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Protein

Folate receptor beta

Gene

FOLR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97FolateCombined sources1
Binding sitei101FolateCombined sources1
Binding sitei190FolateCombined sources1

GO - Molecular functioni

  • drug binding Source: BHF-UCL
  • folic acid binding Source: UniProtKB
  • folic acid receptor activity Source: UniProtKB
  • methotrexate binding Source: BHF-UCL
  • signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-196757 Metabolism of folate and pterines

Names & Taxonomyi

Protein namesi
Recommended name:
Folate receptor beta
Short name:
FR-beta
Alternative name(s):
Folate receptor 2
Folate receptor, fetal/placental
Placental folate-binding protein
Short name:
FBP
Gene namesi
Name:FOLR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165457.13
HGNCiHGNC:3793 FOLR2
MIMi136425 gene
neXtProtiNX_P14207

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2350
OpenTargetsiENSG00000165457
PharmGKBiPA28209

Chemistry databases

ChEMBLiCHEMBL5064
DrugBankiDB05168 EC145
DB00158 Folic Acid

Polymorphism and mutation databases

BioMutaiFOLR2
DMDMi116241366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000000880617 – 230Folate receptor betaAdd BLAST214
PropeptideiPRO_0000008807231 – 255Removed in mature formAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 59Combined sources1 Publication
Disulfide bondi51 ↔ 99Combined sources1 Publication
Disulfide bondi60 ↔ 103Combined sources1 Publication
Disulfide bondi83 ↔ 169Combined sources1 Publication
Disulfide bondi90 ↔ 140Combined sources1 Publication
Glycosylationi115N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi129 ↔ 203Combined sources1 Publication
Disulfide bondi133 ↔ 183Combined sources1 Publication
Disulfide bondi146 ↔ 163Combined sources1 Publication
Glycosylationi195N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Lipidationi230GPI-anchor amidated asparagine1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP14207
PeptideAtlasiP14207
PRIDEiP14207
ProteomicsDBi53031

PTM databases

GlyConnecti1249
iPTMnetiP14207

Expressioni

Tissue specificityi

Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.2 Publications

Inductioni

Up-regulated by retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000165457 Expressed in 215 organ(s), highest expression level in esophagus
CleanExiHS_FOLR2
ExpressionAtlasiP14207 baseline and differential
GenevisibleiP14207 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298223

Chemistry databases

BindingDBiP14207

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14207
SMRiP14207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 122Folate bindingCombined sources5
Regioni151 – 156Folate bindingCombined sources6

Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiP14207
KOiK13649
OMAiKNACCSA
OrthoDBiEOG091G0GIA
PhylomeDBiP14207
TreeFamiTF328532

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032937 FOLR2
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF8 PTHR10517:SF8, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P14207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWKWMPLLL LLVCVATMCS AQDRTDLLNV CMDAKHHKTK PGPEDKLHDQ
60 70 80 90 100
CSPWKKNACC TASTSQELHK DTSRLYNFNW DHCGKMEPAC KRHFIQDTCL
110 120 130 140 150
YECSPNLGPW IQQVNQSWRK ERFLDVPLCK EDCQRWWEDC HTSHTCKSNW
160 170 180 190 200
HRGWDWTSGV NKCPAGALCR TFESYFPTPA ALCEGLWSHS YKVSNYSRGS
210 220 230 240 250
GRCIQMWFDS AQGNPNEEVA RFYAAAMHVN AGEMLHGTGG LLLSLALMLQ

