UniProtKB - P14061 (DHB1_HUMAN)

BLAST

>sp|P14061|DHB1_HUMAN Estradiol 17-beta-dehydrogenase 1 OS=Homo sapiens OX=9606 GN=HSD17B1 PE=1 SV=3
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ

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History
Entry version 196 (12 Sep 2018)
Sequence version 3 (30 Nov 2010)
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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

HSD17B1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Catalytic activityⁱ

17-beta-estradiol + NAD(P)⁺ = estrone + NAD(P)H.

Pathwayⁱ: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	66	NADP1 Publication	1
Binding siteⁱ	143	Substrate1 Publication	1
Active siteⁱ	156	Proton acceptor	1
Binding siteⁱ	160	NADP1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 38	NADP1 PublicationAdd BLAST		29

GO - Molecular functionⁱ

catalytic activity
Source: ProtInc
Traceable author statementⁱ
- 8547176
estradiol 17-beta-dehydrogenase activity
Source: CAFA
Inferred from direct assayⁱ
estradiol binding
Source: CAFA
Inferred from direct assayⁱ
- 10625652
NADP+ binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 9525918
steroid binding
Source: CAFA
Inferred from direct assayⁱ
- 4396689

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

estrogen biosynthetic process Source: Reactome
estrogen metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2584224
steroid biosynthetic process
Source: ProtInc
Traceable author statementⁱ
- 8547176

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
Ligand	NADP

Enzyme and pathway databases

BRENDAⁱ	1.1.1.62 2681
Reactomeⁱ	R-HSA-193144 Estrogen biosynthesis R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SABIO-RKⁱ	P14061
UniPathwayⁱ	UPA00769

Chemistry databases

SwissLipidsⁱ	SLP:000001218

SwissLipidsⁱ

SLP:000001218

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62) Alternative name(s): 17-beta-hydroxysteroid dehydrogenase type 1 Short name: 17-beta-HSD 1 20 alpha-hydroxysteroid dehydrogenase Short name: 20-alpha-HSD E2DH Placental 17-beta-hydroxysteroid dehydrogenase Short chain dehydrogenase/reductase family 28C member 1
Gene namesⁱ	Name:HSD17B1 Synonyms:E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108786.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5210 HSD17B1
MIMⁱ	109684 gene
neXtProtⁱ	NX_P14061

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	150	L → V: Alters substrate specificity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3292
Open Targets More...OpenTargetsⁱ	ENSG00000108786
PharmGKBⁱ	PA29478

Chemistry databases

ChEMBLⁱ	CHEMBL3181
Drug and drug target database More...DrugBankⁱ	DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose DB01536 4-Androstenedione DB01561 Androstanedione DB02901 Dihydrotestosterone DB02323 EM-1745 DB02187 Equilin DB00157 NADH DB01708 Prasterone

Polymorphism and mutation databases

BioMutaⁱ	HSD17B1
DMDMⁱ	313104233

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000054567	2 – 328	Estradiol 17-beta-dehydrogenase 1Add BLAST		327

Proteomic databases

PaxDbⁱ	P14061
PeptideAtlas More...PeptideAtlasⁱ	P14061
PRIDEⁱ	P14061
ProteomicsDBⁱ	53018

PTM databases

SwissPalmⁱ	P14061

SwissPalmⁱ

P14061

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108786 Expressed in 114 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_HSD17B1
ExpressionAtlasⁱ	P14061 baseline and differential
Genevisibleⁱ	P14061 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021032 HPA065296

HPAⁱ

HPA021032
HPA065296

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Protein-protein interaction databases

BioGridⁱ	109525, 15 interactors
IntActⁱ	P14061, 2 interactors
STRINGⁱ	9606.ENSP00000466799

Chemistry databases

BindingDBⁱ

P14061

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 9	Combined sources	6
Helixⁱ	14 – 24	Combined sources	11
Beta strandⁱ	31 – 38	Combined sources	8
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	44 – 52	Combined sources	9
Beta strandⁱ	59 – 64	Combined sources	6
Helixⁱ	70 – 78	Combined sources	9
Beta strandⁱ	86 – 90	Combined sources	5
Helixⁱ	100 – 102	Combined sources	3
Helixⁱ	105 – 115	Combined sources	11
Helixⁱ	117 – 133	Combined sources	17
Beta strandⁱ	136 – 143	Combined sources	8
Helixⁱ	144 – 146	Combined sources	3
Helixⁱ	154 – 174	Combined sources	21
Helixⁱ	175 – 177	Combined sources	3
Beta strandⁱ	179 – 186	Combined sources	8
Beta strandⁱ	189 – 192	Combined sources	4
Turnⁱ	193 – 196	Combined sources	4
Helixⁱ	201 – 206	Combined sources	6
Helixⁱ	210 – 230	Combined sources	21
Helixⁱ	234 – 246	Combined sources	13
Beta strandⁱ	252 – 256	Combined sources	5
Beta strandⁱ	258 – 260	Combined sources	3
Helixⁱ	261 – 269	Combined sources	9
Helixⁱ	274 – 285	Combined sources	12

