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Entry version 169 (26 Feb 2020)
Sequence version 2 (23 Jan 2002)
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Protein

Protein ref(2)P

Gene

ref(2)P

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs (PubMed:12446795, PubMed:2510997).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri121 – 167ZZ-typePROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5205685 Pink/Parkin Mediated Mitophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ref(2)P
Alternative name(s):
Refractory to sigma P
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ref(2)P
ORF Names:CG10360
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003231 ref(2)P

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Males are sterile, spermatids exhibit degenerated mitochondria. Reduced activation of the Drs promoter. Double mutants for ref2P and scny die 96 hours after egg laying (PubMed:22622177).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972371 – 599Protein ref(2)PAdd BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei447Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P14199

PRoteomics IDEntifications database

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PRIDEi
P14199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P14199

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0003231 Expressed in adult organism and 24 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14199 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with aPKC and Traf6.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
61223, 44 interactors

Database of interacting proteins

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DIPi
DIP-18088N

Protein interaction database and analysis system

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IntActi
P14199, 4 interactors

Molecular INTeraction database

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MINTi
P14199

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080794

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 88PB1PROSITE-ProRule annotationAdd BLAST86
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati386 – 39318
Repeati399 – 40628
Repeati407 – 41337
Domaini550 – 595UBAPROSITE-ProRule annotationAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni386 – 4133 X 8 AA repeats of S-A-N-Q-S-X-X-PAdd BLAST28

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 167ZZ-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQZA Eukaryota
ENOG410XWHN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030132_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14199

Identification of Orthologs from Complete Genome Data

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OMAi
QNDYEIF

Database of Orthologous Groups

More...
OrthoDBi
1275680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14199

