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UniProtKB - P14151 (LYAM1_HUMAN)

Protein

L-selectin

Gene

SELL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).1 Publication2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi118CalciumCombined sources2 Publications1
Metal bindingi120CalciumCombined sources2 Publications1
Metal bindingi126CalciumCombined sources2 Publications1
Metal bindingi143CalciumCombined sources2 Publications1
Metal bindingi144CalciumCombined sources2 Publications1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • carbohydrate binding Source: ProtInc
  • cell adhesion molecule binding Source: Ensembl
  • glycosphingolipid binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • oligosaccharide binding Source: UniProtKB
  • protease binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell adhesion
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

UniLectiniP14151

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name:
LAM-11 Publication
Leukocyte surface antigen Leu-8
Leukocyte-endothelial cell adhesion molecule 1
Short name:
LECAM1
Lymph node homing receptor1 Publication
TQ12 Publications
gp90-MEL
CD_antigen: CD62L
Gene namesi
Name:SELL
Synonyms:LNHR, LYAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188404.8
HGNCiHGNC:10720 SELL
MIMi153240 gene
neXtProtiNX_P14151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 332ExtracellularSequence analysisAdd BLAST294
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Topological domaini356 – 372CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi60N → Q: Loss of one glycosylation site. 1 Publication1
Mutagenesisi104N → Q: Loss of one glycosylation site. 1 Publication1
Mutagenesisi126E → D: Impairs interaction with cognate oligosaccharide. Abolishes cell rolling on glycan ligands. 1 Publication1
Mutagenesisi177N → Q: Loss of one glycosylation site. 1 Publication1

Organism-specific databases

DisGeNETi6402
OpenTargetsiENSG00000188404
Orphaneti34145 Berger disease
PharmGKBiPA35642

Chemistry databases

ChEMBLiCHEMBL3161

Polymorphism and mutation databases

BioMutaiSELL
DMDMi126178

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
PropeptideiPRO_000001747529 – 3810
ChainiPRO_000001747639 – 372L-selectinAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 155Combined sources2 Publications
Glycosylationi60N-linked (GlcNAc...) asparagineCombined sources1 Publication3 Publications1
Glycosylationi104N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Disulfide bondi128 ↔ 147Combined sources2 Publications
Disulfide bondi160 ↔ 171Combined sources2 Publications
Disulfide bondi165 ↔ 180Combined sources2 Publications
Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi182 ↔ 191Combined sources2 Publications
Disulfide bondi197 ↔ 241By similarity
Disulfide bondi227 ↔ 254By similarity
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 303By similarity
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi289 ↔ 316By similarity

Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP14151
PaxDbiP14151
PeptideAtlasiP14151
PRIDEiP14151
ProteomicsDBi53028
53029 [P14151-2]

PTM databases

GlyConnecti346
iPTMnetiP14151
PhosphoSitePlusiP14151
UniCarbKBiP14151

Miscellaneous databases

PMAP-CutDBiP14151

Expressioni

Tissue specificityi

Expressed in B-cell lines and T-lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000188404 Expressed in 164 organ(s), highest expression level in blood
CleanExiHS_SELL
ExpressionAtlasiP14151 baseline and differential
GenevisibleiP14151 HS

Organism-specific databases

HPAiCAB002144
HPA051972

Interactioni

Subunit structurei

Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112302, 13 interactors
IntActiP14151, 1 interactor
STRINGi9606.ENSP00000236147

Chemistry databases

BindingDBiP14151

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14151
SMRiP14151
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14151

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 155C-type lectinPROSITE-ProRule annotationAdd BLAST101
Domaini156 – 192EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini195 – 256Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini257 – 318Sushi 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3T Eukaryota
ENOG410YB82 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375
InParanoidiP14151
KOiK06495
OMAiEAENWGD
OrthoDBiEOG091G09HU
PhylomeDBiP14151
TreeFamiTF326910

Family and domain databases

CDDicd00033 CCP, 2 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR016348 L-selectin
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 2 hits
PIRSFiPIRSF002421 L-selectin, 1 hit
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket
Note: The start of isoform 1 corresponds to the N-terminus of mammalian orthologs. The start codon for isoform 2 is in the same exon and reading frame as that for isoform 1, suggesting alternative initiation.Curated
Isoform 1 (identifier: P14151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW 
        60         70         80         90        100
QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW 
       110        120        130        140        150
VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL 
       160        170        180        190        200
KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL 
       210        220        230        240        250
EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP 
       260        270        280        290        300
EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK 
       310        320        330        340        350
TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF 
       360        370 
IIWLARRLKK GKKSKRSMND PY
Length:372
Mass (Da):42,187
Last modified:February 1, 1991 - v2
Checksum:i6EA9918ECA2D3643
GO
Isoform 2 (identifier: P14151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGCRRTREGPSKAM

