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UniProtKB - P14061 (DHB1_HUMAN)

Entry version 200 (13 Feb 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

HSD17B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei66NADP1 Publication1
Binding sitei143Substrate1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei156Proton acceptor1
Binding sitei160NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 38NADP1 PublicationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • catalytic activity Source: ProtInc
  • estradiol 17-beta-dehydrogenase activity Source: CAFA
  • estradiol binding Source: CAFA
  • NADP+ binding Source: CAFA
  • steroid binding Source: CAFA
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.62 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193144 Estrogen biosynthesis
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P14061

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00769

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001218

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
20 alpha-hydroxysteroid dehydrogenase
Short name:
20-alpha-HSD
E2DH
Placental 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 28C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD17B1
Synonyms:E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108786.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:5210 HSD17B1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		109684 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14061

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150L → V: Alters substrate specificity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3292

Open Targets

More...OpenTargetsi		ENSG00000108786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29478

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3181

Drug and drug target database

More...DrugBanki		DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01536 4-Androstenedione
DB01561 Androstanedione
DB02901 Dihydrotestosterone
DB02323 EM-1745
DB02187 Equilin
DB00157 NADH
DB01708 Prasterone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HSD17B1

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104233

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000545672 – 328Estradiol 17-beta-dehydrogenase 1Add BLAST327

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14061

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14061

PeptideAtlas

More...PeptideAtlasi		P14061

PRoteomics IDEntifications database

More...PRIDEi		P14061

ProteomicsDB human proteome resource

More...ProteomicsDBi		53018

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P14061

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108786 Expressed in 114 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14061 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14061 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA021032
HPA065296

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109525, 15 interactors

Protein interaction database and analysis system

More...IntActi		P14061, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000466799

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14061

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A27X-ray1.90A2-290[»]
1BHSX-ray2.20A2-328[»]
1DHTX-ray2.24A2-328[»]
1EQUX-ray3.00A/B2-328[»]
1FDSX-ray1.70A2-328[»]
1FDTX-ray2.20A2-328[»]
1FDUX-ray2.70A/B/C/D2-328[»]
1FDVX-ray3.10A/B/C/D2-328[»]
1FDWX-ray2.70A2-328[»]
1I5RX-ray1.60A2-328[»]
1IOLX-ray2.30A2-328[»]
1JTVX-ray1.54A2-328[»]
1QYVX-ray1.81A2-328[»]
1QYWX-ray1.63A2-328[»]
1QYXX-ray1.89A2-328[»]
3DEYX-ray1.70X2-328[»]
3DHEX-ray2.30A2-328[»]
3HB4X-ray2.21X2-328[»]
3HB5X-ray2.00X2-328[»]
3KLMX-ray1.70X2-328[»]
3KLPX-ray2.50X2-328[»]
3KM0X-ray2.30A/B2-328[»]
6DTPX-ray2.00A/B1-328[»]

Database of protein disorder

More...DisProti		DP00023

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P14061

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14061

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14061

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1205 Eukaryota
COG1028 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160415

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG014077

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14061

KEGG Orthology (KO)

More...KOi		K00044

Database of Orthologous Groups

More...OrthoDBi		319635at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14061

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106 adh_short, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000095 17beta-HSD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P14061-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA 
        60         70         80         90        100
RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL 
       110        120        130        140        150
EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL 
       160        170        180        190        200
PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS 
       210        220        230        240        250
PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP 
       260        270        280        290        300
TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 
       310        320 
GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
Length:328
Mass (Da):34,950
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B5C8909F9120832
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS7A0A0A0MQS7_HUMAN
Estradiol 17-beta-dehydrogenase 1
HSD17B1
329Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DU11B4DU11_HUMAN
Estradiol 17-beta-dehydrogenase 1
HSD17B1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3R → E AA sequence (PubMed:5045524).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_006951238A → V1 PublicationCorresponds to variant dbSNP:rs147402365Ensembl.1
Natural variantiVAR_006952313G → S10 PublicationsCorresponds to variant dbSNP:rs605059Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X13440 mRNA Translation: CAA31792.1
M36263 mRNA Translation: AAA35600.1
M27138 Genomic DNA Translation: AAB16941.1
M84472 Genomic DNA Translation: AAB16942.1
U34879 Genomic DNA Translation: AAD05019.1
AK127832 mRNA Translation: BAG54583.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60836.1
BC104752 mRNA Translation: AAI04753.1
BC111935 mRNA Translation: AAI11936.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11428.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36081 DEHUE7

