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Protein

40S ribosomal protein SA

Gene

Rpsa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10.UniRule annotation5 Publications

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

GO - Molecular functioni

  • laminin binding Source: MGI
  • laminin receptor activity Source: UniProtKB-UniRule
  • ribosome binding Source: MGI
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor, Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
Alternative name(s):
37 kDa laminin receptor precursorUniRule annotation
Short name:
37LRPUniRule annotation
37 kDa oncofetal antigen
37/67 kDa laminin receptorUniRule annotation
Short name:
LRP/LRUniRule annotation
67 kDa laminin receptorUniRule annotation
Short name:
67LRUniRule annotation
Laminin receptor 1UniRule annotation
Short name:
LamRUniRule annotation
Laminin-binding protein precursor p40UniRule annotation
Short name:
LBP/p40UniRule annotation
OFA/iLRP
Gene namesi
Name:Rpsa
Synonyms:Lamr1, P40-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:105381 Rpsa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001343592 – 29540S ribosomal protein SAAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineUniRule annotation1 Publication1
Modified residuei43PhosphoserineBy similarity1
Modified residuei52N6-acetyllysineBy similarity1
Modified residuei89N6-acetyllysine; alternateCombined sources1
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei97PhosphothreonineBy similarity1

Post-translational modificationi

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.UniRule annotation
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei115 – 116Cleavage; by ST3; site 1UniRule annotation2
Sitei133 – 134Cleavage; by ST3; site 2UniRule annotation2

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP14206
MaxQBiP14206
PaxDbiP14206
PeptideAtlasiP14206
PRIDEiP14206

2D gel databases

REPRODUCTION-2DPAGEiIPI00123604
P14206
SWISS-2DPAGEiP14206

PTM databases

iPTMnetiP14206
PhosphoSitePlusiP14206
SwissPalmiP14206

Expressioni

Gene expression databases

BgeeiENSMUSG00000032518 Expressed in 127 organ(s), highest expression level in thymus
CleanExiMM_RPSA
ExpressionAtlasiP14206 baseline and differential
GenevisibleiP14206 MM

Interactioni

Subunit structurei

Monomer (37LRP) and homodimer (67LR) (By similarity). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21 (By similarity). Interacts with several laminins including at least LAMB1. Interacts with MDK. Interacts with PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B (By similarity).UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201107, 5 interactors
DIPiDIP-38089N
IntActiP14206, 19 interactors
MINTiP14206
STRINGi10090.ENSMUSP00000035105

Structurei

3D structure databases

ProteinModelPortaliP14206
SMRiP14206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati230 – 232[DE]-W-[ST] 13
Repeati247 – 249[DE]-W-[ST] 23
Repeati266 – 268[DE]-W-[ST] 33
Repeati275 – 277[DE]-W-[ST] 43
Repeati293 – 295[DE]-W-[ST] 53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 113Interaction with PPP1R16BUniRule annotationAdd BLAST60
Regioni161 – 180Laminin-bindingUniRule annotationAdd BLAST20
Regioni205 – 229Laminin-bindingUniRule annotationAdd BLAST25
Regioni242 – 295Laminin-bindingUniRule annotationAdd BLAST54

Sequence similaritiesi

Belongs to the universal ribosomal protein uS2 family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0830 Eukaryota
COG0052 LUCA
GeneTreeiENSGT00390000015036
HOGENOMiHOG000232073
HOVERGENiHBG054466
InParanoidiP14206
KOiK02998
OMAiQQKTKDM
OrthoDBiEOG091G0J0Q
PhylomeDBiP14206
TreeFamiTF300100

