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Protein

60S ribosomal protein L7

Gene

Rpl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7
Gene namesi
Name:Rpl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98073 Rpl7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001046341 – 27060S ribosomal protein L7Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei149N6-succinyllysineCombined sources1
Modified residuei161PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP14148
PaxDbiP14148
PeptideAtlasiP14148
PRIDEiP14148
TopDownProteomicsiP14148

PTM databases

iPTMnetiP14148
PhosphoSitePlusiP14148
SwissPalmiP14148

Expressioni

Gene expression databases

BgeeiENSMUSG00000043716 Expressed in 47 organ(s), highest expression level in female gonad
CleanExiMM_RPL7
ExpressionAtlasiP14148 baseline and differential
GenevisibleiP14148 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Homodimer. Interacts with DHX33 (PubMed:26100019).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202988, 6 interactors
CORUMiP14148
IntActiP14148, 13 interactors
MINTiP14148
STRINGi10090.ENSMUSP00000071616

Structurei

3D structure databases

ProteinModelPortaliP14148
SMRiP14148
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 181Add BLAST12
Repeati19 – 292Add BLAST11
Repeati30 – 403Add BLAST11
Repeati41 – 524Add BLAST12
Repeati53 – 645Add BLAST12
Repeati65 – 766Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 766 X 12 AA tandem repeatsAdd BLAST70

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3184 Eukaryota
COG1841 LUCA
GeneTreeiENSGT00390000006213
HOGENOMiHOG000170917
HOVERGENiHBG003280
InParanoidiP14148
KOiK02937
OMAiPTGGWRT
PhylomeDBiP14148
TreeFamiTF300740

Family and domain databases

CDDicd01657 Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 1 hit
InterProiView protein in InterPro
IPR036919 L30_ferredoxin-like_sf
IPR023106 Ribosomal_L30_central_dom_arc
IPR018038 Ribosomal_L30_CS
IPR016082 Ribosomal_L30_ferredoxin-like
IPR012988 Ribosomal_L30_N
IPR039699 Ribosomal_L7/L30
IPR005998 Ribosomal_L7_euk
IPR035808 Ribosomal_L7_euk_arc
PANTHERiPTHR11524 PTHR11524, 1 hit
PfamiView protein in Pfam
PF00327 Ribosomal_L30, 1 hit
PF08079 Ribosomal_L30_N, 1 hit
SUPFAMiSSF55129 SSF55129, 1 hit
TIGRFAMsiTIGR01310 uL30_euk, 1 hit
PROSITEiView protein in PROSITE
PS00634 RIBOSOMAL_L30, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14148-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAVPEKKKK VATVPGTLKK KVPAGPKTLK KKVPAVPETL KKKRRNFAEL
60 70 80 90 100
KVKRLRKKFA LKTLRKARRK LIYEKAKHYH KEYRQMYRTE IRMARMARKA
110 120 130 140 150
GNFYVPAEPK LAFVIRIRGI NGVSPKVRKV LQLLRLRQIF NGTFVKLNKA
160 170 180 190 200
SINMLRIVEP YIAWGYPNLK SVNELIYKRG YGKINKKRIA LTDNSLIARS
210 220 230 240 250
LGKFGIICME DLIHEIYTVG KRFKEANNFL WPFKLSSPRG GMKKKTTHFV
260 270
EGGDAGNRED QINRLIRRMN
Length:270
Mass (Da):31,420
Last modified:February 1, 1996 - v2
Checksum:iD006EDFB8CF95EFD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6XI62F6XI62_MOUSE
60S ribosomal protein L7
Rpl7
279Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 29GPKTL → WAKNS in AAA40064 (Ref. 2) Curated5
Sequence conflicti40L → R in AAA40064 (Ref. 2) Curated1
Sequence conflicti64L → V in AAA40064 (Ref. 2) Curated1
Sequence conflicti84R → G in AAH51261 (PubMed:15489334).Curated1
Sequence conflicti268R → Q in AAA40069 (PubMed:2365680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29015 Genomic DNA Translation: AAA40069.1
M29016 mRNA Translation: AAA40070.1
M85235 mRNA Translation: AAA40064.1
BC025909 mRNA Translation: AAH25909.1
BC051261 mRNA Translation: AAH51261.1
X57960 mRNA Translation: CAA41028.1
X57961 mRNA Translation: CAA41029.1
CCDSiCCDS14829.1
PIRiA37055
RefSeqiNP_035421.2, NM_011291.5
UniGeneiMm.319659
Mm.379004
Mm.397450

Genome annotation databases

EnsembliENSMUST00000058437; ENSMUSP00000071616; ENSMUSG00000043716
GeneIDi19989
KEGGimmu:19989
UCSCiuc007ajl.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29015 Genomic DNA Translation: AAA40069.1
M29016 mRNA Translation: AAA40070.1
M85235 mRNA Translation: AAA40064.1
BC025909 mRNA Translation: AAH25909.1
BC051261 mRNA Translation: AAH51261.1
X57960 mRNA Translation: CAA41028.1
X57961 mRNA Translation: CAA41029.1
CCDSiCCDS14829.1
PIRiA37055
RefSeqiNP_035421.2, NM_011291.5
UniGeneiMm.319659
Mm.379004
Mm.397450

3D structure databases

ProteinModelPortaliP14148
SMRiP14148
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202988, 6 interactors
CORUMiP14148
IntActiP14148, 13 interactors
MINTiP14148
STRINGi10090.ENSMUSP00000071616

PTM databases

iPTMnetiP14148
PhosphoSitePlusiP14148
SwissPalmiP14148

Proteomic databases

EPDiP14148
PaxDbiP14148
PeptideAtlasiP14148
PRIDEiP14148
TopDownProteomicsiP14148

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058437; ENSMUSP00000071616; ENSMUSG00000043716
GeneIDi19989
KEGGimmu:19989
UCSCiuc007ajl.3 mouse

Organism-specific databases

CTDi6129
MGIiMGI:98073 Rpl7

Phylogenomic databases

eggNOGiKOG3184 Eukaryota
COG1841 LUCA
GeneTreeiENSGT00390000006213
HOGENOMiHOG000170917
HOVERGENiHBG003280
InParanoidiP14148
KOiK02937
OMAiPTGGWRT
PhylomeDBiP14148
TreeFamiTF300740

Miscellaneous databases

ChiTaRSiRpl7 mouse
PROiPR:P14148
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043716 Expressed in 47 organ(s), highest expression level in female gonad
CleanExiMM_RPL7
ExpressionAtlasiP14148 baseline and differential
GenevisibleiP14148 MM

Family and domain databases

CDDicd01657 Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 1 hit
InterProiView protein in InterPro
IPR036919 L30_ferredoxin-like_sf
IPR023106 Ribosomal_L30_central_dom_arc
IPR018038 Ribosomal_L30_CS
IPR016082 Ribosomal_L30_ferredoxin-like
IPR012988 Ribosomal_L30_N
IPR039699 Ribosomal_L7/L30
IPR005998 Ribosomal_L7_euk
IPR035808 Ribosomal_L7_euk_arc
PANTHERiPTHR11524 PTHR11524, 1 hit
PfamiView protein in Pfam
PF00327 Ribosomal_L30, 1 hit
PF08079 Ribosomal_L30_N, 1 hit
SUPFAMiSSF55129 SSF55129, 1 hit
TIGRFAMsiTIGR01310 uL30_euk, 1 hit
PROSITEiView protein in PROSITE
PS00634 RIBOSOMAL_L30, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL7_MOUSE
AccessioniPrimary (citable) accession number: P14148
Secondary accession number(s): Q80UR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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