gnd

Functionⁱ

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO₂, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityⁱ

6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH.

Pathwayⁱ: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Glucose-6-phosphate 1-dehydrogenase (zwf)
6-phosphogluconolactonase (pgl)
6-phosphogluconate dehydrogenase, decarboxylating (gnd)

This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	102	NADPBy similarity	1
Binding siteⁱ	102	SubstrateBy similarity	1
Active siteⁱ	183	Proton acceptorBy similarity	1
Active siteⁱ	190	Proton donorBy similarity	1
Binding siteⁱ	191	SubstrateBy similarity	1
Binding siteⁱ	260	Substrate; via amide nitrogenBy similarity	1
Binding siteⁱ	287	SubstrateBy similarity	1
Binding siteⁱ	445	Substrate; shared with dimeric partnerBy similarity	1
Binding siteⁱ	451	Substrate; shared with dimeric partnerBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	10 – 15	NADPBy similarity	6
Nucleotide bindingⁱ	33 – 35	NADPBy similarity	3
Nucleotide bindingⁱ	74 – 76	NADPBy similarity	3

GO - Molecular functionⁱ

phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

D-gluconate metabolic process Source: UniProtKB-KW
pentose-phosphate shunt Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Gluconate utilization, Pentose shunt
Ligand	NADP

Enzyme and pathway databases

BioCycⁱ	SENT99287:G1FZD-2100-MONOMER
UniPathwayⁱ	UPA00115; UER00410

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesⁱ	Name:gnd Ordered Locus Names:STM2081
Organismⁱ	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifierⁱ	99287 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium
Proteomesⁱ	UP000001014 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090047	1 – 468	6-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST		468

Proteomic databases

PaxDbⁱ	P14062
PRIDEⁱ	P14062

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	99287.STM2081

STRINGⁱ

99287.STM2081

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P14062
SMRⁱ	P14062
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	128 – 130	Substrate bindingBy similarity		3
Regionⁱ	186 – 187	Substrate bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the 6-phosphogluconate dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105C7Q Bacteria COG0362 LUCA
HOGENOMⁱ	HOG000255147
KEGG Orthology (KO) More...KOⁱ	K00033
OMAⁱ	NSHYPDS
PhylomeDBⁱ	P14062

Family and domain databases

Gene3Dⁱ	1.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR006114 6PGDH_C IPR006113 6PGDH_Gnd/GntZ IPR006115 6PGDH_NADP-bd IPR006184 6PGdom_BS IPR036291 NAD(P)-bd_dom_sf IPR006183 Pgluconate_DH
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00393 6PGD, 1 hit PF03446 NAD_binding_2, 1 hit
PIRSFⁱ	PIRSF000109 6PGD, 1 hit
PRINTSⁱ	PR00076 6PGDHDRGNASE
SMARTⁱ	View protein in SMART SM01350 6PGD, 1 hit
SUPFAMⁱ	SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR00873 gnd, 1 hit
PROSITEⁱ	View protein in PROSITE PS00461 6PGD, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P14062-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK 
        60         70         80         90        100
LVPYYTVKEF VESLETPRRI LLMVKAGAGT DAAIDSLKPY LEKGDIIIDG 
       110        120        130        140        150
GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKDAYE 
       160        170        180        190        200
LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA 
       210        220        230        240        250
YSLLKGGLNL SNEELANTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV 
       260        270        280        290        300
DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS 
       310        320        330        340        350
KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASDEYHWD 
       360        370        380        390        400
LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NADIANLLLA PYFKKIADEY 
       410        420        430        440        450
QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA 
       460 
HTYKRTDKEG IFHTEWLE