Family and domain databases

CDDicd01425 RPS2, 1 hit
HAMAPiMF_03015 Ribosomal_S2_euk, 1 hit
MF_03016 Ribosomal_S2_laminin_receptor, 1 hit
InterProiView protein in InterPro
IPR027504 40S_ribosomal_SA
IPR032281 40S_SA_C
IPR001865 Ribosomal_S2
IPR018130 Ribosomal_S2_CS
IPR027498 Ribosomal_S2_euk
IPR005707 Ribosomal_S2_euk/arc
IPR023591 Ribosomal_S2_flav_dom_sf
PANTHERiPTHR11489 PTHR11489, 1 hit
PfamiView protein in Pfam
PF16122 40S_SA_C, 1 hit
PF00318 Ribosomal_S2, 2 hits
PRINTSiPR00395 RIBOSOMALS2
SUPFAMiSSF52313 SSF52313, 1 hit
TIGRFAMsiTIGR01012 uS2_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00962 RIBOSOMAL_S2_1, 1 hit
PS00963 RIBOSOMAL_S2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P14206-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN
60 70 80 90 100
LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA
110 120 130 140 150
GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT
160 170 180 190 200
DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD
210 220 230 240 250
LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA AQPEVADWSE
260 270 280 290
GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTEWS
Length:295
Mass (Da):32,838
Last modified:May 1, 2007 - v4
Checksum:iC698CFA6B759FD2E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRW0A0A1L1SRW0_MOUSE
40S ribosomal protein SA
Rpsa
93Annotation score:
A0A1L1SUK3A0A1L1SUK3_MOUSE
40S ribosomal protein SA
Rpsa
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18F → L in AAA39413 (PubMed:2531008).Curated1
Sequence conflicti29N → H in BAB27355 (PubMed:16141072).Curated1
Sequence conflicti155R → A in AAA39413 (PubMed:2531008).Curated1
Sequence conflicti243P → T in AAH92041 (PubMed:15489334).Curated1
Sequence conflicti249S → Y in BAC38701 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02870 mRNA Translation: AAA39413.1
X06406 mRNA Translation: CAA29696.1
AF140348 mRNA Translation: AAD26866.1
DQ360291 Genomic DNA Translation: ABC95972.1
DQ360292 Genomic DNA Translation: ABC95977.1
AK010423 mRNA Translation: BAB26926.1
AK010985 mRNA Translation: BAB27306.1
AK011041 mRNA Translation: BAB27353.1
AK011043 mRNA Translation: BAB27355.1
AK075778 mRNA Translation: BAC35952.1
AK075790 mRNA Translation: BAC35960.1
AK082935 mRNA Translation: BAC38701.1
AK088954 mRNA Translation: BAC40671.1
AK134224 mRNA Translation: BAE22057.1
AK135488 mRNA Translation: BAE22550.1
AK160551 mRNA Translation: BAE35867.1
AK160625 mRNA Translation: BAE35924.1
AK165219 mRNA Translation: BAE38083.1
AK166697 mRNA Translation: BAE38953.1
AK166874 mRNA Translation: BAE39085.1
AK167132 mRNA Translation: BAE39278.1
BC003829 mRNA Translation: AAH03829.1
BC037195 mRNA Translation: AAH37195.1
BC055886 mRNA Translation: AAH55886.1
BC081461 mRNA Translation: AAH81461.1
BC084677 mRNA Translation: AAH84677.1
BC092041 mRNA Translation: AAH92041.1
BC094902 mRNA Translation: AAH94902.1
BC099601 mRNA Translation: AAH99601.1
BC110285 mRNA Translation: AAI10286.1
CCDSiCCDS23623.1
PIRiA29395
RefSeqiNP_035159.3, NM_011029.4
UniGeneiMm.311972
Mm.391708
Mm.4071

