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Protein

Macrophage migration inhibitory factor

Gene

MIF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.3 Publications

Miscellaneous

Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=249 µM for phenylpyruvate1 Publication
  2. KM=168 µM for p-hydroxyphenylpyruvate1 Publication
  1. Vmax=2113 µmol/min/mg enzyme toward phenylpyruvate1 Publication
  2. Vmax=524 µmol/min/mg enzyme toward p-hydroxyphenylpyruvate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2Proton acceptor; via imino nitrogen1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33Substrate1
Binding sitei65Substrate; via amide nitrogen1
Binding sitei98Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Isomerase
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.3.2.1 2681
5.3.3.12 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P14174

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Macrophage migration inhibitory factor (EC:5.3.2.1)
Short name:
MIF
Alternative name(s):
Glycosylation-inhibiting factor
Short name:
GIF
L-dopachrome isomerase
L-dopachrome tautomerase (EC:5.3.3.12)
Phenylpyruvate tautomerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIF
Synonyms:GLIF, MMIF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000240972.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7097 MIF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153620 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14174

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Rheumatoid arthritis systemic juvenile (RASJ)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.Curated
Disease descriptionAn inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
See also OMIM:604302

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi111N → C: Causes formation of interchain disulfide bonds with Cys-81 from another subunit. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4282

MalaCards human disease database

More...
MalaCardsi
MIF
MIMi604302 phenotype

Open Targets

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OpenTargetsi
ENSG00000240972

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
85414 Systemic-onset juvenile idiopathic arthritis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30819

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2085

Drug and drug target database

More...
DrugBanki
DB07718 3-(4-HYDROXY-PHENYL)PYRUVIC ACID
DB08334 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
DB08333 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
DB02728 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester
DB04272 Citric Acid

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1170955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001580622 – 115Macrophage migration inhibitory factorAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78N6-acetyllysine; alternateCombined sources1
Modified residuei78N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P14174

MaxQB - The MaxQuant DataBase

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MaxQBi
P14174

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14174

PeptideAtlas

More...
PeptideAtlasi
P14174

PRoteomics IDEntifications database

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PRIDEi
P14174

ProteomicsDB human proteome resource

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ProteomicsDBi
53030

Consortium for Top Down Proteomics

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TopDownProteomicsi
P14174

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P14174

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P14174

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P14174

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P14174

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000240972 Expressed in 89 organ(s), highest expression level in left adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_MIF

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P14174 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P14174 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005284
HPA003868

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110428, 62 interactors

Database of interacting proteins

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DIPi
DIP-31137N

Protein interaction database and analysis system

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IntActi
P14174, 23 interactors

Molecular INTeraction database

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MINTi
P14174

STRING: functional protein association networks

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STRINGi
9606.ENSP00000215754

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P14174

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P14174

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P14174

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P14174

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1759 Eukaryota
ENOG41122MF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155608

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112325

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003240

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14174

KEGG Orthology (KO)

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KOi
K07253

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDRIYIN

Database of Orthologous Groups

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OrthoDBi
EOG091G0ZNJ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14174

TreeFam database of animal gene trees

More...
TreeFami
TF313853

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.429.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11954 PTHR11954, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01187 MIF, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55331 SSF55331, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01158 MIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P14174-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF
60 70 80 90 100
GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY
110
DMNAANVGWN NSTFA
Length:115
Mass (Da):12,476
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56D51107C05286B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57 – 59CAL → WAF in ABQ95571 (Ref. 6) Curated3
Sequence conflicti67K → R in CAG46452 (Ref. 9) Curated1
Sequence conflicti79L → Q in CAG46452 (Ref. 9) Curated1
Sequence conflicti81C → F in ABQ95571 (Ref. 6) Curated1
Sequence conflicti106N → S in AAA36315 (PubMed:2552447).Curated1
Sequence conflicti113T → P in ABQ95571 (Ref. 6) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M25639 mRNA Translation: AAA36315.1
L10612 mRNA Translation: AAA35892.1
Z23063 mRNA Translation: CAA80598.1
L19686 Genomic DNA Translation: AAA21814.1
AF469046 mRNA Translation: AAL78635.1
EF611126 mRNA Translation: ABQ95571.1
CR456520 mRNA Translation: CAG30406.1
AK311929 mRNA Translation: BAG34870.1
CR407644 mRNA Translation: CAG28572.1
CR541651 mRNA Translation: CAG46452.1
BT007148 mRNA Translation: AAP35812.1
DQ307455 Genomic DNA Translation: ABB96245.1
CH471095 Genomic DNA Translation: EAW59620.1
BC000447 mRNA Translation: AAH00447.1
BC007676 mRNA Translation: AAH07676.1
BC008914 mRNA Translation: AAH08914.1
BC013976 mRNA Translation: AAH13976.1
BC022414 mRNA Translation: AAH22414.1
BC053376 mRNA Translation: AAH53376.1
M95775 mRNA Translation: AAA36179.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13819.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A48793

NCBI Reference Sequences

More...
RefSeqi
NP_002406.1, NM_002415.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.407995

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215754; ENSP00000215754; ENSG00000240972
ENST00000613839; ENSP00000482779; ENSG00000276701

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4282

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4282

UCSC genome browser

More...
UCSCi
uc002zyr.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25639 mRNA Translation: AAA36315.1
L10612 mRNA Translation: AAA35892.1
Z23063 mRNA Translation: CAA80598.1
L19686 Genomic DNA Translation: AAA21814.1
AF469046 mRNA Translation: AAL78635.1
EF611126 mRNA Translation: ABQ95571.1
CR456520 mRNA Translation: CAG30406.1
AK311929 mRNA Translation: BAG34870.1
CR407644 mRNA Translation: CAG28572.1
CR541651 mRNA Translation: CAG46452.1
BT007148 mRNA Translation: AAP35812.1
DQ307455 Genomic DNA Translation: ABB96245.1
CH471095 Genomic DNA Translation: EAW59620.1
BC000447 mRNA Translation: AAH00447.1
BC007676 mRNA Translation: AAH07676.1
BC008914 mRNA Translation: AAH08914.1
BC013976 mRNA Translation: AAH13976.1
BC022414 mRNA Translation: AAH22414.1
BC053376 mRNA Translation: AAH53376.1
M95775 mRNA Translation: AAA36179.1
CCDSiCCDS13819.1
PIRiA48793
RefSeqiNP_002406.1, NM_002415.1
UniGeneiHs.407995

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CA7X-ray2.50A/B/C2-115[»]
1CGQX-ray2.00A/B/C2-115[»]
1GCZX-ray1.90A/B/C2-115[»]
1GD0X-ray1.50A/B/C2-115[»]
1GIFX-ray1.90A/B/C1-115[»]
1LJTX-ray2.00A/B/C2-115[»]
1MIFX-ray2.60A/B/C1-115[»]
1P1GX-ray2.50A/B/C2-115[»]
2OOHX-ray1.85A/B/C2-115[»]
2OOWX-ray1.75A/B/C2-115[»]
2OOZX-ray1.80A/B/C2-115[»]
3B9SX-ray1.80A/B/C2-115[»]
3CE4X-ray1.55A/B/C2-115[»]
3DJHX-ray1.25A/B/C2-115[»]
3DJIX-ray1.95A/B/C/D/E/F2-115[»]
3HOFX-ray1.90A/B/C1-115[»]
3IJGX-ray1.70A/B/C2-115[»]
3IJJX-ray1.25A/B/C2-115[»]
3JSFX-ray1.93A/B/C2-115[»]
3JSGX-ray1.58A/B/C2-115[»]
3JTUX-ray1.86A/B/C2-115[»]
3L5PX-ray1.80A/B/C2-115[»]
3L5RX-ray1.94A/B/C2-115[»]
3L5SX-ray1.86A/B/C2-115[»]
3L5TX-ray1.86A/B/C2-115[»]
3L5UX-ray1.90A/B/C2-115[»]
3L5VX-ray1.70A/B/C2-115[»]
3SMBX-ray1.60A/B/C2-115[»]
3SMCX-ray1.80A/B/C2-115[»]
3U18X-ray1.90A/B/C2-115[»]
3WNRX-ray2.01A/B/C2-115[»]
3WNSX-ray1.66A/B/C2-115[»]
3WNTX-ray2.07A/B/C2-115[»]
4ETGX-ray1.61A/B/C2-115[»]
4EUIX-ray1.70A/B/C2-115[»]
4EVGX-ray1.70A/B/C2-115[»]
4F2KX-ray1.53A/B/C2-115[»]
4GRNX-ray1.25A/B/C2-115[»]
4GROX-ray2.00A/B/C/D/E/F/G/H2-115[»]
4GRPX-ray1.27A/B/C2-115[»]
4GRQX-ray1.65A/B/C2-115[»]
4GRRX-ray1.47A/B/C3-115[»]
4GRUX-ray1.92A/B/C2-115[»]
4GUMX-ray2.33A/B/C/D/E/F/G/H/I2-115[»]
4K9GX-ray1.55A/B/C2-115[»]
4OSFX-ray1.62A/B/C2-115[»]
4OYQX-ray1.70A/B/C2-115[»]
4P01X-ray2.07A/B/C2-115[»]
4P0HX-ray1.93A/B/C2-115[»]
4PKKX-ray1.78A/B/C2-115[»]
4PKZX-ray1.90A/B/C2-115[»]
4PLUX-ray1.63A/B/C2-115[»]
4TRFX-ray1.63A/B/C2-115[»]
4TRUX-ray1.81A/B/C2-115[»]
4WR8X-ray2.60A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-115[»]
4WRBX-ray1.81A/B/C2-115[»]
4XX7X-ray1.77A/B/C2-115[»]
4XX8X-ray1.77A/B/C3-115[»]
4Z15X-ray1.60A/B/C3-115[»]
4Z1TX-ray1.50A/B/C3-115[»]
4Z1UX-ray2.05A/B/C/D/E/F3-115[»]
5B4OX-ray1.37A/B/C2-115[»]
5BS9X-ray1.98A/B/C2-115[»]
5BSCX-ray1.89A/B/C2-115[»]
5BSIX-ray2.00A/B/C/D/E/F/G/J2-115[»]
5BSJX-ray2.00A/B/C2-115[»]
5EIZX-ray1.96A/B/C2-115[»]
5HVSX-ray1.75A/B/C2-115[»]
5HVTX-ray1.75A/B/C2-115[»]
5HVVX-ray1.90A/B/C3-115[»]
5J7PX-ray1.85A/B/C2-115[»]
5J7QX-ray2.05A/B/C2-115[»]
5UMJX-ray1.61A/B/C2-115[»]
5UMKX-ray1.73A/B/C2-115[»]
5UZYX-ray1.71A/B/C2-115[»]
5V70X-ray1.94A/B/C2-115[»]
5V73X-ray1.68A/B/C2-115[»]
5XEJX-ray2.50A/B/C2-115[»]
6B1CX-ray2.16A/B/C2-115[»]
6B1KX-ray1.17A/B/C2-115[»]
6B2CX-ray2.00A/B/C2-115[»]
6BG6X-ray1.52A/B/C2-115[»]
6BG7X-ray2.54A/B/C2-115[»]
6CB5X-ray1.78A/B/C2-115[»]
6CBFX-ray2.30A/B/C2-115[»]
6CBGX-ray2.00A/B/C2-115[»]
6CBHX-ray2.00A/B/C2-115[»]
6FVEX-ray1.41A/B/C2-115[»]
6FVHX-ray1.40A/B/C2-115[»]
ProteinModelPortaliP14174
SMRiP14174
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110428, 62 interactors
DIPiDIP-31137N
IntActiP14174, 23 interactors
MINTiP14174
STRINGi9606.ENSP00000215754

Chemistry databases

BindingDBiP14174
ChEMBLiCHEMBL2085
DrugBankiDB07718 3-(4-HYDROXY-PHENYL)PYRUVIC ACID
DB08334 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
DB08333 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
DB02728 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester
DB04272 Citric Acid

PTM databases

iPTMnetiP14174
PhosphoSitePlusiP14174
SwissPalmiP14174

Polymorphism and mutation databases

DMDMi1170955

2D gel databases

SWISS-2DPAGEiP14174

Proteomic databases

EPDiP14174
MaxQBiP14174
PaxDbiP14174
PeptideAtlasiP14174
PRIDEiP14174
ProteomicsDBi53030
TopDownProteomicsiP14174

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4282
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215754; ENSP00000215754; ENSG00000240972
ENST00000613839; ENSP00000482779; ENSG00000276701
GeneIDi4282
KEGGihsa:4282
UCSCiuc002zyr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4282
DisGeNETi4282
EuPathDBiHostDB:ENSG00000240972.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MIF

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0041297
HGNCiHGNC:7097 MIF
HPAiCAB005284
HPA003868
MalaCardsiMIF
MIMi153620 gene
604302 phenotype
neXtProtiNX_P14174
OpenTargetsiENSG00000240972
Orphaneti85414 Systemic-onset juvenile idiopathic arthritis
PharmGKBiPA30819

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1759 Eukaryota
ENOG41122MF LUCA
GeneTreeiENSGT00940000155608
HOGENOMiHOG000112325
HOVERGENiHBG003240
InParanoidiP14174
KOiK07253
OMAiPDRIYIN
OrthoDBiEOG091G0ZNJ
PhylomeDBiP14174
TreeFamiTF313853

Enzyme and pathway databases

BRENDAi5.3.2.1 2681
5.3.3.12 2681
ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP14174

Miscellaneous databases

EvolutionaryTraceiP14174

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Macrophage_migration_inhibitory_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4282

Protein Ontology

More...
PROi
PR:P14174

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000240972 Expressed in 89 organ(s), highest expression level in left adrenal gland
CleanExiHS_MIF
ExpressionAtlasiP14174 baseline and differential
GenevisibleiP14174 HS

Family and domain databases

Gene3Di3.30.429.10, 1 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14174
Secondary accession number(s): A5Z1R8
, B2R4S3, Q2V4Y5, Q6FHV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 218 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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