Show »
Length:385
Mass (Da):43,618
Checksum:i1205F691BA638EF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37D → Y in CAA34203 (PubMed:2663882).Curated1
Sequence conflicti178Y → H in CAA34203 (PubMed:2663882).Curated1
Sequence conflicti214L → F in CAA34203 (PubMed:2663882).Curated1
Sequence conflicti218 – 220SFS → NFN in CAA34275 (PubMed:2473156).Curated3
Sequence conflicti242G → E in CAA34275 (PubMed:2473156).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019134193F → L3 PublicationsCorresponds to variant dbSNP:rs1131498Ensembl.1
Natural variantiVAR_019135201E → Q1 PublicationCorresponds to variant dbSNP:rs2229568Ensembl.1
Natural variantiVAR_019136213P → S2 PublicationsCorresponds to variant dbSNP:rs2229569Ensembl.1
Natural variantiVAR_019137369N → D1 PublicationCorresponds to variant dbSNP:rs4987382Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426501M → MGCRRTREGPSKAM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25280 mRNA Translation: AAC63053.1
X16150 mRNA Translation: CAA34275.1
X17519 mRNA Translation: CAB43536.1
X17519 mRNA Translation: CAB43537.1
X16070 mRNA Translation: CAA34203.1
M32414
, M32406, M32407, M32408, M32409, M32410, M32411, M32412, M32413 Genomic DNA Translation: AAB60700.1
AJ246000 mRNA Translation: CAB55488.1
AK312673 mRNA Translation: BAG35555.1
AY233976 Genomic DNA Translation: AAO48272.1
AL021940 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90856.1
CH471067 Genomic DNA Translation: EAW90858.1
CCDSiCCDS53427.1 [P14151-2]
RefSeqiNP_000646.2, NM_000655.4 [P14151-2]
UniGeneiHs.728756

Genome annotation databases

EnsembliENST00000236147; ENSP00000236147; ENSG00000188404 [P14151-2]
GeneIDi6402
KEGGihsa:6402
UCSCiuc001ggk.4 human [P14151-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

L-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25280 mRNA Translation: AAC63053.1
X16150 mRNA Translation: CAA34275.1
X17519 mRNA Translation: CAB43536.1
X17519 mRNA Translation: CAB43537.1
X16070 mRNA Translation: CAA34203.1
M32414
, M32406, M32407, M32408, M32409, M32410, M32411, M32412, M32413 Genomic DNA Translation: AAB60700.1
AJ246000 mRNA Translation: CAB55488.1
AK312673 mRNA Translation: BAG35555.1
AY233976 Genomic DNA Translation: AAO48272.1
AL021940 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90856.1
CH471067 Genomic DNA Translation: EAW90858.1
CCDSiCCDS53427.1 [P14151-2]
RefSeqiNP_000646.2, NM_000655.4 [P14151-2]
UniGeneiHs.728756

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJBmodel-A39-158[»]
2LGFNMR-B349-363[»]
3CFWX-ray2.20A39-194[»]
5VC1X-ray1.94A39-195[»]
ProteinModelPortaliP14151
SMRiP14151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112302, 13 interactors
IntActiP14151, 1 interactor
STRINGi9606.ENSP00000236147

Chemistry databases

BindingDBiP14151
ChEMBLiCHEMBL3161

Protein family/group databases

UniLectiniP14151

PTM databases

GlyConnecti346
iPTMnetiP14151
PhosphoSitePlusiP14151
UniCarbKBiP14151

Polymorphism and mutation databases

BioMutaiSELL
DMDMi126178

Proteomic databases

MaxQBiP14151
PaxDbiP14151
PeptideAtlasiP14151
PRIDEiP14151
ProteomicsDBi53028
53029 [P14151-2]

Protocols and materials databases

DNASUi6402
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236147; ENSP00000236147; ENSG00000188404 [P14151-2]
GeneIDi6402
KEGGihsa:6402
UCSCiuc001ggk.4 human [P14151-1]

Organism-specific databases

CTDi6402
DisGeNETi6402
EuPathDBiHostDB:ENSG00000188404.8
GeneCardsiSELL
HGNCiHGNC:10720 SELL
HPAiCAB002144
HPA051972
MIMi153240 gene
neXtProtiNX_P14151
OpenTargetsiENSG00000188404
Orphaneti34145 Berger disease
PharmGKBiPA35642
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS3T Eukaryota
ENOG410YB82 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375
InParanoidiP14151
KOiK06495
OMAiEAENWGD
OrthoDBiEOG091G09HU
PhylomeDBiP14151
TreeFamiTF326910

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiSELL human
EvolutionaryTraceiP14151
GeneWikiiL-selectin
GenomeRNAii6402
PMAP-CutDBiP14151
PROiPR:P14151
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188404 Expressed in 164 organ(s), highest expression level in blood
CleanExiHS_SELL
ExpressionAtlasiP14151 baseline and differential
GenevisibleiP14151 HS

Family and domain databases

CDDicd00033 CCP, 2 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR016348 L-selectin
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 2 hits
PIRSFiPIRSF002421 L-selectin, 1 hit
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM1_HUMAN
AccessioniPrimary (citable) accession number: P14151
Secondary accession number(s): A0A024R8Z0
, B2R6Q8, P15023, Q9UJ43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1991
Last modified: September 12, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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