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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

HSD17B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66NADP1 Publication1
Binding sitei143Substrate1 Publication1
Active sitei156Proton acceptor1
Binding sitei160NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 38NADP1 PublicationAdd BLAST29

GO - Molecular functioni

  • catalytic activity Source: ProtInc
  • estradiol 17-beta-dehydrogenase activity Source: CAFA
  • estradiol binding Source: CAFA
  • NADP+ binding Source: CAFA
  • steroid binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-193144 Estrogen biosynthesis
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SABIO-RKiP14061
UniPathwayi
UPA00769

Chemistry databases

SwissLipidsiSLP:000001218

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
20 alpha-hydroxysteroid dehydrogenase
Short name:
20-alpha-HSD
E2DH
Placental 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 28C member 1
Gene namesi
Name:HSD17B1
Synonyms:E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108786.10
HGNCiHGNC:5210 HSD17B1
MIMi109684 gene
neXtProtiNX_P14061

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi150L → V: Alters substrate specificity. 1 Publication1

Organism-specific databases

DisGeNETi3292
OpenTargetsiENSG00000108786
PharmGKBiPA29478

Chemistry databases

ChEMBLiCHEMBL3181
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01536 4-Androstenedione
DB01561 Androstanedione
DB02901 Dihydrotestosterone
DB02323 EM-1745
DB02187 Equilin
DB00157 NADH
DB01708 Prasterone

Polymorphism and mutation databases

BioMutaiHSD17B1
DMDMi313104233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000545672 – 328Estradiol 17-beta-dehydrogenase 1Add BLAST327

Proteomic databases

PaxDbiP14061
PeptideAtlasiP14061
PRIDEiP14061
ProteomicsDBi53018

PTM databases

SwissPalmiP14061

Expressioni

Gene expression databases

BgeeiENSG00000108786 Expressed in 114 organ(s), highest expression level in chorionic villus
CleanExiHS_HSD17B1
ExpressionAtlasiP14061 baseline and differential
GenevisibleiP14061 HS

Organism-specific databases

HPAiHPA021032
HPA065296

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109525, 15 interactors
IntActiP14061, 2 interactors
STRINGi9606.ENSP00000466799

Chemistry databases

BindingDBiP14061

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00023
ProteinModelPortaliP14061
SMRiP14061
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14061

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00930000150823
HOVERGENiHBG014077
InParanoidiP14061
KOiK00044
PhylomeDBiP14061

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P14061-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA
60 70 80 90 100
RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL
110 120 130 140 150
EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL
160 170 180 190 200
PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS
210 220 230 240 250
PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP
260 270 280 290 300
TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG
310 320
GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
Length:328
Mass (Da):34,950
Last modified:November 30, 2010 - v3
Checksum:i5B5C8909F9120832
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS7A0A0A0MQS7_HUMAN
Estradiol 17-beta-dehydrogenase 1
HSD17B1
329Annotation score:
B4DU11B4DU11_HUMAN
Estradiol 17-beta-dehydrogenase 1
HSD17B1
149Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → E AA sequence (PubMed:5045524).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006951238A → V1 PublicationCorresponds to variant dbSNP:rs147402365Ensembl.1
Natural variantiVAR_006952313G → S10 PublicationsCorresponds to variant dbSNP:rs605059Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA Translation: CAA31792.1
M36263 mRNA Translation: AAA35600.1
M27138 Genomic DNA Translation: AAB16941.1
M84472 Genomic DNA Translation: AAB16942.1
U34879 Genomic DNA Translation: AAD05019.1
AK127832 mRNA Translation: BAG54583.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60836.1
BC104752 mRNA Translation: AAI04753.1
BC111935 mRNA Translation: AAI11936.1
CCDSiCCDS11428.1
PIRiA36081 DEHUE7
RefSeqiNP_000404.2, NM_000413.3
UniGeneiHs.654385
Hs.655222

