UniProtKB - P14069 (S10A6_MOUSE)
Protein
Protein S100-A6
Gene
S100a6
Organism
Mus musculus (Mouse)
Status
Functioni
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 20 – 33 | 1PROSITE-ProRule annotationAdd BLAST | 14 | |
Calcium bindingi | 61 – 72 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein binding Source: MGI
- calcium ion binding Source: UniProtKB
- ion transmembrane transporter activity Source: MGI
- protein homodimerization activity Source: MGI
- S100 protein binding Source: MGI
- tropomyosin binding Source: MGI
- zinc ion binding Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A6Alternative name(s): 5B10 Calcyclin Prolactin receptor-associated protein S100 calcium-binding protein A6 |
Gene namesi | Name:S100a6 Synonyms:Cacy |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339467, S100a6 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Nucleus
- Nucleus envelope By similarity
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Nucleus
- nuclear envelope Source: MGI
- nucleus Source: MGI
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- perinuclear region of cytoplasm Source: MGI
- ruffle Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143985 | 1 – 89 | Protein S100-A6Add BLAST | 89 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 46 | PhosphoserineBy similarity | 1 | |
Modified residuei | 47 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 47 | N6-succinyllysine; alternateCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P14069 |
jPOSTi | P14069 |
PaxDbi | P14069 |
PeptideAtlasi | P14069 |
PRIDEi | P14069 |
2D gel databases
DOSAC-COBS-2DPAGEi | P14069 |
PTM databases
iPTMneti | P14069 |
PhosphoSitePlusi | P14069 |
SwissPalmi | P14069 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001025, Expressed in urinary bladder and 300 other tissues |
Genevisiblei | P14069, MM |
Interactioni
Subunit structurei
Homodimer; head to tail assembly of 2 subunits.
Interacts with CACYBP in a calcium-dependent manner.
Interacts with ANXA2 and ANXA11 (via N-terminus).
Interacts with SUGT1.
Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain.
Interacts with tropomyosin.
Interacts with FKBP4.
Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).
By similarityBinary interactionsi
P14069
With | #Exp. | IntAct |
---|---|---|
Cacybp [Q9CXW3] | 4 | EBI-6478740,EBI-767146 |
GO - Molecular functioni
- calcium-dependent protein binding Source: MGI
- protein homodimerization activity Source: MGI
- S100 protein binding Source: MGI
- tropomyosin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203055, 9 interactors |
IntActi | P14069, 5 interactors |
MINTi | P14069 |
STRINGi | 10090.ENSMUSP00000001051 |
Miscellaneous databases
RNActi | P14069, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P14069 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 47 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 48 – 83 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the S-100 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S6IN, Eukaryota |
GeneTreei | ENSGT00940000161896 |
HOGENOMi | CLU_138624_2_0_1 |
InParanoidi | P14069 |
OMAi | TEMCHEY |
OrthoDBi | 1581517at2759 |
PhylomeDBi | P14069 |
TreeFami | TF332727 |
Family and domain databases
CDDi | cd05029, S-100A6, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034118, S-100A6 IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
i Sequence
Sequence statusi: Complete.
P14069-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGSKLQD
60 70 80
AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 51 | A → R in CAA36521 (PubMed:2177633).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37761 mRNA Translation: AAA37358.1 X66449 mRNA Translation: CAA47065.1 X52278 mRNA Translation: CAA36521.1 BC003832 mRNA Translation: AAH03832.1 BC010774 mRNA Translation: AAH10774.1 |
CCDSi | CCDS38506.1 |
PIRi | A54314 |
RefSeqi | NP_035443.1, NM_011313.2 |
Genome annotation databases
Ensembli | ENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025 ENSMUST00000198128; ENSMUSP00000143111; ENSMUSG00000001025 ENSMUST00000200289; ENSMUSP00000143720; ENSMUSG00000001025 |
GeneIDi | 20200 |
KEGGi | mmu:20200 |
UCSCi | uc008qdb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37761 mRNA Translation: AAA37358.1 X66449 mRNA Translation: CAA47065.1 X52278 mRNA Translation: CAA36521.1 BC003832 mRNA Translation: AAH03832.1 BC010774 mRNA Translation: AAH10774.1 |
CCDSi | CCDS38506.1 |
PIRi | A54314 |
RefSeqi | NP_035443.1, NM_011313.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4P2Y | X-ray | 2.30 | B | 1-89 | [»] | |
SMRi | P14069 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 203055, 9 interactors |
IntActi | P14069, 5 interactors |
MINTi | P14069 |
STRINGi | 10090.ENSMUSP00000001051 |
PTM databases
iPTMneti | P14069 |
PhosphoSitePlusi | P14069 |
SwissPalmi | P14069 |
2D gel databases
DOSAC-COBS-2DPAGEi | P14069 |
Proteomic databases
EPDi | P14069 |
jPOSTi | P14069 |
PaxDbi | P14069 |
PeptideAtlasi | P14069 |
PRIDEi | P14069 |
Protocols and materials databases
Antibodypediai | 1680, 495 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025 ENSMUST00000198128; ENSMUSP00000143111; ENSMUSG00000001025 ENSMUST00000200289; ENSMUSP00000143720; ENSMUSG00000001025 |
GeneIDi | 20200 |
KEGGi | mmu:20200 |
UCSCi | uc008qdb.1, mouse |
Organism-specific databases
CTDi | 6277 |
MGIi | MGI:1339467, S100a6 |
Phylogenomic databases
eggNOGi | ENOG502S6IN, Eukaryota |
GeneTreei | ENSGT00940000161896 |
HOGENOMi | CLU_138624_2_0_1 |
InParanoidi | P14069 |
OMAi | TEMCHEY |
OrthoDBi | 1581517at2759 |
PhylomeDBi | P14069 |
TreeFami | TF332727 |
Miscellaneous databases
BioGRID-ORCSi | 20200, 1 hit in 17 CRISPR screens |
ChiTaRSi | S100a6, mouse |
PROi | PR:P14069 |
RNActi | P14069, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001025, Expressed in urinary bladder and 300 other tissues |
Genevisiblei | P14069, MM |
Family and domain databases
CDDi | cd05029, S-100A6, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034118, S-100A6 IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S10A6_MOUSE | |
Accessioni | P14069Primary (citable) accession number: P14069 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | May 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families