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14320 UBA_SQSTM, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000270 PB1_dom
IPR033741 SQSTM_UBA
IPR015940 UBA
IPR009060 UBA-like_sf
IPR000433 Znf_ZZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00564 PB1, 1 hit
PF16577 UBA_5, 1 hit
PF00569 ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00165 UBA, 1 hit
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46934 SSF46934, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS50030 UBA, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P14199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEKLLKITY QGAGPQKKIN AYLRMPSQNY TILRREIELY LFQERQLPKC
60 70 80 90 100
DVRTFWIDAD KDEIEIVNQN DYEIFLAKCE SNMHVQVAPL APVEEPKATK
110 120 130 140 150
QEGSSANAEA PSVDDPSNFT IHDAVECDGC GLAPLIGFRY KCVQCSNYDL
160 170 180 190 200
CQKCELAHKH PEHLMLRMPT NNGPGMVDAW FTGPGLGRRS GRRSRGHCPF
210 220 230 240 250
QETNQADPAG EPARDSRRER RQARRHAGVL TQFVEMMTNL PLNTTTATAP
260 270 280 290 300
AEPQKPKAAE QTESPPQAEP TVTAEKAAES EAKPTEPKKV NTDQSVPRTE
310 320 330 340 350
DPVTTPRSTQ PTTPVINLDN ISQIVPPEYM SAGIEILNNF SEMFSKIIDT
360 370 380 390 400
TEGGDSGIFA PSTTPSAENK KPEEQGQSSG QSGASSANQS AVPSAAPSAN
410 420 430 440 450
QSNVPSANQS ATPSISGSIP DAQLETEPLN PKPSETTTET EQERRRSDSL
460 470 480 490 500
DPEWQLIDNA YSANNSNLIN LDTTNPTAAP QEPVRDFGQL GELLRQHMNE
510 520 530 540 550
EARVEQASAN TQTAQVDTVS TSTSTTSVTT NSVGTSPAAP DDKRTVPVYH
560 570 580 590
TDESINKSIH AMMAMGFSNE GAWLTQLLES VQGNISAALD VMNVSQNRN
Length:599
Mass (Da):65,303
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i946043CE19AAF126
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188R → S in CAA34861 (PubMed:2510997).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Polymorphic for two allelic forms in natural populations of Drosophila melanogaster, ref2Po and ref2Pp. The latter allele confers resistance to the rhabdovirus sigma infecting wild populations.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti28 – 29QN → G in BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_5A, BPL_5D, BPL_5F, BPL_6D, BPL_6E, BPL_7F, BPL_8A, BPL_8C, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B, BPL_13A, BPL_13F, Florida1Slow and Paris. 3 Publications2
Natural varianti32I → A in strain: AfricaFast, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, FloridaFast, Florida1Slow, Paris and WashingtonFast. 3 Publications1
Natural varianti32I → M in strain: JapanSlow. 1 Publication1
Natural varianti32I → V in strain: BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B and BPL_13A. 1
Natural varianti43Q → L in strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, FloridaFast, JapanSlow, Oregon-R, Paris and WashingtonFast. 4 Publications1
Natural varianti60D → Y in strain: BPL_1A, BPL_1G, BPL_2A, BPL_2G, BPL_2H, BPL_3C, BPL_4A, BPL_4C, BPL_4G, BPL_5H, BPL_6H, BPL_7C, BPL_10E, BPL_11C, BPL_11H, BPL_12A and WashingtonFast. 2 Publications1
Natural varianti79C → R in strain: BPL_1B, BPL_9F and BPL_13D. 1 Publication1
Natural varianti186 – 192Missing in strain: Paris. 2 Publications7
Natural varianti231T → S in strain: BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7H, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_9A, BPL_9C, BPL_9F, BPL_9H, FrenchSlow and Paris. 3 Publications1
