UniProtKB - P14151 (LYAM1_HUMAN)
L-selectin
SELL
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 118 | CalciumCombined sources2 Publications | 1 | |
Metal bindingi | 120 | CalciumCombined sources2 Publications | 1 | |
Metal bindingi | 126 | CalciumCombined sources2 Publications | 1 | |
Metal bindingi | 143 | CalciumCombined sources2 Publications | 1 | |
Metal bindingi | 144 | CalciumCombined sources2 Publications | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- carbohydrate binding Source: ProtInc
- cell adhesion molecule binding Source: Ensembl
- glycosphingolipid binding Source: BHF-UCL
- heparin binding Source: BHF-UCL
- oligosaccharide binding Source: UniProtKB
- protease binding Source: BHF-UCL
GO - Biological processi
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- cell adhesion Source: ProtInc
- leukocyte migration Source: Reactome
- leukocyte tethering or rolling Source: UniProtKB
- neutrophil degranulation Source: Reactome
- regulation of immune response Source: Reactome
- response to ATP Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Lectin, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P14151 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-6798695, Neutrophil degranulation |
Protein family/group databases
UniLectini | P14151 |
Names & Taxonomyi
Protein namesi | Recommended name: L-selectinAlternative name(s): CD62 antigen-like family member L Leukocyte adhesion molecule 1 Short name: LAM-11 Publication Leukocyte surface antigen Leu-8 Leukocyte-endothelial cell adhesion molecule 1 Short name: LECAM1 Lymph node homing receptor1 Publication TQ12 Publications gp90-MEL CD_antigen: CD62L |
Gene namesi | Name:SELL Synonyms:LNHR, LYAM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188404.8 |
HGNCi | HGNC:10720, SELL |
MIMi | 153240, gene |
neXtProti | NX_P14151 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- secretory granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 39 – 332 | ExtracellularSequence analysisAdd BLAST | 294 | |
Transmembranei | 333 – 355 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 356 – 372 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 60 | N → Q: Loss of one glycosylation site. 1 Publication | 1 | |
Mutagenesisi | 104 | N → Q: Loss of one glycosylation site. 1 Publication | 1 | |
Mutagenesisi | 126 | E → D: Impairs interaction with cognate oligosaccharide. Abolishes cell rolling on glycan ligands. 1 Publication | 1 | |
Mutagenesisi | 177 | N → Q: Loss of one glycosylation site. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6402 |
OpenTargetsi | ENSG00000188404 |
PharmGKBi | PA35642 |
Miscellaneous databases
Pharosi | P14151, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3161 |
Polymorphism and mutation databases
BioMutai | SELL |
DMDMi | 126178 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Add BLAST | 28 | |
PropeptideiPRO_0000017475 | 29 – 38 | 10 | ||
ChainiPRO_0000017476 | 39 – 372 | L-selectinAdd BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 155 | Combined sources2 Publications | ||
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineCombined sources1 Publication3 Publications | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Disulfide bondi | 128 ↔ 147 | Combined sources2 Publications | ||
Disulfide bondi | 160 ↔ 171 | Combined sources2 Publications | ||
Disulfide bondi | 165 ↔ 180 | Combined sources2 Publications | ||
Glycosylationi | 177 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 182 ↔ 191 | Combined sources2 Publications | ||
Disulfide bondi | 197 ↔ 241 | By similarity | ||
Disulfide bondi | 227 ↔ 254 | By similarity | ||
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 246 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 259 ↔ 303 | By similarity | ||
Glycosylationi | 271 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 289 ↔ 316 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P14151 |
MassIVEi | P14151 |
MaxQBi | P14151 |
PaxDbi | P14151 |
PeptideAtlasi | P14151 |
PRIDEi | P14151 |
ProteomicsDBi | 53028 [P14151-1] 53029 [P14151-2] |
PTM databases
GlyConnecti | 346, 26 N-Linked glycans (1 site) |
GlyGeni | P14151, 6 sites |
iPTMneti | P14151 |
PhosphoSitePlusi | P14151 |