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00023
ProteinModelPortalⁱ	P14061
SMRⁱ	P14061
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P14061

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1205 Eukaryota COG1028 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148940
HOVERGENⁱ	HBG014077
InParanoidⁱ	P14061
KEGG Orthology (KO) More...KOⁱ	K00044
PhylomeDBⁱ	P14061

Family and domain databases

InterProⁱ	View protein in InterPro IPR011348 17beta_DH IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PIRSFⁱ	PIRSF000095 17beta-HSD, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.ⁱShow all

P14061-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA 
        60         70         80         90        100
RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL 
       110        120        130        140        150
EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL 
       160        170        180        190        200
PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS 
       210        220        230        240        250
PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP 
       260        270        280        290        300
TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 
       310        320 
GAGPGAEDEA GRGAVGDPEL GDPPAAPQ

Length:328

Mass (Da):34,950

Last modified:November 30, 2010 - v3

Checksum:ⁱ5B5C8909F9120832

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A0A0MQS7	A0A0A0MQS7_HUMAN		Estradiol 17-beta-dehydrogenase 1 Estradiol 17-beta-dehydrogenase 1	HSD17B1	329	Annotation score:
	B4DU11	B4DU11_HUMAN		Estradiol 17-beta-dehydrogenase 1 Estradiol 17-beta-dehydrogenase 1 (cDNA FLJ50217, highly similar to Estradiol 17-beta-dehydrogenase 1)	HSD17B1	149	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3	R → E AA sequence (PubMed:5045524).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_006951	238	A → V1 PublicationCorresponds to variant dbSNP:rs147402365Ensembl.		1
Natural variantⁱVAR_006952	313	G → S10 PublicationsCorresponds to variant dbSNP:rs605059Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13440 mRNA Translation: CAA31792.1 M36263 mRNA Translation: AAA35600.1 M27138 Genomic DNA Translation: AAB16941.1 M84472 Genomic DNA Translation: AAB16942.1 U34879 Genomic DNA Translation: AAD05019.1 AK127832 mRNA Translation: BAG54583.1 AC067852 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60836.1 BC104752 mRNA Translation: AAI04753.1 BC111935 mRNA Translation: AAI11936.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11428.1
PIRⁱ	A36081 DEHUE7
NCBI Reference Sequences More...RefSeqⁱ	NP_000404.2, NM_000413.3
UniGeneⁱ	Hs.654385 Hs.655222

Genome annotation databases

Ensemblⁱ	ENST00000585807; ENSP00000466799; ENSG00000108786
GeneIDⁱ	3292
KEGGⁱ	hsa:3292
UCSC genome browser More...UCSCⁱ	uc002hzw.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14061	Hydroxysteroid (17-beta) dehydrogenase 1 isoform		HUMAN		359	UniRef90_P14061
Uncharacterized protein		PANPA		351
UPI000CEFFD19		PONAB		355
Estradiol 17-beta-dehydrogenase 1		HUMAN		329
UPI000011035B		HUMAN		289
+3

Protein	Similar proteins		Species	Score	Length	Source
P14061	Estradiol 17-beta-dehydrogenase 1		PANTR		328	UniRef50_P14061
Estradiol 17-beta-dehydrogenase 1		MOUSE		344
Estradiol 17-beta-dehydrogenase 1		RAT		344
Hydroxysteroid (17-beta) dehydrogenase 1 isoform		HUMAN		359
Uncharacterized protein		PANPA		351
+105

Cross-referencesⁱ

Web resourcesⁱ

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13440 mRNA Translation: CAA31792.1 M36263 mRNA Translation: AAA35600.1 M27138 Genomic DNA Translation: AAB16941.1 M84472 Genomic DNA Translation: AAB16942.1 U34879 Genomic DNA Translation: AAD05019.1 AK127832 mRNA Translation: BAG54583.1 AC067852 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60836.1 BC104752 mRNA Translation: AAI04753.1 BC111935 mRNA Translation: AAI11936.1
CCDSⁱ	CCDS11428.1
PIRⁱ	A36081 DEHUE7
RefSeqⁱ	NP_000404.2, NM_000413.3
UniGeneⁱ	Hs.654385 Hs.655222