Natural varianti247A → D in strain: BPL_7A, BPL_9D, BPL_10A and BPL_11E. 1 Publication1
Natural varianti274A → V in strain: BPL_1E. 1 Publication1
Natural varianti290V → D in strain: BPL_3G. 1 Publication1
Natural varianti331S → R in strain: AfricaFast, AfricaSlow, BPL_10A, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_12F, BPL_13A, BPL_13B, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1F, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2F, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7A, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_7H, BPL_8A, BPL_8B, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_8H, BPL_9A, BPL_9B, BPL_9C, BPL_9D, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, FrenchFast, FrenchSlow, JapanFast, JapanSlow, Paris and WashingtonFast. 3 Publications1
Natural varianti356S → L in strain: BPL_6H, BPL_7C, BPL_11F and BPL_12A. 1 Publication1
Natural varianti389Q → E in strain: BPL_1C. 1 Publication1
Natural varianti393P → L in strain: BPL_1H, BPL_3H, BPL_4B, BPL_5E, BPL_7B, BPL_7H, BPL_8G, BPL_10H and BPL_13C. 1 Publication1
Natural varianti397P → S in strain: FrenchSlow. 1 Publication1
Natural varianti403 – 410Missing in strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, Paris and WashingtonFast. 3 Publications8
Natural varianti432K → M in strain: FrenchFast. 2 Publications1
Natural varianti444R → I in strain: BPL_3B and BPL_8F. 1 Publication1
Natural varianti542D → E in strain: AfricaSlow, AfricaFast, FloridaFast, Florida1Slow, Florida2Slow, FrenchSlow, JapanSlow, Paris and WashingtonFast. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16993 Genomic DNA Translation: CAA34861.1
X69828 Genomic DNA Translation: CAA49482.1
X69829 mRNA Translation: CAA49483.1
X69830 mRNA Translation: CAA49484.1
U23923 Genomic DNA Translation: AAA98832.1
U23924 Genomic DNA Translation: AAA98833.1
U23925 Genomic DNA Translation: AAA98834.1
U23926 Genomic DNA Translation: AAA98835.1
U23927 Genomic DNA Translation: AAA98836.1
U23928 Genomic DNA Translation: AAA98837.1
U23929 Genomic DNA Translation: AAA98838.1
U23931 Genomic DNA Translation: AAA98839.1
U23932 Genomic DNA Translation: AAA98840.1
U23933 Genomic DNA Translation: AAA98841.1
AE014134 Genomic DNA Translation: AAF53824.1
AE014134 Genomic DNA Translation: AAX52671.1
AY089494 mRNA Translation: AAL90232.1
AM114104 Genomic DNA Translation: CAJ34995.2
AM114105 Genomic DNA Translation: CAJ34996.2
AM114106 Genomic DNA Translation: CAJ34997.2
AM114107 Genomic DNA Translation: CAJ34998.2
AM114108 Genomic DNA Translation: CAJ34999.2
AM114109 Genomic DNA Translation: CAJ35000.2
AM114110 Genomic DNA Translation: CAJ35001.2
AM114111 Genomic DNA Translation: CAJ35002.2
AM114112 Genomic DNA Translation: CAJ35003.2
AM114113 Genomic DNA Translation: CAJ35004.2
AM114114 Genomic DNA Translation: CAJ35005.2
AM114115 Genomic DNA Translation: CAJ35006.2
AM114116 Genomic DNA Translation: CAJ35007.2
AM114117 Genomic DNA Translation: CAJ35008.2
AM114118 Genomic DNA Translation: CAJ35009.2
AM114119 Genomic DNA Translation: CAJ35010.2
AM114120 Genomic DNA Translation: CAJ35011.1
AM114120 Genomic DNA Translation: CAJ38290.1
AM114121 Genomic DNA Translation: CAJ35012.2
AM114122 Genomic DNA Translation: CAJ35013.2
AM114123 Genomic DNA Translation: CAJ35014.2
