UniProtKB - P14207 (FOLR2_HUMAN)
Protein
Folate receptor beta
Gene
FOLR2
Organism
Homo sapiens (Human)
Status
Functioni
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 97 | FolateCombined sources | 1 | |
Binding sitei | 101 | FolateCombined sources | 1 | |
Binding sitei | 190 | FolateCombined sources | 1 |
GO - Molecular functioni
- drug binding Source: BHF-UCL
- folic acid binding Source: UniProtKB
- folic acid receptor activity Source: UniProtKB
- methotrexate binding Source: BHF-UCL
- signaling receptor activity Source: GO_Central
GO - Biological processi
- cell adhesion Source: GO_Central
- folate import across plasma membrane Source: InterPro
- folic acid metabolic process Source: Reactome
- folic acid transport Source: UniProtKB
- fusion of sperm to egg plasma membrane involved in single fertilization Source: GO_Central
- inflammatory response Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- receptor-mediated endocytosis Source: BHF-UCL
- regulation of thymidylate synthase biosynthetic process Source: BHF-UCL
- sperm-egg recognition Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Ligand | Folate-binding |
Enzyme and pathway databases
PathwayCommonsi | P14207 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins R-HSA-196757, Metabolism of folate and pterines |
Names & Taxonomyi
Protein namesi | Recommended name: Folate receptor betaShort name: FR-beta Alternative name(s): Folate receptor 2 Folate receptor, fetal/placental Placental folate-binding protein Short name: FBP |
Gene namesi | Name:FOLR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165457.13 |
HGNCi | HGNC:3793, FOLR2 |
MIMi | 136425, gene |
neXtProti | NX_P14207 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Plasma membrane
Extracellular region or secreted
- extracellular region Source: Reactome
Plasma Membrane
- anchored component of external side of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cell surface Source: BHF-UCL
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2350 |
OpenTargetsi | ENSG00000165457 |
PharmGKBi | PA28209 |
Miscellaneous databases
Pharosi | P14207, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5064 |
DrugBanki | DB00158, Folic acid DB00563, Methotrexate DB05168, Vintafolide |
DrugCentrali | P14207 |
Polymorphism and mutation databases
BioMutai | FOLR2 |
DMDMi | 116241366 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Add BLAST | 16 | |
ChainiPRO_0000008806 | 17 – 230 | Folate receptor betaAdd BLAST | 214 | |
PropeptideiPRO_0000008807 | 231 – 255 | Removed in mature formAdd BLAST | 25 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 59 | Combined sources1 Publication | ||
Disulfide bondi | 51 ↔ 99 | Combined sources1 Publication | ||
Disulfide bondi | 60 ↔ 103 | Combined sources1 Publication | ||
Disulfide bondi | 83 ↔ 169 | Combined sources1 Publication | ||
Disulfide bondi | 90 ↔ 140 | Combined sources1 Publication | ||
Glycosylationi | 115 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 129 ↔ 203 | Combined sources1 Publication | ||
Disulfide bondi | 133 ↔ 183 | Combined sources1 Publication | ||
Disulfide bondi | 146 ↔ 163 | Combined sources1 Publication | ||
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Lipidationi | 230 | GPI-anchor amidated asparagine1 Publication | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P14207 |
MassIVEi | P14207 |
PaxDbi | P14207 |
PeptideAtlasi | P14207 |
PRIDEi | P14207 |
ProteomicsDBi | 53031 |
PTM databases
