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UniProtKB - P14061 (DHB1_HUMAN)

Entry version 214 (02 Dec 2020)
Sequence version 3 (30 Nov 2010)
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Protein

17-beta-hydroxysteroid dehydrogenase type 1

Gene

HSD17B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.11 µM for 17beta-estradiol1 Publication
  2. KM=0.9 µM for estrone1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: estrogen biosynthesis

    This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.1 Publication
    View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei66NADP1 Publication1
    Binding sitei143Substrate1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei156Proton acceptor1
    Binding sitei160NADP1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 38NADP1 PublicationAdd BLAST29

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
    LigandNADP

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.1.1.62, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P14061

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-193144, Estrogen biosynthesis
    R-HSA-2453902, The canonical retinoid cycle in rods (twilight vision)

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P14061

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00769

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000001218

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    17-beta-hydroxysteroid dehydrogenase type 1Curated (EC:1.1.1.51By similarity)
    Short name:
    17-beta-HSD 1
    Alternative name(s):
    20 alpha-hydroxysteroid dehydrogenase
    Short name:
    20-alpha-HSD
    E2DH
    Estradiol 17-beta-dehydrogenase 1Curated (EC:1.1.1.621 Publication)
    Placental 17-beta-hydroxysteroid dehydrogenase
    Short chain dehydrogenase/reductase family 28C member 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HSD17B1Imported
    Synonyms:E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000108786.10

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:5210, HSD17B1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		109684, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P14061

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi112 – 114LDV → F: Loss of 17-beta-hydroxysteroid dehydrogenase activity. 1 Publication3
    Mutagenesisi135S → A: Abolishes phosphorylation. No effect on 17-beta-hydroxysteroid dehydrogenase activity. 1 Publication1
    Mutagenesisi143S → A: Loss of 17-beta-hydroxysteroid dehydrogenase activity. 1 Publication1
    Mutagenesisi150L → V: Alters substrate specificity. 1 Publication1
    Mutagenesisi156Y → A: Loss of 17-beta-hydroxysteroid dehydrogenase activity. 1 Publication1
    Mutagenesisi160K → A: Loss of 17-beta-hydroxysteroid dehydrogenase activity. 1 Publication1
    Mutagenesisi171A → AEF: Loss of 17-beta-hydroxysteroid dehydrogenase activity. 1 Publication1
    Mutagenesisi222H → A: No effect on conversion of estrone to 17beta-estradiol. 1 Publication1
    Mutagenesisi283E → A: No effect on conversion of estrone to 17beta-estradiol. 1 Publication1
    Mutagenesisi283E → Q: No effect on conversion of estrone to 17beta-estradiol. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		3292

    Open Targets

    More...    OpenTargetsi    		ENSG00000108786

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA29478

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P14061, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3181

    Drug and drug target database

    More...    DrugBanki    		DB01561, Androstanedione
    DB01536, Androstenedione
    DB02323, EM-1745
    DB02187, Equilin
    DB00157, NADH
    DB03461, Nicotinamide adenine dinucleotide phosphate
    DB01708, Prasterone
    DB02901, Stanolone
    DB13951, Stanolone acetate

    DrugCentral

    More...    DrugCentrali    		P14061

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		HSD17B1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		313104233

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000545672 – 32817-beta-hydroxysteroid dehydrogenase type 1Add BLAST327

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei135Phosphoserine; by PKA1 Publication1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P14061

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P14061

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P14061

    PeptideAtlas

    More...    PeptideAtlasi    		P14061

    PRoteomics IDEntifications database

    More...    PRIDEi    		P14061

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		53018

    PTM databases

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P14061

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000108786, Expressed in chorionic villus and 139 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P14061, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P14061, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000108786, Tissue enriched (placenta)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer. Exists predominantly as an homodimer but also exits as monomer.

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		109525, 16 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P14061, 2 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000466799

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P14061

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P14061, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1328
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P14061

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P14061

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1205, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000160415

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_010194_2_9_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P14061

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P14061

    Family and domain databases

    Database of protein disorder

    More...    DisProti    		DP00023

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR011348, 17beta_DH
    IPR036291, NAD(P)-bd_dom_sf
    IPR020904, Sc_DH/Rdtase_CS
    IPR002347, SDR_fam

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00106, adh_short, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF000095, 17beta-HSD, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00081, GDHRDH
    PR00080, SDRFAMILY

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51735, SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00061, ADH_SHORT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    P14061-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA 
            60         70         80         90        100
    RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL 
           110        120        130        140        150
    EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL 
           160        170        180        190        200
    PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS 
           210        220        230        240        250
    PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP 
           260        270        280        290        300
    TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 
           310        320 
    GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
    Length:328
    Mass (Da):34,950
    Last modified:November 30, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B5C8909F9120832
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A0A0A0MQS7A0A0A0MQS7_HUMAN
    Estradiol 17-beta-dehydrogenase
    HSD17B1
    		329Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B4DU11B4DU11_HUMAN
    Estradiol 17-beta-dehydrogenase 1
    HSD17B1
    		149Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3R → E AA sequence (PubMed:5045524).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_006951238A → V1 PublicationCorresponds to variant dbSNP:rs147402365Ensembl.1
    Natural variantiVAR_006952313G → S10 PublicationsCorresponds to variant dbSNP:rs605059Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		X13440 mRNA Translation: CAA31792.1
    M36263 mRNA Translation: AAA35600.1
    M27138 Genomic DNA Translation: AAB16941.1
    M84472 Genomic DNA Translation: AAB16942.1
    U34879 Genomic DNA Translation: AAD05019.1
    AK127832 mRNA Translation: BAG54583.1
    AC067852 Genomic DNA No translation available.
    CH471152 Genomic DNA Translation: EAW60836.1
    BC104752 mRNA Translation: AAI04753.1
    BC111935 mRNA Translation: AAI11936.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS11428.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A36081, DEHUE7

