UniProtKB - P14062 (6PGD_SALTY)
Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
gnd
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Functioni
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity
Catalytic activityi
- EC:1.1.1.44
: pentose phosphate pathway Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (zwf)
- 6-phosphogluconolactonase (pgl)
- 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 102 | NADPBy similarity | 1 | |
Binding sitei | 102 | SubstrateBy similarity | 1 | |
Active sitei | 183 | Proton acceptorBy similarity | 1 | |
Active sitei | 190 | Proton donorBy similarity | 1 | |
Binding sitei | 191 | SubstrateBy similarity | 1 | |
Binding sitei | 260 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 287 | SubstrateBy similarity | 1 | |
Binding sitei | 445 | Substrate; shared with dimeric partnerBy similarity | 1 | |
Binding sitei | 451 | Substrate; shared with dimeric partnerBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 15 | NADPBy similarity | 6 | |
Nucleotide bindingi | 33 – 35 | NADPBy similarity | 3 | |
Nucleotide bindingi | 74 – 76 | NADPBy similarity | 3 |
GO - Molecular functioni
- NADP binding Source: GO_Central
- phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB
GO - Biological processi
- D-gluconate catabolic process Source: GO_Central
- pentose-phosphate shunt Source: UniProtKB
- pentose-phosphate shunt, oxidative branch Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Gluconate utilization, Pentose shunt |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00410 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gnd Ordered Locus Names:STM2081 |
Organismi | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
Taxonomic identifieri | 99287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090047 | 1 – 468 | 6-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST | 468 |
Proteomic databases
PaxDbi | P14062 |
PRIDEi | P14062 |
Interactioni
Subunit structurei
Homodimer.
By similarityFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 128 – 130 | Substrate bindingBy similarity | 3 | |
Regioni | 186 – 187 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the 6-phosphogluconate dehydrogenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_024540_4_2_6 |
OMAi | VIMVKAG |
PhylomeDBi | P14062 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006114, 6PGDH_C IPR006113, 6PGDH_Gnd/GntZ IPR006115, 6PGDH_NADP-bd IPR006184, 6PGdom_BS IPR036291, NAD(P)-bd_dom_sf IPR006183, Pgluconate_DH |
PANTHERi | PTHR11811, PTHR11811, 1 hit |
Pfami | View protein in Pfam PF00393, 6PGD, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000109, 6PGD, 1 hit |
PRINTSi | PR00076, 6PGDHDRGNASE |
SMARTi | View protein in SMART SM01350, 6PGD, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00873, gnd, 1 hit |
PROSITEi | View protein in PROSITE PS00461, 6PGD, 1 hit |
i Sequence
Sequence statusi: Complete.
P14062-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK
60 70 80 90 100
LVPYYTVKEF VESLETPRRI LLMVKAGAGT DAAIDSLKPY LEKGDIIIDG
110 120 130 140 150
GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKDAYE
160 170 180 190 200
LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA
210 220 230 240 250
YSLLKGGLNL SNEELANTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV
260 270 280 290 300
DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS
310 320 330 340 350
KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASDEYHWD
360 370 380 390 400
LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NADIANLLLA PYFKKIADEY
410 420 430 440 450
QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA
460
HTYKRTDKEG IFHTEWLE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15651 Genomic DNA Translation: CAA33677.1 M64332 Genomic DNA Translation: AAA27137.1 AE006468 Genomic DNA Translation: AAL20985.1 X56793 Genomic DNA Translation: CAA40131.1 |
PIRi | S04397 |
RefSeqi | NP_461026.1, NC_003197.2 WP_000043530.1, NC_003197.2 |
Genome annotation databases
EnsemblBacteriai | AAL20985; AAL20985; STM2081 |
GeneIDi | 1253602 |
KEGGi | stm:STM2081 |
PATRICi | fig|99287.12.peg.2203 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15651 Genomic DNA Translation: CAA33677.1 M64332 Genomic DNA Translation: AAA27137.1 AE006468 Genomic DNA Translation: AAL20985.1 X56793 Genomic DNA Translation: CAA40131.1 |
PIRi | S04397 |
RefSeqi | NP_461026.1, NC_003197.2 WP_000043530.1, NC_003197.2 |
3D structure databases
SMRi | P14062 |
ModBasei | Search... |
Proteomic databases
PaxDbi | P14062 |
PRIDEi | P14062 |
Genome annotation databases
EnsemblBacteriai | AAL20985; AAL20985; STM2081 |
GeneIDi | 1253602 |
KEGGi | stm:STM2081 |
PATRICi | fig|99287.12.peg.2203 |
Phylogenomic databases
HOGENOMi | CLU_024540_4_2_6 |
OMAi | VIMVKAG |
PhylomeDBi | P14062 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00410 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006114, 6PGDH_C IPR006113, 6PGDH_Gnd/GntZ IPR006115, 6PGDH_NADP-bd IPR006184, 6PGdom_BS IPR036291, NAD(P)-bd_dom_sf IPR006183, Pgluconate_DH |
PANTHERi | PTHR11811, PTHR11811, 1 hit |
Pfami | View protein in Pfam PF00393, 6PGD, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000109, 6PGD, 1 hit |
PRINTSi | PR00076, 6PGDHDRGNASE |
SMARTi | View protein in SMART SM01350, 6PGD, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00873, gnd, 1 hit |
PROSITEi | View protein in PROSITE PS00461, 6PGD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 6PGD_SALTY | |
Accessioni | P14062Primary (citable) accession number: P14062 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families