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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

Atp1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:Atp1b1
Synonyms:Atp4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88108 Atp1b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini63 – 304ExtracellularSequence analysisAdd BLAST242

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190981 – 304Sodium/potassium-transporting ATPase subunit beta-1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei101PhosphotyrosineCombined sources1
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi159 ↔ 175By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi214 ↔ 277By similarity
Glycosylationi266N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Glutathionylated.1 Publication

Keywords - PTMi

Disulfide bond, Glutathionylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP14094
PeptideAtlasiP14094
PRIDEiP14094

PTM databases

iPTMnetiP14094
PhosphoSitePlusiP14094
SwissPalmiP14094

Expressioni

Tissue specificityi

Expressed in cardiac muscle and in flexor digitorum brevis (FDB) muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026576 Expressed in 402 organ(s), highest expression level in olfactory bulb
CleanExiMM_ATP1B1
MM_ATP4B
ExpressionAtlasiP14094 baseline and differential
GenevisibleiP14094 MM

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (PubMed:15743908). Interacts with NKAIN1, NKAIN2 and NKAIN4 (PubMed:17606467). Interacts with MLC1 (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity). Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (PubMed:23392350).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198244, 5 interactors
ComplexPortaliCPX-126 Sodium:potassium-exchanging ATPase complex
IntActiP14094, 99 interactors
MINTiP14094
STRINGi10090.ENSMUSP00000027863

Structurei

3D structure databases

ProteinModelPortaliP14094
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 304immunoglobulin-likeBy similarityAdd BLAST114

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP14094
KOiK01540
OMAiDTEPKWK
OrthoDBiEOG091G0DJ4
PhylomeDBiP14094
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR015565 Na/K_ATPase_sub_beta_chordates
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PTHR11523:SF10 PTHR11523:SF10, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14094-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISELKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA
110 120 130 140 150
YVLNIIRFLE KYKDSAQKDD MIFEDCGNVP SEPKERGDIN HERGERKVCR
160 170 180 190 200
FKLDWLGNCS GLNDDSYGYR EGKPCIIIKL NRVLGFKPKP PKNESLETYP
210 220 230 240 250
LMMKYNPNVL PVQCTGKRDE DKDKVGNIEY FGMGGYYGFP LQYYPYYGKL
260 270 280 290 300
LQPKYLQPLL AVQFTNLTVD TEIRVECKAY GENIGYSEKD RFQGRFDVKI

EIKS
Length:304
Mass (Da):35,195
Last modified:January 1, 1990 - v1
Checksum:i8E15D8F860932680
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YX05A0A0A6YX05_MOUSE
Sodium/potassium-transporting ATPas...
Atp1b1
132Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16646 mRNA Translation: CAA34639.1
BC027319 mRNA Translation: AAH27319.1
X61433 mRNA Translation: CAA43675.1
CCDSiCCDS35755.1
PIRiS09601
RefSeqiNP_033851.1, NM_009721.6
UniGeneiMm.4550

Genome annotation databases

EnsembliENSMUST00000027863; ENSMUSP00000027863; ENSMUSG00000026576
GeneIDi11931
KEGGimmu:11931
UCSCiuc007dip.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16646 mRNA Translation: CAA34639.1
BC027319 mRNA Translation: AAH27319.1
X61433 mRNA Translation: CAA43675.1
CCDSiCCDS35755.1
PIRiS09601
RefSeqiNP_033851.1, NM_009721.6
UniGeneiMm.4550

3D structure databases

ProteinModelPortaliP14094
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198244, 5 interactors
ComplexPortaliCPX-126 Sodium:potassium-exchanging ATPase complex
IntActiP14094, 99 interactors
MINTiP14094
STRINGi10090.ENSMUSP00000027863

PTM databases

iPTMnetiP14094
PhosphoSitePlusiP14094
SwissPalmiP14094

Proteomic databases

PaxDbiP14094
PeptideAtlasiP14094
PRIDEiP14094

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027863; ENSMUSP00000027863; ENSMUSG00000026576
GeneIDi11931
KEGGimmu:11931
UCSCiuc007dip.2 mouse

Organism-specific databases

CTDi481
MGIiMGI:88108 Atp1b1

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP14094
KOiK01540
OMAiDTEPKWK
OrthoDBiEOG091G0DJ4
PhylomeDBiP14094
TreeFamiTF314618

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiAtp1b1 mouse
PROiPR:P14094
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026576 Expressed in 402 organ(s), highest expression level in olfactory bulb
CleanExiMM_ATP1B1
MM_ATP4B
ExpressionAtlasiP14094 baseline and differential
GenevisibleiP14094 MM

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR015565 Na/K_ATPase_sub_beta_chordates
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PTHR11523:SF10 PTHR11523:SF10, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B1_MOUSE
AccessioniPrimary (citable) accession number: P14094
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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