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Protein

60S ribosomal protein L27a

Gene

Rpl27a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L27a
Alternative name(s):
L29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpl27a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1347076 Rpl27a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001048801 – 14860S ribosomal protein L27aAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39(3S)-3-hydroxyhistidineBy similarity1
Modified residuei47N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysineBy similarity1
Modified residuei68PhosphoserineCombined sources1
Modified residuei110N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hydroxylated on His-39 by MINA.By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P14115

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P14115

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14115

PeptideAtlas

More...
PeptideAtlasi
P14115

PRoteomics IDEntifications database

More...
PRIDEi
P14115

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14115

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P14115

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P14115

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046364 Expressed in 48 organ(s), highest expression level in spleen

CleanEx database of gene expression profiles

More...
CleanExi
MM_RPL27A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P14115 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14115 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
205001, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P14115, 5 interactors

Molecular INTeraction database

More...
MINTi
P14115

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000123410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P14115

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14115

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1742 Eukaryota
COG0200 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231263

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054587

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14115

KEGG Orthology (KO)

More...
KOi
K02900

Identification of Orthologs from Complete Genome Data

More...
OMAi
WGRVGQH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0TQF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14115

TreeFam database of animal gene trees

More...
TreeFami
TF313742

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01341 Ribosomal_L15, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR001196 Ribosomal_L15_CS
IPR021131 Ribosomal_L18e/L15P

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00828 Ribosomal_L27A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52080 SSF52080, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00475 RIBOSOMAL_L15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14115-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGMHH HRINFDKYHP
60 70 80 90 100
GYFGKVGMRH YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGVAPI
110 120 130 140
IDVVRSGYYK VLGKGKLPKQ PVIVKAKFFS RRAEEKIKGV GGACVLVA
Length:148
Mass (Da):16,605
Last modified:October 5, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6E11FA50E24D206
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZV5G3UZV5_MOUSE
60S ribosomal protein L27a
Rpl27a
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30G → S in CAA28678 (PubMed:2434927).Curated1
Sequence conflicti78L → P in CAA28678 (PubMed:2434927).Curated1
Sequence conflicti78L → P in BAA77362 (PubMed:10449908).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X05021 mRNA Translation: CAA28678.1
AB020237 Genomic DNA Translation: BAA77362.1
AJ307670 Genomic DNA Translation: CAC38113.1
AK007837 mRNA Translation: BAB25295.1
AK008531 mRNA Translation: BAB25724.1
AK010286 mRNA Translation: BAB26822.1
AK150907 mRNA Translation: BAE29949.1
AK167792 mRNA Translation: BAE39822.1
AK167915 mRNA Translation: BAE39922.1
CH466531 Genomic DNA Translation: EDL16941.1
BC056958 mRNA Translation: AAH56958.1
BC081430 mRNA Translation: AAH81430.1
BC086939 mRNA Translation: AAH86939.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40083.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S11557 R5MS27

NCBI Reference Sequences

More...
RefSeqi
NP_036105.2, NM_011975.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.305750

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000143107; ENSMUSP00000123410; ENSMUSG00000046364

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:26451

UCSC genome browser

More...
UCSCi
uc009jdr.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05021 mRNA Translation: CAA28678.1
AB020237 Genomic DNA Translation: BAA77362.1
AJ307670 Genomic DNA Translation: CAC38113.1
AK007837 mRNA Translation: BAB25295.1
AK008531 mRNA Translation: BAB25724.1
AK010286 mRNA Translation: BAB26822.1
AK150907 mRNA Translation: BAE29949.1
AK167792 mRNA Translation: BAE39822.1
AK167915 mRNA Translation: BAE39922.1
CH466531 Genomic DNA Translation: EDL16941.1
BC056958 mRNA Translation: AAH56958.1
BC081430 mRNA Translation: AAH81430.1
BC086939 mRNA Translation: AAH86939.1
CCDSiCCDS40083.1
PIRiS11557 R5MS27
RefSeqiNP_036105.2, NM_011975.3
UniGeneiMm.305750

3D structure databases

ProteinModelPortaliP14115
SMRiP14115
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205001, 3 interactors
IntActiP14115, 5 interactors
MINTiP14115
STRINGi10090.ENSMUSP00000123410

PTM databases

iPTMnetiP14115
PhosphoSitePlusiP14115
SwissPalmiP14115

Proteomic databases

EPDiP14115
MaxQBiP14115
PaxDbiP14115
PeptideAtlasiP14115
PRIDEiP14115

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143107; ENSMUSP00000123410; ENSMUSG00000046364
GeneIDi26451
KEGGimmu:26451
UCSCiuc009jdr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6157
MGIiMGI:1347076 Rpl27a

Phylogenomic databases

eggNOGiKOG1742 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000005534
HOGENOMiHOG000231263
HOVERGENiHBG054587
InParanoidiP14115
KOiK02900
OMAiWGRVGQH
OrthoDBiEOG091G0TQF
PhylomeDBiP14115
TreeFamiTF313742

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P14115

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046364 Expressed in 48 organ(s), highest expression level in spleen
CleanExiMM_RPL27A
ExpressionAtlasiP14115 baseline and differential
GenevisibleiP14115 MM

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR001196 Ribosomal_L15_CS
IPR021131 Ribosomal_L18e/L15P
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS00475 RIBOSOMAL_L15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL27A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14115
Secondary accession number(s): Q9CQ16, Q9R1X6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 136 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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