Genome annotation databases

EnsembliENSMUST00000035105; ENSMUSP00000035105; ENSMUSG00000032518
ENSMUST00000217317; ENSMUSP00000148933; ENSMUSG00000032518
GeneIDi16785
KEGGimmu:16785
UCSCiuc009scd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02870 mRNA Translation: AAA39413.1
X06406 mRNA Translation: CAA29696.1
AF140348 mRNA Translation: AAD26866.1
DQ360291 Genomic DNA Translation: ABC95972.1
DQ360292 Genomic DNA Translation: ABC95977.1
AK010423 mRNA Translation: BAB26926.1
AK010985 mRNA Translation: BAB27306.1
AK011041 mRNA Translation: BAB27353.1
AK011043 mRNA Translation: BAB27355.1
AK075778 mRNA Translation: BAC35952.1
AK075790 mRNA Translation: BAC35960.1
AK082935 mRNA Translation: BAC38701.1
AK088954 mRNA Translation: BAC40671.1
AK134224 mRNA Translation: BAE22057.1
AK135488 mRNA Translation: BAE22550.1
AK160551 mRNA Translation: BAE35867.1
AK160625 mRNA Translation: BAE35924.1
AK165219 mRNA Translation: BAE38083.1
AK166697 mRNA Translation: BAE38953.1
AK166874 mRNA Translation: BAE39085.1
AK167132 mRNA Translation: BAE39278.1
BC003829 mRNA Translation: AAH03829.1
BC037195 mRNA Translation: AAH37195.1
BC055886 mRNA Translation: AAH55886.1
BC081461 mRNA Translation: AAH81461.1
BC084677 mRNA Translation: AAH84677.1
BC092041 mRNA Translation: AAH92041.1
BC094902 mRNA Translation: AAH94902.1
BC099601 mRNA Translation: AAH99601.1
BC110285 mRNA Translation: AAI10286.1
CCDSiCCDS23623.1
PIRiA29395
RefSeqiNP_035159.3, NM_011029.4
UniGeneiMm.311972
Mm.391708
Mm.4071

3D structure databases

ProteinModelPortaliP14206
SMRiP14206
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201107, 5 interactors
DIPiDIP-38089N
IntActiP14206, 19 interactors
MINTiP14206
STRINGi10090.ENSMUSP00000035105

Chemistry databases

ChEMBLiCHEMBL1075301

PTM databases

iPTMnetiP14206
PhosphoSitePlusiP14206
SwissPalmiP14206

2D gel databases

REPRODUCTION-2DPAGEiIPI00123604
P14206
SWISS-2DPAGEiP14206

Proteomic databases

EPDiP14206
MaxQBiP14206
PaxDbiP14206
PeptideAtlasiP14206
PRIDEiP14206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035105; ENSMUSP00000035105; ENSMUSG00000032518
ENSMUST00000217317; ENSMUSP00000148933; ENSMUSG00000032518
GeneIDi16785
KEGGimmu:16785
UCSCiuc009scd.2 mouse

Organism-specific databases

CTDi3921
MGIiMGI:105381 Rpsa

Phylogenomic databases

eggNOGiKOG0830 Eukaryota
COG0052 LUCA
GeneTreeiENSGT00390000015036
HOGENOMiHOG000232073
HOVERGENiHBG054466
InParanoidiP14206
KOiK02998
OMAiQQKTKDM
OrthoDBiEOG091G0J0Q
PhylomeDBiP14206
TreeFamiTF300100

Miscellaneous databases

ChiTaRSiRpsa mouse
PROiPR:P14206
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032518 Expressed in 127 organ(s), highest expression level in thymus
CleanExiMM_RPSA
ExpressionAtlasiP14206 baseline and differential
GenevisibleiP14206 MM

Family and domain databases

CDDicd01425 RPS2, 1 hit
HAMAPiMF_03015 Ribosomal_S2_euk, 1 hit
MF_03016 Ribosomal_S2_laminin_receptor, 1 hit
InterProiView protein in InterPro
IPR027504 40S_ribosomal_SA
IPR032281 40S_SA_C
IPR001865 Ribosomal_S2
IPR018130 Ribosomal_S2_CS
IPR027498 Ribosomal_S2_euk
IPR005707 Ribosomal_S2_euk/arc
IPR023591 Ribosomal_S2_flav_dom_sf
PANTHERiPTHR11489 PTHR11489, 1 hit
PfamiView protein in Pfam
PF16122 40S_SA_C, 1 hit
PF00318 Ribosomal_S2, 2 hits
PRINTSiPR00395 RIBOSOMALS2
SUPFAMiSSF52313 SSF52313, 1 hit
TIGRFAMsiTIGR01012 uS2_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00962 RIBOSOMAL_S2_1, 1 hit
PS00963 RIBOSOMAL_S2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSSA_MOUSE
AccessioniPrimary (citable) accession number: P14206
Secondary accession number(s): Q58E74
, Q8BHL0, Q8BNL2, Q91V31, Q9CY13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 180 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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