UniProtKB - P14194 (CTC_BACSU)
Protein
General stress protein CTC
Gene
ctc
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Not required for exponential growth; probably functions in vegetatively growing cells, maybe required for accurate translation under stress conditions.
GO - Molecular functioni
- 5S rRNA binding Source: GO_Central
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | BSUB:BSU00520-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: General stress protein CTCAlternative name(s): 50S ribosomal protein L25 |
Gene namesi | Name:ctc Ordered Locus Names:BSU00520 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Cells sporulate poorly at 48 degrees Celsius.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000181512 | 2 – 204 | General stress protein CTCAdd BLAST | 203 |
Proteomic databases
jPOSTi | P14194 |
PaxDbi | P14194 |
PRIDEi | P14194 |
Expressioni
Developmental stagei
Expressed at the end of exponential growth under conditions in which the enzymes of the TCA cycle are repressed.
Inductioni
By heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation.
Interactioni
Subunit structurei
Part of the ribosome (presumably the 50S subunit) under heat-stress but not control growth conditions. Binds 5S rRNA.
Protein-protein interaction databases
STRINGi | 224308.BSU00520 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1825, Bacteria |
InParanoidi | P14194 |
OMAi | GDSIHIS |
PhylomeDBi | P14194 |
Family and domain databases
CDDi | cd00495, Ribosomal_L25_TL5_CTC, 1 hit |
Gene3Di | 2.170.120.20, 1 hit 2.40.240.10, 1 hit |
HAMAPi | MF_01334, Ribosomal_L25_CTC, 1 hit |
InterProi | View protein in InterPro IPR020056, Rbsml_L25/Gln-tRNA_synth_N IPR029751, Ribosomal_L25 IPR011035, Ribosomal_L25/Gln-tRNA_synth IPR020057, Ribosomal_L25_b-dom IPR037121, Ribosomal_L25_C IPR001021, Ribosomal_L25_long |
Pfami | View protein in Pfam PF01386, Ribosomal_L25p, 1 hit PF14693, Ribosomal_TL5_C, 1 hit |
SUPFAMi | SSF50715, SSF50715, 1 hit |
TIGRFAMsi | TIGR00731, bL25_bact_ctc, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P14194-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLTAKERT DFTRSSLRNI RTSGHVPGII YGKDTGNKPV SLDSVELIKT
60 70 80 90 100
LRDEGKNAVI TLEVSGEKHS VMVTDLQTDP LKNEITHADF QVVNMSEDIE
110 120 130 140 150
VEVPIHLTGE AIGVKNGGVL QQPLYALTVK AKPKAIPQTI EADISSLDVN
160 170 180 190 200
EVLTIADLPA GGDYSFNHES DEVVASILPP QQQEAAEVDE EESADAQPEG
ENEQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 2 | A → R in strain: IS58. | 1 | |
Natural varianti | 10 | T → Q in strain: IS58. | 1 | |
Natural varianti | 13 | T → I in strain: IS58. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26185 Genomic DNA Translation: BAA05287.1 AL009126 Genomic DNA Translation: CAB11828.1 X16518 Genomic DNA Translation: CAA34524.1 |
PIRi | S66082 |
RefSeqi | NP_387933.1, NC_000964.3 WP_003243443.1, NZ_JNCM01000028.1 |
Genome annotation databases
EnsemblBacteriai | CAB11828; CAB11828; BSU00520 |
GeneIDi | 936984 |
KEGGi | bsu:BSU00520 |
PATRICi | fig|224308.179.peg.52 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26185 Genomic DNA Translation: BAA05287.1 AL009126 Genomic DNA Translation: CAB11828.1 X16518 Genomic DNA Translation: CAA34524.1 |
PIRi | S66082 |
RefSeqi | NP_387933.1, NC_000964.3 WP_003243443.1, NZ_JNCM01000028.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 224308.BSU00520 |
Proteomic databases
jPOSTi | P14194 |
PaxDbi | P14194 |
PRIDEi | P14194 |
Genome annotation databases
EnsemblBacteriai | CAB11828; CAB11828; BSU00520 |
GeneIDi | 936984 |
KEGGi | bsu:BSU00520 |
PATRICi | fig|224308.179.peg.52 |
Phylogenomic databases
eggNOGi | COG1825, Bacteria |
InParanoidi | P14194 |
OMAi | GDSIHIS |
PhylomeDBi | P14194 |
Enzyme and pathway databases
BioCyci | BSUB:BSU00520-MONOMER |
Family and domain databases
CDDi | cd00495, Ribosomal_L25_TL5_CTC, 1 hit |
Gene3Di | 2.170.120.20, 1 hit 2.40.240.10, 1 hit |
HAMAPi | MF_01334, Ribosomal_L25_CTC, 1 hit |
InterProi | View protein in InterPro IPR020056, Rbsml_L25/Gln-tRNA_synth_N IPR029751, Ribosomal_L25 IPR011035, Ribosomal_L25/Gln-tRNA_synth IPR020057, Ribosomal_L25_b-dom IPR037121, Ribosomal_L25_C IPR001021, Ribosomal_L25_long |
Pfami | View protein in Pfam PF01386, Ribosomal_L25p, 1 hit PF14693, Ribosomal_TL5_C, 1 hit |
SUPFAMi | SSF50715, SSF50715, 1 hit |
TIGRFAMsi | TIGR00731, bL25_bact_ctc, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTC_BACSU | |
Accessioni | P14194Primary (citable) accession number: P14194 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families