UniCarbKBi | P14151 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000188404, Expressed in blood and 182 other tissues |
ExpressionAtlasi | P14151, baseline and differential |
Genevisiblei | P14151, HS |
Organism-specific databases
HPAi | ENSG00000188404, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
3 PublicationsBinary interactionsi
Isoform 2 [P14151-2]
With | #Exp. | IntAct |
---|---|---|
SLC30A2 [Q9BRI3] | 3 | EBI-17865914,EBI-8644112 |
GO - Molecular functioni
- cell adhesion molecule binding Source: Ensembl
- protease binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112302, 14 interactors |
IntActi | P14151, 1 interactor |
STRINGi | 9606.ENSP00000236147 |
Chemistry databases
BindingDBi | P14151 |
Miscellaneous databases
RNActi | P14151, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P14151 |
SMRi | P14151 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14151 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 155 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 156 – 192 | EGF-likePROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 195 – 256 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 257 – 318 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 62 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000162076 |
HOGENOMi | CLU_065067_0_0_1 |
InParanoidi | P14151 |
OMAi | WVWTVLC |
OrthoDBi | 445079at2759 |
PhylomeDBi | P14151 |
TreeFami | TF326910 |
Family and domain databases
CDDi | cd00033, CCP, 2 hits cd03592, CLECT_selectins_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR016348, L-selectin IPR033991, Selectin_CTLD IPR002396, Selectin_superfamily IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit PF00084, Sushi, 2 hits |
PIRSFi | PIRSF002421, L-selectin, 1 hit |
PRINTSi | PR00343, SELECTIN |
SMARTi | View protein in SMART SM00032, CCP, 2 hits SM00034, CLECT, 1 hit SM00181, EGF, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50923, SUSHI, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW
60 70 80 90 100
QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW
110 120 130 140 150
VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL
160 170 180 190 200
KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL
210 220 230 240 250
EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP
260 270 280 290 300
EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK
310 320 330 340 350
TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
IIWLARRLKK GKKSKRSMND PY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494C0S7 | A0A494C0S7_HUMAN | L-selectin | SELL | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | D → Y in CAA34203 (PubMed:2663882).Curated | 1 | |
Sequence conflicti | 178 | Y → H in CAA34203 (PubMed:2663882).Curated | 1 | |
Sequence conflicti | 214 | L → F in CAA34203 (PubMed:2663882).Curated | 1 | |
Sequence conflicti | 218 – 220 | SFS → NFN in CAA34275 (PubMed:2473156).Curated | 3 | |
Sequence conflicti | 242 | G → E in CAA34275 (PubMed:2473156).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019134 | 193 | F → L3 PublicationsCorresponds to variant dbSNP:rs1131498Ensembl. | 1 | |
Natural variantiVAR_019135 | 201 | E → Q1 PublicationCorresponds to variant dbSNP:rs2229568EnsemblClinVar. | 1 | |
Natural variantiVAR_019136 | 213 | P → S2 PublicationsCorresponds to variant dbSNP:rs2229569Ensembl. | 1 | |
Natural variantiVAR_019137 | 369 | N → D1 PublicationCorresponds to variant dbSNP:rs4987382Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042650 | 1 | M → MGCRRTREGPSKAM in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25280 mRNA Translation: AAC63053.1 X16150 mRNA Translation: CAA34275.1 X17519 mRNA Translation: CAB43536.1 X17519 mRNA Translation: CAB43537.1 X16070 mRNA Translation: CAA34203.1 M32414 , M32406, M32407, M32408, M32409, M32410, M32411, M32412, M32413 Genomic DNA Translation: AAB60700.1 AJ246000 mRNA Translation: CAB55488.1 AK312673 mRNA Translation: BAG35555.1 AY233976 Genomic DNA Translation: AAO48272.1 AL021940 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90856.1 CH471067 Genomic DNA Translation: EAW90858.1 |
CCDSi | CCDS53427.1 [P14151-1] |
RefSeqi | NP_000646.2, NM_000655.4 [P14151-1] |
