Glucosamine DB02264, O2-Sulfo-Glucuronic Acid |
Protein family/group databases
MEROPSi | S01.976 |
PTM databases
GlyConnecti | 219, 8 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P14210, 5 sites, 8 N-linked glycans (4 sites), 1 O-linked glycan (1 site) |
iPTMneti | P14210 |
PhosphoSitePlusi | P14210 |
Genetic variation databases
BioMutai | HGF |
DMDMi | 123116 |
Proteomic databases
EPDi | P14210 |
MassIVEi | P14210 |
MaxQBi | P14210 |
PaxDbi | P14210 |
PeptideAtlasi | P14210 |
PRIDEi | P14210 |
ProteomicsDBi | 53034 [P14210-1] 53035 [P14210-2] 53036 [P14210-3] 53037 [P14210-4] 53038 [P14210-5] 53039 [P14210-6] |
Protocols and materials databases
ABCDi | P14210, 12 sequenced antibodies |
Antibodypediai | 4150, 1049 antibodies |
DNASUi | 3082 |
Genome annotation databases
Ensembli | ENST00000222390; ENSP00000222390; ENSG00000019991 [P14210-1] ENST00000423064; ENSP00000413829; ENSG00000019991 [P14210-6] ENST00000444829; ENSP00000389854; ENSG00000019991 [P14210-2] ENST00000453411; ENSP00000408270; ENSG00000019991 [P14210-5] ENST00000457544; ENSP00000391238; ENSG00000019991 [P14210-3] |
GeneIDi | 3082 |
KEGGi | hsa:3082 |
UCSCi | uc003uhl.4, human [P14210-1] |
Organism-specific databases
CTDi | 3082 |
DisGeNETi | 3082 |
GeneCardsi | HGF |
GeneReviewsi | HGF |
HGNCi | HGNC:4893, HGF |
HPAi | ENSG00000019991, Tissue enhanced (placenta) |
MalaCardsi | HGF |
MIMi | 142409, gene 608265, phenotype |
neXtProti | NX_P14210 |
OpenTargetsi | ENSG00000019991 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA29269 |
VEuPathDBi | HostDB:ENSG00000019991.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR40, Eukaryota |
GeneTreei | ENSGT00940000156019 |
HOGENOMi | CLU_017565_1_0_1 |
InParanoidi | P14210 |
OMAi | TNIPQCG |
OrthoDBi | 164039at2759 |
PhylomeDBi | P14210 |
TreeFami | TF329901 |
Enzyme and pathway databases
PathwayCommonsi | P14210 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1266695, Interleukin-7 signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-6806942, MET Receptor Activation R-HSA-6807004, Negative regulation of MET activity R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8851805, MET activates RAS signaling R-HSA-8851907, MET activates PI3K/AKT signaling R-HSA-8865999, MET activates PTPN11 R-HSA-8874081, MET activates PTK2 signaling R-HSA-8875513, MET interacts with TNS proteins R-HSA-8875555, MET activates RAP1 and RAC1 R-HSA-8875656, MET receptor recycling R-HSA-8875791, MET activates STAT3 |
SignaLinki | P14210 |
SIGNORi | P14210 |
Miscellaneous databases
BioGRID-ORCSi | 3082, 31 hits in 880 CRISPR screens |
ChiTaRSi | HGF, human |
EvolutionaryTracei | P14210 |
GeneWikii | Hepatocyte_growth_factor |
GenomeRNAii | 3082 |
Pharosi | P14210, Tchem |
PROi | PR:P14210 |
RNActi | P14210, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000019991, Expressed in placenta and 194 other tissues |
ExpressionAtlasi | P14210, baseline and differential |
Genevisiblei | P14210, HS |
Family and domain databases
CDDi | cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom |
Pfami | View protein in Pfam PF00051, Kringle, 4 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 4 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HGF_HUMAN | |
Accessioni | P14210Primary (citable) accession number: P14210 Secondary accession number(s): A1L3U6 Q9UDU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | August 1, 1991 | |
Last modified: | February 10, 2021 | |
This is version 241 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Peptidase families
Classification of peptidase families and list of entries