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Entry version 128 (17 Jun 2020)
Sequence version 1 (01 Jan 1990)
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Protein

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).By similarity
Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-9026527 Activated NTRK2 signals through PLCG1
R-SSC-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-SSC-9032759 NTRK2 activates RAC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Cleaved into the following chain:
BDNF precursor formCurated
Short name:
ProBDNFCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BDNF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2
  • UP000008227 Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:85795 BDNF

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044753819 – 252BDNF precursor formCuratedAdd BLAST234
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001963919 – 133By similarityAdd BLAST115
ChainiPRO_0000019640134 – 252Brain-derived neurotrophic factorAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi146 ↔ 213By similarity
Disulfide bondi191 ↔ 242By similarity
Disulfide bondi201 ↔ 244By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and glycosulfated, contrary to mature BDNF.By similarity
Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei57 – 58Cleavage; by MBTPS1By similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14082

PRoteomics IDEntifications database

More...
PRIDEi
P14082

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain and central nervous system.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000013333 Expressed in lung and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P14082 baseline

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14082 SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000014166

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH7X Eukaryota
ENOG410XRPH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007725

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_059942_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P14082

KEGG Orthology (KO)

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KOi
K04355

Identification of Orthologs from Complete Genome Data

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OMAi
YPGMRTH

TreeFam database of animal gene trees

More...
TreeFami
TF106463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00243 NGF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001789 NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01912 BDNFACTOR
PR00268 NGF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00140 NGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14082-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEANVRGQG SLAYPGVRTH GTLESVNGPK
60 70 80 90 100
AGSRGLTSSS SSSLADTFEH VIEELLDEDQ KVRPNEENNK DADMYTSRVM
110 120 130 140 150
LSSQVPLEPP LLFLLEEYKN YLDAANMSMR VRRHSDPARR GELSVCDSIS
160 170 180 190 200
EWVTAADKKT AVDMSGGTVT VLEKVPVSKG QLKQYFYETK CNPMGYTKEG
210 220 230 240 250
CRGIDKRHWN SQCRTTQSYV RALTMDSKKR IGWRFIRIDT SCVCTLTIKR

GR
Length:252
Mass (Da):28,287
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DABB45F73BE0B7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287AS34A0A287AS34_PIG
Brain-derived neurotrophic factor
BDNF
260Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16713 mRNA Translation: CAA34685.1

Protein sequence database of the Protein Information Resource

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PIRi
A30361

NCBI Reference Sequences

More...
RefSeqi
NP_999424.1, NM_214259.2
XP_005654742.1, XM_005654685.2
XP_005654743.1, XM_005654686.2
XP_013842732.1, XM_013987278.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000014561; ENSSSCP00000014166; ENSSSCG00000013333
ENSSSCT00000053649; ENSSSCP00000058570; ENSSSCG00000013333
ENSSSCT00000073803; ENSSSCP00000059903; ENSSSCG00000013333
ENSSSCT00005018179; ENSSSCP00005010873; ENSSSCG00005011774
ENSSSCT00005018197; ENSSSCP00005010885; ENSSSCG00005011774
ENSSSCT00015062752; ENSSSCP00015025177; ENSSSCG00015046833
ENSSSCT00015063053; ENSSSCP00015025291; ENSSSCG00015046833
ENSSSCT00015063388; ENSSSCP00015025409; ENSSSCG00015046833
ENSSSCT00025092825; ENSSSCP00025040736; ENSSSCG00025067546
ENSSSCT00025092926; ENSSSCP00025040777; ENSSSCG00025067546
ENSSSCT00025093020; ENSSSCP00025040821; ENSSSCG00025067546
ENSSSCT00030061437; ENSSSCP00030028100; ENSSSCG00030044027
ENSSSCT00030061473; ENSSSCP00030028109; ENSSSCG00030044027
ENSSSCT00030061511; ENSSSCP00030028130; ENSSSCG00030044027
ENSSSCT00035016735; ENSSSCP00035005789; ENSSSCG00035013262
ENSSSCT00035016746; ENSSSCP00035005798; ENSSSCG00035013262
ENSSSCT00035016754; ENSSSCP00035005804; ENSSSCG00035013262
ENSSSCT00045008037; ENSSSCP00045005429; ENSSSCG00045004861
ENSSSCT00045008039; ENSSSCP00045005430; ENSSSCG00045004861
ENSSSCT00045008041; ENSSSCP00045005432; ENSSSCG00045004861
ENSSSCT00050022067; ENSSSCP00050009286; ENSSSCG00050016207
ENSSSCT00050022084; ENSSSCP00050009295; ENSSSCG00050016207
ENSSSCT00050022110; ENSSSCP00050009311; ENSSSCG00050016207
ENSSSCT00055025515; ENSSSCP00055020262; ENSSSCG00055012979
ENSSSCT00055025539; ENSSSCP00055020284; ENSSSCG00055012979
ENSSSCT00055025549; ENSSSCP00055020294; ENSSSCG00055012979
ENSSSCT00060014675; ENSSSCP00060005698; ENSSSCG00060011248
ENSSSCT00060014681; ENSSSCP00060005700; ENSSSCG00060011248
ENSSSCT00060014687; ENSSSCP00060005702; ENSSSCG00060011248
ENSSSCT00065035893; ENSSSCP00065015033; ENSSSCG00065026682
ENSSSCT00065035896; ENSSSCP00065015035; ENSSSCG00065026682
ENSSSCT00065035899; ENSSSCP00065015036; ENSSSCG00065026682
ENSSSCT00070009213; ENSSSCP00070007563; ENSSSCG00070004870
ENSSSCT00070009223; ENSSSCP00070007572; ENSSSCG00070004870
ENSSSCT00070009245; ENSSSCP00070007590; ENSSSCG00070004870