LWLLG
Length:255
Mass (Da):29,280
Last modified:October 17, 2006 - v4
Checksum:iF585715CF5631C98
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQP4J3KQP4_HUMAN
Folate receptor beta
FOLR2
251Annotation score:
F5H3Z4F5H3Z4_HUMAN
Folate receptor beta
FOLR2
198Annotation score:
E7EU04E7EU04_HUMAN
Folate receptor beta
FOLR2
210Annotation score:
F5GZ45F5GZ45_HUMAN
Folate receptor beta
FOLR2
180Annotation score:
F5H4Z6F5H4Z6_HUMAN
Folate receptor beta
FOLR2
171Annotation score:
A0A087WWY2A0A087WWY2_HUMAN
Folate receptor beta
FOLR2
244Annotation score:
F5GXV3F5GXV3_HUMAN
Folate receptor beta
FOLR2
169Annotation score:
J3KR13J3KR13_HUMAN
Folate receptor beta
FOLR2
214Annotation score:
F5H5L8F5H5L8_HUMAN
Folate receptor beta
FOLR2
148Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103C → V AA sequence (PubMed:2561247).Curated1
Sequence conflicti111 – 112IQ → VR AA sequence (PubMed:2561247).Curated2
Sequence conflicti115N → D AA sequence (PubMed:2561247).Curated1
Sequence conflicti117S → T in AAA35821 (PubMed:2605182).Curated1
Sequence conflicti117S → T in AAA17370 (PubMed:8106441).Curated1
Sequence conflicti117S → T AA sequence (PubMed:2561247).Curated1
Sequence conflicti141H → L in AAA17370 (PubMed:8106441).Curated1
Sequence conflicti244S → R in AAA17370 (PubMed:8106441).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036408236H → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69516 Genomic DNA Translation: CAA49267.1
J02876 mRNA Translation: AAA35821.1
U02714, U02716 Genomic DNA Translation: AAA17370.1
AK222643 mRNA Translation: BAD96363.1
BC058036 mRNA Translation: AAH58036.1
BC027894 mRNA Translation: AAH27894.1
CCDSiCCDS8212.1
PIRiA53315 A33417
RefSeqiNP_000794.3, NM_000803.4
NP_001107006.1, NM_001113534.1
NP_001107007.1, NM_001113535.1
NP_001107008.1, NM_001113536.1
UniGeneiHs.433159

Genome annotation databases

EnsembliENST00000298223; ENSP00000298223; ENSG00000165457
GeneIDi2350
KEGGihsa:2350
UCSCiuc001ose.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69516 Genomic DNA Translation: CAA49267.1
J02876 mRNA Translation: AAA35821.1
U02714, U02716 Genomic DNA Translation: AAA17370.1
AK222643 mRNA Translation: BAD96363.1
BC058036 mRNA Translation: AAH58036.1
BC027894 mRNA Translation: AAH27894.1
CCDSiCCDS8212.1
PIRiA53315 A33417
RefSeqiNP_000794.3, NM_000803.4
NP_001107006.1, NM_001113534.1
NP_001107007.1, NM_001113535.1
NP_001107008.1, NM_001113536.1
UniGeneiHs.433159

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KMYX-ray1.80A24-228[»]
4KMZX-ray2.30A24-228[»]
4KN0X-ray2.10A24-228[»]
4KN1X-ray2.30A24-228[»]
4KN2X-ray2.60A/B/C24-227[»]
ProteinModelPortaliP14207
SMRiP14207
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298223

Chemistry databases

BindingDBiP14207
ChEMBLiCHEMBL5064
DrugBankiDB05168 EC145
DB00158 Folic Acid

PTM databases

GlyConnecti1249
iPTMnetiP14207

Polymorphism and mutation databases

BioMutaiFOLR2
DMDMi116241366

Proteomic databases

PaxDbiP14207
PeptideAtlasiP14207
PRIDEiP14207
ProteomicsDBi53031

Protocols and materials databases

DNASUi2350
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298223; ENSP00000298223; ENSG00000165457
GeneIDi2350
KEGGihsa:2350
UCSCiuc001ose.5 human

Organism-specific databases

CTDi2350
DisGeNETi2350
EuPathDBiHostDB:ENSG00000165457.13
GeneCardsiFOLR2
HGNCiHGNC:3793 FOLR2
MIMi136425 gene
neXtProtiNX_P14207
OpenTargetsiENSG00000165457
PharmGKBiPA28209
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiP14207
KOiK13649
OMAiKNACCSA
OrthoDBiEOG091G0GIA
PhylomeDBiP14207
TreeFamiTF328532

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-196757 Metabolism of folate and pterines

Miscellaneous databases

ChiTaRSiFOLR2 human
GeneWikiiFOLR2
GenomeRNAii2350
PROiPR:P14207
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165457 Expressed in 215 organ(s), highest expression level in esophagus
CleanExiHS_FOLR2
ExpressionAtlasiP14207 baseline and differential
GenevisibleiP14207 HS

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032937 FOLR2
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF8 PTHR10517:SF8, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOLR2_HUMAN
AccessioniPrimary (citable) accession number: P14207
Secondary accession number(s): Q05CA5, Q6GTE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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