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Protein

Cathepsin E

Gene

CTSE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.06 mM for hemoglobin1 Publication
  2. KM=0.13 mM for Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu1 Publication
  3. KM=0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei96PROSITE-ProRule annotation1
    Active sitei281PROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • aspartic-type endopeptidase activity Source: UniProtKB
    • protein homodimerization activity Source: Ensembl

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.23.34 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2132295 MHC class II antigen presentation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P14091

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    A01.010

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cathepsin E (EC:3.4.23.34)
    Cleaved into the following 2 chains:
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CTSE
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000196188.10

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:2530 CTSE

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    116890 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P14091

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Endosome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60C → A: Abolishes homodimerization. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1510

    Open Targets

    More...
    OpenTargetsi
    ENSG00000196188

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27030

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3092

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2346

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CTSE

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    46397366

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002597420 – 53Activation peptide2 PublicationsAdd BLAST34
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002597554 – 396Cathepsin E form IAdd BLAST343
    ChainiPRO_000035466857 – 396Cathepsin E form IIAdd BLAST340

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60Interchain1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagine1
    Disulfide bondi109 ↔ 114By similarity
    Disulfide bondi272 ↔ 276By similarity
    Disulfide bondi314 ↔ 351By similarity

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.3 Publications
    Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P14091

    PeptideAtlas

    More...
    PeptideAtlasi
    P14091

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P14091

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    53019
    53020 [P14091-1]
    53021 [P14091-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P14091

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P14091

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...
    PMAP-CutDBi
    P14091

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000196188 Expressed in 96 organ(s), highest expression level in duodenum

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_CTSE

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P14091 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB032687
    HPA012940

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    107890, 8 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P14091, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000350911

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P14091

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1396
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P14091

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P14091

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P14091

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 396Peptidase A1PROSITE-ProRule annotationAdd BLAST319

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1339 Eukaryota
    ENOG410XNV7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161300

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000197681

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG000482

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P14091

    KEGG Orthology (KO)

    More...
    KOi
    K01382

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GYWQIQL

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0JP7

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P14091

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314990

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.70.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR012848 Aspartic_peptidase_N
    IPR033145 Cathepsin_E
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR13683 PTHR13683, 1 hit
    PTHR13683:SF81 PTHR13683:SF81, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07966 A1_Propeptide, 1 hit
    PF00026 Asp, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00792 PEPSIN

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50630 SSF50630, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00141 ASP_PROTEASE, 2 hits
    PS51767 PEPTIDASE_A1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: P14091-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN
    60 70 80 90 100
    LDMIQFTESC SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS
    110 120 130 140 150
    NLWVPSVYCT SPACKTHSRF QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA
    160 170 180 190 200
    DQVSVEGLTV VGQQFGESVT EPGQTFVDAE FDGILGLGYP SLAVGGVTPV
    210 220 230 240 250
    FDNMMAQNLV DLPMFSVYMS SNPEGGAGSE LIFGGYDHSH FSGSLNWVPV
    260 270 280 290 300
    TKQAYWQIAL DNIQVGGTVM FCSEGCQAIV DTGTSLITGP SDKIKQLQNA
    310 320 330 340 350
    IGAAPVDGEY AVECANLNVM PDVTFTINGV PYTLSPTAYT LLDFVDGMQF
    360 370 380 390
    CSSGFQGLDI HPPAGPLWIL GDVFIRQFYS VFDRGNNRVG LAPAVP
    Length:396
    Mass (Da):42,794
    Last modified:March 28, 2018 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40B643C5FB01521E
    GO
    Isoform 2 (identifier: P14091-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         263-395: IQVGGTVMFC...NNRVGLAPAV → MLWSVPTLTS...PCVCACLSDR

    Show »
    Length:363
    Mass (Da):39,553
    Checksum:i4443819D6393C1FC
    GO
    Isoform 3 (identifier: P14091-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-154: S → SAFATQ

    Note: Dubious isoform produced through aberrant splice sites.Curated
    Show »
    Length:401
    Mass (Da):43,312
    Checksum:i46A2BA35266032CB
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06173182I → V. Corresponds to variant dbSNP:rs57621203Ensembl.1
    Natural variantiVAR_014572324T → I. Corresponds to variant dbSNP:rs6503Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059425154S → SAFATQ in isoform 3. 1 Publication1
    Alternative sequenceiVSP_059426263 – 395IQVGG…LAPAV → MLWSVPTLTSCRMSPSPLTE SPIPSAQLPTPYWTSWMECS SAAVAFKDLTSTLQLGPSGS WGMSSFDSFTQSLTVGITVW DWPQQSPKEGPCVCACLSDR in isoform 2. 1 PublicationAdd BLAST133