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000404.2, NM_000413.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000585807; ENSP00000466799; ENSG00000108786

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		3292

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:3292

    UCSC genome browser

    More...    UCSCi    		uc002hzw.4, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		X13440 mRNA Translation: CAA31792.1
    M36263 mRNA Translation: AAA35600.1
    M27138 Genomic DNA Translation: AAB16941.1
    M84472 Genomic DNA Translation: AAB16942.1
    U34879 Genomic DNA Translation: AAD05019.1
    AK127832 mRNA Translation: BAG54583.1
    AC067852 Genomic DNA No translation available.
    CH471152 Genomic DNA Translation: EAW60836.1
    BC104752 mRNA Translation: AAI04753.1
    BC111935 mRNA Translation: AAI11936.1
    CCDSiCCDS11428.1
    PIRiA36081, DEHUE7
    RefSeqiNP_000404.2, NM_000413.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1A27X-ray1.90A2-290[»]
    1BHSX-ray2.20A2-328[»]
    1DHTX-ray2.24A2-328[»]
    1EQUX-ray3.00A/B2-328[»]
    1FDSX-ray1.70A2-328[»]
    1FDTX-ray2.20A2-328[»]
    1FDUX-ray2.70A/B/C/D2-328[»]
    1FDVX-ray3.10A/B/C/D2-328[»]
    1FDWX-ray2.70A2-328[»]
    1I5RX-ray1.60A2-328[»]
    1IOLX-ray2.30A2-328[»]
    1JTVX-ray1.54A2-328[»]
    1QYVX-ray1.81A2-328[»]
    1QYWX-ray1.63A2-328[»]
    1QYXX-ray1.89A2-328[»]
    3DEYX-ray1.70X2-328[»]
    3DHEX-ray2.30A2-328[»]
    3HB4X-ray2.21X2-328[»]
    3HB5X-ray2.00X2-328[»]
    3KLMX-ray1.70X2-328[»]
    3KLPX-ray2.50X2-328[»]
    3KM0X-ray2.30A/B2-328[»]
    6CGCX-ray2.10A/B1-328[»]
    6CGEX-ray2.20A/B1-328[»]
    6DTPX-ray2.00A/B1-328[»]
    6MNCX-ray2.40A/B1-328[»]
    6MNEX-ray1.86A/B1-328[»]
    SMRiP14061
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi109525, 16 interactors
    IntActiP14061, 2 interactors
    STRINGi9606.ENSP00000466799

    Chemistry databases

    BindingDBiP14061
    ChEMBLiCHEMBL3181
    DrugBankiDB01561, Androstanedione
    DB01536, Androstenedione
    DB02323, EM-1745
    DB02187, Equilin
    DB00157, NADH
    DB03461, Nicotinamide adenine dinucleotide phosphate
    DB01708, Prasterone
    DB02901, Stanolone
    DB13951, Stanolone acetate
    DrugCentraliP14061
    SwissLipidsiSLP:000001218

    PTM databases

    SwissPalmiP14061

    Polymorphism and mutation databases

    BioMutaiHSD17B1
    DMDMi313104233

    Proteomic databases

    jPOSTiP14061
    MassIVEiP14061
    PaxDbiP14061
    PeptideAtlasiP14061
    PRIDEiP14061
    ProteomicsDBi53018

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		16966, 284 antibodies

    Genome annotation databases

    EnsembliENST00000585807; ENSP00000466799; ENSG00000108786
    GeneIDi3292
    KEGGihsa:3292
    UCSCiuc002hzw.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		3292
    DisGeNETi3292
    EuPathDBiHostDB:ENSG00000108786.10

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		HSD17B1
    HGNCiHGNC:5210, HSD17B1
    HPAiENSG00000108786, Tissue enriched (placenta)
    MIMi109684, gene
    neXtProtiNX_P14061
    OpenTargetsiENSG00000108786
    PharmGKBiPA29478

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1205, Eukaryota
    GeneTreeiENSGT00940000160415
    HOGENOMiCLU_010194_2_9_1
    InParanoidiP14061
    PhylomeDBiP14061

    Enzyme and pathway databases

    UniPathwayiUPA00769
    BRENDAi1.1.1.62, 2681
    PathwayCommonsiP14061
    ReactomeiR-HSA-193144, Estrogen biosynthesis
    R-HSA-2453902, The canonical retinoid cycle in rods (twilight vision)
    SABIO-RKiP14061

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		3292, 3 hits in 844 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		HSD17B1, human
    EvolutionaryTraceiP14061

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		HSD17B1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		3292
    PharosiP14061, Tchem

    Protein Ontology

    More...    PROi    		PR:P14061
    RNActiP14061, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000108786, Expressed in chorionic villus and 139 other tissues
    ExpressionAtlasiP14061, baseline and differential
    GenevisibleiP14061, HS

    Family and domain databases

    DisProtiDP00023
    InterProiView protein in InterPro
    IPR011348, 17beta_DH
    IPR036291, NAD(P)-bd_dom_sf
    IPR020904, Sc_DH/Rdtase_CS
    IPR002347, SDR_fam
    PfamiView protein in Pfam
    PF00106, adh_short, 1 hit
    PIRSFiPIRSF000095, 17beta-HSD, 1 hit
    PRINTSiPR00081, GDHRDH
    PR00080, SDRFAMILY
    SUPFAMiSSF51735, SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00061, ADH_SHORT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHB1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14061
    Secondary accession number(s): B3KXS1, Q2M2L8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: November 30, 2010
    Last modified: December 2, 2020
    This is version 214 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
    6. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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