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Protein

50S ribosomal protein L5

Gene

rpl5

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is 1 of 5 proteins that mediates the attachment of the 5S rRNA onto the large ribosomal subunit, stabilizing the orientation of adjacent RNA domains. Forms part of the central protuberance. Modeling places the A and P site tRNAs in close proximity to this protein; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. In the 70S ribosome it is thought to contact protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L5
Alternative name(s):
Hl13
Hmal5
Gene namesi
Name:rpl5
Ordered Locus Names:rrnAC1598
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001250512 – 17750S ribosomal protein L5Add BLAST176

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts with protein L18 and the 5S rRNA, and probably with tRNAs. Forms a bridge to the 30S subunit in the 70S ribosome (By similarity).By similarity

Protein-protein interaction databases

STRINGi272569.rrnAC1598

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14124
SMRiP14124
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14124

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04092 Archaea
COG0094 LUCA
HOGENOMiHOG000231312
KOiK02931
OMAiEQVMFHE
OrthoDBiPOG093Z0D78

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
HAMAPiMF_01333_A Ribosomal_L5_A, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR022804 Ribosomal_L5_arc
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14124-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESESGGD FHEMREPRIE KVVVHMGIGH GGRDLANAED ILGEITGQMP
60 70 80 90 100
VRTKAKRTVG EFDIREGDPI GAKVTLRDEM AEEFLQTALP LAELATSQFD
110 120 130 140 150
DTGNFSFGVE EHTEFPSQEY DPSIGIYGLD VTVNLVRPGY RVAKRDKASR
160 170
SIPTKHRLNP ADAVAFIEST YDVEVSE
Length:177
Mass (Da):19,528
Last modified:January 23, 2007 - v4
Checksum:i565902FAA3D95FB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134N → R AA sequence (PubMed:2198942).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58395 Genomic DNA Translation: CAA41284.1
AY596297 Genomic DNA Translation: AAV46516.1
PIRiS16535 R5HSL5
RefSeqiWP_004957391.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV46516; AAV46516; rrnAC1598
GeneIDi3128287
KEGGihma:rrnAC1598
PATRICifig|272569.17.peg.2288

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58395 Genomic DNA Translation: CAA41284.1
AY596297 Genomic DNA Translation: AAV46516.1
PIRiS16535 R5HSL5
RefSeqiWP_004957391.1, NC_006396.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40D2-177[»]
1JJ2X-ray2.40D2-177[»]
1K73X-ray3.01F2-177[»]
1K8AX-ray3.00F2-177[»]
1K9MX-ray3.00F2-177[»]
1KC8X-ray3.01F2-177[»]
1KD1X-ray3.00F2-177[»]
1KQSX-ray3.10D2-177[»]
1M1KX-ray3.20F2-177[»]
1M90X-ray2.80F2-177[»]
1N8RX-ray3.00F2-177[»]
1NJIX-ray3.00F2-177[»]
1Q7YX-ray3.20F2-177[»]
1Q81X-ray2.95F2-177[»]
1Q82X-ray2.98F2-177[»]
1Q86X-ray3.00F2-177[»]
1QVFX-ray3.10D2-177[»]
1QVGX-ray2.90D2-177[»]
1S72X-ray2.40D1-177[»]
1VQ4X-ray2.70D1-177[»]
1VQ5X-ray2.60D1-177[»]
1VQ6X-ray2.70D1-177[»]
1VQ7X-ray2.50D1-177[»]
1VQ8X-ray2.20D1-177[»]
1VQ9X-ray2.40D1-177[»]
1VQKX-ray2.30D1-177[»]
1VQLX-ray2.30D1-177[»]
1VQMX-ray2.30D1-177[»]
1VQNX-ray2.40D1-177[»]
1VQOX-ray2.20D1-177[»]
1VQPX-ray2.25D1-177[»]
1W2BX-ray3.50D2-177[»]
1YHQX-ray2.40D1-177[»]
1YI2X-ray2.65D1-177[»]
1YIJX-ray2.60D1-177[»]
1YITX-ray2.80D1-177[»]
1YJ9X-ray2.90D1-177[»]
1YJNX-ray3.00D1-177[»]
1YJWX-ray2.90D1-177[»]
2OTJX-ray2.90D1-177[»]
2OTLX-ray2.70D1-177[»]
2QA4X-ray3.00D1-177[»]
2QEXX-ray2.90D1-177[»]
3CC2X-ray2.40D1-177[»]
3CC4X-ray2.70D1-177[»]
3CC7X-ray2.70D1-177[»]
3CCEX-ray2.75D1-177[»]
3CCJX-ray2.70D1-177[»]
3CCLX-ray2.90D1-177[»]
3CCMX-ray2.55D1-177[»]
3CCQX-ray2.90D1-177[»]
3CCRX-ray3.00D1-177[»]
3CCSX-ray2.95D1-177[»]
3CCUX-ray2.80D1-177[»]
3CCVX-ray2.90D1-177[»]
3CD6X-ray2.75D1-177[»]
3CMAX-ray2.80D1-177[»]
3CMEX-ray2.95D1-177[»]
3CPWX-ray2.70D1-177[»]
3CXCX-ray3.00D2-177[»]
3G4SX-ray3.20D1-177[»]
3G6EX-ray2.70D1-177[»]
3G71X-ray2.85D1-177[»]
3I55X-ray3.11D1-177[»]
3I56X-ray2.90D1-177[»]
3OW2X-ray2.70D11-175[»]
4ADXelectron microscopy6.60D1-177[»]
4V4SX-ray6.76G2-177[»]
4V4TX-ray6.46G2-177[»]
4V9FX-ray2.40D1-177[»]
ProteinModelPortaliP14124
SMRiP14124
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1598

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46516; AAV46516; rrnAC1598
GeneIDi3128287
KEGGihma:rrnAC1598
PATRICifig|272569.17.peg.2288

Phylogenomic databases

eggNOGiarCOG04092 Archaea
COG0094 LUCA
HOGENOMiHOG000231312
KOiK02931
OMAiEQVMFHE
OrthoDBiPOG093Z0D78

Miscellaneous databases

EvolutionaryTraceiP14124

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
HAMAPiMF_01333_A Ribosomal_L5_A, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR022804 Ribosomal_L5_arc
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_HALMA
AccessioniPrimary (citable) accession number: P14124
Secondary accession number(s): Q5V1T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 139 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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