NCBI Reference Sequences

More...RefSeqi		NP_000404.2, NM_000413.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.654385
Hs.655222

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000585807; ENSP00000466799; ENSG00000108786

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3292

UCSC genome browser

More...UCSCi		uc002hzw.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA Translation: CAA31792.1
M36263 mRNA Translation: AAA35600.1
M27138 Genomic DNA Translation: AAB16941.1
M84472 Genomic DNA Translation: AAB16942.1
U34879 Genomic DNA Translation: AAD05019.1
AK127832 mRNA Translation: BAG54583.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60836.1
BC104752 mRNA Translation: AAI04753.1
BC111935 mRNA Translation: AAI11936.1
CCDSiCCDS11428.1
PIRiA36081 DEHUE7
RefSeqiNP_000404.2, NM_000413.3
UniGeneiHs.654385
Hs.655222

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A27X-ray1.90A2-290[»]
1BHSX-ray2.20A2-328[»]
1DHTX-ray2.24A2-328[»]
1EQUX-ray3.00A/B2-328[»]
1FDSX-ray1.70A2-328[»]
1FDTX-ray2.20A2-328[»]
1FDUX-ray2.70A/B/C/D2-328[»]
1FDVX-ray3.10A/B/C/D2-328[»]
1FDWX-ray2.70A2-328[»]
1I5RX-ray1.60A2-328[»]
1IOLX-ray2.30A2-328[»]
1JTVX-ray1.54A2-328[»]
1QYVX-ray1.81A2-328[»]
1QYWX-ray1.63A2-328[»]
1QYXX-ray1.89A2-328[»]
3DEYX-ray1.70X2-328[»]
3DHEX-ray2.30A2-328[»]
3HB4X-ray2.21X2-328[»]
3HB5X-ray2.00X2-328[»]
3KLMX-ray1.70X2-328[»]
3KLPX-ray2.50X2-328[»]
3KM0X-ray2.30A/B2-328[»]
6DTPX-ray2.00A/B1-328[»]
DisProtiDP00023
ProteinModelPortaliP14061
SMRiP14061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109525, 15 interactors
IntActiP14061, 2 interactors
STRINGi9606.ENSP00000466799

Chemistry databases

BindingDBiP14061
ChEMBLiCHEMBL3181
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01536 4-Androstenedione
DB01561 Androstanedione
DB02901 Dihydrotestosterone
DB02323 EM-1745
DB02187 Equilin
DB00157 NADH
DB01708 Prasterone
SwissLipidsiSLP:000001218

PTM databases

SwissPalmiP14061

Polymorphism and mutation databases

BioMutaiHSD17B1
DMDMi313104233

Proteomic databases

jPOSTiP14061
PaxDbiP14061
PeptideAtlasiP14061
PRIDEiP14061
ProteomicsDBi53018

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585807; ENSP00000466799; ENSG00000108786
GeneIDi3292
KEGGihsa:3292
UCSCiuc002hzw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3292
DisGeNETi3292
EuPathDBiHostDB:ENSG00000108786.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		HSD17B1

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0202506
HGNCiHGNC:5210 HSD17B1
HPAiHPA021032
HPA065296
MIMi109684 gene
neXtProtiNX_P14061
OpenTargetsiENSG00000108786
PharmGKBiPA29478

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00940000160415
HOVERGENiHBG014077
InParanoidiP14061
KOiK00044
OrthoDBi319635at2759
PhylomeDBiP14061

Enzyme and pathway databases

UniPathwayi
UPA00769

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-193144 Estrogen biosynthesis
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SABIO-RKiP14061

Miscellaneous databases

EvolutionaryTraceiP14061

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HSD17B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3292

Protein Ontology

More...PROi		PR:P14061

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108786 Expressed in 114 organ(s), highest expression level in chorionic villus
ExpressionAtlasiP14061 baseline and differential
GenevisibleiP14061 HS

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14061
Secondary accession number(s): B3KXS1, Q2M2L8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 200 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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