Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 4

Gene

Ccl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Immune activation protein 2
Short name:
ACT-2
Short name:
ACT2
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Protein H400
SIS-gamma
Small-inducible cytokine A4
Gene namesi
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98261 Ccl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000516624 – 92C-C motif chemokine 4Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14097
PeptideAtlasiP14097
PRIDEiP14097

Expressioni

Gene expression databases

BgeeiENSMUSG00000018930 Expressed in 45 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_CCL4
ExpressionAtlasiP14097 baseline and differential
GenevisibleiP14097 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019074

Structurei

3D structure databases

ProteinModelPortaliP14097
SMRiP14097
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP14097
KOiK12964
OMAiWVQEYVD
OrthoDBiEOG091G14Y2
PhylomeDBiP14097
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14097-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD
60 70 80 90
YYETSSLCSK PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN
Length:92
Mass (Da):10,168
Last modified:February 1, 1996 - v3
Checksum:i8853FD58FDE61BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35590 mRNA Translation: AAA39708.1
M23503 mRNA Translation: AAA40148.1
X62502 Genomic DNA Translation: CAA44364.1
AF128218 mRNA Translation: AAF22559.1
AF128219 mRNA Translation: AAF22560.1
CCDSiCCDS36256.1
PIRiC30552
RefSeqiNP_038680.1, NM_013652.2
XP_011247134.1, XM_011248832.1
UniGeneiMm.244263

Genome annotation databases

EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930
GeneIDi20303
KEGGimmu:20303
UCSCiuc007kpp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35590 mRNA Translation: AAA39708.1
M23503 mRNA Translation: AAA40148.1
X62502 Genomic DNA Translation: CAA44364.1
AF128218 mRNA Translation: AAF22559.1
AF128219 mRNA Translation: AAF22560.1
CCDSiCCDS36256.1
PIRiC30552
RefSeqiNP_038680.1, NM_013652.2
XP_011247134.1, XM_011248832.1
UniGeneiMm.244263

3D structure databases

ProteinModelPortaliP14097
SMRiP14097
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019074

Proteomic databases

PaxDbiP14097
PeptideAtlasiP14097
PRIDEiP14097

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930
GeneIDi20303
KEGGimmu:20303
UCSCiuc007kpp.1 mouse

Organism-specific databases

CTDi6351
MGIiMGI:98261 Ccl4

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP14097
KOiK12964
OMAiWVQEYVD
OrthoDBiEOG091G14Y2
PhylomeDBiP14097
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P14097
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018930 Expressed in 45 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_CCL4
ExpressionAtlasiP14097 baseline and differential
GenevisibleiP14097 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL4_MOUSE
AccessioniPrimary (citable) accession number: P14097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again