Length:468

Mass (Da):51,395

Last modified:January 1, 1990 - v1

Checksum:ⁱD8EBB53A2DAADBF7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15651 Genomic DNA Translation: CAA33677.1 M64332 Genomic DNA Translation: AAA27137.1 AE006468 Genomic DNA Translation: AAL20985.1 X56793 Genomic DNA Translation: CAA40131.1
PIRⁱ	S04397
NCBI Reference Sequences More...RefSeqⁱ	NP_461026.1, NC_003197.2 WP_000043530.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaⁱ	AAL20985; AAL20985; STM2081
GeneIDⁱ	1253602
KEGGⁱ	stm:STM2081
PATRICⁱ	fig\|99287.12.peg.2203

Protein	Similar proteins		Species	Score	Length
P14062	6-phosphogluconate dehydrogenase, decarboxylating	)	ECOLI		468
6-phosphogluconate dehydrogenase, decarboxylating		ECOLX		468
6-phosphogluconate dehydrogenase, decarboxylating		SHIBO		468
6-phosphogluconate dehydrogenase, decarboxylating		Escherichia coli DORA_A_5_14_21		468
6-phosphogluconate dehydrogenase, decarboxylating		Escherichia coli M056		468
+2333

Protein	Similar proteins		Species	Score	Length
P14062	6-phosphogluconate dehydrogenase, decarboxylating	)	ECOLI		468
6-phosphogluconate dehydrogenase, decarboxylating		ECOLX		468
6-phosphogluconate dehydrogenase, decarboxylating		SHIBO		468
6-phosphogluconate dehydrogenase, decarboxylating		Escherichia coli DORA_A_5_14_21		468
6-phosphogluconate dehydrogenase, decarboxylating		Escherichia coli M056		468
+3278

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15651 Genomic DNA Translation: CAA33677.1 M64332 Genomic DNA Translation: AAA27137.1 AE006468 Genomic DNA Translation: AAL20985.1 X56793 Genomic DNA Translation: CAA40131.1
PIRⁱ	S04397
NCBI Reference Sequences More...RefSeqⁱ	NP_461026.1, NC_003197.2 WP_000043530.1, NC_003197.2

3D structure databases

ProteinModelPortalⁱ	P14062
SMRⁱ	P14062
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	99287.STM2081

STRINGⁱ

99287.STM2081

Proteomic databases

PaxDbⁱ	P14062
PRIDEⁱ	P14062

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAL20985; AAL20985; STM2081
GeneIDⁱ	1253602
KEGGⁱ	stm:STM2081
PATRICⁱ	fig\|99287.12.peg.2203

Phylogenomic databases

eggNOGⁱ	ENOG4105C7Q Bacteria COG0362 LUCA
HOGENOMⁱ	HOG000255147
KEGG Orthology (KO) More...KOⁱ	K00033
OMAⁱ	NSHYPDS
PhylomeDBⁱ	P14062

Enzyme and pathway databases

UniPathwayⁱ	UPA00115; UER00410
BioCycⁱ	SENT99287:G1FZD-2100-MONOMER

Family and domain databases

Gene3Dⁱ	1.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR006114 6PGDH_C IPR006113 6PGDH_Gnd/GntZ IPR006115 6PGDH_NADP-bd IPR006184 6PGdom_BS IPR036291 NAD(P)-bd_dom_sf IPR006183 Pgluconate_DH
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00393 6PGD, 1 hit PF03446 NAD_binding_2, 1 hit
PIRSFⁱ	PIRSF000109 6PGD, 1 hit
PRINTSⁱ	PR00076 6PGDHDRGNASE
SMARTⁱ	View protein in SMART SM01350 6PGD, 1 hit
SUPFAMⁱ	SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR00873 gnd, 1 hit
PROSITEⁱ	View protein in PROSITE PS00461 6PGD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	6PGD_SALTY
Accessionⁱ	P14062Primary (citable) accession number: P14062
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	February 28, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - P14062 (6PGD_SALTY)

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6-phosphogluconate dehydrogenase, decarboxylating

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

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Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

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Proteomic databases

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Functionⁱ

Pathwayⁱ: pentose phosphate pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