AM114124 Genomic DNA Translation: CAJ35015.2
AM114125 Genomic DNA Translation: CAJ35016.2
AM114126 Genomic DNA Translation: CAJ35017.2
AM114127 Genomic DNA Translation: CAJ35018.2
AM114128 Genomic DNA Translation: CAJ35019.2
AM114129 Genomic DNA Translation: CAJ35020.2
AM114130 Genomic DNA Translation: CAJ35021.2
AM114131 Genomic DNA Translation: CAJ35022.2
AM114132 Genomic DNA Translation: CAJ35023.2
AM114133 Genomic DNA Translation: CAJ35024.2
AM114134 Genomic DNA Translation: CAJ35025.2
AM114135 Genomic DNA Translation: CAJ35026.2
AM114136 Genomic DNA Translation: CAJ35027.2
AM114137 Genomic DNA Translation: CAJ35028.2
AM114138 Genomic DNA Translation: CAJ35029.2
AM114139 Genomic DNA Translation: CAJ35030.2
AM114140 Genomic DNA Translation: CAJ35031.2
AM114141 Genomic DNA Translation: CAJ35032.2
AM114142 Genomic DNA Translation: CAJ35033.2
AM114143 Genomic DNA Translation: CAJ35034.2
AM114144 Genomic DNA Translation: CAJ35035.2
AM114145 Genomic DNA Translation: CAJ35036.2
AM114146 Genomic DNA Translation: CAJ35037.2
AM114147 Genomic DNA Translation: CAJ35038.2
AM114148 Genomic DNA Translation: CAJ35039.2
AM114149 Genomic DNA Translation: CAJ35040.2
AM114150 Genomic DNA Translation: CAJ35041.2
AM114151 Genomic DNA Translation: CAJ35042.2
AM114152 Genomic DNA Translation: CAJ35043.2
AM114153 Genomic DNA Translation: CAJ35044.2
AM114154 Genomic DNA Translation: CAJ35045.2
AM114155 Genomic DNA Translation: CAJ35046.2
AM114156 Genomic DNA Translation: CAJ35047.2
AM114157 Genomic DNA Translation: CAJ35048.2
AM114158 Genomic DNA Translation: CAJ35049.2
AM114159 Genomic DNA Translation: CAJ35050.2
AM114160 Genomic DNA Translation: CAJ35051.2
AM114161 Genomic DNA Translation: CAJ35052.2
AM114162 Genomic DNA Translation: CAJ35053.2
AM114163 Genomic DNA Translation: CAJ35054.2
AM114164 Genomic DNA Translation: CAJ35055.1
AM114164 Genomic DNA Translation: CAJ38334.1
AM114165 Genomic DNA Translation: CAJ35056.2
AM114166 Genomic DNA Translation: CAJ35057.2
AM114167 Genomic DNA Translation: CAJ35058.2
AM114168 Genomic DNA Translation: CAJ35059.2
AM114169 Genomic DNA Translation: CAJ35060.2
AM114170 Genomic DNA Translation: CAJ35061.2
AM114171 Genomic DNA Translation: CAJ35062.2
AM114172 Genomic DNA Translation: CAJ35063.2
AM114173 Genomic DNA Translation: CAJ35064.2
AM114174 Genomic DNA Translation: CAJ35065.2
AM114175 Genomic DNA Translation: CAJ35066.2
AM114176 Genomic DNA Translation: CAJ35067.2
AM114177 Genomic DNA Translation: CAJ35068.2
AM114178 Genomic DNA Translation: CAJ35069.2
AM114179 Genomic DNA Translation: CAJ35070.2
AM114180 Genomic DNA Translation: CAJ35071.2
AM114181 Genomic DNA Translation: CAJ35072.2
AM114182 Genomic DNA Translation: CAJ35073.2
AM114183 Genomic DNA Translation: CAJ35074.2
AM114184 Genomic DNA Translation: CAJ35075.1
AM114184 Genomic DNA Translation: CAJ38354.1
AM114185 Genomic DNA Translation: CAJ35076.2
AM114186 Genomic DNA Translation: CAJ35077.2
AM114187 Genomic DNA Translation: CAJ35078.2
AM114188 Genomic DNA Translation: CAJ35079.1
AM114188 Genomic DNA Translation: CAJ38358.1
AM114189 Genomic DNA Translation: CAJ35080.2
AM114190 Genomic DNA Translation: CAJ35081.2
AM114191 Genomic DNA Translation: CAJ35082.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S06785
S33562 S29961
S33563 S29963
S33564 S29964