GlyGeni | P14207, 3 sites |
iPTMneti | P14207 |
Expressioni
Tissue specificityi
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.2 Publications
Inductioni
Up-regulated by retinoic acid.1 Publication
Gene expression databases
Bgeei | ENSG00000165457, Expressed in esophagus and 229 other tissues |
ExpressionAtlasi | P14207, baseline and differential |
Genevisiblei | P14207, HS |
Organism-specific databases
HPAi | ENSG00000165457, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000298223 |
Chemistry databases
BindingDBi | P14207 |
Miscellaneous databases
RNActi | P14207, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P14207 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 122 | Folate bindingCombined sources | 5 | |
Regioni | 151 – 156 | Folate bindingCombined sources | 6 |
Sequence similaritiesi
Belongs to the folate receptor family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000183144 |
InParanoidi | P14207 |
OMAi | KDDFTCK |
OrthoDBi | 1534387at2759 |
PhylomeDBi | P14207 |
TreeFami | TF328532 |
Family and domain databases
InterProi | View protein in InterPro IPR004269, Folate_rcpt IPR018143, Folate_rcpt-like IPR032937, FOLR2 |
PANTHERi | PTHR10517, PTHR10517, 1 hit PTHR10517:SF8, PTHR10517:SF8, 1 hit |
Pfami | View protein in Pfam PF03024, Folate_rec, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
P14207-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWKWMPLLL LLVCVATMCS AQDRTDLLNV CMDAKHHKTK PGPEDKLHDQ
60 70 80 90 100
CSPWKKNACC TASTSQELHK DTSRLYNFNW DHCGKMEPAC KRHFIQDTCL
110 120 130 140 150
YECSPNLGPW IQQVNQSWRK ERFLDVPLCK EDCQRWWEDC HTSHTCKSNW
160 170 180 190 200
HRGWDWTSGV NKCPAGALCR TFESYFPTPA ALCEGLWSHS YKVSNYSRGS
210 220 230 240 250
GRCIQMWFDS AQGNPNEEVA RFYAAAMHVN AGEMLHGTGG LLLSLALMLQ
LWLLG
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H3Z4 | F5H3Z4_HUMAN | Folate receptor beta | FOLR2 | 198 | Annotation score: | ||
E7EU04 | E7EU04_HUMAN | Folate receptor beta | FOLR2 | 210 | Annotation score: | ||
F5GZ45 | F5GZ45_HUMAN | Folate receptor beta | FOLR2 | 180 | Annotation score: | ||
J3KQP4 | J3KQP4_HUMAN | Folate receptor beta | FOLR2 | 251 | Annotation score: | ||
A0A087WWY2 | A0A087WWY2_HUMAN | Folate receptor beta | FOLR2 | 244 | Annotation score: | ||
F5GXV3 | F5GXV3_HUMAN | Folate receptor beta | FOLR2 | 169 | Annotation score: | ||
F5H4Z6 | F5H4Z6_HUMAN | Folate receptor beta | FOLR2 | 171 | Annotation score: | ||
F5H5L8 | F5H5L8_HUMAN | Folate receptor beta | FOLR2 | 148 | Annotation score: | ||
J3KR13 | J3KR13_HUMAN | Folate receptor beta | FOLR2 | 214 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | C → V AA sequence (PubMed:2561247).Curated | 1 | |
Sequence conflicti | 111 – 112 | IQ → VR AA sequence (PubMed:2561247).Curated | 2 | |
Sequence conflicti | 115 | N → D AA sequence (PubMed:2561247).Curated | 1 | |
Sequence conflicti | 117 | S → T in AAA35821 (PubMed:2605182).Curated | 1 | |
Sequence conflicti | 117 | S → T in AAA17370 (PubMed:8106441).Curated | 1 | |
Sequence conflicti | 117 | S → T AA sequence (PubMed:2561247).Curated | 1 | |
Sequence conflicti | 141 | H → L in AAA17370 (PubMed:8106441).Curated | 1 | |
Sequence conflicti | 244 | S → R in AAA17370 (PubMed:8106441).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036408 | 236 | H → N in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69516 Genomic DNA Translation: CAA49267.1 J02876 mRNA Translation: AAA35821.1 U02714, U02716 Genomic DNA Translation: AAA17370.1 AK222643 mRNA Translation: BAD96363.1 BC058036 mRNA Translation: AAH58036.1 BC027894 mRNA Translation: AAH27894.1 |