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A27	X-ray	1.90	A	2-290	[»]
	1BHS	X-ray	2.20	A	2-328	[»]
	1DHT	X-ray	2.24	A	2-328	[»]
	1EQU	X-ray	3.00	A/B	2-328	[»]
	1FDS	X-ray	1.70	A	2-328	[»]
	1FDT	X-ray	2.20	A	2-328	[»]
	1FDU	X-ray	2.70	A/B/C/D	2-328	[»]
	1FDV	X-ray	3.10	A/B/C/D	2-328	[»]
	1FDW	X-ray	2.70	A	2-328	[»]
	1I5R	X-ray	1.60	A	2-328	[»]
	1IOL	X-ray	2.30	A	2-328	[»]
	1JTV	X-ray	1.54	A	2-328	[»]
	1QYV	X-ray	1.81	A	2-328	[»]
	1QYW	X-ray	1.63	A	2-328	[»]
	1QYX	X-ray	1.89	A	2-328	[»]
	3DEY	X-ray	1.70	X	2-328	[»]
	3DHE	X-ray	2.30	A	2-328	[»]
	3HB4	X-ray	2.21	X	2-328	[»]
	3HB5	X-ray	2.00	X	2-328	[»]
	3KLM	X-ray	1.70	X	2-328	[»]
	3KLP	X-ray	2.50	X	2-328	[»]
	3KM0	X-ray	2.30	A/B	2-328	[»]
DisProtⁱ	DP00023
ProteinModelPortalⁱ	P14061
SMRⁱ	P14061
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109525, 15 interactors
IntActⁱ	P14061, 2 interactors
STRINGⁱ	9606.ENSP00000466799

Chemistry databases

BindingDBⁱ	P14061
ChEMBLⁱ	CHEMBL3181
DrugBankⁱ	DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose DB01536 4-Androstenedione DB01561 Androstanedione DB02901 Dihydrotestosterone DB02323 EM-1745 DB02187 Equilin DB00157 NADH DB01708 Prasterone
SwissLipidsⁱ	SLP:000001218

PTM databases

SwissPalmⁱ	P14061

SwissPalmⁱ

P14061

Polymorphism and mutation databases

BioMutaⁱ	HSD17B1
DMDMⁱ	313104233

Proteomic databases

PaxDbⁱ	P14061
PeptideAtlasⁱ	P14061
PRIDEⁱ	P14061
ProteomicsDBⁱ	53018

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000585807; ENSP00000466799; ENSG00000108786
GeneIDⁱ	3292
KEGGⁱ	hsa:3292
UCSCⁱ	uc002hzw.4 human

Organism-specific databases

CTDⁱ	3292
DisGeNETⁱ	3292
EuPathDBⁱ	HostDB:ENSG00000108786.10
GeneCardsⁱ	HSD17B1
H-InvDBⁱ	HIX0202506
HGNCⁱ	HGNC:5210 HSD17B1
HPAⁱ	HPA021032 HPA065296
MIMⁱ	109684 gene
neXtProtⁱ	NX_P14061
OpenTargetsⁱ	ENSG00000108786
PharmGKBⁱ	PA29478
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1205 Eukaryota COG1028 LUCA
GeneTreeⁱ	ENSGT00920000148940
HOVERGENⁱ	HBG014077
InParanoidⁱ	P14061
KOⁱ	K00044
PhylomeDBⁱ	P14061

Enzyme and pathway databases

UniPathwayⁱ	UPA00769
BRENDAⁱ	1.1.1.62 2681
Reactomeⁱ	R-HSA-193144 Estrogen biosynthesis R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SABIO-RKⁱ	P14061

Miscellaneous databases

EvolutionaryTraceⁱ	P14061
GeneWikiⁱ	HSD17B1
GenomeRNAiⁱ	3292
Protein Ontology More...PROⁱ	PR:P14061
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108786 Expressed in 114 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_HSD17B1
ExpressionAtlasⁱ	P14061 baseline and differential
Genevisibleⁱ	P14061 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011348 17beta_DH IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PIRSFⁱ	PIRSF000095 17beta-HSD, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHB1_HUMAN
Accessionⁱ	P14061Primary (citable) accession number: P14061 Secondary accession number(s): B3KXS1, Q2M2L8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	November 30, 2010
	Last modified:	September 12, 2018
	This is version 196 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P14061 (DHB1_HUMAN)

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Estradiol 17-beta-dehydrogenase 1

HSD17B1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: estrogen biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: estrogen biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