Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L27a

Gene

Rpl27a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27a
Alternative name(s):
L29
Gene namesi
Name:Rpl27a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347076 Rpl27a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001048801 – 14860S ribosomal protein L27aAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39(3S)-3-hydroxyhistidineBy similarity1
Modified residuei47N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysineBy similarity1
Modified residuei68PhosphoserineCombined sources1
Modified residuei110N6-acetyllysineBy similarity1

Post-translational modificationi

Hydroxylated on His-39 by MINA.By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Phosphoprotein

Proteomic databases

EPDiP14115
MaxQBiP14115
PaxDbiP14115
PeptideAtlasiP14115
PRIDEiP14115

PTM databases

iPTMnetiP14115
PhosphoSitePlusiP14115
SwissPalmiP14115

Expressioni

Gene expression databases

BgeeiENSMUSG00000046364 Expressed in 48 organ(s), highest expression level in spleen
CleanExiMM_RPL27A
ExpressionAtlasiP14115 baseline and differential
GenevisibleiP14115 MM

Interactioni

Protein-protein interaction databases

BioGridi205001, 3 interactors
IntActiP14115, 5 interactors
MINTiP14115
STRINGi10090.ENSMUSP00000123410

Structurei

3D structure databases

ProteinModelPortaliP14115
SMRiP14115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1742 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000005534
HOGENOMiHOG000231263
HOVERGENiHBG054587
InParanoidiP14115
KOiK02900
OMAiWGRVGQH
OrthoDBiEOG091G0TQF
PhylomeDBiP14115
TreeFamiTF313742

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR001196 Ribosomal_L15_CS
IPR021131 Ribosomal_L18e/L15P
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS00475 RIBOSOMAL_L15, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14115-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGMHH HRINFDKYHP
60 70 80 90 100
GYFGKVGMRH YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGVAPI
110 120 130 140
IDVVRSGYYK VLGKGKLPKQ PVIVKAKFFS RRAEEKIKGV GGACVLVA
Length:148
Mass (Da):16,605
Last modified:October 5, 2010 - v5
Checksum:iD6E11FA50E24D206
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZV5G3UZV5_MOUSE
60S ribosomal protein L27a
Rpl27a
41Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30G → S in CAA28678 (PubMed:2434927).Curated1
Sequence conflicti78L → P in CAA28678 (PubMed:2434927).Curated1
Sequence conflicti78L → P in BAA77362 (PubMed:10449908).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05021 mRNA Translation: CAA28678.1
AB020237 Genomic DNA Translation: BAA77362.1
AJ307670 Genomic DNA Translation: CAC38113.1
AK007837 mRNA Translation: BAB25295.1
AK008531 mRNA Translation: BAB25724.1
AK010286 mRNA Translation: BAB26822.1
AK150907 mRNA Translation: BAE29949.1
AK167792 mRNA Translation: BAE39822.1
AK167915 mRNA Translation: BAE39922.1
CH466531 Genomic DNA Translation: EDL16941.1
BC056958 mRNA Translation: AAH56958.1
BC081430 mRNA Translation: AAH81430.1
BC086939 mRNA Translation: AAH86939.1
CCDSiCCDS40083.1
PIRiS11557 R5MS27
RefSeqiNP_036105.2, NM_011975.3
UniGeneiMm.305750

Genome annotation databases

EnsembliENSMUST00000143107; ENSMUSP00000123410; ENSMUSG00000046364
GeneIDi26451
KEGGimmu:26451
UCSCiuc009jdr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05021 mRNA Translation: CAA28678.1
AB020237 Genomic DNA Translation: BAA77362.1
AJ307670 Genomic DNA Translation: CAC38113.1
AK007837 mRNA Translation: BAB25295.1
AK008531 mRNA Translation: BAB25724.1
AK010286 mRNA Translation: BAB26822.1
AK150907 mRNA Translation: BAE29949.1
AK167792 mRNA Translation: BAE39822.1
AK167915 mRNA Translation: BAE39922.1
CH466531 Genomic DNA Translation: EDL16941.1
BC056958 mRNA Translation: AAH56958.1
BC081430 mRNA Translation: AAH81430.1
BC086939 mRNA Translation: AAH86939.1
CCDSiCCDS40083.1
PIRiS11557 R5MS27
RefSeqiNP_036105.2, NM_011975.3
UniGeneiMm.305750

3D structure databases

ProteinModelPortaliP14115
SMRiP14115
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205001, 3 interactors
IntActiP14115, 5 interactors
MINTiP14115
STRINGi10090.ENSMUSP00000123410

PTM databases

iPTMnetiP14115
PhosphoSitePlusiP14115
SwissPalmiP14115

Proteomic databases

EPDiP14115
MaxQBiP14115
PaxDbiP14115
PeptideAtlasiP14115
PRIDEiP14115

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143107; ENSMUSP00000123410; ENSMUSG00000046364
GeneIDi26451
KEGGimmu:26451
UCSCiuc009jdr.1 mouse

Organism-specific databases

CTDi6157
MGIiMGI:1347076 Rpl27a

Phylogenomic databases

eggNOGiKOG1742 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000005534
HOGENOMiHOG000231263
HOVERGENiHBG054587
InParanoidiP14115
KOiK02900
OMAiWGRVGQH
OrthoDBiEOG091G0TQF
PhylomeDBiP14115
TreeFamiTF313742

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PROiPR:P14115
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046364 Expressed in 48 organ(s), highest expression level in spleen
CleanExiMM_RPL27A
ExpressionAtlasiP14115 baseline and differential
GenevisibleiP14115 MM

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR001196 Ribosomal_L15_CS
IPR021131 Ribosomal_L18e/L15P
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS00475 RIBOSOMAL_L15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL27A_MOUSE
AccessioniPrimary (citable) accession number: P14115
Secondary accession number(s): Q9CQ16, Q9R1X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 135 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again