NCBI Reference Sequences

More...
RefSeqi
NP_001014491.1, NM_001014491.2
NP_476700.1, NM_057352.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081253; FBpp0080794; FBgn0003231
FBtr0100289; FBpp0099683; FBgn0003231

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10360

UCSC genome browser

More...
UCSCi
CG10360-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16993 Genomic DNA Translation: CAA34861.1
X69828 Genomic DNA Translation: CAA49482.1
X69829 mRNA Translation: CAA49483.1
X69830 mRNA Translation: CAA49484.1
U23923 Genomic DNA Translation: AAA98832.1
U23924 Genomic DNA Translation: AAA98833.1
U23925 Genomic DNA Translation: AAA98834.1
U23926 Genomic DNA Translation: AAA98835.1
U23927 Genomic DNA Translation: AAA98836.1
U23928 Genomic DNA Translation: AAA98837.1
U23929 Genomic DNA Translation: AAA98838.1
U23931 Genomic DNA Translation: AAA98839.1
U23932 Genomic DNA Translation: AAA98840.1
U23933 Genomic DNA Translation: AAA98841.1
AE014134 Genomic DNA Translation: AAF53824.1
AE014134 Genomic DNA Translation: AAX52671.1
AY089494 mRNA Translation: AAL90232.1
AM114104 Genomic DNA Translation: CAJ34995.2
AM114105 Genomic DNA Translation: CAJ34996.2
AM114106 Genomic DNA Translation: CAJ34997.2
AM114107 Genomic DNA Translation: CAJ34998.2
AM114108 Genomic DNA Translation: CAJ34999.2
AM114109 Genomic DNA Translation: CAJ35000.2
AM114110 Genomic DNA Translation: CAJ35001.2
AM114111 Genomic DNA Translation: CAJ35002.2
AM114112 Genomic DNA Translation: CAJ35003.2
AM114113 Genomic DNA Translation: CAJ35004.2
AM114114 Genomic DNA Translation: CAJ35005.2
AM114115 Genomic DNA Translation: CAJ35006.2
AM114116 Genomic DNA Translation: CAJ35007.2
AM114117 Genomic DNA Translation: CAJ35008.2
AM114118 Genomic DNA Translation: CAJ35009.2
AM114119 Genomic DNA Translation: CAJ35010.2
AM114120 Genomic DNA Translation: CAJ35011.1
AM114120 Genomic DNA Translation: CAJ38290.1
AM114121 Genomic DNA Translation: CAJ35012.2
AM114122 Genomic DNA Translation: CAJ35013.2
AM114123 Genomic DNA Translation: CAJ35014.2
AM114124 Genomic DNA Translation: CAJ35015.2
AM114125 Genomic DNA Translation: CAJ35016.2
AM114126 Genomic DNA Translation: CAJ35017.2
AM114127 Genomic DNA Translation: CAJ35018.2
AM114128 Genomic DNA Translation: CAJ35019.2
AM114129 Genomic DNA Translation: CAJ35020.2
AM114130 Genomic DNA Translation: CAJ35021.2
AM114131 Genomic DNA Translation: CAJ35022.2
AM114132 Genomic DNA Translation: CAJ35023.2
AM114133 Genomic DNA Translation: CAJ35024.2
AM114134 Genomic DNA Translation: CAJ35025.2
AM114135 Genomic DNA Translation: CAJ35026.2
AM114136 Genomic DNA Translation: CAJ35027.2
AM114137 Genomic DNA Translation: CAJ35028.2
AM114138 Genomic DNA Translation: CAJ35029.2
AM114139 Genomic DNA Translation: CAJ35030.2
AM114140 Genomic DNA Translation: CAJ35031.2
AM114141 Genomic DNA Translation: CAJ35032.2
AM114142 Genomic DNA Translation: CAJ35033.2
AM114143 Genomic DNA Translation: CAJ35034.2
AM114144 Genomic DNA Translation: CAJ35035.2
AM114145 Genomic DNA Translation: CAJ35036.2
AM114146 Genomic DNA Translation: CAJ35037.2
AM114147 Genomic DNA Translation: CAJ35038.2
AM114148 Genomic DNA Translation: CAJ35039.2
AM114149 Genomic DNA Translation: CAJ35040.2
AM114150 Genomic DNA Translation: CAJ35041.2
AM114151 Genomic DNA Translation: CAJ35042.2
AM114152 Genomic DNA Translation: CAJ35043.2
AM114153 Genomic DNA Translation: CAJ35044.2
AM114154 Genomic DNA Translation: CAJ35045.2
AM114155 Genomic DNA Translation: CAJ35046.2
AM114156 Genomic DNA Translation: CAJ35047.2
AM114157 Genomic DNA Translation: CAJ35048.2
AM114158 Genomic DNA Translation: CAJ35049.2
AM114159 Genomic DNA Translation: CAJ35050.2
AM114160 Genomic DNA Translation: CAJ35051.2
AM114161 Genomic DNA Translation: CAJ35052.2
AM114162 Genomic DNA Translation: CAJ35053.2
AM114163 Genomic DNA Translation: CAJ35054.2
AM114164 Genomic DNA Translation: CAJ35055.1
AM114164 Genomic DNA Translation: CAJ38334.1
AM114165 Genomic DNA Translation: CAJ35056.2
AM114166 Genomic DNA Translation: CAJ35057.2
AM114167 Genomic DNA Translation: CAJ35058.2
AM114168 Genomic DNA Translation: CAJ35059.2
AM114169 Genomic DNA Translation: CAJ35060.2
AM114170 Genomic DNA Translation: CAJ35061.2
AM114171 Genomic DNA Translation: CAJ35062.2
AM114172 Genomic DNA Translation: CAJ35063.2
AM114173 Genomic DNA Translation: CAJ35064.2
AM114174 Genomic DNA Translation: CAJ35065.2
AM114175 Genomic DNA Translation: CAJ35066.2
AM114176 Genomic DNA Translation: CAJ35067.2
AM114177 Genomic DNA Translation: CAJ35068.2
AM114178 Genomic DNA Translation: CAJ35069.2
AM114179 Genomic DNA Translation: CAJ35070.2
AM114180 Genomic DNA Translation: CAJ35071.2
AM114181 Genomic DNA Translation: CAJ35072.2
AM114182 Genomic DNA Translation: CAJ35073.2
AM114183 Genomic DNA Translation: CAJ35074.2
AM114184 Genomic DNA Translation: CAJ35075.1
AM114184 Genomic DNA Translation: CAJ38354.1
AM114185 Genomic DNA Translation: CAJ35076.2
AM114186 Genomic DNA Translation: CAJ35077.2
AM114187 Genomic DNA Translation: CAJ35078.2
AM114188 Genomic DNA Translation: CAJ35079.1
AM114188 Genomic DNA Translation: CAJ38358.1
AM114189 Genomic DNA Translation: CAJ35080.2
AM114190 Genomic DNA Translation: CAJ35081.2
AM114191 Genomic DNA Translation: CAJ35082.2
PIRiS06785
S33562 S29961
S33563 S29963
S33564 S29964
RefSeqiNP_001014491.1, NM_001014491.2
NP_476700.1, NM_057352.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi61223, 44 interactors
DIPiDIP-18088N
IntActiP14199, 4 interactors
MINTiP14199
STRINGi7227.FBpp0080794