Genome annotation databases

EnsembliENST00000585807; ENSP00000466799; ENSG00000108786
GeneIDi3292
KEGGihsa:3292
UCSCiuc002hzw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA Translation: CAA31792.1
M36263 mRNA Translation: AAA35600.1
M27138 Genomic DNA Translation: AAB16941.1
M84472 Genomic DNA Translation: AAB16942.1
U34879 Genomic DNA Translation: AAD05019.1
AK127832 mRNA Translation: BAG54583.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60836.1
BC104752 mRNA Translation: AAI04753.1
BC111935 mRNA Translation: AAI11936.1
CCDSiCCDS11428.1
PIRiA36081 DEHUE7
RefSeqiNP_000404.2, NM_000413.3
UniGeneiHs.654385
Hs.655222

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A27X-ray1.90A2-290[»]
1BHSX-ray2.20A2-328[»]
1DHTX-ray2.24A2-328[»]
1EQUX-ray3.00A/B2-328[»]
1FDSX-ray1.70A2-328[»]
1FDTX-ray2.20A2-328[»]
1FDUX-ray2.70A/B/C/D2-328[»]
1FDVX-ray3.10A/B/C/D2-328[»]
1FDWX-ray2.70A2-328[»]
1I5RX-ray1.60A2-328[»]
1IOLX-ray2.30A2-328[»]
1JTVX-ray1.54A2-328[»]
1QYVX-ray1.81A2-328[»]
1QYWX-ray1.63A2-328[»]
1QYXX-ray1.89A2-328[»]
3DEYX-ray1.70X2-328[»]
3DHEX-ray2.30A2-328[»]
3HB4X-ray2.21X2-328[»]
3HB5X-ray2.00X2-328[»]
3KLMX-ray1.70X2-328[»]
3KLPX-ray2.50X2-328[»]
3KM0X-ray2.30A/B2-328[»]
6DTPX-ray2.00A/B1-328[»]
DisProtiDP00023
ProteinModelPortaliP14061
SMRiP14061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109525, 15 interactors
IntActiP14061, 2 interactors
STRINGi9606.ENSP00000466799

Chemistry databases

BindingDBiP14061
ChEMBLiCHEMBL3181
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01536 4-Androstenedione
DB01561 Androstanedione
DB02901 Dihydrotestosterone
DB02323 EM-1745
DB02187 Equilin
DB00157 NADH
DB01708 Prasterone
SwissLipidsiSLP:000001218

PTM databases

SwissPalmiP14061

Polymorphism and mutation databases

BioMutaiHSD17B1
DMDMi313104233

Proteomic databases

PaxDbiP14061
PeptideAtlasiP14061
PRIDEiP14061
ProteomicsDBi53018

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585807; ENSP00000466799; ENSG00000108786
GeneIDi3292
KEGGihsa:3292
UCSCiuc002hzw.4 human

Organism-specific databases

CTDi3292
DisGeNETi3292
EuPathDBiHostDB:ENSG00000108786.10
GeneCardsiHSD17B1
H-InvDBiHIX0202506
HGNCiHGNC:5210 HSD17B1
HPAiHPA021032
HPA065296
MIMi109684 gene
neXtProtiNX_P14061
OpenTargetsiENSG00000108786
PharmGKBiPA29478
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00930000150823
HOVERGENiHBG014077
InParanoidiP14061
KOiK00044
PhylomeDBiP14061

Enzyme and pathway databases

UniPathwayi
UPA00769

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-193144 Estrogen biosynthesis
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SABIO-RKiP14061

Miscellaneous databases

EvolutionaryTraceiP14061
GeneWikiiHSD17B1
GenomeRNAii3292
PROiPR:P14061
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108786 Expressed in 114 organ(s), highest expression level in chorionic villus
CleanExiHS_HSD17B1
ExpressionAtlasiP14061 baseline and differential
GenevisibleiP14061 HS

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHB1_HUMAN
AccessioniPrimary (citable) accession number: P14061
Secondary accession number(s): B3KXS1, Q2M2L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 197 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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