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Protein

Protein S100-A6

Gene

S100a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331PROSITE-ProRule annotationAdd BLAST14
Calcium bindingi61 – 722PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A6
Alternative name(s):
5B10
Calcyclin
Prolactin receptor-associated protein
S100 calcium-binding protein A6
Gene namesi
Name:S100a6
Synonyms:Cacy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1339467 S100a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439851 – 89Protein S100-A6Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-acetyllysineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei47N6-acetyllysine; alternateCombined sources1
Modified residuei47N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP14069
PaxDbiP14069
PeptideAtlasiP14069
PRIDEiP14069

2D gel databases

DOSAC-COBS-2DPAGEiP14069

PTM databases

iPTMnetiP14069
PhosphoSitePlusiP14069
SwissPalmiP14069

Expressioni

Gene expression databases

BgeeiENSMUSG00000001025 Expressed in 283 organ(s), highest expression level in urinary bladder
CleanExiMM_S100A6
ExpressionAtlasiP14069 baseline and differential
GenevisibleiP14069 MM

Interactioni

Subunit structurei

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CacybpQ9CXW34EBI-6478740,EBI-767146

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203055, 2 interactors
IntActiP14069, 5 interactors
MINTiP14069
STRINGi10090.ENSMUSP00000001051

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14069
SMRiP14069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYT5 Eukaryota
ENOG410Z6I6 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP14069
OMAiQVVNFQE
OrthoDBiEOG091G10JX
PhylomeDBiP14069
TreeFamiTF332727

Family and domain databases

CDDicd05029 S-100A6, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034118 S-100A6
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P14069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGSKLQD
60 70 80
AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK
Length:89
Mass (Da):10,051
Last modified:May 1, 1991 - v3
Checksum:i2AA1A4018B8CA687
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51A → R in CAA36521 (PubMed:2177633).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37761 mRNA Translation: AAA37358.1
X66449 mRNA Translation: CAA47065.1
X52278 mRNA Translation: CAA36521.1
BC003832 mRNA Translation: AAH03832.1
BC010774 mRNA Translation: AAH10774.1
CCDSiCCDS38506.1
PIRiA54314
RefSeqiNP_035443.1, NM_011313.2
UniGeneiMm.100144

Genome annotation databases

EnsembliENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025
ENSMUST00000198128; ENSMUSP00000143111; ENSMUSG00000001025
ENSMUST00000200289; ENSMUSP00000143720; ENSMUSG00000001025
GeneIDi20200
KEGGimmu:20200
UCSCiuc008qdb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37761 mRNA Translation: AAA37358.1
X66449 mRNA Translation: CAA47065.1
X52278 mRNA Translation: CAA36521.1
BC003832 mRNA Translation: AAH03832.1
BC010774 mRNA Translation: AAH10774.1
CCDSiCCDS38506.1
PIRiA54314
RefSeqiNP_035443.1, NM_011313.2
UniGeneiMm.100144

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P2YX-ray2.30B1-89[»]
ProteinModelPortaliP14069
SMRiP14069
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203055, 2 interactors
IntActiP14069, 5 interactors
MINTiP14069
STRINGi10090.ENSMUSP00000001051

PTM databases

iPTMnetiP14069
PhosphoSitePlusiP14069
SwissPalmiP14069

2D gel databases

DOSAC-COBS-2DPAGEiP14069

Proteomic databases

EPDiP14069
PaxDbiP14069
PeptideAtlasiP14069
PRIDEiP14069

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025
ENSMUST00000198128; ENSMUSP00000143111; ENSMUSG00000001025
ENSMUST00000200289; ENSMUSP00000143720; ENSMUSG00000001025
GeneIDi20200
KEGGimmu:20200
UCSCiuc008qdb.1 mouse

Organism-specific databases

CTDi6277
MGIiMGI:1339467 S100a6

Phylogenomic databases

eggNOGiENOG410IYT5 Eukaryota
ENOG410Z6I6 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP14069
OMAiQVVNFQE
OrthoDBiEOG091G10JX
PhylomeDBiP14069
TreeFamiTF332727

Miscellaneous databases

ChiTaRSiS100a6 mouse
PROiPR:P14069
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001025 Expressed in 283 organ(s), highest expression level in urinary bladder
CleanExiMM_S100A6
ExpressionAtlasiP14069 baseline and differential
GenevisibleiP14069 MM

Family and domain databases

CDDicd05029 S-100A6, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034118 S-100A6
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A6_MOUSE
AccessioniPrimary (citable) accession number: P14069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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