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Protein

Arginine kinase

Gene
N/A
Organism
Homarus gammarus (European lobster) (Homarus vulgaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei185ATPPROSITE-ProRule annotation1
Binding sitei225SubstrateBy similarity1
Binding sitei229ATPPROSITE-ProRule annotation1
Binding sitei271SubstrateBy similarity1
Binding sitei314SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 126ATPPROSITE-ProRule annotation5
Nucleotide bindingi280 – 284ATPPROSITE-ProRule annotation5
Nucleotide bindingi309 – 314ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
OrganismiHomarus gammarus (European lobster) (Homarus vulgaris)
Taxonomic identifieri6707 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Pathology & Biotechi

Protein family/group databases

Allergomei791 Hom g 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002119992 – 356Arginine kinaseAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP14208

Structurei

3D structure databases

ProteinModelPortaliP14208
SMRiP14208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 91Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini119 – 356Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 68Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749 ATP-guanido_PTrfase
IPR022415 ATP-guanido_PTrfase_AS
IPR022414 ATP-guanido_PTrfase_cat
IPR022413 ATP-guanido_PTrfase_N
IPR036802 ATP-guanido_PTrfase_N_sf
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547 PTHR11547, 1 hit
PfamiView protein in Pfam
PF00217 ATP-gua_Ptrans, 1 hit
PF02807 ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034 SSF48034, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112 PHOSPHAGEN_KINASE, 1 hit
PS51510 PHOSPHAGEN_KINASE_C, 1 hit
PS51509 PHOSPHAGEN_KINASE_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14208-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAATIAKL EEGFKKLEAA TDCKSLLKKY LSKDIFDSLK AKKTSLGATL
60 70 80 90 100
LDVIQSGVEN LDSGVGIYAP DAEAYSLFAP LFDPIIEDYH KGFKQTDKHP
110 120 130 140 150
AKDFGDVSKF INVDPEGTFV ISTRVRCGRS MEGYPFNPCL TEAQYKEMEE
160 170 180 190 200
KVSSTLSGLE GELKGSYFPL TGMTKEVQQK LIDDHFLFKE GDRFLQAANA
210 220 230 240 250
CRYWPAGRGI YHNDNKTFLV WCNEEDHLRI ISMQMGGDLG QVYRRLVSAV
260 270 280 290 300
NDIEKRVPFS HHDRLGFLTF CPTNLGTTVR ASVHIKLPKL AANREKLEEV
310 320 330 340 350
AAKFSLQVRG TRGEHTEAEG GIYDISNKRR MGLTEFQAVK EMQDGILELI

KIEKEM
Length:356
Mass (Da):39,984
Last modified:January 23, 2007 - v4
Checksum:iF0A77136EBC0CA99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68703 mRNA Translation: CAA48654.1
PIRiA48590 AKLO

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68703 mRNA Translation: CAA48654.1
PIRiA48590 AKLO

3D structure databases

ProteinModelPortaliP14208
SMRiP14208
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei791 Hom g 2

PTM databases

iPTMnetiP14208

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749 ATP-guanido_PTrfase
IPR022415 ATP-guanido_PTrfase_AS
IPR022414 ATP-guanido_PTrfase_cat
IPR022413 ATP-guanido_PTrfase_N
IPR036802 ATP-guanido_PTrfase_N_sf
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547 PTHR11547, 1 hit
PfamiView protein in Pfam
PF00217 ATP-gua_Ptrans, 1 hit
PF02807 ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034 SSF48034, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112 PHOSPHAGEN_KINASE, 1 hit
PS51510 PHOSPHAGEN_KINASE_C, 1 hit
PS51509 PHOSPHAGEN_KINASE_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKARG_HOMGA
AccessioniPrimary (citable) accession number: P14208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 83 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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