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397495

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16713 mRNA Translation: CAA34685.1
PIRiA30361
RefSeqiNP_999424.1, NM_214259.2
XP_005654742.1, XM_005654685.2
XP_005654743.1, XM_005654686.2
XP_013842732.1, XM_013987278.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014166

Proteomic databases

PaxDbiP14082
PRIDEiP14082

Genome annotation databases

EnsembliENSSSCT00000014561; ENSSSCP00000014166; ENSSSCG00000013333
ENSSSCT00000053649; ENSSSCP00000058570; ENSSSCG00000013333
ENSSSCT00000073803; ENSSSCP00000059903; ENSSSCG00000013333
ENSSSCT00005018179; ENSSSCP00005010873; ENSSSCG00005011774
ENSSSCT00005018197; ENSSSCP00005010885; ENSSSCG00005011774
ENSSSCT00015062752; ENSSSCP00015025177; ENSSSCG00015046833
ENSSSCT00015063053; ENSSSCP00015025291; ENSSSCG00015046833
ENSSSCT00015063388; ENSSSCP00015025409; ENSSSCG00015046833
ENSSSCT00025092825; ENSSSCP00025040736; ENSSSCG00025067546
ENSSSCT00025092926; ENSSSCP00025040777; ENSSSCG00025067546
ENSSSCT00025093020; ENSSSCP00025040821; ENSSSCG00025067546
ENSSSCT00030061437; ENSSSCP00030028100; ENSSSCG00030044027
ENSSSCT00030061473; ENSSSCP00030028109; ENSSSCG00030044027
ENSSSCT00030061511; ENSSSCP00030028130; ENSSSCG00030044027
ENSSSCT00035016735; ENSSSCP00035005789; ENSSSCG00035013262
ENSSSCT00035016746; ENSSSCP00035005798; ENSSSCG00035013262
ENSSSCT00035016754; ENSSSCP00035005804; ENSSSCG00035013262
ENSSSCT00045008037; ENSSSCP00045005429; ENSSSCG00045004861
ENSSSCT00045008039; ENSSSCP00045005430; ENSSSCG00045004861
ENSSSCT00045008041; ENSSSCP00045005432; ENSSSCG00045004861
ENSSSCT00050022067; ENSSSCP00050009286; ENSSSCG00050016207
ENSSSCT00050022084; ENSSSCP00050009295; ENSSSCG00050016207
ENSSSCT00050022110; ENSSSCP00050009311; ENSSSCG00050016207
ENSSSCT00055025515; ENSSSCP00055020262; ENSSSCG00055012979
ENSSSCT00055025539; ENSSSCP00055020284; ENSSSCG00055012979
ENSSSCT00055025549; ENSSSCP00055020294; ENSSSCG00055012979
ENSSSCT00060014675; ENSSSCP00060005698; ENSSSCG00060011248
ENSSSCT00060014681; ENSSSCP00060005700; ENSSSCG00060011248
ENSSSCT00060014687; ENSSSCP00060005702; ENSSSCG00060011248
ENSSSCT00065035893; ENSSSCP00065015033; ENSSSCG00065026682
ENSSSCT00065035896; ENSSSCP00065015035; ENSSSCG00065026682
ENSSSCT00065035899; ENSSSCP00065015036; ENSSSCG00065026682
ENSSSCT00070009213; ENSSSCP00070007563; ENSSSCG00070004870
ENSSSCT00070009223; ENSSSCP00070007572; ENSSSCG00070004870
ENSSSCT00070009245; ENSSSCP00070007590; ENSSSCG00070004870
GeneIDi397495
KEGGissc:397495

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
627
VGNCiVGNC:85795 BDNF

Phylogenomic databases

eggNOGiENOG410IH7X Eukaryota
ENOG410XRPH LUCA
GeneTreeiENSGT00390000007725
HOGENOMiCLU_059942_0_0_1
InParanoidiP14082
KOiK04355
OMAiYPGMRTH
TreeFamiTF106463

Enzyme and pathway databases

ReactomeiR-SSC-9026527 Activated NTRK2 signals through PLCG1
R-SSC-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-SSC-9032759 NTRK2 activates RAC1

Gene expression databases

BgeeiENSSSCG00000013333 Expressed in lung and 4 other tissues
ExpressionAtlasiP14082 baseline
GenevisibleiP14082 SS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01912 BDNFACTOR
PR00268 NGF
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBDNF_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14082
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 17, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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