CCDSi | CCDS8212.1 |
PIRi | A53315, A33417 |
RefSeqi | NP_000794.3, NM_000803.4 NP_001107006.1, NM_001113534.1 NP_001107007.1, NM_001113535.1 NP_001107008.1, NM_001113536.1 |
Genome annotation databases
Ensembli | ENST00000298223; ENSP00000298223; ENSG00000165457 |
GeneIDi | 2350 |
KEGGi | hsa:2350 |
UCSCi | uc001ose.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69516 Genomic DNA Translation: CAA49267.1 J02876 mRNA Translation: AAA35821.1 U02714, U02716 Genomic DNA Translation: AAA17370.1 AK222643 mRNA Translation: BAD96363.1 BC058036 mRNA Translation: AAH58036.1 BC027894 mRNA Translation: AAH27894.1 |
CCDSi | CCDS8212.1 |
PIRi | A53315, A33417 |
RefSeqi | NP_000794.3, NM_000803.4 NP_001107006.1, NM_001113534.1 NP_001107007.1, NM_001113535.1 NP_001107008.1, NM_001113536.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4KMY | X-ray | 1.80 | A | 24-228 | [»] | |
4KMZ | X-ray | 2.30 | A | 24-228 | [»] | |
4KN0 | X-ray | 2.10 | A | 24-228 | [»] | |
4KN1 | X-ray | 2.30 | A | 24-228 | [»] | |
4KN2 | X-ray | 2.60 | A/B/C | 24-227 | [»] | |
SMRi | P14207 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000298223 |
Chemistry databases
BindingDBi | P14207 |
ChEMBLi | CHEMBL5064 |
DrugBanki | DB00158, Folic acid DB00563, Methotrexate DB05168, Vintafolide |
DrugCentrali | P14207 |
PTM databases
GlyGeni | P14207, 3 sites |
iPTMneti | P14207 |
Polymorphism and mutation databases
BioMutai | FOLR2 |
DMDMi | 116241366 |
Proteomic databases
jPOSTi | P14207 |
MassIVEi | P14207 |
PaxDbi | P14207 |
PeptideAtlasi | P14207 |
PRIDEi | P14207 |
ProteomicsDBi | 53031 |
Protocols and materials databases
ABCDi | P14207, 4 sequenced antibodies |
Antibodypediai | 30818, 339 antibodies |
DNASUi | 2350 |
Genome annotation databases
Ensembli | ENST00000298223; ENSP00000298223; ENSG00000165457 |
GeneIDi | 2350 |
KEGGi | hsa:2350 |
UCSCi | uc001ose.5, human |
Organism-specific databases
CTDi | 2350 |
DisGeNETi | 2350 |
EuPathDBi | HostDB:ENSG00000165457.13 |
GeneCardsi | FOLR2 |
HGNCi | HGNC:3793, FOLR2 |
HPAi | ENSG00000165457, Low tissue specificity |
MIMi | 136425, gene |
neXtProti | NX_P14207 |
OpenTargetsi | ENSG00000165457 |
PharmGKBi | PA28209 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000183144 |
InParanoidi | P14207 |
OMAi | KDDFTCK |
OrthoDBi | 1534387at2759 |
PhylomeDBi | P14207 |
TreeFami | TF328532 |
Enzyme and pathway databases
PathwayCommonsi | P14207 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins R-HSA-196757, Metabolism of folate and pterines |
Miscellaneous databases
BioGRID-ORCSi | 2350, 9 hits in 847 CRISPR screens |
ChiTaRSi | FOLR2, human |
GeneWikii | FOLR2 |
GenomeRNAii | 2350 |
Pharosi | P14207, Tchem |
PROi | PR:P14207 |
RNActi | P14207, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165457, Expressed in esophagus and 229 other tissues |
ExpressionAtlasi | P14207, baseline and differential |
Genevisiblei | P14207, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004269, Folate_rcpt IPR018143, Folate_rcpt-like IPR032937, FOLR2 |
PANTHERi | PTHR10517, PTHR10517, 1 hit PTHR10517:SF8, PTHR10517:SF8, 1 hit |
Pfami | View protein in Pfam PF03024, Folate_rec, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOLR2_HUMAN | |
Accessioni | P14207Primary (citable) accession number: P14207 Secondary accession number(s): Q05CA5, Q6GTE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations