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Protein

Osmotin

Gene

AP24

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Inhibits the germination and growth of the fungus Phytophthora infestans.

GO - Biological processi

Keywordsi

Molecular functionPathogenesis-related protein
Biological processPlant defense, Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Osmotin
Gene namesi
Name:AP24
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

Pathology & Biotechi

Protein family/group databases

Allergomei9618 Nic t Osmotin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003404322 – 246OsmotinAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 225
Disulfide bondi72 ↔ 82
Disulfide bondi87 ↔ 93
Disulfide bondi141 ↔ 213
Disulfide bondi146 ↔ 196
Disulfide bondi154 ↔ 164
Disulfide bondi168 ↔ 177
Disulfide bondi178 ↔ 183

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP14170

Expressioni

Tissue specificityi

Highly expressed in roots and flower buds.1 Publication

Inductioni

By salt stress, abscisic acid (ABA), viral infection and wounding.1 Publication

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Beta strandi30 – 32Combined sources3
Beta strandi34 – 39Combined sources6
Turni40 – 42Combined sources3
Beta strandi43 – 47Combined sources5
Beta strandi52 – 56Combined sources5
Beta strandi63 – 74Combined sources12
Beta strandi78 – 85Combined sources8
Beta strandi88 – 92Combined sources5
Beta strandi103 – 108Combined sources6
Turni110 – 112Combined sources3
Beta strandi113 – 120Combined sources8
Beta strandi125 – 127Combined sources3
Beta strandi129 – 135Combined sources7
Beta strandi144 – 146Combined sources3
Helixi150 – 153Combined sources4
Turni156 – 158Combined sources3
Helixi167 – 171Combined sources5
Helixi174 – 177Combined sources4
Helixi187 – 195Combined sources9
Helixi206 – 209Combined sources4
Beta strandi211 – 214Combined sources4
Beta strandi220 – 224Combined sources5

3D structure databases

ProteinModelPortaliP14170
SMRiP14170
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14170

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10, 1 hit
InterProiView protein in InterPro
IPR037176 Osmotin/thaumatin-like_sf
IPR001938 Thaumatin
IPR017949 Thaumatin_CS
PANTHERiPTHR31048 PTHR31048, 1 hit
PfamiView protein in Pfam
PF00314 Thaumatin, 1 hit
PIRSFiPIRSF002703 Thaumatin, 1 hit
PRINTSiPR00347 THAUMATIN
SMARTiView protein in SMART
SM00205 THN, 1 hit
SUPFAMiSSF49870 SSF49870, 1 hit
PROSITEiView protein in PROSITE
PS00316 THAUMATIN_1, 1 hit
PS51367 THAUMATIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNLRSSFVF FLLALVTYTY AATIEVRNNC PYTVWAASTP IGGGRRLDRG
60 70 80 90 100
QTWVINAPRG TKMARVWGRT NCNFNAAGRG TCQTGDCGGV LQCTGWGKPP
110 120 130 140 150
NTLAEYALDQ FSGLDFWDIS LVDGFNIPMT FAPTNPSGGK CHAIHCTANI
160 170 180 190 200
NGECPRELRV PGGCNNPCTT FGGQQYCCTQ GPCGPTFFSK FFKQRCPDAY
210 220 230 240
SYPQDDPTST FTCPGGSTNY RVIFCPNGQA HPNFPLEMPG SDEVAK
Length:246
Mass (Da):26,681
Last modified:October 1, 1996 - v2
Checksum:i3CDBA991ACA2B0B1
GO

Sequence cautioni

The sequence CAA46623 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3GN → EY in CAA64620 (Ref. 5) Curated2
Sequence conflicti15L → F in CAA64620 (Ref. 5) Curated1
Sequence conflicti18Y → C in CAA64620 (Ref. 5) Curated1
Sequence conflicti62K → N in CAA43854 (PubMed:1536937).Curated1
Sequence conflicti66V → I in CAA64620 (Ref. 5) Curated1
Sequence conflicti122V → L in AAA34089 (PubMed:16666857).Curated1
Sequence conflicti129M → I in AAA34089 (PubMed:16666857).Curated1
Sequence conflicti132Missing in AAA34089 (PubMed:16666857).Curated1
Sequence conflicti144 – 145IH → L in AAA34089 (PubMed:16666857).Curated2
Sequence conflicti149Missing in AAA34089 (PubMed:16666857).Curated1
Sequence conflicti151 – 155NGECP → RRMS in CAA43854 (PubMed:1536937).Curated5
Sequence conflicti156R → A in AAA34089 (PubMed:16666857).Curated1
Sequence conflicti181G → R in AAA34089 (PubMed:16666857).Curated1
Sequence conflicti221R → K in CAA64620 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65700 mRNA Translation: CAA46622.1
X65701 Genomic DNA Translation: CAA46623.1 Different initiation.
S40046 Genomic DNA Translation: AAB22459.2
M29279 mRNA Translation: AAA34089.1
X61679 mRNA Translation: CAA43854.1
X95308 Genomic DNA Translation: CAA64620.1
S44889 mRNA Translation: AAB23375.1
PIRiS30157
S34794
RefSeqiNP_001312374.1, NM_001325445.1
XP_016464912.1, XM_016609426.1
UniGeneiNta.2852
Nta.5214

Genome annotation databases

GeneIDi107787819
KEGGinta:107787819

Similar proteinsi

Entry informationi

Entry nameiOSMO_TOBAC
AccessioniPrimary (citable) accession number: P14170
Secondary accession number(s): Q40529, Q6LDD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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