PTM databases

iPTMnetiP14199

Proteomic databases

PaxDbiP14199
PRIDEiP14199

Genome annotation databases

EnsemblMetazoaiFBtr0081253; FBpp0080794; FBgn0003231
FBtr0100289; FBpp0099683; FBgn0003231
GeneIDi35246
KEGGidme:Dmel_CG10360
UCSCiCG10360-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35246
FlyBaseiFBgn0003231 ref(2)P

Phylogenomic databases

eggNOGiENOG410IQZA Eukaryota
ENOG410XWHN LUCA
GeneTreeiENSGT00390000002781
HOGENOMiCLU_030132_0_0_1
InParanoidiP14199
OMAiQNDYEIF
OrthoDBi1275680at2759
PhylomeDBiP14199

Enzyme and pathway databases

ReactomeiR-DME-5205685 Pink/Parkin Mediated Mitophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ref(2)P fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35246

Protein Ontology

More...
PROi
PR:P14199

Gene expression databases

BgeeiFBgn0003231 Expressed in adult organism and 24 other tissues
GenevisibleiP14199 DM

Family and domain databases

CDDicd14320 UBA_SQSTM, 1 hit
InterProiView protein in InterPro
IPR000270 PB1_dom
IPR033741 SQSTM_UBA
IPR015940 UBA
IPR009060 UBA-like_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF16577 UBA_5, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50030 UBA, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREF2P_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14199
Secondary accession number(s): A6PX28
, A6PX29, A6PX30, A6PX31, A6PX32, A6PX33, A6PX35, A6PX37, A6PX38, A6PX44, A6PX45, A6PX46, A6PX51, A6PX56, A6PX61, A6PX72, A6PX73, A6PX89, A6PX90, A6PXA2, A6PXA4, A6PXB0, A6PXB1, Q04576, Q04577, Q04578, Q24063, Q24064, Q24065, Q24066, Q24067, Q24068, Q24069, Q24070, Q24071, Q24072, Q541D1, Q9VIU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2002
Last modified: February 26, 2020
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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