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J05036 mRNA Translation: AAA52130.1
    M84424
    , M84413, M84417, M84418, M84419, M84420, M84421, M84422 Genomic DNA Translation: AAA52300.1
    AJ250716 mRNA Translation: CAB82849.1
    AJ250717 mRNA Translation: CAB82850.1
    AK292057 mRNA Translation: BAF84746.1
    BX571818 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW91592.1
    CH471067 Genomic DNA Translation: EAW91593.1
    BC042537 mRNA Translation: AAH42537.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS73012.1 [P14091-2]
    CCDS73013.1 [P14091-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A42038 A34401

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001304260.1, NM_001317331.1
    NP_001901.1, NM_001910.3 [P14091-1]
    NP_683865.1, NM_148964.2 [P14091-2]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.644082

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000358184; ENSP00000350911; ENSG00000196188 [P14091-1]
    ENST00000360218; ENSP00000353350; ENSG00000196188 [P14091-2]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    1510

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:1510

    UCSC genome browser

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    UCSCi
    uc001hdu.3 human [P14091-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J05036 mRNA Translation: AAA52130.1
    M84424
    , M84413, M84417, M84418, M84419, M84420, M84421, M84422 Genomic DNA Translation: AAA52300.1
    AJ250716 mRNA Translation: CAB82849.1
    AJ250717 mRNA Translation: CAB82850.1
    AK292057 mRNA Translation: BAF84746.1
    BX571818 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW91592.1
    CH471067 Genomic DNA Translation: EAW91593.1
    BC042537 mRNA Translation: AAH42537.1
    CCDSiCCDS73012.1 [P14091-2]
    CCDS73013.1 [P14091-1]
    PIRiA42038 A34401
    RefSeqiNP_001304260.1, NM_001317331.1
    NP_001901.1, NM_001910.3 [P14091-1]
    NP_683865.1, NM_148964.2 [P14091-2]
    UniGeneiHs.644082

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1LCGmodel-A1-396[»]
    1TZSX-ray2.35A54-396[»]
    P19-53[»]
    ProteinModelPortaliP14091
    SMRiP14091
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi107890, 8 interactors
    IntActiP14091, 2 interactors
    STRINGi9606.ENSP00000350911

    Chemistry databases

    BindingDBiP14091
    ChEMBLiCHEMBL3092
    GuidetoPHARMACOLOGYi2346

    Protein family/group databases

    MEROPSiA01.010

    PTM databases

    iPTMnetiP14091
    PhosphoSitePlusiP14091

    Polymorphism and mutation databases

    BioMutaiCTSE
    DMDMi46397366

    Proteomic databases

    PaxDbiP14091
    PeptideAtlasiP14091
    PRIDEiP14091
    ProteomicsDBi53019
    53020 [P14091-1]
    53021 [P14091-2]

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    1510
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000358184; ENSP00000350911; ENSG00000196188 [P14091-1]
    ENST00000360218; ENSP00000353350; ENSG00000196188 [P14091-2]
    GeneIDi1510
    KEGGihsa:1510
    UCSCiuc001hdu.3 human [P14091-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    1510
    DisGeNETi1510
    EuPathDBiHostDB:ENSG00000196188.10

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CTSE
    HGNCiHGNC:2530 CTSE
    HPAiCAB032687
    HPA012940
    MIMi116890 gene
    neXtProtiNX_P14091
    OpenTargetsiENSG00000196188
    PharmGKBiPA27030

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1339 Eukaryota
    ENOG410XNV7 LUCA
    GeneTreeiENSGT00940000161300
    HOGENOMiHOG000197681
    HOVERGENiHBG000482
    InParanoidiP14091
    KOiK01382
    OMAiGYWQIQL
    OrthoDBiEOG091G0JP7
    PhylomeDBiP14091
    TreeFamiTF314990

    Enzyme and pathway databases

    BRENDAi3.4.23.34 2681
    ReactomeiR-HSA-2132295 MHC class II antigen presentation
    SABIO-RKiP14091

    Miscellaneous databases

    EvolutionaryTraceiP14091

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    Cathepsin_E

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1510
    PMAP-CutDBiP14091

    Protein Ontology

    More...
    PROi
    PR:P14091

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000196188 Expressed in 96 organ(s), highest expression level in duodenum
    CleanExiHS_CTSE
    GenevisibleiP14091 HS

    Family and domain databases

    Gene3Di2.40.70.10, 2 hits
    InterProiView protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR012848 Aspartic_peptidase_N
    IPR033145 Cathepsin_E
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf
    PANTHERiPTHR13683 PTHR13683, 1 hit
    PTHR13683:SF81 PTHR13683:SF81, 1 hit
    PfamiView protein in Pfam
    PF07966 A1_Propeptide, 1 hit
    PF00026 Asp, 1 hit
    PRINTSiPR00792 PEPSIN
    SUPFAMiSSF50630 SSF50630, 1 hit
    PROSITEiView protein in PROSITE
    PS00141 ASP_PROTEASE, 2 hits
    PS51767 PEPTIDASE_A1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATE_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14091
    Secondary accession number(s): Q5TZ01
    , Q5TZ02, Q9NY58, Q9UCE3, Q9UCE4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: March 28, 2018
    Last modified: December 5, 2018
    This is version 199 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    7. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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