Genome annotation databases
Ensembli | ENST00000236147; ENSP00000236147; ENSG00000188404 [P14151-1] ENST00000650983; ENSP00000498227; ENSG00000188404 [P14151-2] |
GeneIDi | 6402 |
KEGGi | hsa:6402 |
UCSCi | uc001ggk.4, human [P14151-1] |
Keywords - Coding sequence diversityi
Alternative initiation, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Functional Glycomics Gateway - Glycan Binding L-selectin |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25280 mRNA Translation: AAC63053.1 X16150 mRNA Translation: CAA34275.1 X17519 mRNA Translation: CAB43536.1 X17519 mRNA Translation: CAB43537.1 X16070 mRNA Translation: CAA34203.1 M32414 , M32406, M32407, M32408, M32409, M32410, M32411, M32412, M32413 Genomic DNA Translation: AAB60700.1 AJ246000 mRNA Translation: CAB55488.1 AK312673 mRNA Translation: BAG35555.1 AY233976 Genomic DNA Translation: AAO48272.1 AL021940 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90856.1 CH471067 Genomic DNA Translation: EAW90858.1 |
CCDSi | CCDS53427.1 [P14151-1] |
RefSeqi | NP_000646.2, NM_000655.4 [P14151-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KJB | model | - | A | 39-158 | [»] | |
2LGF | NMR | - | B | 349-363 | [»] | |
3CFW | X-ray | 2.20 | A | 39-194 | [»] | |
5VC1 | X-ray | 1.94 | A | 39-195 | [»] | |
BMRBi | P14151 | |||||
SMRi | P14151 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112302, 14 interactors |
IntActi | P14151, 1 interactor |
STRINGi | 9606.ENSP00000236147 |
Chemistry databases
BindingDBi | P14151 |
ChEMBLi | CHEMBL3161 |
Protein family/group databases
UniLectini | P14151 |
PTM databases
GlyConnecti | 346, 26 N-Linked glycans (1 site) |
GlyGeni | P14151, 6 sites |
iPTMneti | P14151 |
PhosphoSitePlusi | P14151 |
UniCarbKBi | P14151 |
Polymorphism and mutation databases
BioMutai | SELL |
DMDMi | 126178 |
Proteomic databases
jPOSTi | P14151 |
MassIVEi | P14151 |
MaxQBi | P14151 |
PaxDbi | P14151 |
PeptideAtlasi | P14151 |
PRIDEi | P14151 |
ProteomicsDBi | 53028 [P14151-1] 53029 [P14151-2] |
Protocols and materials databases
ABCDi | P14151, 4 sequenced antibodies |
Antibodypediai | 3683, 1487 antibodies |
DNASUi | 6402 |
Genome annotation databases
Ensembli | ENST00000236147; ENSP00000236147; ENSG00000188404 [P14151-1] ENST00000650983; ENSP00000498227; ENSG00000188404 [P14151-2] |
GeneIDi | 6402 |
KEGGi | hsa:6402 |
UCSCi | uc001ggk.4, human [P14151-1] |
Organism-specific databases
CTDi | 6402 |
DisGeNETi | 6402 |
EuPathDBi | HostDB:ENSG00000188404.8 |
GeneCardsi | SELL |
HGNCi | HGNC:10720, SELL |
HPAi | ENSG00000188404, Group enriched (blood, lymphoid tissue) |
MIMi | 153240, gene |
neXtProti | NX_P14151 |
OpenTargetsi | ENSG00000188404 |
PharmGKBi | PA35642 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000162076 |
HOGENOMi | CLU_065067_0_0_1 |
InParanoidi | P14151 |
OMAi | WVWTVLC |
OrthoDBi | 445079at2759 |
PhylomeDBi | P14151 |
TreeFami | TF326910 |
Enzyme and pathway databases
PathwayCommonsi | P14151 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 6402, 4 hits in 842 CRISPR screens |
ChiTaRSi | SELL, human |
EvolutionaryTracei | P14151 |
GeneWikii | L-selectin |
GenomeRNAii | 6402 |
Pharosi | P14151, Tchem |
PROi | PR:P14151 |
RNActi | P14151, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188404, Expressed in blood and 182 other tissues |
ExpressionAtlasi | P14151, baseline and differential |
Genevisiblei | P14151, HS |
Family and domain databases
CDDi | cd00033, CCP, 2 hits cd03592, CLECT_selectins_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR016348, L-selectin IPR033991, Selectin_CTLD IPR002396, Selectin_superfamily IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit PF00084, Sushi, 2 hits |
PIRSFi | PIRSF002421, L-selectin, 1 hit |
PRINTSi | PR00343, SELECTIN |
SMARTi | View protein in SMART SM00032, CCP, 2 hits SM00034, CLECT, 1 hit SM00181, EGF, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50923, SUSHI, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYAM1_HUMAN | |
Accessioni | P14151Primary (citable) accession number: P14151 Secondary accession number(s): A0A024R8Z0 Q9UJ43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | February 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries